RU94028266A - Бициклические производные имидазола, метод их получения, новые полученные промежуточные продукты, их применение в качестве медикаментов и содержащие их фармацевтические соединения - Google Patents

Бициклические производные имидазола, метод их получения, новые полученные промежуточные продукты, их применение в качестве медикаментов и содержащие их фармацевтические соединения

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Publication number
RU94028266A
RU94028266A RU94028266/04A RU94028266A RU94028266A RU 94028266 A RU94028266 A RU 94028266A RU 94028266/04 A RU94028266/04 A RU 94028266/04A RU 94028266 A RU94028266 A RU 94028266A RU 94028266 A RU94028266 A RU 94028266A
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RU
Russia
Prior art keywords
medicaments
alkenyl
preparation
alkyl
integer
Prior art date
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RU94028266/04A
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English (en)
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RU2141481C1 (ru
Inventor
Корбье Ален
Fr]
Поль Вевер Жан
Зханг Жидонг
Cn]
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Руссель Юклаф (FR)
Руссель Юклаф
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Publication of RU94028266A publication Critical patent/RU94028266A/ru
Application granted granted Critical
Publication of RU2141481C1 publication Critical patent/RU2141481C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Предметом изобретения являются продукты формулы, приведенной в описании, где X- алкил, алкенил, алкинил, алкокси или алкилтио, n- целое число от О до 4, А, А, Аи А- -(СН)-, -CH=, -N=, -NH-, >C=R, -S- и -O-, где n - целое число от О до 2, R- кислород, алкенил или =N - O -R, где R- водород, карбокси, ацил, амино, алкил, алкенил, алкокси, алкильтио, фенил, бензил, фенокси, X- циано, карбокси, -(СН)-SO-Z-R, где n= 0 или 1, Z - -NH-, -NH-CO-, -NH-CO-O, -N = CH-N-R, -NH-CO-NH- или простая связь, а Rи R- водород, алкил, алкенил, цикл, а также их соли, их получение и их применение в качестве медикаментов.

Claims (1)

  1. Предметом изобретения являются продукты формулы, приведенной в описании, где X1 - алкил, алкенил, алкинил, алкокси или алкилтио, n1 - целое число от О до 4, А1, А2, А3 и А4 - -(СН2)n-, -CH=, -N=, -NH-, >C=R3, -S- и -O-, где n - целое число от О до 2, R3 - кислород, алкенил или =N - O -R4, где R4 - водород, карбокси, ацил, амино, алкил, алкенил, алкокси, алкильтио, фенил, бензил, фенокси, X2 - циано, карбокси, -(СН2)n-SO2-Z-R5, где n2 = 0 или 1, Z - -NH-, -NH-CO-, -NH-CO-O, -N = CH-N-R6, -NH-CO-NH- или простая связь, а R5 и R6 - водород, алкил, алкенил, цикл, а также их соли, их получение и их применение в качестве медикаментов.
RU94028266A 1993-08-05 1994-08-04 Бициклические производные имидазола и способ их получения, промежуточный продукт и способ его получения, фармацевтическая композиция RU2141481C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9309654A FR2708612B1 (fr) 1993-08-05 1993-08-05 Nouveaux dérivés bicycliques de l'imidazole, leur procédé de préparation, les nouveaux intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant.
FR9309654 1993-08-05

Publications (2)

Publication Number Publication Date
RU94028266A true RU94028266A (ru) 1996-07-10
RU2141481C1 RU2141481C1 (ru) 1999-11-20

Family

ID=9449973

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94028266A RU2141481C1 (ru) 1993-08-05 1994-08-04 Бициклические производные имидазола и способ их получения, промежуточный продукт и способ его получения, фармацевтическая композиция

Country Status (16)

Country Link
US (1) US5714508A (ru)
EP (1) EP0638572B1 (ru)
JP (1) JP3766443B2 (ru)
KR (1) KR100349827B1 (ru)
CN (1) CN1054377C (ru)
AT (1) ATE229023T1 (ru)
AU (1) AU690116B2 (ru)
CA (1) CA2129483A1 (ru)
DE (1) DE69431820T2 (ru)
DK (1) DK0638572T3 (ru)
ES (1) ES2183833T3 (ru)
FR (1) FR2708612B1 (ru)
HU (1) HU218379B (ru)
PT (1) PT638572E (ru)
RU (1) RU2141481C1 (ru)
ZA (1) ZA945882B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157026A (en) * 1989-05-30 1992-10-20 Merck & Co., Inc. Oxo-purines as angiotensin II antagonists
JPH04235974A (ja) * 1990-06-08 1992-08-25 Roussel Uclaf 新規なイミダゾール誘導体、それらの製造法、得られる新規な中間体、それらの薬剤としての使用及びそれらを含有する製薬組成物
CN1028755C (zh) * 1991-01-04 1995-06-07 赫彻斯特股份公司 咪唑衍生物的制备方法
CA2058198A1 (en) * 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
TW300219B (ru) * 1991-09-14 1997-03-11 Hoechst Ag
DE4225835A1 (de) * 1992-08-05 1994-02-10 Merck Patent Gmbh Verfahren zur Herstellung von Imidazopyridinen
DE4242459A1 (de) * 1992-12-16 1994-06-23 Merck Patent Gmbh Imidazopyridine
DE4318813A1 (de) * 1993-06-07 1994-12-08 Merck Patent Gmbh Imidazopyridine

Also Published As

Publication number Publication date
FR2708612A1 (fr) 1995-02-10
ATE229023T1 (de) 2002-12-15
CN1112112A (zh) 1995-11-22
DE69431820T2 (de) 2003-05-28
CA2129483A1 (fr) 1995-02-06
US5714508A (en) 1998-02-03
HU9402282D0 (en) 1994-09-28
RU2141481C1 (ru) 1999-11-20
DK0638572T3 (da) 2003-03-24
EP0638572B1 (fr) 2002-12-04
KR950005810A (ko) 1995-03-20
HU218379B (hu) 2000-08-28
KR100349827B1 (ko) 2003-01-08
PT638572E (pt) 2003-04-30
FR2708612B1 (fr) 1996-03-01
JPH07145150A (ja) 1995-06-06
AU690116B2 (en) 1998-04-23
ES2183833T3 (es) 2003-04-01
AU6748994A (en) 1995-02-16
JP3766443B2 (ja) 2006-04-12
DE69431820D1 (de) 2003-01-16
EP0638572A1 (fr) 1995-02-15
HUT70940A (en) 1995-11-28
CN1054377C (zh) 2000-07-12
ZA945882B (en) 1995-08-07

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