ATE444755T1 - Verwendung von topotecan zur herstellung eines medikaments zur verwendung in der behandlung von ovarialkrebs - Google Patents

Verwendung von topotecan zur herstellung eines medikaments zur verwendung in der behandlung von ovarialkrebs

Info

Publication number
ATE444755T1
ATE444755T1 AT92907833T AT92907833T ATE444755T1 AT E444755 T1 ATE444755 T1 AT E444755T1 AT 92907833 T AT92907833 T AT 92907833T AT 92907833 T AT92907833 T AT 92907833T AT E444755 T1 ATE444755 T1 AT E444755T1
Authority
AT
Austria
Prior art keywords
topotecan
treatment
pharmaceutical composition
human
medication
Prior art date
Application number
AT92907833T
Other languages
English (en)
Inventor
Randall Johnson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE444755T1 publication Critical patent/ATE444755T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT92907833T 1991-02-21 1992-02-07 Verwendung von topotecan zur herstellung eines medikaments zur verwendung in der behandlung von ovarialkrebs ATE444755T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65894891A 1991-02-21 1991-02-21
PCT/US1992/001028 WO1992014469A1 (en) 1991-02-21 1992-02-07 Treatment of ovarian cancer

Publications (1)

Publication Number Publication Date
ATE444755T1 true ATE444755T1 (de) 2009-10-15

Family

ID=24643386

Family Applications (2)

Application Number Title Priority Date Filing Date
AT92907833T ATE444755T1 (de) 1991-02-21 1992-02-07 Verwendung von topotecan zur herstellung eines medikaments zur verwendung in der behandlung von ovarialkrebs
AT05076845T ATE476182T1 (de) 1991-02-21 1992-02-07 Pharmazeutische zusammensetzung zur verwendung in der behandlung von eierstockkrebs

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT05076845T ATE476182T1 (de) 1991-02-21 1992-02-07 Pharmazeutische zusammensetzung zur verwendung in der behandlung von eierstockkrebs

Country Status (13)

Country Link
EP (3) EP0572557B1 (de)
JP (1) JP2778632B2 (de)
KR (1) KR930702983A (de)
AT (2) ATE444755T1 (de)
AU (1) AU663312B2 (de)
CA (1) CA2103708C (de)
DE (2) DE69233793D1 (de)
DK (2) DK0572557T3 (de)
ES (2) ES2349037T3 (de)
HK (1) HK1012265A1 (de)
MX (1) MX9200754A (de)
PT (1) PT100156B (de)
WO (1) WO1992014469A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101255406B (zh) * 2005-04-22 2010-05-26 李红霞 人卵巢癌耐药细胞株
ES2371171B1 (es) * 2010-06-08 2012-11-16 Consejo Superior De Investigaciones Científicas (Csic) Derivados de camptotecina como agentes antitumorales.
CN102477042A (zh) * 2010-11-26 2012-05-30 复旦大学 10-羟基喜树碱衍生物及其制备方法和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004758A (en) 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells

Also Published As

Publication number Publication date
DK0572557T3 (da) 2010-02-01
EP1690542A3 (de) 2008-03-26
JP2778632B2 (ja) 1998-07-23
EP1707568A2 (de) 2006-10-04
DE69233793D1 (de) 2010-09-16
HK1012265A1 (en) 1999-07-30
EP1707568B1 (de) 2010-08-04
CA2103708A1 (en) 1992-08-22
ES2334178T3 (es) 2010-03-05
MX9200754A (es) 1992-08-01
EP0572557A1 (de) 1993-12-08
AU663312B2 (en) 1995-10-05
ATE476182T1 (de) 2010-08-15
EP0572557B1 (de) 2009-10-07
PT100156A (pt) 1993-05-31
JPH06505740A (ja) 1994-06-30
DE69233773D1 (de) 2009-11-19
WO1992014469A1 (en) 1992-09-03
EP1707568A3 (de) 2008-03-26
EP1690542A2 (de) 2006-08-16
CA2103708C (en) 2004-04-27
EP0572557A4 (en) 1993-12-29
ES2349037T3 (es) 2010-12-22
PT100156B (pt) 1999-09-30
AU1461692A (en) 1992-09-15
KR930702983A (ko) 1993-11-29
DK1707568T3 (da) 2010-11-08

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