CN101928331B - 一种化合物及其应用 - Google Patents
一种化合物及其应用 Download PDFInfo
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- CN101928331B CN101928331B CN200910053906.9A CN200910053906A CN101928331B CN 101928331 B CN101928331 B CN 101928331B CN 200910053906 A CN200910053906 A CN 200910053906A CN 101928331 B CN101928331 B CN 101928331B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
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- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
# | 测试用菌株性质 | LYV07ww01(MIC值) |
1 | 耐万古霉素肠球菌 | 128μg/ml |
2 | 耐万古霉素肠球菌 | 32μg/ml |
3 | 肠球菌 | 0.5μg/ml |
4 | MRSA | 0.5μg/ml |
5 | MRSA | 0.5μg/ml |
6 | MRSA | 0.5μg/ml |
7 | MRSA | 1μg/ml |
8 | MRSA | 0.5μg/ml |
9 | MRSA | 0.5μg/ml |
10 | MRSA | 0.5μg/ml |
11 | MRSA | 0.5μg/ml |
12 | MRSA | 0.5μg/ml |
13 | MRSA | 0.5μg/ml |
14 | MRSA | 0.5μg/ml |
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910053906.9A CN101928331B (zh) | 2009-06-26 | 2009-06-26 | 一种化合物及其应用 |
PCT/CN2010/074202 WO2010149016A1 (zh) | 2009-06-26 | 2010-06-22 | 一种新的化合物及其应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910053906.9A CN101928331B (zh) | 2009-06-26 | 2009-06-26 | 一种化合物及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101928331A CN101928331A (zh) | 2010-12-29 |
CN101928331B true CN101928331B (zh) | 2014-05-28 |
Family
ID=43367800
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910053906.9A Active CN101928331B (zh) | 2009-06-26 | 2009-06-26 | 一种化合物及其应用 |
Country Status (2)
Country | Link |
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CN (1) | CN101928331B (zh) |
WO (1) | WO2010149016A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107151264B (zh) * | 2011-03-23 | 2021-11-23 | 浙江医药股份有限公司新昌制药厂 | 新型糖肽类抗生素衍生物及药物组合物、以及其制备方法和用途 |
CN102690330B (zh) * | 2011-03-23 | 2014-10-08 | 浙江医药股份有限公司新昌制药厂 | 三取代糖肽类衍生物及药物组合物、以及其制备方法和用途 |
CN102690331B (zh) * | 2011-03-23 | 2015-05-20 | 浙江医药股份有限公司新昌制药厂 | 单糖糖肽类衍生物及药物组合物及其制备方法和用途以及中间体的制备方法 |
CN103897040B (zh) | 2012-12-27 | 2018-05-22 | 浙江医药股份有限公司新昌制药厂 | 新型糖肽类化合物或其药用盐及其制备方法、以及药物组合物和用途 |
CN107619433B (zh) * | 2016-07-15 | 2023-03-17 | 上海来益生物药物研究开发中心有限责任公司 | 糖肽类衍生物及其药学可接受的盐、制备方法和应用 |
CN108929860B (zh) * | 2017-05-23 | 2023-08-22 | 上海来益生物药物研究开发中心有限责任公司 | 一种产chloroeremomycin的基因工程菌及其制备方法和应用 |
CN108409837B (zh) | 2018-03-06 | 2021-09-24 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1052483A (zh) * | 1989-12-13 | 1991-06-26 | 伊莱利利公司 | 糖肽衍生物的改进及有关的糖肽衍生物 |
CN1276728A (zh) * | 1997-08-22 | 2000-12-13 | 伊莱利利公司 | 对金黄色葡萄球菌的治疗 |
CN1061095C (zh) * | 1986-09-19 | 2001-01-24 | 伊莱利利公司 | 糖肽抗生素的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5071749A (en) * | 1987-04-16 | 1991-12-10 | Shionogi & Co., Ltd. | Glycopetide antibiotic pa-45052-b |
CA1339808C (en) * | 1988-10-19 | 1998-04-07 | Manuel Debono | Glycopeptide antibiotics |
US6087143A (en) * | 1997-09-05 | 2000-07-11 | Eli Lilly And Company | Glycosyltransferase gene gtfA from Amycolatopsis orientalis |
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2009
- 2009-06-26 CN CN200910053906.9A patent/CN101928331B/zh active Active
-
2010
- 2010-06-22 WO PCT/CN2010/074202 patent/WO2010149016A1/zh active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1061095C (zh) * | 1986-09-19 | 2001-01-24 | 伊莱利利公司 | 糖肽抗生素的制备方法 |
CN1052483A (zh) * | 1989-12-13 | 1991-06-26 | 伊莱利利公司 | 糖肽衍生物的改进及有关的糖肽衍生物 |
CN1276728A (zh) * | 1997-08-22 | 2000-12-13 | 伊莱利利公司 | 对金黄色葡萄球菌的治疗 |
Non-Patent Citations (2)
Title |
---|
In Vitro Activity of LY264826, a New Glycopeptide Antibiotic, against Gram-Positive Bacteria Isolated from Patients with Cancer;Rolston K.等;《Antimicrobial Agents and Chemotherapy》;19901130;第34卷(第11期);第2137-2141页 * |
Rolston K.等.In Vitro Activity of LY264826, a New Glycopeptide Antibiotic, against Gram-Positive Bacteria Isolated from Patients with Cancer.《Antimicrobial Agents and Chemotherapy》.1990,第34卷(第11期),第2137-2141页. |
Also Published As
Publication number | Publication date |
---|---|
CN101928331A (zh) | 2010-12-29 |
WO2010149016A1 (zh) | 2010-12-29 |
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Effective date of registration: 20210811 Address after: 201109 room 318, building 2, No. 920, Jianchuan Road, Minhang District, Shanghai Patentee after: Shanghai Health Creation Center for Biopharmaceutical R&D Co.,Ltd. Patentee after: Zhejiang Medicine Co.,Ltd. Xinchang Pharmaceutical Factory Patentee after: Center for excellence and innovation in molecular plant science, Chinese Academy of Sciences Address before: 201203 floor 5, building 8, No. 200, Newton Road, Zhangjiang, Pudong, Shanghai Patentee before: Shanghai Health Creation Center for Biopharmaceutical R&D Co.,Ltd. Patentee before: Zhejiang Medicine Co.,Ltd. Xinchang Pharmaceutical Factory Patentee before: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES |