JPS53121998A - Preparation of maytansiol, maytansine and maytansinol propionate - Google Patents

Preparation of maytansiol, maytansine and maytansinol propionate

Info

Publication number
JPS53121998A
JPS53121998A JP3716777A JP3716777A JPS53121998A JP S53121998 A JPS53121998 A JP S53121998A JP 3716777 A JP3716777 A JP 3716777A JP 3716777 A JP3716777 A JP 3716777A JP S53121998 A JPS53121998 A JP S53121998A
Authority
JP
Japan
Prior art keywords
maytansine
maytansiol
preparation
maytansinol
propionate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3716777A
Other languages
Japanese (ja)
Other versions
JPS6010718B2 (en
Inventor
Eiji Higashide
Mitsuko Asai
Seiichi Tanida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP52037167A priority Critical patent/JPS6010718B2/en
Priority to US05/811,442 priority patent/US4151042A/en
Priority to AU29073/77A priority patent/AU507869B2/en
Priority to SU772533351A priority patent/SU938746A3/en
Priority to FR7730340A priority patent/FR2385798A1/en
Priority to YU02437/77A priority patent/YU243777A/en
Priority to CS776677A priority patent/CS214881B2/en
Priority to SE7711543A priority patent/SE7711543L/en
Priority to HU77TA1458A priority patent/HU177391B/en
Priority to NL7711273A priority patent/NL7711273A/en
Priority to CA288,732A priority patent/CA1092999A/en
Priority to DE2746253A priority patent/DE2746253C2/en
Priority to DK458977A priority patent/DK143570C/en
Priority to AT736377A priority patent/AT362058B/en
Priority to CH1260477A priority patent/CH631740A5/en
Priority to IE2100/77A priority patent/IE45888B1/en
Priority to GB42821/77A priority patent/GB1554395A/en
Priority to ES463206A priority patent/ES463206A1/en
Priority to PL1977201539A priority patent/PL108863B1/en
Priority to IT21819/78A priority patent/IT1094003B/en
Priority to PT67853A priority patent/PT67853B/en
Publication of JPS53121998A publication Critical patent/JPS53121998A/en
Publication of JPS6010718B2 publication Critical patent/JPS6010718B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PURPOSE: To prepare maytansine, maytansinol, and maytansinol propionate, useful as antitumor substances, from cells and cultivation medium obtained by the cultivation of microbials belonging to Nocardia genus.
COPYRIGHT: (C)1978,JPO&Japio
JP52037167A 1977-03-31 1977-03-31 Process for producing maytansinol, maytanacin and maytansinol propionate Expired JPS6010718B2 (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
JP52037167A JPS6010718B2 (en) 1977-03-31 1977-03-31 Process for producing maytansinol, maytanacin and maytansinol propionate
US05/811,442 US4151042A (en) 1977-03-31 1977-06-29 Method for producing maytansinol and its derivatives
AU29073/77A AU507869B2 (en) 1977-03-31 1977-09-23 Microbiological production of maytansinol and its derivatives
SU772533351A SU938746A3 (en) 1977-03-31 1977-10-07 Process for producing alkoloids of methanezinol, methaneacine and methanezinol propionate
FR7730340A FR2385798A1 (en) 1977-03-31 1977-10-07 PROCESS FOR THE PRODUCTION OF MAYTANSINOL AND ITS DERIVATIVES BY MICROBIOLOGICAL USE
YU02437/77A YU243777A (en) 1977-03-31 1977-10-10 Process for producing maytansinol and derivatives thereof
CS776677A CS214881B2 (en) 1977-03-31 1977-10-13 Method of making the maytanacine or maytanasinol propionate
SE7711543A SE7711543L (en) 1977-03-31 1977-10-13 PROCEDURE FOR MAKING MAYTANSINOL, MAYTANACIN OR MAYTANSINOL PROPIONATE
HU77TA1458A HU177391B (en) 1977-03-31 1977-10-13 Process for producing maytanzinol and derivatives
NL7711273A NL7711273A (en) 1977-03-31 1977-10-13 PROCESS FOR THE PREPARATION OF MAYTANSINOL AND ITS DEVICES.
CA288,732A CA1092999A (en) 1977-03-31 1977-10-14 Method for producing maytansinol and its derivatives
DE2746253A DE2746253C2 (en) 1977-03-31 1977-10-14 Process for the preparation of Maytansinol and its derivatives
DK458977A DK143570C (en) 1977-03-31 1977-10-14 METHOD OF PREPARING MAYTANSINOL, MAYTANACIN AND / OR MAYTANSINOL PROPIONATE
AT736377A AT362058B (en) 1977-03-31 1977-10-14 METHOD FOR PRODUCING THE ANTIBIOTICS MAYTANSINOL, MAYTANACIN AND MAYTANSINOL PROPIONATE
CH1260477A CH631740A5 (en) 1977-03-31 1977-10-14 Process for the preparation of maytansinol and its derivatives
IE2100/77A IE45888B1 (en) 1977-03-31 1977-10-14 Method for producing maytansinol and its derivatives
GB42821/77A GB1554395A (en) 1977-03-31 1977-10-14 Method for producing maytansinol and its derivatives
ES463206A ES463206A1 (en) 1977-03-31 1977-10-14 Method for producing maytansinol and its derivatives
PL1977201539A PL108863B1 (en) 1977-03-31 1977-10-15 Method of producing maytansinol and derivatives thereof
IT21819/78A IT1094003B (en) 1977-03-31 1978-03-30 PROCEDURE FOR PRODUCING MAITANSINOL AND ITS DERIVATIVES
PT67853A PT67853B (en) 1977-03-31 1978-03-30 Method for producing maytansinol and its derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52037167A JPS6010718B2 (en) 1977-03-31 1977-03-31 Process for producing maytansinol, maytanacin and maytansinol propionate

Publications (2)

Publication Number Publication Date
JPS53121998A true JPS53121998A (en) 1978-10-24
JPS6010718B2 JPS6010718B2 (en) 1985-03-19

Family

ID=12490032

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52037167A Expired JPS6010718B2 (en) 1977-03-31 1977-03-31 Process for producing maytansinol, maytanacin and maytansinol propionate

Country Status (20)

Country Link
JP (1) JPS6010718B2 (en)
AT (1) AT362058B (en)
AU (1) AU507869B2 (en)
CA (1) CA1092999A (en)
CH (1) CH631740A5 (en)
CS (1) CS214881B2 (en)
DE (1) DE2746253C2 (en)
DK (1) DK143570C (en)
ES (1) ES463206A1 (en)
FR (1) FR2385798A1 (en)
GB (1) GB1554395A (en)
HU (1) HU177391B (en)
IE (1) IE45888B1 (en)
IT (1) IT1094003B (en)
NL (1) NL7711273A (en)
PL (1) PL108863B1 (en)
PT (1) PT67853B (en)
SE (1) SE7711543L (en)
SU (1) SU938746A3 (en)
YU (1) YU243777A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6010720B2 (en) * 1977-11-18 1985-03-19 武田薬品工業株式会社 Production method of antibiotic C-15003 P-4
JPS6016236B2 (en) * 1977-11-18 1985-04-24 武田薬品工業株式会社 Production method of antibiotic C-15003 P-3
JPS55162791A (en) * 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
EP0028683A1 (en) * 1979-09-21 1981-05-20 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PHO and production thereof
US6573074B2 (en) * 2000-04-12 2003-06-03 Smithkline Beecham Plc Methods for ansamitocin production
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US7432088B2 (en) 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
CN116239607B (en) * 2023-01-04 2024-04-09 山东大学 Maytansine derivative and biosynthesis method and application thereof

Also Published As

Publication number Publication date
NL7711273A (en) 1978-10-03
PL201539A1 (en) 1978-09-25
AU2907377A (en) 1979-03-29
DE2746253C2 (en) 1986-08-21
FR2385798A1 (en) 1978-10-27
PT67853A (en) 1978-04-01
AU507869B2 (en) 1980-02-28
PT67853B (en) 1980-05-05
IT1094003B (en) 1985-07-26
IT7821819A0 (en) 1978-03-30
CS214881B2 (en) 1982-06-25
IE45888L (en) 1978-09-30
DK143570C (en) 1982-02-08
PL108863B1 (en) 1980-05-31
SU938746A3 (en) 1982-06-23
DK143570B (en) 1981-09-07
AT362058B (en) 1981-04-27
GB1554395A (en) 1979-10-17
ES463206A1 (en) 1978-08-16
DE2746253A1 (en) 1978-10-05
YU243777A (en) 1982-06-30
JPS6010718B2 (en) 1985-03-19
CA1092999A (en) 1981-01-06
SE7711543L (en) 1978-10-01
DK458977A (en) 1978-10-01
HU177391B (en) 1981-09-28
FR2385798B1 (en) 1980-04-25
CH631740A5 (en) 1982-08-31
ATA736377A (en) 1980-09-15
IE45888B1 (en) 1982-12-29

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