DE69432141T2 - Taxane mit furyl-oder thienyl substituierten seitenketten - Google Patents
Taxane mit furyl-oder thienyl substituierten seitenkettenInfo
- Publication number
- DE69432141T2 DE69432141T2 DE69432141T DE69432141T DE69432141T2 DE 69432141 T2 DE69432141 T2 DE 69432141T2 DE 69432141 T DE69432141 T DE 69432141T DE 69432141 T DE69432141 T DE 69432141T DE 69432141 T2 DE69432141 T2 DE 69432141T2
- Authority
- DE
- Germany
- Prior art keywords
- furyl
- taxane
- side chains
- thienyl substituted
- substituted side
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3485293A | 1993-03-22 | 1993-03-22 | |
US9471793A | 1993-07-20 | 1993-07-20 | |
PCT/US1994/003097 WO1994021651A1 (en) | 1993-03-22 | 1994-03-21 | Taxanes having furyl or thienyl substituted side-chain |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69432141D1 DE69432141D1 (de) | 2003-03-27 |
DE69432141T2 true DE69432141T2 (de) | 2003-07-31 |
Family
ID=26711460
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69434373T Expired - Fee Related DE69434373T2 (de) | 1993-03-22 | 1994-03-21 | Beta-laktame zur Herstellung von Taxanen mit Furyl oder Thienyl substituierter Seitenkette |
DE69434374T Expired - Fee Related DE69434374T2 (de) | 1993-03-22 | 1994-03-21 | Taxane mit Furyl oder Thienyl enthaltender substituierter Seitenkette |
DE69432141T Expired - Fee Related DE69432141T2 (de) | 1993-03-22 | 1994-03-21 | Taxane mit furyl-oder thienyl substituierten seitenketten |
DE69433355T Expired - Fee Related DE69433355T2 (de) | 1993-03-22 | 1994-03-21 | Taxane ohne die c-9 oxo gruppe und diese enthaltende pharmazeutische präparate |
DE69434190T Expired - Fee Related DE69434190T2 (de) | 1993-03-22 | 1994-03-21 | Pharmazeutische Zusammenstellungen enthaltende eine furyl oder thienyl substituierte Seitenkette |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69434373T Expired - Fee Related DE69434373T2 (de) | 1993-03-22 | 1994-03-21 | Beta-laktame zur Herstellung von Taxanen mit Furyl oder Thienyl substituierter Seitenkette |
DE69434374T Expired - Fee Related DE69434374T2 (de) | 1993-03-22 | 1994-03-21 | Taxane mit Furyl oder Thienyl enthaltender substituierter Seitenkette |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69433355T Expired - Fee Related DE69433355T2 (de) | 1993-03-22 | 1994-03-21 | Taxane ohne die c-9 oxo gruppe und diese enthaltende pharmazeutische präparate |
DE69434190T Expired - Fee Related DE69434190T2 (de) | 1993-03-22 | 1994-03-21 | Pharmazeutische Zusammenstellungen enthaltende eine furyl oder thienyl substituierte Seitenkette |
Country Status (12)
Country | Link |
---|---|
EP (6) | EP1228759B1 (de) |
JP (2) | JPH08508469A (de) |
AT (5) | ATE295164T1 (de) |
AU (3) | AU6367994A (de) |
CA (2) | CA2158454C (de) |
DE (5) | DE69434373T2 (de) |
DK (5) | DK0689436T3 (de) |
ES (5) | ES2241923T3 (de) |
IL (4) | IL180090A0 (de) |
PT (5) | PT1260223E (de) |
SG (3) | SG68049A1 (de) |
WO (2) | WO1994021651A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2712289B1 (fr) * | 1993-11-08 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent. |
US5677470A (en) * | 1994-06-28 | 1997-10-14 | Tanabe Seiyaku Co., Ltd. | Baccatin derivatives and processes for preparing the same |
AU4133096A (en) * | 1994-10-28 | 1996-05-23 | Research Foundation Of The State University Of New York, The | Taxoid derivatives, their preparation and their use as antitumor agents |
US6500858B2 (en) | 1994-10-28 | 2002-12-31 | The Research Foundation Of The State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
US6458976B1 (en) | 1994-10-28 | 2002-10-01 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods |
CA2162759A1 (en) * | 1994-11-17 | 1996-05-18 | Kenji Tsujihara | Baccatin derivatives and processes for preparing the same |
BR9608040B1 (pt) * | 1995-04-28 | 2010-02-23 | composto taxàide pentacÍclico. | |
JP2001524067A (ja) * | 1995-09-13 | 2001-11-27 | フロリダ・ステイト・ユニバーシティ | 放射線感作性タキサン類およびその医薬製剤 |
FR2745814B1 (fr) * | 1996-03-06 | 1998-04-03 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2746797B1 (fr) * | 1996-03-27 | 1998-06-19 | Centre Nat Rech Scient | Nouveaux derives du 10-acetyldocetaxel et leur procede de preparation |
JP2000510470A (ja) * | 1996-05-06 | 2000-08-15 | フロリダ・ステイト・ユニバーシティ | 1―デオキシバッカチンiii、1―デオキシタキソールおよび1―デオキシタキソール類似体、ならびにこれらの製造方法 |
WO1998017656A1 (en) * | 1996-10-24 | 1998-04-30 | Institute Armand-Frappier | A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof |
CN1362957A (zh) * | 2000-02-02 | 2002-08-07 | 佛罗里达州立大学研究基金有限公司 | 作为抗肿瘤剂的c7杂取代乙酸酯取代的紫杉烷 |
AR030188A1 (es) * | 2000-02-02 | 2003-08-13 | Univ Florida State Res Found | Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos |
JP2003522172A (ja) * | 2000-02-02 | 2003-07-22 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 抗腫瘍剤としてのc10エステル置換タキサン |
EP1785416A3 (de) | 2003-09-25 | 2007-05-30 | Tapestry Pharmaceuticals, Inc. | 9, 10-Alpha, Alpha-OH-Taxan-Analogen und Herstellungsverfahren dafür |
EP1810968A3 (de) * | 2003-09-25 | 2007-08-08 | Tapestry Pharmaceuticals, Inc. | 9, 10-a, a-OH-Taxan-Analoge und Herstellungsverfahren dafür |
EP1737444A4 (de) * | 2004-03-05 | 2008-05-21 | Univ Florida State Res Found | C7-lactyloxa-substituierte taxane |
BRPI0611959A2 (pt) * | 2005-06-10 | 2011-12-20 | Univ Florida State Res Found | resolução de misturas enantioméricas de beta-lactamas |
US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
WO2008109360A1 (en) | 2007-02-28 | 2008-09-12 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6075458A (ja) * | 1983-06-17 | 1985-04-27 | Osaka Soda Co Ltd | 3,4−ジフエニル−1−(4−置換)アリ−ルメチルアゼチジン−2−オンの製法 |
US4751299A (en) * | 1983-11-18 | 1988-06-14 | Takeda Chemical Industries, Ltd. | Optically active β-lactams and method of their production |
JPS61243079A (ja) * | 1985-04-01 | 1986-10-29 | Mect Corp | 1−(アルコキシカルボニルアルキル)−4−(2−フリル)−3−置換−2−アゼチジノン及びその製造方法 |
FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
US5006650A (en) * | 1987-02-11 | 1991-04-09 | The Upjohn Company | Novel N-1 substituted beta-lactams as antibiotics |
US4942184A (en) * | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
US5175315A (en) * | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
AU637109B2 (en) * | 1989-06-22 | 1993-05-20 | Rijksuniversiteit Utrecht | Improved synthesis of beta-lactams using a metal compound |
US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
US5283253A (en) * | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5243045A (en) * | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
DE69230379T2 (de) * | 1991-09-23 | 2000-05-25 | Univ Florida State | 10-disacetoxytaxolderivate |
US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
US5284865A (en) * | 1991-09-23 | 1994-02-08 | Holton Robert A | Cyclohexyl substituted taxanes and pharmaceutical compositions containing them |
US5229526A (en) * | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
US5250683A (en) * | 1991-09-23 | 1993-10-05 | Florida State University | Certain substituted taxanes and pharmaceutical compositions containing them |
ES2214665T3 (es) * | 1991-09-23 | 2004-09-16 | Florida State University | Alcoxidos metalicos. |
FR2688518B1 (fr) * | 1992-03-13 | 1994-05-06 | Rhone Poulenc Rorer Sa | Procede de preparation de derives du taxane. |
ES2134847T3 (es) * | 1992-04-17 | 1999-10-16 | Abbott Lab | Derivados de taxol. |
FR2696460B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
-
1994
- 1994-03-21 SG SG9801036A patent/SG68049A1/en unknown
- 1994-03-21 WO PCT/US1994/003097 patent/WO1994021651A1/en active IP Right Grant
- 1994-03-21 AT AT02019282T patent/ATE295164T1/de not_active IP Right Cessation
- 1994-03-21 ES ES02009840T patent/ES2241923T3/es not_active Expired - Lifetime
- 1994-03-21 DE DE69434373T patent/DE69434373T2/de not_active Expired - Fee Related
- 1994-03-21 EP EP02009839A patent/EP1228759B1/de not_active Expired - Lifetime
- 1994-03-21 JP JP6521307A patent/JPH08508469A/ja active Pending
- 1994-03-21 PT PT02019282T patent/PT1260223E/pt unknown
- 1994-03-21 ES ES94911675T patent/ES2193155T3/es not_active Expired - Lifetime
- 1994-03-21 CA CA002158454A patent/CA2158454C/en not_active Expired - Fee Related
- 1994-03-21 AU AU63679/94A patent/AU6367994A/en not_active Abandoned
- 1994-03-21 EP EP02009840A patent/EP1227093B1/de not_active Expired - Lifetime
- 1994-03-21 PT PT02009839T patent/PT1228759E/pt unknown
- 1994-03-21 IL IL180090A patent/IL180090A0/en unknown
- 1994-03-21 CA CA002158862A patent/CA2158862C/en not_active Expired - Fee Related
- 1994-03-21 DK DK94910982T patent/DK0689436T3/da active
- 1994-03-21 DK DK02009840T patent/DK1227093T3/da active
- 1994-03-21 AT AT94910982T patent/ATE254914T1/de not_active IP Right Cessation
- 1994-03-21 SG SG9904638A patent/SG89298A1/en unknown
- 1994-03-21 ES ES02019282T patent/ES2242807T3/es not_active Expired - Lifetime
- 1994-03-21 AT AT02009840T patent/ATE295363T1/de not_active IP Right Cessation
- 1994-03-21 ES ES02009839T patent/ES2232694T3/es not_active Expired - Lifetime
- 1994-03-21 DK DK94911675T patent/DK0690867T3/da active
- 1994-03-21 ES ES94910982T patent/ES2211879T3/es not_active Expired - Lifetime
- 1994-03-21 DE DE69434374T patent/DE69434374T2/de not_active Expired - Fee Related
- 1994-03-21 EP EP02019282A patent/EP1260223B1/de not_active Expired - Lifetime
- 1994-03-21 SG SG1996006328A patent/SG73401A1/en unknown
- 1994-03-21 DK DK02009839T patent/DK1228759T3/da active
- 1994-03-21 DE DE69432141T patent/DE69432141T2/de not_active Expired - Fee Related
- 1994-03-21 AT AT94911675T patent/ATE232871T1/de not_active IP Right Cessation
- 1994-03-21 PT PT02009840T patent/PT1227093E/pt unknown
- 1994-03-21 PT PT94911675T patent/PT690867E/pt unknown
- 1994-03-21 EP EP03027078A patent/EP1398028A3/de not_active Withdrawn
- 1994-03-21 EP EP94910982A patent/EP0689436B1/de not_active Expired - Lifetime
- 1994-03-21 PT PT94910982T patent/PT689436E/pt unknown
- 1994-03-21 DK DK02019282T patent/DK1260223T3/da active
- 1994-03-21 EP EP94911675A patent/EP0690867B1/de not_active Expired - Lifetime
- 1994-03-21 IL IL10905094A patent/IL109050A0/xx unknown
- 1994-03-21 JP JP6521330A patent/JPH08508255A/ja active Pending
- 1994-03-21 DE DE69433355T patent/DE69433355T2/de not_active Expired - Fee Related
- 1994-03-21 IL IL109052A patent/IL109052A/en not_active IP Right Cessation
- 1994-03-21 DE DE69434190T patent/DE69434190T2/de not_active Expired - Fee Related
- 1994-03-21 AU AU64138/94A patent/AU691804B2/en not_active Ceased
- 1994-03-21 WO PCT/US1994/003053 patent/WO1994021250A1/en active IP Right Grant
- 1994-03-21 AT AT02009839T patent/ATE284689T1/de not_active IP Right Cessation
-
1998
- 1998-08-03 AU AU78636/98A patent/AU714180B2/en not_active Ceased
-
2008
- 2008-04-17 IL IL190945A patent/IL190945A0/en unknown
Also Published As
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