DE69308154D1 - Verfahren zur herstellung von taxan-derivaten - Google Patents

Verfahren zur herstellung von taxan-derivaten

Info

Publication number
DE69308154D1
DE69308154D1 DE69308154T DE69308154T DE69308154D1 DE 69308154 D1 DE69308154 D1 DE 69308154D1 DE 69308154 T DE69308154 T DE 69308154T DE 69308154 T DE69308154 T DE 69308154T DE 69308154 D1 DE69308154 D1 DE 69308154D1
Authority
DE
Germany
Prior art keywords
pct
radical
vii
formula
date apr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69308154T
Other languages
English (en)
Other versions
DE69308154T2 (de
Inventor
Alain Commercon
Eric Didier
Elie Fouque
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of DE69308154D1 publication Critical patent/DE69308154D1/de
Application granted granted Critical
Publication of DE69308154T2 publication Critical patent/DE69308154T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69308154T 1992-10-05 1993-10-04 Verfahren zur herstellung von taxan-derivaten Expired - Fee Related DE69308154T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9211743A FR2696460B1 (fr) 1992-10-05 1992-10-05 Procédé de préparation de dérivés du taxane.
PCT/FR1993/000969 WO1994007879A1 (fr) 1992-10-05 1993-10-04 Procede de preparation de derives du taxane

Publications (2)

Publication Number Publication Date
DE69308154D1 true DE69308154D1 (de) 1997-03-27
DE69308154T2 DE69308154T2 (de) 1997-09-25

Family

ID=9434121

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69308154T Expired - Fee Related DE69308154T2 (de) 1992-10-05 1993-10-04 Verfahren zur herstellung von taxan-derivaten

Country Status (24)

Country Link
US (3) US5621121A (de)
EP (1) EP0663908B1 (de)
JP (1) JP3014762B2 (de)
KR (1) KR100301237B1 (de)
AT (1) ATE148882T1 (de)
AU (1) AU690080B2 (de)
CA (1) CA2146249A1 (de)
CZ (1) CZ283291B6 (de)
DE (1) DE69308154T2 (de)
DK (1) DK0663908T3 (de)
ES (1) ES2098060T3 (de)
FI (1) FI951592A0 (de)
FR (1) FR2696460B1 (de)
GR (1) GR3022616T3 (de)
HU (1) HUT72613A (de)
MX (1) MX9305768A (de)
NO (1) NO311255B1 (de)
NZ (1) NZ256447A (de)
PL (1) PL184556B1 (de)
RU (1) RU2115649C1 (de)
SK (1) SK280577B6 (de)
TW (1) TW393474B (de)
WO (1) WO1994007879A1 (de)
ZA (1) ZA937320B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2697522B1 (fr) * 1992-10-30 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
DE69433297T2 (de) 1993-02-05 2004-10-21 Bryn Mawr College Bryn Mawr Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten
DE69432141T2 (de) * 1993-03-22 2003-07-31 Univ Florida State Taxane mit furyl-oder thienyl substituierten seitenketten
SI0703909T1 (en) * 1993-06-11 2000-08-31 Pharmacia & Upjohn Company Delta 6,7 -taxols antineoplastic use and pharmaceutical compositions containing them
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
KR100354309B1 (ko) * 1993-11-12 2003-01-06 파마시아 앤드 업존 캄파니 피리미딘-티오알킬및알킬에테르화합물
IL112412A (en) * 1994-01-28 2000-02-29 Upjohn Co Delta 12,13-iso-taxol analogs and antineoplastic pharmaceutical compositions containing them
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
DE69731005T2 (de) * 1996-05-08 2005-10-06 Pharmacia & Upjohn Co., Kalamazoo Verfahren zu Herstellung von Taxol
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
AU739303B2 (en) * 1997-08-21 2001-10-11 Florida State University Method for the synthesis of taxanes
US5917062A (en) * 1997-11-21 1999-06-29 Indena S.P.A Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
IT1308636B1 (it) 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
EP1229934B1 (de) 1999-10-01 2014-03-05 Immunogen, Inc. Zusammensetzungen und verfahren zur behandlung von krebs mittels immunkonjugaten und chemotherapeutischen agenzien
HUP0302599A3 (en) 2000-09-22 2005-05-30 Bristol Myers Squibb Co Method for reducing toxicity of combined chemotherapic compositions
WO2002076967A1 (en) * 2001-03-23 2002-10-03 George Scholemer Process for making taxane derivatives
JP2006513152A (ja) * 2002-10-09 2006-04-20 ファイトジェン ライフ サイエンシズ インコーポレイテッド 新規タキサンならびにその使用および調製に関する方法
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
DE102004034140A1 (de) * 2004-07-15 2006-02-23 Covion Organic Semiconductors Gmbh Verwendung von Polymeren für Up-conversion und Vorrichtungen zur Up-conversion
AU2007309534B2 (en) * 2006-10-20 2012-08-16 Scinopharm Singapore Pte, Ltd. Process for making crystalline anhydrous docetaxel
KR100847331B1 (ko) * 2006-12-14 2008-07-21 한미약품 주식회사 도세탁셀의 제조방법 및 이에 사용되는 중간체
EP2080764B1 (de) 2008-01-18 2012-08-22 INDENA S.p.A. Feste Formen von Ortataxel
KR101003820B1 (ko) 2008-06-19 2010-12-27 주식회사 셀트리온화학연구소 도세탁셀의 제조방법 및 도세탁셀의 제조를 위한 신규한중간체
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
JP2014079364A (ja) * 2012-10-16 2014-05-08 Tokai Medical Care Holdings Co Ltd 歩行訓練補助器

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
SI0703909T1 (en) * 1993-06-11 2000-08-31 Pharmacia & Upjohn Company Delta 6,7 -taxols antineoplastic use and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FR2696460B1 (fr) 1994-11-25
CZ84395A3 (en) 1995-09-13
AU690080B2 (en) 1998-04-23
DK0663908T3 (de) 1997-03-17
JPH08501790A (ja) 1996-02-27
SK280577B6 (sk) 2000-04-10
US5861515A (en) 1999-01-19
HU9500968D0 (en) 1995-06-28
PL184556B1 (pl) 2002-11-29
NO311255B1 (no) 2001-11-05
TW393474B (en) 2000-06-11
NO951203D0 (no) 1995-03-29
NZ256447A (en) 1997-01-29
KR100301237B1 (ko) 2001-11-22
FR2696460A1 (fr) 1994-04-08
US5621121A (en) 1997-04-15
US5726318A (en) 1998-03-10
SK43495A3 (en) 1995-08-09
MX9305768A (es) 1994-05-31
FI951592A (fi) 1995-04-04
AU5115293A (en) 1994-04-26
EP0663908B1 (de) 1997-02-12
HUT72613A (en) 1996-05-28
WO1994007879A1 (fr) 1994-04-14
ZA937320B (en) 1994-04-25
RU95110682A (ru) 1996-12-27
JP3014762B2 (ja) 2000-02-28
ATE148882T1 (de) 1997-02-15
RU2115649C1 (ru) 1998-07-20
ES2098060T3 (es) 1997-04-16
DE69308154T2 (de) 1997-09-25
FI951592A0 (fi) 1995-04-04
CZ283291B6 (cs) 1998-02-18
PL308242A1 (en) 1995-07-24
CA2146249A1 (fr) 1994-04-14
GR3022616T3 (en) 1997-05-31
EP0663908A1 (de) 1995-07-26
NO951203L (no) 1995-03-29
KR950703548A (ko) 1995-09-20

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY, FR

8339 Ceased/non-payment of the annual fee