BR9707887A - Taxóides, processo para sua preparação, produto e composição farmacêutica - Google Patents

Taxóides, processo para sua preparação, produto e composição farmacêutica

Info

Publication number
BR9707887A
BR9707887A BR9707887-5A BR9707887A BR9707887A BR 9707887 A BR9707887 A BR 9707887A BR 9707887 A BR9707887 A BR 9707887A BR 9707887 A BR9707887 A BR 9707887A
Authority
BR
Brazil
Prior art keywords
radical
general formula
preparation
taxoids
substituted
Prior art date
Application number
BR9707887-5A
Other languages
English (en)
Inventor
Herve Bouchard
Jean-Dominique Bourzat
Alain Commercon
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of BR9707887A publication Critical patent/BR9707887A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/061,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

TAXóIDES, PROCESSO PARA SUA PREPARAçãO, PRODUTO E COMPOSIçãO FARMACêUTICA. Novos taxóides de fórmula geral (I): sua preparação e as composições farmacêuticas que os contêm. Na fórmula geral (I): Z representa um átomo de hidrogênio ou um radical de fórmula geral (II): na qual R~ 1~ representa um radical benzoíla eventualmente substituído ou um radical R~ 2~-O-CO- no qual R~ 2~ representa um radical alcoíla, alcenila, alcinila, cicloalcoíla, cicloalcenila, bicicloalcoíla, fenila eventualmente substituído ou heterociclila, R~ 3~ representa um radical alcoíla, alcenila, alcinila, cicloalcoíla, fenila, naftila ou heterocíclico aromático, R~ 4~ representa um radical hidróxi ou um radical alcóxi, alcenilóxi, alcinilóxi eventualmente substituído, alcanoilóxi, alcenoiloxi, alcinoilóxi, alcoxiacetila, alcoilóxicarbonilóxi, ou um radical cicloalcoilóxi ou cicloalcenilóxi ou arilcarbonilóxi ou heterociclilcarbonilóxi, e R~ 5~ representa um radical alcóxi eventualmente substituído ou um radical cicloalcoilóxi ou cicloalcenilóxi. Os novos produtos de fórmula geral (I) na qual Z representa um radical de fórmula geral (II) apresentam propriedades antitumorais e antileucêmicas notáveis.
BR9707887-5A 1996-03-06 1997-03-05 Taxóides, processo para sua preparação, produto e composição farmacêutica BR9707887A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9602804A FR2745814B1 (fr) 1996-03-06 1996-03-06 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1997/000386 WO1997032869A1 (fr) 1996-03-06 1997-03-05 Taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BR9707887A true BR9707887A (pt) 1999-09-21

Family

ID=9489910

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9707887-5A BR9707887A (pt) 1996-03-06 1997-03-05 Taxóides, processo para sua preparação, produto e composição farmacêutica

Country Status (34)

Country Link
US (1) US6160135A (pt)
EP (1) EP0885208B1 (pt)
JP (1) JP2000506158A (pt)
KR (1) KR19990087398A (pt)
CN (1) CN1210525A (pt)
AP (1) AP1023A (pt)
AT (1) ATE204266T1 (pt)
AU (1) AU715228B2 (pt)
BG (1) BG63693B1 (pt)
BR (1) BR9707887A (pt)
CA (1) CA2248195A1 (pt)
CZ (1) CZ283498A3 (pt)
DE (1) DE69706146T2 (pt)
DK (1) DK0885208T3 (pt)
EA (1) EA001516B1 (pt)
EE (1) EE03611B1 (pt)
ES (1) ES2161446T3 (pt)
FR (1) FR2745814B1 (pt)
GE (1) GEP20012517B (pt)
GR (1) GR3036410T3 (pt)
HU (1) HUP9902425A3 (pt)
IL (1) IL125998A (pt)
IS (1) IS4809A (pt)
NO (1) NO983472D0 (pt)
NZ (1) NZ331040A (pt)
OA (1) OA10855A (pt)
PL (1) PL328691A1 (pt)
PT (1) PT885208E (pt)
SK (1) SK121598A3 (pt)
TR (1) TR199801732T2 (pt)
TW (1) TW474928B (pt)
WO (1) WO1997032869A1 (pt)
YU (1) YU38398A (pt)
ZA (1) ZA971746B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
EP1044971A4 (en) * 1997-12-19 2001-11-07 Yakult Honsha Kk TAXANE DERIVATIVES
EP1020188A1 (en) * 1999-01-13 2000-07-19 Aventis Pharma S.A. New use of taxoid derivatives
RU2264400C2 (ru) 2000-02-02 2005-11-20 Флорида Стейт Юниверсити Рисерч Фаундейшн, Инк. Таксан, фармацевтическая композиция на его основе и способ ингибирования роста опухоли
CO5280224A1 (es) * 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
WO2005087222A1 (en) 2004-03-05 2005-09-22 Florida State University Research Foundation, Inc. C7 lactyloxy-substituted taxanes
WO2009023967A1 (en) * 2007-08-22 2009-02-26 6570763 Canada Inc. Process for converting 9-dihydro-13-acetylbaccatin iii into docetaxel or paclitaxel
FR2926551A1 (fr) * 2008-01-17 2009-07-24 Aventis Pharma Sa Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation
AU2010310986A1 (en) 2009-10-29 2012-06-14 Aventis Pharma S.A. Novel antitumoral use of cabazitaxel
CN104650012A (zh) 2013-11-22 2015-05-27 天士力控股集团有限公司 一种紫杉烷类化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
CA2092705C (en) * 1991-07-17 1995-11-07 Koji Saito Compound having antitumor activity, nsc-lsc1, and process for producing the same
CA2100808A1 (en) * 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
ES2242807T3 (es) * 1993-03-22 2005-11-16 Florida State University Taxanos que tienen furilo o tienilo sustituido en la cadena lateral sustituida.
FR2711369B1 (fr) * 1993-10-20 1995-11-17 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent.
CN1073105C (zh) * 1994-07-26 2001-10-17 因迪纳有限公司 具有抗肿瘤活性的半合成紫杉烷
US6201140B1 (en) * 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives

Also Published As

Publication number Publication date
SK121598A3 (en) 1999-01-11
AU715228B2 (en) 2000-01-20
GEP20012517B (en) 2001-08-27
EP0885208A1 (fr) 1998-12-23
DK0885208T3 (da) 2001-10-15
YU38398A (sh) 1999-07-28
HUP9902425A3 (en) 2001-08-28
JP2000506158A (ja) 2000-05-23
CZ283498A3 (cs) 1999-01-13
BG102753A (en) 1999-09-30
FR2745814A1 (fr) 1997-09-12
NO983472L (no) 1998-07-28
KR19990087398A (ko) 1999-12-27
CN1210525A (zh) 1999-03-10
AP9801335A0 (en) 1998-09-30
PL328691A1 (en) 1999-02-15
IS4809A (is) 1998-07-24
AP1023A (en) 2001-11-16
HUP9902425A2 (hu) 2001-04-28
PT885208E (pt) 2001-11-30
CA2248195A1 (fr) 1997-09-12
EA199800795A1 (ru) 1999-02-25
EA001516B1 (ru) 2001-04-23
OA10855A (fr) 2003-02-05
IL125998A (en) 2002-02-10
IL125998A0 (en) 1999-04-11
ZA971746B (en) 1997-09-16
EE9800264A (et) 1999-02-15
ES2161446T3 (es) 2001-12-01
WO1997032869A1 (fr) 1997-09-12
TW474928B (en) 2002-02-01
NO983472D0 (no) 1998-07-28
US6160135A (en) 2000-12-12
DE69706146T2 (de) 2002-05-02
TR199801732T2 (xx) 1998-12-21
FR2745814B1 (fr) 1998-04-03
NZ331040A (en) 2000-02-28
AU2030297A (en) 1997-09-22
EE03611B1 (et) 2002-02-15
GR3036410T3 (en) 2001-11-30
DE69706146D1 (de) 2001-09-20
ATE204266T1 (de) 2001-09-15
EP0885208B1 (fr) 2001-08-16
BG63693B1 (bg) 2002-09-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A , 7A E 8A E 9A ANUIDADES.