CN101928331A - 一种新的化合物及其应用 - Google Patents
一种新的化合物及其应用 Download PDFInfo
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- CN101928331A CN101928331A CN2009100539069A CN200910053906A CN101928331A CN 101928331 A CN101928331 A CN 101928331A CN 2009100539069 A CN2009100539069 A CN 2009100539069A CN 200910053906 A CN200910053906 A CN 200910053906A CN 101928331 A CN101928331 A CN 101928331A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
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- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
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Abstract
Description
# | 测试用菌株性质 | LYV07ww01(MIC值) |
1 | 耐万古霉素肠球菌 | 128μg/ml |
2 | 耐万古霉素肠球菌 | 32μg/ml |
3 | 肠球菌 | 0.5μg/ml |
4 | MRSA | 0.5μg/ml |
5 | MRSA | 0.5μg/ml |
6 | MRSA | 0.5μg/ml |
7 | MRSA | 1μg/ml |
8 | MRSA | 0.5μg/ml |
9 | MRSA | 0.5μg/ml |
10 | MRSA | 0.5μg/ml |
11 | MRSA | 0.5μg/ml |
12 | MRSA | 0.5μg/ml |
13 | MRSA | 0.5μg/ml |
14 | MRSA | 0.5μg/ml |
Claims (10)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910053906.9A CN101928331B (zh) | 2009-06-26 | 2009-06-26 | 一种化合物及其应用 |
PCT/CN2010/074202 WO2010149016A1 (zh) | 2009-06-26 | 2010-06-22 | 一种新的化合物及其应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910053906.9A CN101928331B (zh) | 2009-06-26 | 2009-06-26 | 一种化合物及其应用 |
Publications (2)
Publication Number | Publication Date |
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CN101928331A true CN101928331A (zh) | 2010-12-29 |
CN101928331B CN101928331B (zh) | 2014-05-28 |
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CN200910053906.9A Active CN101928331B (zh) | 2009-06-26 | 2009-06-26 | 一种化合物及其应用 |
Country Status (2)
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CN (1) | CN101928331B (zh) |
WO (1) | WO2010149016A1 (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102690331A (zh) * | 2011-03-23 | 2012-09-26 | 浙江医药股份有限公司新昌制药厂 | 单糖糖肽类衍生物及药物组合物及其制备方法和用途以及中间体的制备方法 |
CN102690330A (zh) * | 2011-03-23 | 2012-09-26 | 浙江医药股份有限公司新昌制药厂 | 三取代糖肽类衍生物及药物组合物、以及其制备方法和用途 |
CN102690332A (zh) * | 2011-03-23 | 2012-09-26 | 浙江医药股份有限公司新昌制药厂 | 新型糖肽类抗生素衍生物及药物组合物、以及其制备方法和用途 |
WO2014101294A1 (zh) | 2012-12-27 | 2014-07-03 | 浙江医药股份有限公司新昌制药厂 | 糖肽类化合物或其药用盐及其制备方法、以及药物组合物和用途 |
WO2018010476A1 (zh) * | 2016-07-15 | 2018-01-18 | 上海来益生物药物研究开发中心有限责任公司 | 糖肽类衍生物及其药学可接受的盐、制备方法和应用 |
CN108409837A (zh) * | 2018-03-06 | 2018-08-17 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用 |
CN108929860A (zh) * | 2017-05-23 | 2018-12-04 | 上海来益生物药物研究开发中心有限责任公司 | 一种产chloroeremomycin的基因工程菌及其制备方法和应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1052483A (zh) * | 1989-12-13 | 1991-06-26 | 伊莱利利公司 | 糖肽衍生物的改进及有关的糖肽衍生物 |
CN1276728A (zh) * | 1997-08-22 | 2000-12-13 | 伊莱利利公司 | 对金黄色葡萄球菌的治疗 |
CN1061095C (zh) * | 1986-09-19 | 2001-01-24 | 伊莱利利公司 | 糖肽抗生素的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5071749A (en) * | 1987-04-16 | 1991-12-10 | Shionogi & Co., Ltd. | Glycopetide antibiotic pa-45052-b |
CA1339808C (en) * | 1988-10-19 | 1998-04-07 | Manuel Debono | Glycopeptide antibiotics |
US6087143A (en) * | 1997-09-05 | 2000-07-11 | Eli Lilly And Company | Glycosyltransferase gene gtfA from Amycolatopsis orientalis |
-
2009
- 2009-06-26 CN CN200910053906.9A patent/CN101928331B/zh active Active
-
2010
- 2010-06-22 WO PCT/CN2010/074202 patent/WO2010149016A1/zh active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1061095C (zh) * | 1986-09-19 | 2001-01-24 | 伊莱利利公司 | 糖肽抗生素的制备方法 |
CN1052483A (zh) * | 1989-12-13 | 1991-06-26 | 伊莱利利公司 | 糖肽衍生物的改进及有关的糖肽衍生物 |
CN1276728A (zh) * | 1997-08-22 | 2000-12-13 | 伊莱利利公司 | 对金黄色葡萄球菌的治疗 |
Non-Patent Citations (1)
Title |
---|
ROLSTON K.等: "In Vitro Activity of LY264826, a New Glycopeptide Antibiotic, against Gram-Positive Bacteria Isolated from Patients with Cancer", 《ANTIMICROBIAL AGENTS AND CHEMOTHERAPY》 * |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107151264B (zh) * | 2011-03-23 | 2021-11-23 | 浙江医药股份有限公司新昌制药厂 | 新型糖肽类抗生素衍生物及药物组合物、以及其制备方法和用途 |
CN107151264A (zh) * | 2011-03-23 | 2017-09-12 | 浙江医药股份有限公司新昌制药厂 | 新型糖肽类抗生素衍生物及药物组合物、以及其制备方法和用途 |
CN102690332A (zh) * | 2011-03-23 | 2012-09-26 | 浙江医药股份有限公司新昌制药厂 | 新型糖肽类抗生素衍生物及药物组合物、以及其制备方法和用途 |
CN102690330B (zh) * | 2011-03-23 | 2014-10-08 | 浙江医药股份有限公司新昌制药厂 | 三取代糖肽类衍生物及药物组合物、以及其制备方法和用途 |
CN102690331B (zh) * | 2011-03-23 | 2015-05-20 | 浙江医药股份有限公司新昌制药厂 | 单糖糖肽类衍生物及药物组合物及其制备方法和用途以及中间体的制备方法 |
CN102690332B (zh) * | 2011-03-23 | 2017-06-27 | 浙江医药股份有限公司新昌制药厂 | 新型糖肽类抗生素衍生物及药物组合物、以及其制备方法和用途 |
CN102690331A (zh) * | 2011-03-23 | 2012-09-26 | 浙江医药股份有限公司新昌制药厂 | 单糖糖肽类衍生物及药物组合物及其制备方法和用途以及中间体的制备方法 |
CN102690330A (zh) * | 2011-03-23 | 2012-09-26 | 浙江医药股份有限公司新昌制药厂 | 三取代糖肽类衍生物及药物组合物、以及其制备方法和用途 |
WO2014101294A1 (zh) | 2012-12-27 | 2014-07-03 | 浙江医药股份有限公司新昌制药厂 | 糖肽类化合物或其药用盐及其制备方法、以及药物组合物和用途 |
WO2018010476A1 (zh) * | 2016-07-15 | 2018-01-18 | 上海来益生物药物研究开发中心有限责任公司 | 糖肽类衍生物及其药学可接受的盐、制备方法和应用 |
CN108929860B (zh) * | 2017-05-23 | 2023-08-22 | 上海来益生物药物研究开发中心有限责任公司 | 一种产chloroeremomycin的基因工程菌及其制备方法和应用 |
CN108929860A (zh) * | 2017-05-23 | 2018-12-04 | 上海来益生物药物研究开发中心有限责任公司 | 一种产chloroeremomycin的基因工程菌及其制备方法和应用 |
WO2019170046A1 (zh) | 2018-03-06 | 2019-09-12 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用 |
KR20210011907A (ko) * | 2018-03-06 | 2021-02-02 | 샹하이 라이이 센터 포 바이오파마수티컬 알앤디 코., 엘티디. | 약제 내성 박테리아 활성에 대한 저항성을 갖는 글리코펩티드계 화합물, 이의 제조 방법 및 응용 |
JP2021515809A (ja) * | 2018-03-06 | 2021-06-24 | シャンハイ ライイー センター フォー バイオファーマスーティカル アール アンド ディー カンパニー リミテッド | 一組の抗薬剤耐性細菌活性を有する糖ペプチド化合物、その調製方法および応用 |
CN108409837B (zh) * | 2018-03-06 | 2021-09-24 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用 |
JP7339288B2 (ja) | 2018-03-06 | 2023-09-05 | シャンハイ ライイー センター フォー バイオファーマスーティカル アール アンド ディー カンパニー リミテッド | 一組の抗薬剤耐性細菌活性を有する糖ペプチド化合物、その調製方法および応用 |
US11696937B2 (en) | 2018-03-06 | 2023-07-11 | Shanghai Laiyi Center For Biopharmaceutical R&D Co., Ltd. | Glycopeptide compounds having activity of resisting drug-resistant bacteria, and preparation method and application thereof |
CN108409837A (zh) * | 2018-03-06 | 2018-08-17 | 上海来益生物药物研究开发中心有限责任公司 | 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用 |
KR102571953B1 (ko) * | 2018-03-06 | 2023-08-28 | 샹하이 라이이 센터 포 바이오파마수티컬 알앤디 코., 엘티디. | 약제 내성 박테리아 활성에 대한 저항성을 갖는 글리코펩티드계 화합물, 이의 제조 방법 및 응용 |
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WO2010149016A1 (zh) | 2010-12-29 |
CN101928331B (zh) | 2014-05-28 |
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Effective date of registration: 20210811 Address after: 201109 room 318, building 2, No. 920, Jianchuan Road, Minhang District, Shanghai Patentee after: Shanghai Health Creation Center for Biopharmaceutical R&D Co.,Ltd. Patentee after: Zhejiang Medicine Co.,Ltd. Xinchang Pharmaceutical Factory Patentee after: Center for excellence and innovation in molecular plant science, Chinese Academy of Sciences Address before: 201203 floor 5, building 8, No. 200, Newton Road, Zhangjiang, Pudong, Shanghai Patentee before: Shanghai Health Creation Center for Biopharmaceutical R&D Co.,Ltd. Patentee before: Zhejiang Medicine Co.,Ltd. Xinchang Pharmaceutical Factory Patentee before: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES |