RU95110682A - Способ получения производных таксана, исходные и промежуточные продукты для его получения - Google Patents

Способ получения производных таксана, исходные и промежуточные продукты для его получения

Info

Publication number
RU95110682A
RU95110682A RU95110682/04A RU95110682A RU95110682A RU 95110682 A RU95110682 A RU 95110682A RU 95110682/04 A RU95110682/04 A RU 95110682/04A RU 95110682 A RU95110682 A RU 95110682A RU 95110682 A RU95110682 A RU 95110682A
Authority
RU
Russia
Prior art keywords
production
derivatives
phenyl
taxane
origin
Prior art date
Application number
RU95110682/04A
Other languages
English (en)
Other versions
RU2115649C1 (ru
Inventor
Коммерсон Ален
Fr]
Дидье Эрик
Фуке Эли
Original Assignee
Рон-Пуленк Роре С.А. (FR)
Рон-Пуленк Роре С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк Роре С.А. (FR), Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А. (FR)
Publication of RU95110682A publication Critical patent/RU95110682A/ru
Application granted granted Critical
Publication of RU2115649C1 publication Critical patent/RU2115649C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Предложен способ получения производных таксана указанной в описании формулы I путем этерификации защищенного баккатина III или 10-дезацети-баккатина III с помощью кислоты, указанной в описании формулы VII, удаления защитных групп, последующего ацилирования функциональных аминогрупп бокового звена. Соединение формулы I обладает противоопухолевыми и противолейкемическими свойствами.

Claims (1)

  1. Предложен способ получения производных таксана указанной в описании формулы I путем этерификации защищенного баккатина III или 10-дезацети-баккатина III с помощью кислоты, указанной в описании формулы VII, удаления защитных групп, последующего ацилирования функциональных аминогрупп бокового звена. Соединение формулы I обладает противоопухолевыми и противолейкемическими свойствами.
RU95110682/04A 1992-10-05 1993-10-04 Способ получения производных таксана и исходные и промежуточные продукты для его получения RU2115649C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9211743A FR2696460B1 (fr) 1992-10-05 1992-10-05 Procédé de préparation de dérivés du taxane.
FR9211743 1992-10-05
PCT/FR1993/000969 WO1994007879A1 (fr) 1992-10-05 1993-10-04 Procede de preparation de derives du taxane

Publications (2)

Publication Number Publication Date
RU95110682A true RU95110682A (ru) 1996-12-27
RU2115649C1 RU2115649C1 (ru) 1998-07-20

Family

ID=9434121

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95110682/04A RU2115649C1 (ru) 1992-10-05 1993-10-04 Способ получения производных таксана и исходные и промежуточные продукты для его получения

Country Status (24)

Country Link
US (3) US5621121A (ru)
EP (1) EP0663908B1 (ru)
JP (1) JP3014762B2 (ru)
KR (1) KR100301237B1 (ru)
AT (1) ATE148882T1 (ru)
AU (1) AU690080B2 (ru)
CA (1) CA2146249A1 (ru)
CZ (1) CZ283291B6 (ru)
DE (1) DE69308154T2 (ru)
DK (1) DK0663908T3 (ru)
ES (1) ES2098060T3 (ru)
FI (1) FI951592A0 (ru)
FR (1) FR2696460B1 (ru)
GR (1) GR3022616T3 (ru)
HU (1) HUT72613A (ru)
MX (1) MX9305768A (ru)
NO (1) NO311255B1 (ru)
NZ (1) NZ256447A (ru)
PL (1) PL184556B1 (ru)
RU (1) RU2115649C1 (ru)
SK (1) SK280577B6 (ru)
TW (1) TW393474B (ru)
WO (1) WO1994007879A1 (ru)
ZA (1) ZA937320B (ru)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2697522B1 (fr) * 1992-10-30 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
EP1260507A1 (en) 1993-02-05 2002-11-27 Bryn Mawr College Synthesis of taxol, analogs and intermediates with variable A-nng side chains
ES2242807T3 (es) * 1993-03-22 2005-11-16 Florida State University Taxanos que tienen furilo o tienilo sustituido en la cadena lateral sustituida.
US5965739A (en) * 1993-06-11 1999-10-12 Pharmacia & Upjohn Company Δ6,7 -taxols antineoplastic use and pharmaceutical compositions containing them
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
EP1247804A1 (en) * 1993-11-12 2002-10-09 PHARMACIA & UPJOHN COMPANY Pyrimidine-thioalkyl and alkylether compounds
IL127599A (en) * 1994-01-28 2004-06-01 Upjohn Co Process for preparing isotaxol analogs
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
PT1114815E (pt) * 1996-05-08 2005-01-31 Upjohn Co Processo para a preparacao de taxol
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
ATE234800T1 (de) 1997-08-21 2003-04-15 Univ Florida State Verfahren zur synthese von taxanen
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
IT1308636B1 (it) 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
ITMI991483A1 (it) 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CZ2003837A3 (cs) 2000-09-22 2004-12-15 Bristol-Myers Squibb Company Způsob pro snížení toxicity při kombinovaných chemoterapiích
DE60144113D1 (de) * 2001-03-23 2011-04-07 Scinopharm Taiwan Ltd Verfahren zur herstellung von taxanderivaten
AU2003273671A1 (en) * 2002-10-09 2004-05-04 Phytogen Life Sciences, Inc. Novel taxanes and methods related to use and preparation thereof
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
DE102004034140A1 (de) * 2004-07-15 2006-02-23 Covion Organic Semiconductors Gmbh Verwendung von Polymeren für Up-conversion und Vorrichtungen zur Up-conversion
CA2756603C (en) * 2006-10-20 2013-05-28 Scinopharm Singapore Pte, Ltd. Process for making crystalline docetaxel trihydrate
KR100847331B1 (ko) * 2006-12-14 2008-07-21 한미약품 주식회사 도세탁셀의 제조방법 및 이에 사용되는 중간체
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
KR101003820B1 (ko) 2008-06-19 2010-12-27 주식회사 셀트리온화학연구소 도세탁셀의 제조방법 및 도세탁셀의 제조를 위한 신규한중간체
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
JP2014079364A (ja) * 2012-10-16 2014-05-08 Tokai Medical Care Holdings Co Ltd 歩行訓練補助器

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5965739A (en) * 1993-06-11 1999-10-12 Pharmacia & Upjohn Company Δ6,7 -taxols antineoplastic use and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE69308154D1 (de) 1997-03-27
HUT72613A (en) 1996-05-28
KR100301237B1 (ko) 2001-11-22
AU690080B2 (en) 1998-04-23
KR950703548A (ko) 1995-09-20
FR2696460B1 (fr) 1994-11-25
ATE148882T1 (de) 1997-02-15
US5861515A (en) 1999-01-19
NO951203D0 (no) 1995-03-29
NO311255B1 (no) 2001-11-05
SK280577B6 (sk) 2000-04-10
SK43495A3 (en) 1995-08-09
ES2098060T3 (es) 1997-04-16
GR3022616T3 (en) 1997-05-31
US5621121A (en) 1997-04-15
US5726318A (en) 1998-03-10
DE69308154T2 (de) 1997-09-25
JPH08501790A (ja) 1996-02-27
PL184556B1 (pl) 2002-11-29
FR2696460A1 (fr) 1994-04-08
JP3014762B2 (ja) 2000-02-28
WO1994007879A1 (fr) 1994-04-14
EP0663908A1 (fr) 1995-07-26
HU9500968D0 (en) 1995-06-28
NZ256447A (en) 1997-01-29
AU5115293A (en) 1994-04-26
CZ84395A3 (en) 1995-09-13
RU2115649C1 (ru) 1998-07-20
DK0663908T3 (ru) 1997-03-17
PL308242A1 (en) 1995-07-24
FI951592A (fi) 1995-04-04
CA2146249A1 (fr) 1994-04-14
FI951592A0 (fi) 1995-04-04
MX9305768A (es) 1994-05-31
CZ283291B6 (cs) 1998-02-18
NO951203L (no) 1995-03-29
TW393474B (en) 2000-06-11
EP0663908B1 (fr) 1997-02-12
ZA937320B (en) 1994-04-25

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20031005