KR920002795A - 항생제 발히마이신, 이의 제조방법 및 약제로서 이의 용도 - Google Patents

항생제 발히마이신, 이의 제조방법 및 약제로서 이의 용도 Download PDF

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KR920002795A
KR920002795A KR1019910012751A KR910012751A KR920002795A KR 920002795 A KR920002795 A KR 920002795A KR 1019910012751 A KR1019910012751 A KR 1019910012751A KR 910012751 A KR910012751 A KR 910012751A KR 920002795 A KR920002795 A KR 920002795A
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루드라 나드카르니 수레쉬
차테르지 수가타
비탈브하이 파텔 마헤쉬
라자고팔란 데시칸 칼리아나푸람
코테스와라 사트야 비자야쿠마 에라
나레쉬 강굴리 비말
블룸바흐 위르겐
훼흘하버 한스-볼프람
코글러 헤르베르트
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이센브룩, 라피체
훽스트 아크티엔게젤샤프트
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Abstract

내용 없음

Description

항생제 발히마이신, 이의 제조방법 및 약제로서 이의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 HPLC에서 발히마이신의 보유시간(retention time)을 나타낸다.
제2도는 H NMR(400MHz D2O, 300K)을 나타낸다.

Claims (12)

  1. 분자식 C66H73Cl2N9O24의 화합물인 발히마이신 및 약제학적으로 허용가능한 이의 염.
  2. 악티모마이세트 종 Y-86.21022(DAM 5809) 생산 미생물을 배양하고 이어서 배양 브로쓰로부터 분리 및 정제하여 수득할 수 있는 분자식 C66H73Cl2N9O24의 화합물인 발히마이신 및 약제학적으로 허용가능한 이의 염.
  3. 악티노마이세트 종 Y-86.21022(DAM 5809), 이의 돌연변이체 및/또는 변종을 탄소 및 질소원, 무기 영양염및 미량 원소를 함유하는 영양 배지 중에서 호기 조건하에 배양하고 통상적인 방법으로 화합물을 분리 및 정제함을 특징으로 하여, 제1항 또는 제2항에 청구된 발히마이신을 제조하는 방법.
  4. 제3항에 있어서, 배양을 약 28 내지 32℃의 온도 및 약 6 내지 8의 pH에서 수행하는 방법.
  5. 제3항 또는 제4항에서, 배양을 29℃(±1℃) 및 pH 약 7.0에서 수행하는 방법.
  6. 제3항 내지 제5항 중 어느 한 항에 있어서, 발효를 68 내지 72시간 동안 수행하는 방법.
  7. 제3항 내지 제6항중 어느 한 항에 있어서, 발효를 함침 발효로서 수행하는 방법.
  8. 제1항의 화합물 및, 필요한 경우, 추가로 약제 제조시에 통상적인 보조제 및/또는 부형제를 함유하는 약제.
  9. 항생 작용을 갖는 약제의 제조를 위한 제1항의 화합물의 용도.
  10. 항생제 생합성의 조절을 위한 생화학적 조절제로서의 제1항의 화합물의 용도.
  11. 악티노마이세트 종 Y-86.21022(DAM 5809).
  12. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910012751A 1990-07-27 1991-07-25 항생제 발히마이신, 이의 제조방법 및 이를 포함하는 약제 KR100221687B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP90119883.8 1990-07-27
EP90114471 1990-07-27
EP90114471.7 1990-07-27
EP90119883 1990-10-17

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KR920002795A true KR920002795A (ko) 1992-02-28
KR100221687B1 KR100221687B1 (ko) 1999-10-01

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EP (1) EP0468504B1 (ko)
JP (1) JP3119680B2 (ko)
KR (1) KR100221687B1 (ko)
AT (1) ATE159261T1 (ko)
AU (1) AU648570B2 (ko)
CA (1) CA2047997C (ko)
CY (1) CY2114B1 (ko)
CZ (1) CZ282296B6 (ko)
DE (1) DE69127935T2 (ko)
DK (1) DK0468504T3 (ko)
ES (1) ES2108022T3 (ko)
FI (1) FI101402B1 (ko)
GR (1) GR3025433T3 (ko)
HR (1) HRP940710B1 (ko)
HU (1) HU215146B (ko)
IE (1) IE912643A1 (ko)
IL (1) IL98958A0 (ko)
IN (1) IN171883B (ko)
NO (1) NO305132B1 (ko)
NZ (1) NZ239130A (ko)
PT (1) PT98444B (ko)
RU (1) RU2043418C1 (ko)
YU (1) YU48601B (ko)

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TW213468B (ko) * 1991-06-29 1993-09-21 Hoechst Ag
US5721208A (en) * 1991-06-29 1998-02-24 Hoechst Aktiengesellschaft Glycopeptides a process for their preparation and their use
DE19523394A1 (de) * 1995-06-28 1997-01-09 Hoechst Ag Verwendung von Balhimycin zur Leistungssteigerung bei Tieren sowie leistungssteigernde Mittel
US6509177B1 (en) 1999-02-03 2003-01-21 Biogal Gyogyszergyar Rt. Process for the preparation of pseudomonic acid A antibiotic by microbiological method
DE19926770A1 (de) 1999-06-11 2000-12-14 Basf Ag Nukleinsäurefragment und Vektor, enthaltend eine Halogenase, sowie ein Verfahren zur Halogenierung chemischer Verbindungen

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US3067099A (en) * 1955-09-16 1962-12-04 Lilly Co Eli Vancomycin and method for its preparation

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FI913569A0 (fi) 1991-07-25
HUT61606A (en) 1993-01-28
PT98444A (pt) 1992-05-29
YU48601B (sh) 1998-12-23
CA2047997C (en) 2002-04-30
CS233491A3 (en) 1992-03-18
IL98958A0 (en) 1992-07-15
DK0468504T3 (da) 1998-06-02
JP3119680B2 (ja) 2000-12-25
HRP940710A2 (en) 1997-06-30
JPH04261200A (ja) 1992-09-17
ATE159261T1 (de) 1997-11-15
YU128491A (sh) 1994-12-28
NO305132B1 (no) 1999-04-06
CZ282296B6 (cs) 1997-06-11
EP0468504A1 (en) 1992-01-29
HU215146B (hu) 2000-03-28
DE69127935T2 (de) 1998-03-19
NZ239130A (en) 1993-09-27
FI101402B (fi) 1998-06-15
IE912643A1 (en) 1992-01-29
NO912931L (no) 1992-01-28
HRP940710B1 (en) 2001-02-28
PT98444B (pt) 1999-01-29
KR100221687B1 (ko) 1999-10-01
EP0468504B1 (en) 1997-10-15
CY2114B1 (en) 2002-04-26
DE69127935D1 (de) 1997-11-20
HU912516D0 (en) 1992-01-28
AU648570B2 (en) 1994-04-28
CA2047997A1 (en) 1992-01-28
GR3025433T3 (en) 1998-02-27
NO912931D0 (no) 1991-07-26
AU8145391A (en) 1992-01-30
FI101402B1 (fi) 1998-06-15
FI913569A (fi) 1992-01-28
IN171883B (ko) 1993-01-30
RU2043418C1 (ru) 1995-09-10
ES2108022T3 (es) 1997-12-16

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