EA199800795A1 - Новые таксоиды, их получение и фармацевтические композиции, их содержащие - Google Patents

Новые таксоиды, их получение и фармацевтические композиции, их содержащие

Info

Publication number
EA199800795A1
EA199800795A1 EA199800795A EA199800795A EA199800795A1 EA 199800795 A1 EA199800795 A1 EA 199800795A1 EA 199800795 A EA199800795 A EA 199800795A EA 199800795 A EA199800795 A EA 199800795A EA 199800795 A1 EA199800795 A1 EA 199800795A1
Authority
EA
Eurasian Patent Office
Prior art keywords
radical
general formula
optionally substituted
pharmaceutical compositions
alkynyl
Prior art date
Application number
EA199800795A
Other languages
English (en)
Other versions
EA001516B1 (ru
Inventor
Эрве Бушар
Жан-Доминик Бурза
Ален Коммерсон
Original Assignee
Рон-Пуленк Роре С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А.
Publication of EA199800795A1 publication Critical patent/EA199800795A1/ru
Publication of EA001516B1 publication Critical patent/EA001516B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Новые таксоиды общей формулы:их получение и фармацевтические композиции, которые их содержат.В общей формуле (I):Z означает атом водорода или радикал общей формулы:в которой Rозначает радикал бензоил, возможно замещенный, или радикал R-O-CO-, в котором Rозначает радикал алкил, алкенил, алкинил, циклоалкил, циклоалкенил, бициклоалкил, фенил, возможно замещенный, или гетероцикл;Rозначает радикал алкил, алкенил, алкинил, циклоалкил, фенил, нафтил или ароматический гетероциклический радикал;Rозначает радикал гидрокси или радикал алкокси, алкенилокси, алкинилокси, возможно замещенный, алканоилокси, алкеноилокси, алкоксиацетил, алкилоксикарбонилокси или радикал циклоалкилокси, или циклоалкенилокси, или арилкарбонилокси, или гетероциклилкарбонилокси; иRозначает радикал алкокси, возможно замещенный, или радикал циклоалкилокси, или циклоалкенилокси. Новые соединения общей формулы (I), в которой Z означает радикал общей формулы (II), обладающий противоопухолевыми свойствами и противолейкозными свойствами.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800795A 1996-03-06 1997-03-05 Новые таксоиды, их получение и фармацевтические композиции, их содержащие EA001516B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9602804A FR2745814B1 (fr) 1996-03-06 1996-03-06 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1997/000386 WO1997032869A1 (fr) 1996-03-06 1997-03-05 Taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
EA199800795A1 true EA199800795A1 (ru) 1999-02-25
EA001516B1 EA001516B1 (ru) 2001-04-23

Family

ID=9489910

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800795A EA001516B1 (ru) 1996-03-06 1997-03-05 Новые таксоиды, их получение и фармацевтические композиции, их содержащие

Country Status (34)

Country Link
US (1) US6160135A (ru)
EP (1) EP0885208B1 (ru)
JP (1) JP2000506158A (ru)
KR (1) KR19990087398A (ru)
CN (1) CN1210525A (ru)
AP (1) AP1023A (ru)
AT (1) ATE204266T1 (ru)
AU (1) AU715228B2 (ru)
BG (1) BG63693B1 (ru)
BR (1) BR9707887A (ru)
CA (1) CA2248195A1 (ru)
CZ (1) CZ283498A3 (ru)
DE (1) DE69706146T2 (ru)
DK (1) DK0885208T3 (ru)
EA (1) EA001516B1 (ru)
EE (1) EE03611B1 (ru)
ES (1) ES2161446T3 (ru)
FR (1) FR2745814B1 (ru)
GE (1) GEP20012517B (ru)
GR (1) GR3036410T3 (ru)
HU (1) HUP9902425A3 (ru)
IL (1) IL125998A (ru)
IS (1) IS4809A (ru)
NO (1) NO983472D0 (ru)
NZ (1) NZ331040A (ru)
OA (1) OA10855A (ru)
PL (1) PL328691A1 (ru)
PT (1) PT885208E (ru)
SK (1) SK121598A3 (ru)
TR (1) TR199801732T2 (ru)
TW (1) TW474928B (ru)
WO (1) WO1997032869A1 (ru)
YU (1) YU38398A (ru)
ZA (1) ZA971746B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
AU758418B2 (en) * 1997-12-19 2003-03-20 Kabushiki Kaisha Yakult Honsha Taxane derivatives
EP1020188A1 (en) * 1999-01-13 2000-07-19 Aventis Pharma S.A. New use of taxoid derivatives
CO5280224A1 (es) * 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
HUP0200759A3 (en) 2000-02-02 2002-10-28 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them and their use
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
EP1737444A4 (en) 2004-03-05 2008-05-21 Univ Florida State Res Found C7-LACTYLOXA-SUBSTITUTED TAXANE
EP2183234A4 (en) * 2007-08-22 2012-02-29 Canada Inc 6570763 PROCESS FOR CONVERTING 9-DIHYDRO-13-ACETYLBACCATIN III IN DOCETAXEL OR PACLITAXEL
FR2926551A1 (fr) * 2008-01-17 2009-07-24 Aventis Pharma Sa Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
PE20121429A1 (es) 2009-10-29 2012-11-06 Aventis Pharma Sa Nuevo uso antitumoral de cabazitaxel
CN104650012A (zh) * 2013-11-22 2015-05-27 天士力控股集团有限公司 一种紫杉烷类化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
KR930702323A (ko) * 1991-07-17 1993-09-08 하지메 나까가와 항종양 활성을 가진 화합물(nsc-lsc1) 및 그의 제조방법
CA2100808A1 (en) * 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
IL109052A (en) * 1993-03-22 2009-07-20 Univ Florida State Taxanes having a furyl or thienyl substituted side-chain and pharmaceutical compositions containing them
FR2711369B1 (fr) * 1993-10-20 1995-11-17 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent.
DK0773938T3 (da) * 1994-07-26 1999-09-20 Indena Spa Semi-syntetiske taxaner med anti-tumoraktivitet
US6201140B1 (en) * 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives

Also Published As

Publication number Publication date
EA001516B1 (ru) 2001-04-23
EE03611B1 (et) 2002-02-15
ATE204266T1 (de) 2001-09-15
GR3036410T3 (en) 2001-11-30
CN1210525A (zh) 1999-03-10
IL125998A0 (en) 1999-04-11
PL328691A1 (en) 1999-02-15
CZ283498A3 (cs) 1999-01-13
ES2161446T3 (es) 2001-12-01
YU38398A (sh) 1999-07-28
NO983472L (no) 1998-07-28
BR9707887A (pt) 1999-09-21
KR19990087398A (ko) 1999-12-27
AU715228B2 (en) 2000-01-20
OA10855A (fr) 2003-02-05
EP0885208B1 (fr) 2001-08-16
EP0885208A1 (fr) 1998-12-23
DE69706146T2 (de) 2002-05-02
TW474928B (en) 2002-02-01
FR2745814A1 (fr) 1997-09-12
SK121598A3 (en) 1999-01-11
AP9801335A0 (en) 1998-09-30
EE9800264A (et) 1999-02-15
PT885208E (pt) 2001-11-30
AP1023A (en) 2001-11-16
FR2745814B1 (fr) 1998-04-03
IL125998A (en) 2002-02-10
HUP9902425A3 (en) 2001-08-28
BG63693B1 (bg) 2002-09-30
IS4809A (is) 1998-07-24
JP2000506158A (ja) 2000-05-23
HUP9902425A2 (hu) 2001-04-28
NZ331040A (en) 2000-02-28
AU2030297A (en) 1997-09-22
BG102753A (en) 1999-09-30
CA2248195A1 (fr) 1997-09-12
TR199801732T2 (xx) 1998-12-21
GEP20012517B (en) 2001-08-27
DK0885208T3 (da) 2001-10-15
NO983472D0 (no) 1998-07-28
ZA971746B (en) 1997-09-16
DE69706146D1 (de) 2001-09-20
WO1997032869A1 (fr) 1997-09-12
US6160135A (en) 2000-12-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU