HK1047938A1 - 作為抗腫瘤劑的c7酯取代的紫杉烷 - Google Patents

作為抗腫瘤劑的c7酯取代的紫杉烷

Info

Publication number
HK1047938A1
HK1047938A1 HK03100173.6A HK03100173A HK1047938A1 HK 1047938 A1 HK1047938 A1 HK 1047938A1 HK 03100173 A HK03100173 A HK 03100173A HK 1047938 A1 HK1047938 A1 HK 1047938A1
Authority
HK
Hong Kong
Prior art keywords
antitumor agents
ester substituted
substituted taxanes
taxanes
ester
Prior art date
Application number
HK03100173.6A
Other languages
English (en)
Inventor
R‧A‧霍爾頓
Original Assignee
佛羅裡達州立大學研究基金有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 佛羅裡達州立大學研究基金有限公司 filed Critical 佛羅裡達州立大學研究基金有限公司
Publication of HK1047938A1 publication Critical patent/HK1047938A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK03100173.6A 2000-02-02 2003-01-07 作為抗腫瘤劑的c7酯取代的紫杉烷 HK1047938A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17979400P 2000-02-02 2000-02-02
PCT/US2001/003385 WO2001057027A1 (en) 2000-02-02 2001-02-02 C7 ester substituted taxanes as antitumor agents

Publications (1)

Publication Number Publication Date
HK1047938A1 true HK1047938A1 (zh) 2003-03-14

Family

ID=22658029

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03100173.6A HK1047938A1 (zh) 2000-02-02 2003-01-07 作為抗腫瘤劑的c7酯取代的紫杉烷

Country Status (35)

Country Link
US (3) US6610860B2 (zh)
EP (1) EP1183253B8 (zh)
JP (1) JP2003522167A (zh)
KR (1) KR100784161B1 (zh)
CN (1) CN1362955A (zh)
AR (1) AR030188A1 (zh)
AT (1) ATE396188T1 (zh)
AU (1) AU776051B2 (zh)
BG (1) BG65279B1 (zh)
BR (1) BR0104749A (zh)
CA (1) CA2368993C (zh)
CO (1) CO5280224A1 (zh)
CZ (1) CZ298484B6 (zh)
DE (1) DE60134094D1 (zh)
DK (1) DK1183253T3 (zh)
ES (1) ES2307588T3 (zh)
GE (1) GEP20043322B (zh)
HK (1) HK1047938A1 (zh)
HU (1) HUP0200917A3 (zh)
IL (1) IL145641A0 (zh)
MX (1) MXPA01009901A (zh)
MY (1) MY137637A (zh)
NO (1) NO327982B1 (zh)
NZ (1) NZ514409A (zh)
PL (1) PL202668B1 (zh)
PT (1) PT1183253E (zh)
RO (1) RO121777B1 (zh)
RU (1) RU2265017C2 (zh)
SA (1) SA01220045B1 (zh)
SK (1) SK13712001A3 (zh)
TR (1) TR200102856T1 (zh)
TW (1) TWI291873B (zh)
UA (1) UA75573C2 (zh)
WO (1) WO2001057027A1 (zh)
ZA (1) ZA200108060B (zh)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5280224A1 (es) * 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
CZ20013498A3 (cs) * 2000-02-02 2002-04-17 Florida State University Research Foundation, Inc. Taxanové formulace mající zlepąenou rozpustnost
CA2354486A1 (en) * 2001-07-31 2003-01-31 Florida State University Research Foundation, Inc. C7 ester substituted taxanes
KR100819578B1 (ko) * 2001-08-01 2008-04-04 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 Ｃ７ 에스테르 치환된 탁산
SG125889A1 (en) * 2001-08-01 2006-10-30 Univ Florida State Res Found C7 ester subsituted taxanes
US20030082229A1 (en) * 2001-11-01 2003-05-01 Board Of Regents, The University Of Texas Systems Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use
US8012950B2 (en) * 2003-08-29 2011-09-06 Wisconsin Alumni Research Foundation Method to diagnose and treat degenerative joint disease
SI1664033T1 (sl) * 2003-09-25 2008-04-30 Tapestry Pharmaceuticals Inc Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh
CN1886400A (zh) 2003-09-25 2006-12-27 泰普斯特医药公司 9,10－α,α－OH紫杉烷类似物及其制备方法
SV2006002036A (es) * 2004-03-05 2006-03-16 Univ Florida State Res Found Taxanos con sustituyente lactiloxilo en el c7
TW200533339A (en) * 2004-03-16 2005-10-16 Bristol Myers Squibb Co Therapeutic synergy of anti-cancer compounds
US20090004118A1 (en) * 2004-10-07 2009-01-01 Shuming Nie Multifunctional Nanoparticle Conjugates And Their Use
KR101292026B1 (ko) 2004-10-25 2013-08-01 데크-테크 인코포레이티드 종양 치료제로서의 이소포스포르아미드 머스타드 및 이의동족체의 염
US20060216767A1 (en) * 2005-03-22 2006-09-28 Saladax Biomedical Inc. Docetaxel immunoassay
PL217731B1 (pl) 2006-06-01 2014-08-29 Tomasz Byrski Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
WO2008106621A1 (en) 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US20120128657A1 (en) 2007-02-07 2012-05-24 Bewley Carole A Synthetic macrocyclic compounds and methods for treating cancer
DK2155682T3 (en) 2007-04-06 2015-09-21 Ziopharm Oncology Inc SALTS OF isophosphoramide mustard and analogs thereof
WO2010014841A1 (en) 2008-07-31 2010-02-04 Ziopharm Oncology, Inc. Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
CA2753041A1 (en) 2009-02-24 2010-09-02 Dekk-Tec, Inc. Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents
WO2010138686A1 (en) 2009-05-29 2010-12-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mdri-inverse agents
WO2011112867A1 (en) 2010-03-10 2011-09-15 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
WO2012033601A1 (en) 2010-08-20 2012-03-15 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Thiosemicarbazones with mdr1 - inverse activity
CA2841120C (en) 2011-07-11 2020-10-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibody-ir700 conjugates for photodynamic therapy
US20150157580A1 (en) 2012-05-25 2015-06-11 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Methods of regulating cannabinoid receptor activity-related disorders and diseases
CA3178299A1 (en) 2013-10-11 2015-04-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Tem8 antibodies and their use
US10830678B2 (en) 2014-08-08 2020-11-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Photo-controlled removal of targets in vitro and in vivo
WO2019099615A1 (en) 2017-11-17 2019-05-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of copeptin to modulate the immune response and hematopoiesis, and stimulate bone growth
CN112272676A (zh) 2018-04-10 2021-01-26 美国政府(由卫生和人类服务部的部长所代表) 靶向癌细胞的近红外光免疫疗法与宿主免疫激活的联合使用
EP3994173A1 (en) 2019-07-02 2022-05-11 The United States of America, as represented by the Secretary, Department of Health and Human Services Monoclonal antibodies that bind egfrviii and their use
US20230057461A1 (en) 2020-01-27 2023-02-23 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Rab13 and net1 antisense oligonucleotides to treat metastatic cancer
CA3210086A1 (en) 2021-01-29 2022-08-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Near infrared photoimmunotherapy (nir-pit) combination therapy to treat cancer
EP4329786A1 (en) 2021-04-30 2024-03-06 KaliVir Immunotherapeutics, Inc. Oncolytic viruses for modified mhc expression
WO2024006965A1 (en) 2022-06-30 2024-01-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cd25-specific antibodies and uses thereof

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5321128A (en) * 1988-09-06 1994-06-14 Kabi Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
SE463189B (sv) 1989-03-13 1990-10-22 Eston Joensson Preparat avsett att tillfoeras amalgamfyllningar i taender foer att daerigenom hindra eller minska avgaang av kvicksilver eller kvicksilveraanga
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
FR2679230B1 (fr) 1991-07-16 1993-11-19 Rhone Poulenc Rorer Sa Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
SG46582A1 (en) 1991-09-23 1998-02-20 Univ Florida State 10-Desacetoxytaxol derivatives
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
CA2434312A1 (en) 1992-01-15 1993-07-16 Ramesh N. Patel Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
EP0639186B1 (en) 1992-04-17 1999-06-23 Abbott Laboratories Taxol derivatives
US5248796A (en) 1992-06-18 1993-09-28 Bristol-Myers Squibb Company Taxol derivatives
US5319112A (en) 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
WO1994005282A1 (en) 1992-09-04 1994-03-17 The Scripps Research Institute Water soluble taxol derivatives
CA2100808A1 (en) 1992-10-01 1994-04-02 Vittorio Farina Deoxy paclitaxels
DE69333905T2 (de) 1992-12-23 2006-08-03 Bristol-Myers Squibb Co. Seitenkette tragende Taxane und deren Zwischenprodukte
IL108443A0 (en) * 1993-01-29 1994-04-12 Univ Florida State C7 taxane derivatives and pharmaceutical compositions containing them
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
DK0690711T3 (da) * 1993-03-22 2000-10-16 Univ Florida State Taxaner med en aminosubstitueret sidekæde
ATE209489T1 (de) * 1993-03-22 2001-12-15 Univ Florida State Taxane mit pyridyl-substituierter seitenkette
ATE284689T1 (de) * 1993-03-22 2005-01-15 Univ Florida State Pharmazeutische zusammenstellungen enthaltende eine furyl oder thienyl substituierte seitenkette
ATE192147T1 (de) 1993-06-11 2000-05-15 Upjohn Co Delta 6, 7-taxolen, antineoplastische verwendung und diese enthaltende pharmazeutische zusammenstellungen
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
TW397866B (en) 1993-07-14 2000-07-11 Bristol Myers Squibb Co Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes
FR2711369B1 (fr) 1993-10-20 1995-11-17 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent.
US5415869A (en) * 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
US5414869A (en) * 1993-11-26 1995-05-16 Thomson; Margaret I. Knotless scarf and method of making same
WO1996013495A1 (en) * 1994-10-28 1996-05-09 The Research Foundation Of State University Of New York Taxoid derivatives, their preparation and their use as antitumor agents
TW354293B (en) 1995-06-06 1999-03-11 Bristol Myers Squibb Co Prodrugs of paclitaxel derivatives
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
WO1997009979A1 (en) 1995-09-13 1997-03-20 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
US5767297A (en) 1997-02-05 1998-06-16 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
FR2745814B1 (fr) * 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
JP2000510470A (ja) 1996-05-06 2000-08-15 フロリダ・ステイト・ユニバーシティ １―デオキシバッカチンｉｉｉ、１―デオキシタキソールおよび１―デオキシタキソール類似体、ならびにこれらの製造方法
WO1997044027A1 (en) * 1996-05-17 1997-11-27 Merck & Co., Inc. Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
DK0914116T3 (da) * 1996-05-22 2000-11-20 Protarga Inc Kompositstoffer omfattende konjugater af cis-docosahexaensyre og Taxotere
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US5912264A (en) 1997-03-03 1999-06-15 Bristol-Myers Squibb Company 6-halo-or nitrate-substituted paclitaxels
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
CA2305399A1 (en) * 1997-10-08 1999-04-15 Bio Research Corporation Of Yokohama Taxoid derivatives and process for producing the same
US6136988A (en) 1998-04-10 2000-10-24 Hauser, Inc. 7-hexanoyltaxol and methods for preparing the same
US5964739A (en) * 1998-06-18 1999-10-12 Champ; Raynido A. Safety disposable needle structure
US6146659A (en) * 1998-07-01 2000-11-14 Neopharm, Inc. Method of administering liposomal encapsulated taxane
JP2003502401A (ja) 1999-06-21 2003-01-21 ナプロ バイオセラピューティクス，インコーポレイテッド Ｃ−２ヒドロキシル保護−ｎ−アシル（２ｒ，３ｓ）−３−フェニルイソセリン活性化エステルおよびそれらの製造方法
US6348215B1 (en) 1999-10-06 2002-02-19 The Research Foundation Of State University Of New York Stabilization of taxane-containing dispersed systems
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
CZ20013498A3 (cs) * 2000-02-02 2002-04-17 Florida State University Research Foundation, Inc. Taxanové formulace mající zlepąenou rozpustnost
NZ514073A (en) 2000-02-02 2004-02-27 Univ Florida State Res Found Taxane formulations having improved solubility
IT1319168B1 (it) 2000-03-17 2003-09-26 Indena Spa Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.

Also Published As

Publication number Publication date
EP1183253B8 (en) 2009-01-07
CO5280224A1 (es) 2003-05-30
SK13712001A3 (sk) 2002-05-09
US20040014979A1 (en) 2004-01-22
HU0200917D0 (en) 2002-04-29
CZ298484B6 (cs) 2007-10-17
BR0104749A (pt) 2001-12-26
TWI291873B (en) 2008-01-01
JP2003522167A (ja) 2003-07-22
ATE396188T1 (de) 2008-06-15
HUP0200917A3 (en) 2004-07-28
DK1183253T3 (da) 2008-09-22
US20070249708A1 (en) 2007-10-25
PL202668B1 (pl) 2009-07-31
US20020013346A1 (en) 2002-01-31
KR100784161B1 (ko) 2007-12-12
KR20010111583A (ko) 2001-12-19
IL145641A0 (en) 2002-06-30
ES2307588T3 (es) 2008-12-01
RO121777B1 (ro) 2008-04-30
NO20014759D0 (no) 2001-10-01
WO2001057027A1 (en) 2001-08-09
TR200102856T1 (tr) 2002-06-21
CA2368993A1 (en) 2001-08-09
HUP0200917A2 (en) 2002-08-28
AU776051B2 (en) 2004-08-26
AR030188A1 (es) 2003-08-13
NZ514409A (en) 2004-03-26
PL350026A1 (en) 2002-10-21
EP1183253A1 (en) 2002-03-06
PT1183253E (pt) 2008-08-04
BG65279B1 (bg) 2007-11-30
CA2368993C (en) 2009-10-20
NO20014759L (no) 2001-11-29
GEP20043322B (en) 2003-12-10
CN1362955A (zh) 2002-08-07
EP1183253B1 (en) 2008-05-21
BG105967A (en) 2002-08-30
CZ20013503A3 (cs) 2002-03-13
UA75573C2 (en) 2006-05-15
US7186849B2 (en) 2007-03-06
AU3323901A (en) 2001-08-14
MXPA01009901A (es) 2003-07-28
MY137637A (en) 2009-02-27
NO327982B1 (no) 2009-11-02
SA01220045B1 (ar) 2008-06-07
RU2265017C2 (ru) 2005-11-27
ZA200108060B (en) 2003-12-01
US6610860B2 (en) 2003-08-26
DE60134094D1 (de) 2008-07-03

Similar Documents

Publication Publication Date Title
IL145641A0 (en) C7 ester substituted taxanes as antitumor agents
IL154705A0 (en) Polyarylcarboxamides useful as lipid lowering agents
HK1073310A1 (en) Biphenylcarboxamides useful as lipid lowering agents
PL350075A1 (en) Taxane formulations having improved solubility
IL145635A0 (en) Taxane formulations having improved solubility
GB0025437D0 (en) Esters
IL145636A0 (en) C10 carbonate substituted taxanes as antitumor agents
IL145637A0 (en) C7 carbonate substituted taxanes as antitumor agents
HUP0600302A2 (en) C10 ester substituted taxanes as antitumor agents
HUP0200752A3 (en) C7 carbamoyloxy substituted taxanes as antitumor agents
HK1061978A1 (en) Lipid peroxide-lowering compositions
GB0025438D0 (en) Esters
HU0103247D0 (en) C7 ester substituted taxanes
ZA200106335B (en) C7 ester substituted taxanes.
TW479555U (en) Vertical moving stage
GB0015865D0 (en) Lipid compositions
GB0015568D0 (en) Ester synthesis
GB0017074D0 (en) Ester synthesis
SG129990A1 (en) C10 ester substituted taxanes
HU0103245D0 (en) C10 ester substituted taxanes
HK1047933A1 (zh) 具有改善的溶解度的紫杉烷製劑