KR850007983A - 히알우론산 생산의 발효법 - Google Patents

히알우론산 생산의 발효법 Download PDF

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Publication number
KR850007983A
KR850007983A KR1019850003599A KR850003599A KR850007983A KR 850007983 A KR850007983 A KR 850007983A KR 1019850003599 A KR1019850003599 A KR 1019850003599A KR 850003599 A KR850003599 A KR 850003599A KR 850007983 A KR850007983 A KR 850007983A
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South Korea
Prior art keywords
hyaluronic acid
fermentation method
acid production
streptococcus
strain
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KR1019850003599A
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English (en)
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KR870001815B1 (ko
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히데미찌 아까사까 (외2)
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오오노 요시오
가부시기가이샤 시세이도
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Publication of KR850007983A publication Critical patent/KR850007983A/ko
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Publication of KR870001815B1 publication Critical patent/KR870001815B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/885—Streptococcus

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

내용 없음

Description

히알우론산 생산의 발효법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시예 2에서의 배양중의 배양시간(hr)과 히알우론산의 생산량(g/ℓ), 클루코오스양(%) 또는 세포생장(OD660) 사이의 상관관계를 도해적으로 설명하는 것이며, 제2도는 실시예 2에서 얻은 히알우론산의 적외선흡수 스펙트럼을 나타낸다.

Claims (4)

  1. 비용혈성이며 배양배지에 히알우론산을 생산할 수 있는 스트렙토코쿠스 속에 속하는 미생물을 배양하여 그 배양산물로부터 스트렙토리신이 없는 히알우론산을 분리하는 것을 특징으로하는 히알우론산 생산의 발효법.
  2. 제1항에 있어서, 스트렙토코쿠스 주에피데미쿠스에 속하는 균주를 배양하는 것을 특징으로 하는 발효법.
  3. 제2항에 있어서, 그 균주가 스트렙토코쿠스 주에피데미쿠스 EPRM BP-784인 균주를 특징으로 하는 발효법.
  4. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850003599A 1984-05-25 1985-05-24 발효법에 의한 히알우론산의 제조방법 KR870001815B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59-105942 1984-05-25
JP59105942A JPS60251898A (ja) 1984-05-25 1984-05-25 醗酵法によるヒアルロン酸の製造方法

Publications (2)

Publication Number Publication Date
KR850007983A true KR850007983A (ko) 1985-12-11
KR870001815B1 KR870001815B1 (ko) 1987-10-13

Family

ID=14420898

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850003599A KR870001815B1 (ko) 1984-05-25 1985-05-24 발효법에 의한 히알우론산의 제조방법

Country Status (6)

Country Link
US (1) US4801539A (ko)
JP (1) JPS60251898A (ko)
KR (1) KR870001815B1 (ko)
DE (1) DE3517629A1 (ko)
FR (1) FR2564859B1 (ko)
IT (1) IT1183674B (ko)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2569724B1 (fr) * 1984-09-04 1991-02-08 Chisso Corp Procede pour la preparation d'acide hyaluronique
AR241545A1 (es) * 1985-07-12 1992-08-31 Cornell Res Foundation Inc Un metodo para preparar una cepa de s. equi avirulenta a.t.c.c. 53186 para equinos.
JPS62215397A (ja) * 1986-03-17 1987-09-22 Nippon Kayaku Co Ltd ヒアルロン酸の製造方法
JPS62257382A (ja) * 1986-05-01 1987-11-09 Yakult Honsha Co Ltd 新規なストレプトコツカス・ズ−エピデミカス
US5023175A (en) * 1986-05-01 1991-06-11 Kabushiki Kaisha Yakult Honsha Novel production process of hyaluronic acid and bacterium strain therefor
JPS63156707A (ja) * 1986-12-19 1988-06-29 Yakult Honsha Co Ltd ヒアルロン酸含有化粧料
JPS62257393A (ja) * 1986-05-01 1987-11-09 Yakult Honsha Co Ltd ヒアルロン酸の製造方法
JPH0630604B2 (ja) * 1986-07-22 1994-04-27 電気化学工業株式会社 ヒアルロン酸の製造法
US4977082A (en) * 1987-12-10 1990-12-11 University Of Florida Research Foundation, Inc. Type VI bacterial FC receptors
JPH01265970A (ja) * 1988-04-19 1989-10-24 Shiseido Co Ltd ヒアルロン酸を含有させたコラーゲン水溶液又は水分散液
US4946780A (en) * 1988-10-12 1990-08-07 Denkl Kagaku Kogyo Kabushiki Kaisha Method for producing sodium hyaluronate by fermentation method
US4897349A (en) * 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
US5015577A (en) * 1989-08-29 1991-05-14 Board Of Regents, The University Of Texas System DNA encoding hyaluronate synthase
GB9024223D0 (en) * 1990-11-07 1990-12-19 Fermentech Ltd Production of hyaluronic acid
SE501217C2 (sv) * 1990-12-06 1994-12-12 Skandigen Ab Cellproliferationsmatris och användning därav
JPH0753117B2 (ja) * 1992-10-26 1995-06-07 チッソ株式会社 ヒアルロン酸の製造法
US6951743B2 (en) 1997-10-31 2005-10-04 University Of Oklahoma Board Of Regents Hyaluronan synthase genes and expression thereof in bacillus hosts
US7091008B1 (en) 1994-07-01 2006-08-15 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase genes and expression thereof in Bacillus hosts
US6455304B1 (en) * 1994-07-01 2002-09-24 The Board Of Regents Of The University Of Oklahoma Hyaluronate synthase gene and uses thereof
JP3799626B2 (ja) * 1995-04-25 2006-07-19 有限会社ナイセム 心臓血管修復材及びその製造方法
ES2235378T3 (es) * 1997-10-31 2005-07-01 The Board Of Regents Of The University Of Oklahoma Gen de la hialuronan sintasa y usos del mismo.
CN101113436B (zh) * 1997-10-31 2013-02-06 俄克拉何马大学董事会 透明质酸合酶基因及其应用
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US6987023B2 (en) * 1998-04-02 2006-01-17 The Board Of Regents Of The University Of Oklahoma DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US7094581B2 (en) * 1998-10-26 2006-08-22 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthases and methods of making and using same
US20050287638A1 (en) * 2000-04-25 2005-12-29 Weigel Paul H Hyaluronan receptor for endocytosis, variants thereof, and methods of making and using same
US20070020737A1 (en) * 2001-12-03 2007-01-25 Pummill Philip E Hyaluronan synthases and methods of making and using same
AU2002366711C1 (en) * 2001-12-21 2009-01-22 Novozymes A/S Methods for producing hyaluronan in a recombinant host cell
CN1833026A (zh) * 2003-07-31 2006-09-13 东洋纺织株式会社 生产透明质酸的植物
US20050147715A1 (en) * 2003-12-17 2005-07-07 Novozymes Biopolymer A/S Dairy product comprising texturizers
US20050147732A1 (en) * 2003-12-17 2005-07-07 Novozymes Biopolymer A/S Method for preparing a food product comprising texturizers
EP1772052A1 (de) 2005-10-05 2007-04-11 Bayer CropScience GmbH Verbesserte Verfahren und Mittel zur Herstellung von Hyaluronan
JP2009545637A (ja) 2006-08-04 2009-12-24 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ 分岐ヒアルロン酸及びその製造方法
EP2036983A1 (de) * 2007-09-12 2009-03-18 Bayer CropScience AG Pflanzen, die erhöhte Mengen an Glucosaminglycanen synthetisieren
WO2009077399A1 (en) * 2007-12-19 2009-06-25 Evonik Goldschmidt Gmbh Crosslinked hyaluronic acid in emulsion
EP2213315A1 (en) 2009-01-30 2010-08-04 Mero S.r.L. Antibacterial hydrogel and use thereof in orthopedics
US8557275B2 (en) 2009-07-23 2013-10-15 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA
US9216164B2 (en) 2009-07-23 2015-12-22 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using a mixture of fish oil and fish oil derived, choline based, phospholipid bound fatty acid mixture including polyunsaturated EPA and DHA
US8481072B2 (en) 2009-07-23 2013-07-09 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain
US9399047B2 (en) 2009-07-23 2016-07-26 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using phospholipids and roe extract
US9913810B2 (en) 2009-07-23 2018-03-13 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using phospholipids and astaxanthin
US9238043B2 (en) 2009-07-23 2016-01-19 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using algae based oils
US9402857B2 (en) 2009-07-23 2016-08-02 U.S. Nutraceuticals, LLC Composition and method to alleviate joint pain using low molecular weight hyaluronic acid and astaxanthin
US20110117207A1 (en) * 2009-11-17 2011-05-19 U.S. Nutraceuticals, LLC d/b/a Valensa International State of Incorporation: Use of eggshell membrane formulations to alleviate joint pain
IT1401498B1 (it) 2010-07-30 2013-07-26 Mero Srl Idrogelo a base di acido ialuronico e suo uso in ortopedia
CA2835016A1 (en) 2011-05-30 2012-12-06 Novozymes Biopharma Dk A/S Spray drying of high molecular weight hyaluronic acid
CA2847328A1 (en) 2011-09-02 2013-03-07 Novozymes Biopharma Dk A/S Oral formulations containing hyaluronic acid for sustained drug release
WO2014100837A1 (en) 2012-12-17 2014-06-26 Bui The Duy Computer aided implantation of body implants
EP3103815B1 (en) * 2014-01-14 2018-12-19 Kewpie Corporation Hyaluronic acid and/or salt thereof, method for producing same, and food, cosmetic, and pharmaceutical containing said hyaluronic acid and/or salt thereof
US9561095B1 (en) 2015-10-12 2017-02-07 Phi Nguyen Body augmentation device
CA2896038C (en) 2015-07-03 2022-08-09 Glycobiosciences Inc. Polymer matrix compositions comprising a high concentration of bio-fermented sodium hyaluronate and uses thereof
CN105132494B (zh) * 2015-09-11 2018-10-09 厦门市中萪研生物科技有限公司 一种在发酵过程中使用改性小麦秸秆制备透明质酸的方法
CN108410926B (zh) * 2017-12-03 2021-12-14 新疆阜丰生物科技有限公司 一种制备提取高分子量透明质酸的方法
WO2019158541A1 (en) 2018-02-14 2019-08-22 Frieslandcampina Nederland B.V. Nutritional compositions for musculoskeletal support for athletes
RU2719140C1 (ru) 2019-07-26 2020-04-17 Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" Бактерия рода bacillus, продуцирующая гиалуроновую кислоту, и способ получения гиалуроновой кислоты с использованием указанной бактерии
JP2024511878A (ja) 2021-04-01 2024-03-15 ジボダン エス エー ヒアルロン酸を産生する組換え細胞
EP4067499A1 (en) 2021-04-01 2022-10-05 Givaudan SA Hyaluronic acid-producing recombinant cells
EP4174175A1 (en) 2021-10-26 2023-05-03 Givaudan SA Hyaluronic acid-producing recombinant cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2634898C3 (de) * 1976-08-03 1979-08-30 Veb Arzneimittelwerk Dresden, Ddr 8122 Radebeul Verfahren zur Gewinnung von Streptokokkenstoffwechselprodukten
JPS5837001A (ja) * 1981-08-27 1983-03-04 Green Cross Corp:The ヒアルロン酸の製造法
JPS5856692A (ja) * 1981-09-26 1983-04-04 Shiseido Co Ltd ヒアルロン酸の製造方法
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture

Also Published As

Publication number Publication date
FR2564859A1 (fr) 1985-11-29
DE3517629C2 (ko) 1987-09-03
DE3517629A1 (de) 1985-11-28
IT1183674B (it) 1987-10-22
JPH0378116B2 (ko) 1991-12-12
FR2564859B1 (fr) 1987-09-25
US4801539A (en) 1989-01-31
IT8520869A0 (it) 1985-05-24
JPS60251898A (ja) 1985-12-12
KR870001815B1 (ko) 1987-10-13

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