ATE200491T1 - 2-aminoalkyl-5-aminoalkylamino substituierte isochinoindazole-6 (2h)-on mit antitumorwirkung - Google Patents

2-aminoalkyl-5-aminoalkylamino substituierte isochinoindazole-6 (2h)-on mit antitumorwirkung

Info

Publication number
ATE200491T1
ATE200491T1 AT93921290T AT93921290T ATE200491T1 AT E200491 T1 ATE200491 T1 AT E200491T1 AT 93921290 T AT93921290 T AT 93921290T AT 93921290 T AT93921290 T AT 93921290T AT E200491 T1 ATE200491 T1 AT E200491T1
Authority
AT
Austria
Prior art keywords
alkyl
group
phenylalkyl
hydrogen
nr2r3
Prior art date
Application number
AT93921290T
Other languages
English (en)
Inventor
A Paul Krapcho
Ernesto Via Baracca Menta
Ambrogio Via I Maggio Oliva
Silvano Spinelli
Original Assignee
Univ Vermont
Novuspharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/103,641 external-priority patent/US5519029A/en
Application filed by Univ Vermont, Novuspharma Spa filed Critical Univ Vermont
Application granted granted Critical
Publication of ATE200491T1 publication Critical patent/ATE200491T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT93921290T 1992-09-08 1993-09-08 2-aminoalkyl-5-aminoalkylamino substituierte isochinoindazole-6 (2h)-on mit antitumorwirkung ATE200491T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94160792A 1992-09-08 1992-09-08
US08/103,641 US5519029A (en) 1992-09-08 1993-08-11 2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones
PCT/US1993/008241 WO1994006795A1 (en) 1992-09-08 1993-09-08 2-aminoalkyl-5-aminoalkylamino substituted isoquinoindazole-6-(2h)-ones with antitumour activity

Publications (1)

Publication Number Publication Date
ATE200491T1 true ATE200491T1 (de) 2001-04-15

Family

ID=26800681

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93921290T ATE200491T1 (de) 1992-09-08 1993-09-08 2-aminoalkyl-5-aminoalkylamino substituierte isochinoindazole-6 (2h)-on mit antitumorwirkung

Country Status (17)

Country Link
EP (1) EP0662076B1 (de)
JP (1) JP3497168B2 (de)
CN (1) CN1051549C (de)
AT (1) ATE200491T1 (de)
AU (1) AU680431B2 (de)
CZ (1) CZ288366B6 (de)
DE (1) DE69330131T2 (de)
DK (1) DK0662076T3 (de)
ES (1) ES2155452T3 (de)
FI (1) FI109538B (de)
GR (1) GR3036175T3 (de)
HU (1) HU220616B1 (de)
NO (1) NO302618B1 (de)
PT (1) PT662076E (de)
RU (1) RU2130937C1 (de)
SG (1) SG52494A1 (de)
WO (1) WO1994006795A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5596097A (en) * 1994-03-08 1997-01-21 The University Of Vermont Hetero-annulated indazoles
AU713107B2 (en) * 1995-07-06 1999-11-25 University Of Vermont, The New pyrido-thiopyranoindazoles with antitumor activity
IT1277576B1 (it) * 1995-09-13 1997-11-11 Boehringer Mannheim Italia 2-2-(2-idrossietil) ammino etil -5- 2-metilammino etil ammino indazolo 4,3-gh isochinolin-6 (2h)-one come agente antitumorale
IT1286509B1 (it) * 1996-11-29 1998-07-15 Boehringer Mannheim Italia Derivati 2, 3, 4, 7-tetraidropiridoindazolo-(1,4)benzodiazepinici aventi attivita' antitumorale
US6747039B2 (en) 2002-03-12 2004-06-08 Albany Molecular Research, Inc. Aza-benzothiopyranoindazoles with antitumor activity
CN103787970A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 一锅煮法制备6，9-二氟苯并异喹啉-5，10-二酮的工艺

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL69211A (en) * 1982-07-23 1987-01-30 Warner Lambert Co Substituted anthra(1,9-cd)pyrazol-6(2h)-ones,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
EP0662076B1 (de) 2001-04-11
HUT70145A (en) 1995-09-28
PT662076E (pt) 2001-09-28
WO1994006795A1 (en) 1994-03-31
DE69330131T2 (de) 2001-08-30
SG52494A1 (en) 1998-09-28
CN1101046A (zh) 1995-04-05
EP0662076A1 (de) 1995-07-12
DK0662076T3 (da) 2001-05-07
FI109538B (fi) 2002-08-30
JPH08503933A (ja) 1996-04-30
AU4844193A (en) 1994-04-12
CN1051549C (zh) 2000-04-19
NO950877D0 (no) 1995-03-07
GR3036175T3 (en) 2001-10-31
FI951023A (fi) 1995-03-31
AU680431B2 (en) 1997-07-31
JP3497168B2 (ja) 2004-02-16
RU95110932A (ru) 1996-12-27
ES2155452T3 (es) 2001-05-16
NO950877L (no) 1995-05-08
FI951023A0 (fi) 1995-03-06
HU9500676D0 (en) 1995-04-28
NO302618B1 (no) 1998-03-30
HU220616B1 (hu) 2002-03-28
CZ59895A3 (en) 1995-11-15
RU2130937C1 (ru) 1999-05-27
DE69330131D1 (de) 2001-05-17
CZ288366B6 (en) 2001-06-13

Similar Documents

Publication Publication Date Title
NO20015447L (no) Kinolinderivater som inhibitorer av MEK enzymer
AU3461697A (en) Heterocyclic compounds, their production and use
IS6138A (is) Kínólín afleiður sem latar fyrir MEK ensím
FI943561A (fi) Uudet ainekoostumukset
NO20015446L (no) Kinolin-derivater som inhibitorer for MEK-enzymer
SE8307133D0 (sv) Carboxamido-derivatives of 5h-1,3,4-thiadiazolo(3,2-a)pyrimidines and process for their preparation
MX9201020A (es) 6,9-bis(amino-substituidas)benzo[g]isoquinolin-5,10-dionas.
ATE200491T1 (de) 2-aminoalkyl-5-aminoalkylamino substituierte isochinoindazole-6 (2h)-on mit antitumorwirkung
ES402755A1 (es) Procedimiento para la preparacion de 5-nitro-pirimidinas.
NO920619L (no) Oxazinobenzazolforbindelser
SE7612455L (sv) Aminoetanolderivat
DE69301639D1 (de) Tetrahydronaphtalenderivate, ihre Herstellung und ihre therapeutische Verwendung
MY104630A (en) 4(1h) ouinoline derivatives

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee