DK167689B1 - Hidtil ukendte glycopeptid-antibiotika hoerende til vancomycingruppen, farmaceutisk acceptable salte deraf, en fremgangsmaade til fremstilling af saadanne antibiotika, biologisk oprenset kultur til brug ved fremstillingen samt farmaceutisk praeparat og tilskudsmiddel til dyrefoder indeholdende saadanne antibiotika - Google Patents

Hidtil ukendte glycopeptid-antibiotika hoerende til vancomycingruppen, farmaceutisk acceptable salte deraf, en fremgangsmaade til fremstilling af saadanne antibiotika, biologisk oprenset kultur til brug ved fremstillingen samt farmaceutisk praeparat og tilskudsmiddel til dyrefoder indeholdende saadanne antibiotika Download PDF

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Publication number
DK167689B1
DK167689B1 DK489787A DK489787A DK167689B1 DK 167689 B1 DK167689 B1 DK 167689B1 DK 489787 A DK489787 A DK 489787A DK 489787 A DK489787 A DK 489787A DK 167689 B1 DK167689 B1 DK 167689B1
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DK
Denmark
Prior art keywords
antibiotics
antibiotic
nrrl
culture
acid
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DK489787A
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Danish (da)
English (en)
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DK489787D0 (da
DK489787A (da
Inventor
Robert L Hamill
James Albert Mabe
David Francis Mahoney
Walter Mitsuo Nakatsukasa
Raymond Che-Fong Yao
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Lilly Co Eli
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Publication of DK167689B1 publication Critical patent/DK167689B1/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Fodder In General (AREA)
DK489787A 1986-09-19 1987-09-17 Hidtil ukendte glycopeptid-antibiotika hoerende til vancomycingruppen, farmaceutisk acceptable salte deraf, en fremgangsmaade til fremstilling af saadanne antibiotika, biologisk oprenset kultur til brug ved fremstillingen samt farmaceutisk praeparat og tilskudsmiddel til dyrefoder indeholdende saadanne antibiotika DK167689B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90979186A 1986-09-19 1986-09-19
US90979186 1986-09-19

Publications (3)

Publication Number Publication Date
DK489787D0 DK489787D0 (da) 1987-09-17
DK489787A DK489787A (da) 1988-03-21
DK167689B1 true DK167689B1 (da) 1993-12-06

Family

ID=25427837

Family Applications (1)

Application Number Title Priority Date Filing Date
DK489787A DK167689B1 (da) 1986-09-19 1987-09-17 Hidtil ukendte glycopeptid-antibiotika hoerende til vancomycingruppen, farmaceutisk acceptable salte deraf, en fremgangsmaade til fremstilling af saadanne antibiotika, biologisk oprenset kultur til brug ved fremstillingen samt farmaceutisk praeparat og tilskudsmiddel til dyrefoder indeholdende saadanne antibiotika

Country Status (23)

Country Link
US (2) US5312738A (ko)
EP (1) EP0265071B1 (ko)
JP (2) JP2634174B2 (ko)
KR (1) KR960013093B1 (ko)
CN (1) CN1061095C (ko)
AU (1) AU608534B2 (ko)
CA (1) CA1339033C (ko)
CY (1) CY1691A (ko)
DE (1) DE3782720T2 (ko)
DK (1) DK167689B1 (ko)
EG (1) EG18377A (ko)
ES (1) ES2052574T3 (ko)
FI (1) FI90993C (ko)
GR (1) GR3006311T3 (ko)
HK (1) HK44393A (ko)
HU (1) HU198964B (ko)
IE (1) IE60132B1 (ko)
MX (1) MX168708B (ko)
NZ (1) NZ221856A (ko)
PH (1) PH24288A (ko)
PT (1) PT85742B (ko)
SU (1) SU1724015A3 (ko)
ZA (1) ZA877003B (ko)

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US4946941A (en) * 1986-01-24 1990-08-07 Shionogi & Co., Ltd. Novel glycopeptide antibiotics
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US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b
EP0344234A1 (en) * 1987-09-19 1989-12-06 Beecham Group Plc Antibiotic compounds
US5534420A (en) * 1988-07-28 1996-07-09 Eli Lilly And Company Biotransformation of glycopeptide antibiotics
CA1339808C (en) * 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
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CA2031803C (en) * 1989-12-13 2001-05-29 Ramakrishnan Nagarajan Improvements in or relating to glycopeptide deriveratives
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ATE361931T1 (de) * 1998-05-01 2007-06-15 Lilly Co Eli N1 modifizierte glycopeptide
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US6734165B2 (en) 2001-08-23 2004-05-11 The Trustees Of Columbia University In The City Of New York Method for re-sensitizing vancomycin resistant bacteria which selectively cleave a cell wall depsipeptide
US6551591B1 (en) 2001-09-07 2003-04-22 Essential Therapeutics, Inc. Antibiotics from microbispora
US20050289488A1 (en) * 2004-06-29 2005-12-29 I-Ju Chou System and method for mask defect detection
WO2006010038A2 (en) * 2004-07-08 2006-01-26 Biosearch Technologies, Inc. Inducible fluorescence assay
ES2327840T3 (es) 2004-12-23 2009-11-04 Gpc Biotech Ag Derivados de acido escuarico con actividad antiproliferativa.
CN101245068A (zh) 2007-02-14 2008-08-20 浙江医药股份有限公司新昌制药厂 结晶型态的恩替卡韦及其制备方法和其药物组合物及用途
US8450348B2 (en) * 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity
CN101284799B (zh) 2007-03-23 2013-04-03 浙江医药股份有限公司新昌制药厂 咖啡酰奎宁酸含氮衍生物及其制备方法和其药物组合物及用途
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CN101397333A (zh) * 2007-09-27 2009-04-01 浙江医药股份有限公司新昌制药厂 去羟基万古霉素及其制备方法、和其药物组合物及其用途
CN101545000B8 (zh) * 2008-03-28 2018-09-21 上海来益生物药物研究开发中心有限责任公司 一种提高东方拟无枝酸菌发酵生产eco-0501的产量的方法
CN102037144B (zh) 2008-04-01 2013-09-25 生物检索技术股份有限公司 稳定化的核酸暗猝灭剂-荧光团探针
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
EP2112152A1 (en) 2008-04-22 2009-10-28 GPC Biotech AG Dihydropteridinones as Plk Inhibitors
CN101828693B (zh) 2009-03-09 2013-01-02 浙江医药股份有限公司新昌制药厂 制备低粘度高流动性类胡萝卜素油悬浮液的方法及其应用
CN101928331B (zh) * 2009-06-26 2014-05-28 上海来益生物药物研究开发中心有限责任公司 一种化合物及其应用
EP2325185A1 (en) 2009-10-28 2011-05-25 GPC Biotech AG Plk inhibitor
CN107151264B (zh) * 2011-03-23 2021-11-23 浙江医药股份有限公司新昌制药厂 新型糖肽类抗生素衍生物及药物组合物、以及其制备方法和用途
CN102690330B (zh) * 2011-03-23 2014-10-08 浙江医药股份有限公司新昌制药厂 三取代糖肽类衍生物及药物组合物、以及其制备方法和用途
RU2011122942A (ru) 2011-06-08 2012-12-20 Общество С Ограниченной Ответственностью "Асинэкс Медхим" Новые ингибиторы киназ
JP5996187B2 (ja) * 2011-12-20 2016-09-21 株式会社ダイセル エクオールの製造方法
WO2014160250A2 (en) * 2013-03-13 2014-10-02 Yale University Site-selective functionalization of glycopeptide antibiotics
CN104805161A (zh) * 2014-01-29 2015-07-29 上海医药工业研究院 生产奥利万星前体a82846b的方法及培养基
EP3169345A4 (en) 2014-07-17 2018-01-17 The Medicines Company High purity oritavancin and method of producing same
CN106190854B (zh) * 2015-04-29 2019-09-27 浙江海正药业股份有限公司 一种荒漠拟孢囊菌和奥利万星中间体的制备方法
CN106467570B (zh) * 2015-08-14 2020-04-07 正大天晴药业集团股份有限公司 糖肽类抗生素的还原烷基化方法
CN107619432B (zh) * 2016-07-15 2023-03-17 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用
CN106928323B (zh) * 2017-03-02 2021-08-20 重庆乾泰生物医药有限公司 一种高纯度奥利万星关键中间体a82846b的制备方法
CN108929860B (zh) * 2017-05-23 2023-08-22 上海来益生物药物研究开发中心有限责任公司 一种产chloroeremomycin的基因工程菌及其制备方法和应用
CN109929895B (zh) * 2019-04-02 2021-05-18 博瑞生物医药泰兴市有限公司 一种酸降解液
CN109971809B (zh) * 2019-04-02 2023-04-28 博瑞生物医药（苏州）股份有限公司 一种糖肽类抗生素中间体的发酵制备方法
CN113563426B (zh) * 2021-08-05 2023-03-31 丽珠集团福州福兴医药有限公司 奥利万星母核a82846b的分离纯化方法

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Also Published As

Publication number Publication date
ZA877003B (en) 1989-04-26
CN87106483A (zh) 1988-06-08
EP0265071B1 (en) 1992-11-19
JP2806912B2 (ja) 1998-09-30
DE3782720T2 (de) 1993-04-22
IE60132B1 (en) 1994-06-01
FI90993C (fi) 1994-04-25
FI90993B (fi) 1994-01-14
MX168708B (es) 1993-06-04
KR880004097A (ko) 1988-06-01
EG18377A (en) 1993-04-30
HK44393A (en) 1993-05-14
JP2634174B2 (ja) 1997-07-23
HUT46365A (en) 1988-10-28
CA1339033C (en) 1997-04-01
JPS6393798A (ja) 1988-04-25
US5312738A (en) 1994-05-17
NZ221856A (en) 1991-12-23
DK489787D0 (da) 1987-09-17
GR3006311T3 (ko) 1993-06-21
US5843437A (en) 1998-12-01
PH24288A (en) 1990-05-29
PT85742B (pt) 1990-06-29
DE3782720D1 (de) 1992-12-24
ES2052574T3 (es) 1994-07-16
CY1691A (en) 1994-01-14
AU7865887A (en) 1988-03-24
AU608534B2 (en) 1991-04-11
CN1061095C (zh) 2001-01-24
EP0265071A1 (en) 1988-04-27
IE872529L (en) 1988-03-19
KR960013093B1 (ko) 1996-09-30
PT85742A (en) 1987-10-01
JPH09182581A (ja) 1997-07-15
DK489787A (da) 1988-03-21
HU198964B (en) 1989-12-28
SU1724015A3 (ru) 1992-03-30
FI874082A0 (fi) 1987-09-18
FI874082A (fi) 1988-03-20

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