KR880004097A - 글리코펩티드 항생물질 - Google Patents

글리코펩티드 항생물질 Download PDF

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KR880004097A
KR880004097A KR870010365A KR870010365A KR880004097A KR 880004097 A KR880004097 A KR 880004097A KR 870010365 A KR870010365 A KR 870010365A KR 870010365 A KR870010365 A KR 870010365A KR 880004097 A KR880004097 A KR 880004097A
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nrrl
antibiotic
pharmaceutically acceptable
culture medium
nocardia orientalis
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KR870010365A
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KR960013093B1 (ko
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엘.하밀 로버트
알버트 메이브 제임스
프란시스 마호니 데이비드
미쯔오 나카쯔 카사 월터
체-퐁 야오 레이몬드
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마리 앤 터커
일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia

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Abstract

내용 없음

Description

글리코펩티드 항생물질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 A82846a의 1R 데이타를 도시한 것이다.
제2도는 A82846B의 1R 데이타를 도시한 것이다.
제3도는 A8286C의 1R 데이타를 도시한 것이다.

Claims (12)

  1. 노카르디아 오리엔탈리스 NRRL 18908, NRRL 18099 또는 NRRL 18100를 동화성 탄소원, 질소원 및 무기염원을 함유하는 배양 배지중에서 액침 호기적 발효시킴으로써 제조할 수 있는 글리코펩티드 항생물질.
  2. 항생물질 A 82846, 또는 약제학적으로 허용되는 이의 염.
  3. 항생물질 A 82846 A, 또는 약제학적으로 허용되는 이의 염.
  4. 항생물질 A 82846 B, 또는 약제학적으로 허용되는 이의 염.
  5. 항생물질 A 82846 C, 또는 약제학적으로 허용되는 이의 염.
  6. 노카르디아 오리엔탈리스 NRRL 18908, 18099 또는 18100, 또는 이의 A 82846-생성 후세대(progeny)를 적합한 배양 배지 중에서 액침 호기적 조건하에 충분량의 항균 활성이 생성될 때까지 배양시켜 제조한 항생물질 A 82846.
  7. 노카르디아 오리엔탈리스 NRRL 18099, 18098 또는 18100, 또는 이의 A 82846A-생성 후세대를 적합한 배양 배지 중에서 액침 호기적 조건하에 충분량의 항균 활성이 생성될 때까지 배양시켜 제조한 항생물질 A 82846A.
  8. 노카르디아 오리엔탈리스 NRRL 18908, 18099 또는 18100, 또는 이의 A 82846 B-생성 후세대를 적합한 배양 배지 중에서 액침 호기적 조건하에 충분량의 항균 활성이 생성될 때까지 배양시켜 제조한 항생물질 A 82846B.
  9. 노카르디아 오리엔탈리스 NRRL 18908, NRRL 18099 또는 18100, 또는 이의 A 82846-생성 후세대를 액침 호기적 발효 조건하에 동화성 탄소원, 질소원 및 무기염원을 함유하는 배양 배지 중에서 배양시키고, 이어서 임의로 발효 배지로부터 항생물질을 분리하고/하거나 염의 형태로 존재하지 않을 경우 항생물질을 염화(salification)시킴을 특징으로 하는 항생물질 A 82846, A 82846A, A 82846B 또는 A 82846C의 제조방법.
  10. 노카르디아 오리엔탈리스 NRRL 18908, NRRL 18099 또는 18100, 및 이의 A 82846-생성 후세대 중에서 선택된 생물학적으로 정제된 배양물.
  11. 활성성분으로서 제1항 내지 8항중 어느 한 항에 청구된 화합물과 이에 대한 하나 이상의 약제학적으로 허용되는 담체를 함유하는 약제학적 조성물.
  12. 활성성분으로서 제1항 내지 8항중 어느 한 항에 청구된 화합물과 이에 대한 하나 이상의 농경학적으로 허용되는 담체를 함유하는 동물사료 예비 혼합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870010365A 1986-09-19 1987-09-18 글리코펩티드 항생물질, 이의 제조방법 및 이를 포함하는 약제학적 조성물 KR960013093B1 (ko)

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US90979186A 1986-09-19 1986-09-19
US909,791 1986-09-19
US909791 1986-09-19

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US (2) US5312738A (ko)
EP (1) EP0265071B1 (ko)
JP (2) JP2634174B2 (ko)
KR (1) KR960013093B1 (ko)
CN (1) CN1061095C (ko)
AU (1) AU608534B2 (ko)
CA (1) CA1339033C (ko)
CY (1) CY1691A (ko)
DE (1) DE3782720T2 (ko)
DK (1) DK167689B1 (ko)
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FI (1) FI90993C (ko)
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HU (1) HU198964B (ko)
IE (1) IE60132B1 (ko)
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NZ (1) NZ221856A (ko)
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AU7865887A (en) 1988-03-24
KR960013093B1 (ko) 1996-09-30
CY1691A (en) 1994-01-14
PH24288A (en) 1990-05-29
HK44393A (en) 1993-05-14
AU608534B2 (en) 1991-04-11
FI90993C (fi) 1994-04-25
EG18377A (en) 1993-04-30
HU198964B (en) 1989-12-28
FI874082A (fi) 1988-03-20
EP0265071B1 (en) 1992-11-19
SU1724015A3 (ru) 1992-03-30
ES2052574T3 (es) 1994-07-16
PT85742A (en) 1987-10-01
HUT46365A (en) 1988-10-28
JPH09182581A (ja) 1997-07-15
DE3782720D1 (de) 1992-12-24
IE872529L (en) 1988-03-19
NZ221856A (en) 1991-12-23
DK167689B1 (da) 1993-12-06
DE3782720T2 (de) 1993-04-22
CN1061095C (zh) 2001-01-24
DK489787D0 (da) 1987-09-17
DK489787A (da) 1988-03-21
JP2806912B2 (ja) 1998-09-30
US5312738A (en) 1994-05-17
PT85742B (pt) 1990-06-29
US5843437A (en) 1998-12-01
CA1339033C (en) 1997-04-01
EP0265071A1 (en) 1988-04-27
JP2634174B2 (ja) 1997-07-23
JPS6393798A (ja) 1988-04-25
GR3006311T3 (ko) 1993-06-21
ZA877003B (en) 1989-04-26
CN87106483A (zh) 1988-06-08
IE60132B1 (en) 1994-06-01
MX168708B (es) 1993-06-04
FI874082A0 (fi) 1987-09-18
FI90993B (fi) 1994-01-14

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