AR030188A1 - Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos - Google Patents
Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanosInfo
- Publication number
- AR030188A1 AR030188A1 ARP010100463A ARP010100463A AR030188A1 AR 030188 A1 AR030188 A1 AR 030188A1 AR P010100463 A ARP010100463 A AR P010100463A AR P010100463 A ARP010100463 A AR P010100463A AR 030188 A1 AR030188 A1 AR 030188A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrocarbyl
- substituted
- heterocycle
- groups
- subject
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Compuestos de taxano sustituidos con ésteres en el C7, que tienen la formula: (1) donde Ac es acetilo; Bz es benzoilo; R7 es RaCOO-; R10 es hidroxilo; X3 es alquilo, alquenilo, alquinilo o heterociclo sustituido o insustituido; X5 es ûCOX10, -COOX10 o ûCONHX10; X10 es hidrocarbilo, hidrocarbilo sustituido o heterociclo; y Ra es hidrocarbilo, hidrocarbilo sustituido o heterociclo, donde dicho hidrocarbilo o hidrocarbilo sustituido contiene átomos de carbono en las posiciones alfa y beta respecto del carbono en el cual Ra es un sustituyente. Preferiblemente, los grupos hidrocarbilo o hidrocarbilo sustituido incluyen grupos alquilo, alquenilo, alquinilo y arilo que comprenden de 1 a 20 átomos de carbono. Los sustituyentes pueden incluir halogeno heterociclo, alcoxi, alquenoxi, alquinoxi, ariloxi, hidroxilo, hidroxilo protegido, aciloxi, nitro amino, ciano, tiol, cetales, acetales, y éteres. Preferiblemente, los grupos arilo denotan grupos aromáticos homocíclicos opcionalmente sustituidos, más preferiblemente grupos monocíclicos o bicíclicos que contienen de 6 a 12 átomos de carbono en la porcion del anillo. Preferiblemente el grupo heteroarilo denota grupos aromáticos o no aromáticos monocíclicos o bicíclicos, opcionalmente saturados, completamente saturados o sin saturar, que tienen al menos un heteroátomo en al menos un heteroátomo en el al menos un anillo seleccionado entre átomos de oxígeno, azufre y nitrogeno; y preferiblemente 5 o 6 átomos en cada anillo. Los ejemplos de heterociclos incluyen furilo, tienilo, piridilo, oxazolilo, pirrolilo, indolilo, quinolinilo o isoquinilinilo y semejantes. Los presentes compuestos de taxano tienen excepcional utilidad como agentes antitumor. Composiciones farmacéuticas que comprenden los taxanos y uno o más diluyentes o coadyuvantes inertes o fisiologicamente activos aceptables para el uso farmacéutico. Proceso para tratar un sujeto mamífero que sufre de una condicion que responde a los taxanos que comprende la administracion oral, topica o parenteral al sujeto de la composicion farmacéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17979400P | 2000-02-02 | 2000-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR030188A1 true AR030188A1 (es) | 2003-08-13 |
Family
ID=22658029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010100463A AR030188A1 (es) | 2000-02-02 | 2001-01-31 | Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US6610860B2 (es) |
| EP (1) | EP1183253B8 (es) |
| JP (1) | JP2003522167A (es) |
| KR (1) | KR100784161B1 (es) |
| CN (1) | CN1362955A (es) |
| AR (1) | AR030188A1 (es) |
| AT (1) | ATE396188T1 (es) |
| AU (1) | AU776051B2 (es) |
| BG (1) | BG65279B1 (es) |
| BR (1) | BR0104749A (es) |
| CA (1) | CA2368993C (es) |
| CO (1) | CO5280224A1 (es) |
| CZ (1) | CZ298484B6 (es) |
| DE (1) | DE60134094D1 (es) |
| DK (1) | DK1183253T3 (es) |
| ES (1) | ES2307588T3 (es) |
| GE (1) | GEP20043322B (es) |
| HK (1) | HK1047938A1 (es) |
| HU (1) | HUP0200917A3 (es) |
| IL (1) | IL145641A0 (es) |
| MX (1) | MXPA01009901A (es) |
| MY (1) | MY137637A (es) |
| NO (1) | NO327982B1 (es) |
| NZ (1) | NZ514409A (es) |
| PL (1) | PL202668B1 (es) |
| PT (1) | PT1183253E (es) |
| RO (1) | RO121777B1 (es) |
| RU (1) | RU2265017C2 (es) |
| SA (1) | SA01220045B1 (es) |
| SK (1) | SK13712001A3 (es) |
| TR (1) | TR200102856T1 (es) |
| TW (1) | TWI291873B (es) |
| UA (1) | UA75573C2 (es) |
| WO (1) | WO2001057027A1 (es) |
| ZA (1) | ZA200108060B (es) |
Families Citing this family (36)
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| AR030188A1 (es) | 2000-02-02 | 2003-08-13 | Univ Florida State Res Found | Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos |
| CA2367661A1 (en) * | 2000-02-02 | 2001-08-09 | Robert A. Holton | Taxane formulations having improved solubility |
| CA2354486A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C7 ester substituted taxanes |
| KR100819578B1 (ko) * | 2001-08-01 | 2008-04-04 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | Ｃ７ 에스테르 치환된 탁산 |
| SG125889A1 (en) * | 2001-08-01 | 2006-10-30 | Univ Florida State Res Found | C7 ester subsituted taxanes |
| US20030082229A1 (en) * | 2001-11-01 | 2003-05-01 | Board Of Regents, The University Of Texas Systems | Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use |
| US8012950B2 (en) * | 2003-08-29 | 2011-09-06 | Wisconsin Alumni Research Foundation | Method to diagnose and treat degenerative joint disease |
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| CN1960721A (zh) | 2004-03-05 | 2007-05-09 | 佛罗里达州立大学研究基金有限公司 | C7乳酰氧基取代的紫杉烷类 |
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| PL217731B1 (pl) | 2006-06-01 | 2014-08-29 | Tomasz Byrski | Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi |
| WO2008106621A1 (en) | 2007-02-28 | 2008-09-04 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
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| TWI454266B (zh) | 2008-07-31 | 2014-10-01 | Ziopharm Oncology Inc | 異磷酸醯胺芥子之鹽類及其類似物的合成及調配物 |
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| JP6127045B2 (ja) | 2011-07-11 | 2017-05-10 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 光増感抗体−蛍光団コンジュゲート |
| CA2874655C (en) | 2012-05-25 | 2020-11-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of regulating cannabinoid receptor activity-related disorders and diseases |
| CN105813654B (zh) | 2013-10-11 | 2019-05-31 | 美国政府(由卫生和人类服务部的部长所代表) | Tem8抗体及其用途 |
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| CA2367661A1 (en) * | 2000-02-02 | 2001-08-09 | Robert A. Holton | Taxane formulations having improved solubility |
| WO2001057013A1 (en) | 2000-02-02 | 2001-08-09 | Florida State University Research Foundation, Inc. | Taxane formulations having improved solubility |
| IT1319168B1 (it) | 2000-03-17 | 2003-09-26 | Indena Spa | Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono. |
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2001
- 2001-01-31 AR ARP010100463A patent/AR030188A1/es not_active Application Discontinuation
- 2001-01-31 CO CO01007075A patent/CO5280224A1/es not_active Application Discontinuation
- 2001-02-02 HU HU0200917A patent/HUP0200917A3/hu unknown
- 2001-02-02 EP EP01905349A patent/EP1183253B8/en not_active Expired - Lifetime
- 2001-02-02 AU AU33239/01A patent/AU776051B2/en not_active Ceased
- 2001-02-02 DK DK01905349T patent/DK1183253T3/da active
- 2001-02-02 JP JP2001557859A patent/JP2003522167A/ja active Pending
- 2001-02-02 UA UA2001106734A patent/UA75573C2/uk unknown
- 2001-02-02 PT PT01905349T patent/PT1183253E/pt unknown
- 2001-02-02 DE DE60134094T patent/DE60134094D1/de not_active Expired - Fee Related
- 2001-02-02 RU RU2001129507/04A patent/RU2265017C2/ru not_active IP Right Cessation
- 2001-02-02 TR TR2001/02856T patent/TR200102856T1/xx unknown
- 2001-02-02 CZ CZ20013503A patent/CZ298484B6/cs not_active IP Right Cessation
- 2001-02-02 AT AT01905349T patent/ATE396188T1/de not_active IP Right Cessation
- 2001-02-02 SK SK1371-2001A patent/SK13712001A3/sk unknown
- 2001-02-02 MX MXPA01009901A patent/MXPA01009901A/es active IP Right Grant
- 2001-02-02 KR KR1020017012600A patent/KR100784161B1/ko not_active IP Right Cessation
- 2001-02-02 CN CN01800306A patent/CN1362955A/zh active Pending
- 2001-02-02 RO ROA200101085A patent/RO121777B1/ro unknown
- 2001-02-02 CA CA002368993A patent/CA2368993C/en not_active Expired - Fee Related
- 2001-02-02 NZ NZ514409A patent/NZ514409A/xx unknown
- 2001-02-02 IL IL14564101A patent/IL145641A0/xx unknown
- 2001-02-02 MY MYPI20010481A patent/MY137637A/en unknown
- 2001-02-02 WO PCT/US2001/003385 patent/WO2001057027A1/en active IP Right Grant
- 2001-02-02 PL PL350026A patent/PL202668B1/pl not_active IP Right Cessation
- 2001-02-02 US US09/775,851 patent/US6610860B2/en not_active Expired - Fee Related
- 2001-02-02 BR BR0104749-3A patent/BR0104749A/pt not_active IP Right Cessation
- 2001-02-02 ES ES01905349T patent/ES2307588T3/es not_active Expired - Lifetime
- 2001-02-02 GE GE4514A patent/GEP20043322B/en unknown
- 2001-03-06 TW TW090102237A patent/TWI291873B/zh active
- 2001-04-11 SA SA1220045A patent/SA01220045B1/ar unknown
- 2001-10-01 NO NO20014759A patent/NO327982B1/no not_active IP Right Cessation
- 2001-10-01 ZA ZA200108060A patent/ZA200108060B/en unknown
- 2001-10-01 BG BG105967A patent/BG65279B1/bg unknown
-
2003
- 2003-01-07 HK HK03100173.6A patent/HK1047938A1/zh unknown
- 2003-06-25 US US10/606,027 patent/US7186849B2/en not_active Expired - Fee Related
-
2007
- 2007-01-09 US US11/621,321 patent/US20070249708A1/en not_active Abandoned
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