YU128491A - Postupak za dobijanje novog antibiotika balhimycina, njegovih mutanata i/ili varijanata i njegove farmakološke prihv. soli - Google Patents

Postupak za dobijanje novog antibiotika balhimycina, njegovih mutanata i/ili varijanata i njegove farmakološke prihv. soli

Info

Publication number
YU128491A
YU128491A YU128491A YU128491A YU128491A YU 128491 A YU128491 A YU 128491A YU 128491 A YU128491 A YU 128491A YU 128491 A YU128491 A YU 128491A YU 128491 A YU128491 A YU 128491A
Authority
YU
Yugoslavia
Prior art keywords
mutants
variants
procedure
obtaining
new antibiotic
Prior art date
Application number
YU128491A
Other languages
English (en)
Other versions
YU48601B (sh
Inventor
S.R. Nadkarni
S. Chatterjee
M.V. Patel
K.R. Desikan
E.K.S. Vijayakumar
B.N. Ganguli
J. Blumbach
H. Fehlhaber
H. Kogler
Original Assignee
Hoechst Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag. filed Critical Hoechst Ag.
Priority to HRP-1284/91 priority Critical patent/HRP940710B1/xx
Publication of YU128491A publication Critical patent/YU128491A/sh
Publication of YU48601B publication Critical patent/YU48601B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C07K4/04—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/04—Actinomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVOG ANTIBIOTIKA BALHIMYCINA, NJEGOVIH MUTANATA I/ILI VARIJANATA I NJEGOVE FARMAKOLOSKE PRIHV. SOLI, pronalazak obuhvacen predmetnom prijavom odnosi se na postupak za dobijanje novog antibiotika Balhimycina molekulske formule C66H73Cl2N9O24 njegovih mutanata i ili varijanti kao i njihovih farmaceutski prihvatljivih soli. Predlozeni postupak obuhvata kultiviranje mikroorganizma Actinomycete Y-86,21022 deponovanog u Deutsche Sammlung von Mikroorganismen pod br. DSM 5908, njegovih mutanata i ili varijanti u aerobnim uslovima u hranljivoj podlozi koja sadrzi izvore ugljenika i azota, neorganske hranljive soli i elemente teskih metala u tragovima; izolovanje i preciscavanje navedenog antibiotika iz fermentacione corbe. Kao izvor ugljenika upotrebljavaju se: skrob, glukoza, saharoza, dekstrin, fruktoza, melasa, glicerin, laktoza ili galaktoza; dok je izvor azota sojino brasno, brasno od kikirikija, ekstrakt kvasca, pepton, ekstrakt slada, ekstrakt kukuruza, zelatin ili kazamino kiseline. Izvor hranljivih neorganskih soli cine: natrijum hidro fosfat, kalijum hidro fosfat, natrijum hlorid, kalcijum hlorid, kalcijum karbonat ili kalijum nitrat, amonijum sulfat ili magnezijum sulfat. Hranljiva podloga sadrzi jos u tragovima: soli gvozdja, mangana, bakra, cinka, kobalta ili drugih teskih metala. Fermentacija kulture br. Y-86,21022 se izvodi na temperaturi izmedju 28 i 32°C, pri Ph 6,0 - 8,0; u trajanju od 60 - 72 casa u okruglim sudovima, uz vibraciju. Izolovanje i preciscavanje Balhmycina se izvodi na uobicajeni nacin, adsorbcijom ili eluiranjem. Aktivni elnat koji sadrze Balhimycin se koncentruju a potom preciscavaju brojnim poznatim postupcima kao sto su readsorpcija i eluiranje, filtriranje na gelu, hromatografija sa jonskim izmenjivacima i dr. Dobijeni antibiotik Balhimycin se moze prevesti u njegove farmakoloski prihvatljive soli neorganskim ili organskim kiselinama kao sto su HCl, H2SO4, limunska, mlecna, cilibarna, sircetna ilitrifluorsircetna kiselina, na poznat nacin.
YU128491A 1990-07-27 1991-07-22 Postupak za dobijanje novog antibiotika balhimycina YU48601B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HRP-1284/91 HRP940710B1 (en) 1990-07-27 1994-10-20 A novel antibiotic, balhimycin, a process for its production and its use as pharmaceutical

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90114471 1990-07-27
EP90119883 1990-10-17

Publications (2)

Publication Number Publication Date
YU128491A true YU128491A (sh) 1994-12-28
YU48601B YU48601B (sh) 1998-12-23

Family

ID=26125378

Family Applications (1)

Application Number Title Priority Date Filing Date
YU128491A YU48601B (sh) 1990-07-27 1991-07-22 Postupak za dobijanje novog antibiotika balhimycina

Country Status (23)

Country Link
EP (1) EP0468504B1 (sh)
JP (1) JP3119680B2 (sh)
KR (1) KR100221687B1 (sh)
AT (1) ATE159261T1 (sh)
AU (1) AU648570B2 (sh)
CA (1) CA2047997C (sh)
CY (1) CY2114B1 (sh)
CZ (1) CZ282296B6 (sh)
DE (1) DE69127935T2 (sh)
DK (1) DK0468504T3 (sh)
ES (1) ES2108022T3 (sh)
FI (1) FI101402B (sh)
GR (1) GR3025433T3 (sh)
HR (1) HRP940710B1 (sh)
HU (1) HU215146B (sh)
IE (1) IE912643A1 (sh)
IL (1) IL98958A0 (sh)
IN (1) IN171883B (sh)
NO (1) NO305132B1 (sh)
NZ (1) NZ239130A (sh)
PT (1) PT98444B (sh)
RU (1) RU2043418C1 (sh)
YU (1) YU48601B (sh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721208A (en) * 1991-06-29 1998-02-24 Hoechst Aktiengesellschaft Glycopeptides a process for their preparation and their use
TW213468B (sh) * 1991-06-29 1993-09-21 Hoechst Ag
DE19523394A1 (de) * 1995-06-28 1997-01-09 Hoechst Ag Verwendung von Balhimycin zur Leistungssteigerung bei Tieren sowie leistungssteigernde Mittel
US6509177B1 (en) 1999-02-03 2003-01-21 Biogal Gyogyszergyar Rt. Process for the preparation of pseudomonic acid A antibiotic by microbiological method
DE19926770A1 (de) 1999-06-11 2000-12-14 Basf Ag Nukleinsäurefragment und Vektor, enthaltend eine Halogenase, sowie ein Verfahren zur Halogenierung chemischer Verbindungen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3067099A (en) * 1955-09-16 1962-12-04 Lilly Co Eli Vancomycin and method for its preparation

Also Published As

Publication number Publication date
ATE159261T1 (de) 1997-11-15
PT98444B (pt) 1999-01-29
NO912931L (no) 1992-01-28
IN171883B (sh) 1993-01-30
FI913569A0 (fi) 1991-07-25
CA2047997C (en) 2002-04-30
RU2043418C1 (ru) 1995-09-10
JP3119680B2 (ja) 2000-12-25
HRP940710A2 (en) 1997-06-30
EP0468504B1 (en) 1997-10-15
HU215146B (hu) 2000-03-28
JPH04261200A (ja) 1992-09-17
AU8145391A (en) 1992-01-30
ES2108022T3 (es) 1997-12-16
IL98958A0 (en) 1992-07-15
FI101402B1 (fi) 1998-06-15
KR100221687B1 (ko) 1999-10-01
DE69127935D1 (de) 1997-11-20
AU648570B2 (en) 1994-04-28
CA2047997A1 (en) 1992-01-28
YU48601B (sh) 1998-12-23
GR3025433T3 (en) 1998-02-27
PT98444A (pt) 1992-05-29
NO305132B1 (no) 1999-04-06
EP0468504A1 (en) 1992-01-29
CS233491A3 (en) 1992-03-18
DK0468504T3 (da) 1998-06-02
HRP940710B1 (en) 2001-02-28
CY2114B1 (en) 2002-04-26
NZ239130A (en) 1993-09-27
IE912643A1 (en) 1992-01-29
HU912516D0 (en) 1992-01-28
HUT61606A (en) 1993-01-28
DE69127935T2 (de) 1998-03-19
FI913569A (fi) 1992-01-28
CZ282296B6 (cs) 1997-06-11
KR920002795A (ko) 1992-02-28
FI101402B (fi) 1998-06-15
NO912931D0 (no) 1991-07-26

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