ES2183833T3 - Nuevos derivados biciclicos de imidazol, su procedimiento de preparacion, nuevos productos intermedios obtenidos, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados biciclicos de imidazol, su procedimiento de preparacion, nuevos productos intermedios obtenidos, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2183833T3
ES2183833T3 ES94401805T ES94401805T ES2183833T3 ES 2183833 T3 ES2183833 T3 ES 2183833T3 ES 94401805 T ES94401805 T ES 94401805T ES 94401805 T ES94401805 T ES 94401805T ES 2183833 T3 ES2183833 T3 ES 2183833T3
Authority
ES
Spain
Prior art keywords
new
application
alkenyl
compositions containing
products obtained
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94401805T
Other languages
English (en)
Inventor
Alain Corbier
Jean-Paul Vevert
Jidong Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2183833T3 publication Critical patent/ES2183833T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A LOS PRODUCTOS DE FORMULA (I) EN LA QUE: X1 REPRESENTA PARTICULARMENTE ALQUILO, ALQUENILO, ALQUINILO, ALCOXI O ALQUILTIO, N1 REPRESENTA UN NUMERO ENTERO DE 0 A 4, A1, A2, A3 Y A4 REPRESENTAN (CH2)N=R3, -S R3 REPRESENTA UN ATOMO DE OXIGENO, ALQUENILO, O -N-O-R4 CON R4 REPRESENTANDO HIDROGENO, ALQUILO, ALQUENILO, ACILO O CARBAMOILO, ILO, AMINO, ALQUILO, ALQUENILO, ALCOXI, ALQUILTIO, FENILO, BENCILO, FENOXI, X2 REPRESENTA PARTICULARMENTE CIANO, CARBOXI, -(CH2)N2-SO2-Z-R5 CON N2 REPRESENTANDO 0 Y 1, Z REPRESENTA -NH-, -NH-CO-, -NH-COO-, -NH=CH-NHENTAN HIDROGENO, ALQUILO, ALQUENILO, UN CICLO, Y SUS SALES, SU PREPARACION Y SU APLICACION COMO MEDICAMENTOS.
ES94401805T 1993-08-05 1994-08-04 Nuevos derivados biciclicos de imidazol, su procedimiento de preparacion, nuevos productos intermedios obtenidos, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2183833T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9309654A FR2708612B1 (fr) 1993-08-05 1993-08-05 Nouveaux dérivés bicycliques de l'imidazole, leur procédé de préparation, les nouveaux intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant.

Publications (1)

Publication Number Publication Date
ES2183833T3 true ES2183833T3 (es) 2003-04-01

Family

ID=9449973

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94401805T Expired - Lifetime ES2183833T3 (es) 1993-08-05 1994-08-04 Nuevos derivados biciclicos de imidazol, su procedimiento de preparacion, nuevos productos intermedios obtenidos, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.

Country Status (16)

Country Link
US (1) US5714508A (es)
EP (1) EP0638572B1 (es)
JP (1) JP3766443B2 (es)
KR (1) KR100349827B1 (es)
CN (1) CN1054377C (es)
AT (1) ATE229023T1 (es)
AU (1) AU690116B2 (es)
CA (1) CA2129483A1 (es)
DE (1) DE69431820T2 (es)
DK (1) DK0638572T3 (es)
ES (1) ES2183833T3 (es)
FR (1) FR2708612B1 (es)
HU (1) HU218379B (es)
PT (1) PT638572E (es)
RU (1) RU2141481C1 (es)
ZA (1) ZA945882B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601847B2 (en) 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157026A (en) * 1989-05-30 1992-10-20 Merck & Co., Inc. Oxo-purines as angiotensin II antagonists
JPH04235974A (ja) * 1990-06-08 1992-08-25 Roussel Uclaf 新規なイミダゾール誘導体、それらの製造法、得られる新規な中間体、それらの薬剤としての使用及びそれらを含有する製薬組成物
CN1028755C (zh) * 1991-01-04 1995-06-07 赫彻斯特股份公司 咪唑衍生物的制备方法
CA2058198A1 (en) * 1991-01-04 1992-07-05 Adalbert Wagner Azole derivatives, process for their preparation, and their use
TW300219B (es) * 1991-09-14 1997-03-11 Hoechst Ag
DE4225835A1 (de) * 1992-08-05 1994-02-10 Merck Patent Gmbh Verfahren zur Herstellung von Imidazopyridinen
DE4242459A1 (de) * 1992-12-16 1994-06-23 Merck Patent Gmbh Imidazopyridine
DE4318813A1 (de) * 1993-06-07 1994-12-08 Merck Patent Gmbh Imidazopyridine

Also Published As

Publication number Publication date
FR2708612A1 (fr) 1995-02-10
RU94028266A (ru) 1996-07-10
ATE229023T1 (de) 2002-12-15
CN1112112A (zh) 1995-11-22
DE69431820T2 (de) 2003-05-28
CA2129483A1 (fr) 1995-02-06
US5714508A (en) 1998-02-03
HU9402282D0 (en) 1994-09-28
RU2141481C1 (ru) 1999-11-20
DK0638572T3 (da) 2003-03-24
EP0638572B1 (fr) 2002-12-04
KR950005810A (ko) 1995-03-20
HU218379B (hu) 2000-08-28
KR100349827B1 (ko) 2003-01-08
PT638572E (pt) 2003-04-30
FR2708612B1 (fr) 1996-03-01
JPH07145150A (ja) 1995-06-06
AU690116B2 (en) 1998-04-23
AU6748994A (en) 1995-02-16
JP3766443B2 (ja) 2006-04-12
DE69431820D1 (de) 2003-01-16
EP0638572A1 (fr) 1995-02-15
HUT70940A (en) 1995-11-28
CN1054377C (zh) 2000-07-12
ZA945882B (en) 1995-08-07

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