KR890005139A - 테이코플라닌 유사 유도체 - Google Patents

테이코플라닌 유사 유도체 Download PDF

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Publication number
KR890005139A
KR890005139A KR1019880008743A KR880008743A KR890005139A KR 890005139 A KR890005139 A KR 890005139A KR 1019880008743 A KR1019880008743 A KR 1019880008743A KR 880008743 A KR880008743 A KR 880008743A KR 890005139 A KR890005139 A KR 890005139A
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South Korea
Prior art keywords
compound according
actinoplanes
mixture
teicoplanin
strain
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KR1019880008743A
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English (en)
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란치니 기안카를로
보르기 안젤로
안토니니 피에로
팔룸보 라파엘레
Original Assignee
레나토 스가르비
그루포 레페리트 에스. 피. 에이.
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Application filed by 레나토 스가르비, 그루포 레페리트 에스. 피. 에이. filed Critical 레나토 스가르비
Publication of KR890005139A publication Critical patent/KR890005139A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/827—Actinoplanes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Luminescent Compositions (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)

Abstract

내용 없음

Description

테이코플라닌 유사 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 화합물의 A의1H-NMR 스팩트럼임.
제2도는 화합물의 B의1H-NMR 스펙트럼임.

Claims (12)

  1. 하기 일반식의 테이코플라닌-유사 유도체, 또는 그의 산 또는 염기와의 부가염
    상기 식 중, R은 6-메틸옥타노일 및 n-노나노일기이다.
  2. 약제로서 용도의 제1항에 의한 화합물.
  3. 제1항에 의한 화합물의 동물 성장 인자로서의 용도.
  4. 호기성 조건 하에, 20°및 40℃에서, 탄소, 질소 및 무기염류와 같은 동화할 수 있는 공급원을 함유하는 수용성 영양 배지 중에서 악티노플라네스 테이코마이세티구스(Actinoplanes teichomyceticus) 균주를 배양시키고, 크로마토그라피에 의해 여과된 발효 육즙에서 상기 2가지 생성물을 조 단리물의 기타 성분과 분리시킴으로 되는, 제1항에 의한 화합물의 제조방법.
  5. 제4항에 있어서, 악티노플라네스 테이코마이세티쿠스 균주가 제1항에 의한 화합물을 생성할 수 있는 악티노플라네스 테이코마이세티쿠스 ATCC 53649 또는 그의 돌연변이체 또는 변종인 방법.
  6. 제4항 또는 제5항에 있어서, 여과된 발효 육즙에서 얻은 조 단리물은, 여과된 발효 육즙을 pH 7 및 8에서 고정시킨 D-알라닌-D-알라닌 친화 매트릭스와 접촉시키고, 매트릭스를 pH 9 및 11에서 수용성 염기로 용출시키고, 제1항에 의한 테이코플라닌-유사 화합물의 실행가능량을 함유하는 분획물을 모으고, 모은 분획물을 한외 여과하여 농축시킨 후, 농축물을 동결 건조시켜 얻은 방법.
  7. 제4항 내지 제6항 중 어느 하나의 항에 있어서, 여과된 발효 육즙에서 제1항의 화합물을 조 단리물의 기타 성분과 분리시키는 방법이 이동상으로서 암모늄 포르메이트 수용액; 아세토니트릴 혼합물의 선형단계 구배 혼합물을 사용하여 반-예비 HPLC함으로써 행하는 방법.
  8. 제7항에 있어서, 이동상으로서 사용되는 혼합물이 0.02M 암모늄 포르메이트/아세토니트릴 95:5 및 0.02M 암모늄 포르메이트/아세토니트릴 25:75인 방법.
  9. 악티노플라네스 테이코마이세티쿠스(Actinoplanes teichomyceticus)ATCC 53649.
  10. 제1항에 의한 화합물을 회수가능한 양으로 생성할 수 있는 악티노플라네스 테이코마이세티쿠스 ATCC 53649 균주 또는 그의 돌연변이체 또는 변종의 생물학적 순수 배양액.
  11. 항생 물질로서 사용하기 위한 의약품 제조에 있어서, 제1항에 의한 화합물의 용도.
  12. 제1항에 의한 화합물과 제약상 허용되는 담체의 혼합물로 되는 제약 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880008743A 1987-09-07 1988-07-14 테이코플라닌 유사 유도체 KR890005139A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878720980A GB8720980D0 (en) 1987-09-07 1987-09-07 Derivatives
GB8720980 1987-09-07

Publications (1)

Publication Number Publication Date
KR890005139A true KR890005139A (ko) 1989-05-13

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ID=10623385

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880008743A KR890005139A (ko) 1987-09-07 1988-07-14 테이코플라닌 유사 유도체

Country Status (10)

Country Link
US (1) US5085990A (ko)
EP (1) EP0306645B1 (ko)
JP (1) JPH0763387B2 (ko)
KR (1) KR890005139A (ko)
AT (1) ATE96845T1 (ko)
CA (1) CA1337645C (ko)
DE (1) DE3885394T2 (ko)
DK (1) DK347788A (ko)
ES (1) ES2059443T3 (ko)
GB (1) GB8720980D0 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135857A (en) * 1987-07-03 1992-08-04 Gruppo Lepetit S.P.A. Process for the preparation of de-mannosyl teicoplanin derivatives
DE68925951T2 (de) * 1988-12-27 1996-07-25 Lepetit Spa Chemisches Verfahren zur Herstellung des Antibiotikums L 17392 (Deglukoteicoplanin) und dessen Salze
US5167808A (en) * 1990-08-16 1992-12-01 S&K Products International, Inc. Deionized water purification system
HUT63860A (en) * 1990-12-05 1993-10-28 Lepetit Spa Process for producing 39-decarboxy-38-(hydroxymethyl) derivatives of teikoplanin antibiotics
CA2250578C (en) 1996-04-23 2003-06-24 Versicor Inc. Improved chemical process for preparing amide derivatives of antibiotic a 40926
US5916873A (en) * 1997-04-17 1999-06-29 Eli Lilly And Company Teicoplanin derivatives
DE19807972A1 (de) * 1998-02-25 1999-08-26 Hoechst Marion Roussel De Gmbh Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung
KR100459289B1 (ko) * 2002-05-30 2004-12-03 이연제약주식회사 발효액으로부터 테이코플라닌ａ₂의 회수방법
KR100476818B1 (ko) * 2002-07-19 2005-03-17 종근당바이오 주식회사 테이코플라닌 에이 투 정제 방법
EP3099703A4 (en) * 2014-01-28 2017-08-09 Academia Sinica Teicoplanin analogs and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1496386A (en) * 1975-03-05 1977-12-30 Lepetit Spa Antibiotics
ZA801629B (en) * 1979-04-07 1981-03-25 Lepetit Spa Antibiotic a/16686 and process for the preparation thereof
FI73697C (fi) * 1982-06-08 1987-11-09 Lepetit Spa Foerfarande foer framstaellning av individuella faktorer 1, 2, 3, 4 och 5 av teikomysin a2.
US4778846A (en) * 1983-07-13 1988-10-18 Smithkline Beckman Corporation Affinity chromatography sorbent
GB8512795D0 (en) * 1985-05-21 1985-06-26 Lepetit Spa Increasing ratio of components of teicoplanin a2 complex
US4694069A (en) * 1985-09-30 1987-09-15 Smithkline Beckman Corporation Kibdelosporangium aridum SK&F-AAD-609
GB8621911D0 (en) * 1986-09-11 1986-10-15 Lepetit Spa Increasing ratio of components of anti-biotic complex

Also Published As

Publication number Publication date
DK347788A (da) 1989-03-08
CA1337645C (en) 1995-11-28
DK347788D0 (da) 1988-06-24
DE3885394T2 (de) 1994-03-24
EP0306645B1 (en) 1993-11-03
DE3885394D1 (de) 1993-12-09
EP0306645A3 (en) 1990-07-04
JPS6468393A (en) 1989-03-14
US5085990A (en) 1992-02-04
ATE96845T1 (de) 1993-11-15
GB8720980D0 (en) 1987-10-14
EP0306645A2 (en) 1989-03-15
ES2059443T3 (es) 1994-11-16
JPH0763387B2 (ja) 1995-07-12

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