PT1227093E - Beta-cactamas uteis para a preparacao de taxanos possuindo cadeia lateral substituida com furilo ou tienilo - Google Patents
Beta-cactamas uteis para a preparacao de taxanos possuindo cadeia lateral substituida com furilo ou tieniloInfo
- Publication number
- PT1227093E PT1227093E PT02009840T PT02009840T PT1227093E PT 1227093 E PT1227093 E PT 1227093E PT 02009840 T PT02009840 T PT 02009840T PT 02009840 T PT02009840 T PT 02009840T PT 1227093 E PT1227093 E PT 1227093E
- Authority
- PT
- Portugal
- Prior art keywords
- cactamas
- uteis
- tienyl
- taxans
- fury
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3485293A | 1993-03-22 | 1993-03-22 | |
US9471793A | 1993-07-20 | 1993-07-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1227093E true PT1227093E (pt) | 2005-09-30 |
Family
ID=26711460
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT02019282T PT1260223E (pt) | 1993-03-22 | 1994-03-21 | Taxanos possuindo uma cadeia lateral substituida com furilo ou tienilo |
PT02009839T PT1228759E (pt) | 1993-03-22 | 1994-03-21 | Composicoes farmaceuticas contendo um taxano possuindo uma cadeia lateral substituida com furilo ou tienilo |
PT02009840T PT1227093E (pt) | 1993-03-22 | 1994-03-21 | Beta-cactamas uteis para a preparacao de taxanos possuindo cadeia lateral substituida com furilo ou tienilo |
PT94910982T PT689436E (pt) | 1993-03-22 | 1994-03-21 | Taxanos que nao possuem um grupo oxo em c-9 e composicoes farmaceuticas que os contem |
PT94911675T PT690867E (pt) | 1993-03-22 | 1994-03-21 | Taxanos possuindo uma cadeia lateral substituida com furilo ou tienilo |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT02019282T PT1260223E (pt) | 1993-03-22 | 1994-03-21 | Taxanos possuindo uma cadeia lateral substituida com furilo ou tienilo |
PT02009839T PT1228759E (pt) | 1993-03-22 | 1994-03-21 | Composicoes farmaceuticas contendo um taxano possuindo uma cadeia lateral substituida com furilo ou tienilo |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT94910982T PT689436E (pt) | 1993-03-22 | 1994-03-21 | Taxanos que nao possuem um grupo oxo em c-9 e composicoes farmaceuticas que os contem |
PT94911675T PT690867E (pt) | 1993-03-22 | 1994-03-21 | Taxanos possuindo uma cadeia lateral substituida com furilo ou tienilo |
Country Status (12)
Country | Link |
---|---|
EP (6) | EP1398028A3 (pt) |
JP (2) | JPH08508469A (pt) |
AT (5) | ATE284689T1 (pt) |
AU (3) | AU691804B2 (pt) |
CA (2) | CA2158862C (pt) |
DE (5) | DE69433355T2 (pt) |
DK (5) | DK0689436T3 (pt) |
ES (5) | ES2232694T3 (pt) |
IL (4) | IL109052A (pt) |
PT (5) | PT1260223E (pt) |
SG (3) | SG89298A1 (pt) |
WO (2) | WO1994021250A1 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2712289B1 (fr) * | 1993-11-08 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent. |
US5677470A (en) * | 1994-06-28 | 1997-10-14 | Tanabe Seiyaku Co., Ltd. | Baccatin derivatives and processes for preparing the same |
US6458976B1 (en) | 1994-10-28 | 2002-10-01 | The Research Foundation Of State University Of New York | Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods |
US6500858B2 (en) | 1994-10-28 | 2002-12-31 | The Research Foundation Of The State University Of New York | Taxoid anti-tumor agents and pharmaceutical compositions thereof |
WO1996013495A1 (en) * | 1994-10-28 | 1996-05-09 | The Research Foundation Of State University Of New York | Taxoid derivatives, their preparation and their use as antitumor agents |
CA2162759A1 (en) * | 1994-11-17 | 1996-05-18 | Kenji Tsujihara | Baccatin derivatives and processes for preparing the same |
EP0826688B1 (en) * | 1995-04-28 | 2001-09-05 | Daiichi Pharmaceutical Co., Ltd. | Pentacyclic compounds |
AU728057B2 (en) * | 1995-09-13 | 2001-01-04 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
FR2745814B1 (fr) * | 1996-03-06 | 1998-04-03 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2746797B1 (fr) * | 1996-03-27 | 1998-06-19 | Centre Nat Rech Scient | Nouveaux derives du 10-acetyldocetaxel et leur procede de preparation |
JP2000510470A (ja) * | 1996-05-06 | 2000-08-15 | フロリダ・ステイト・ユニバーシティ | 1―デオキシバッカチンiii、1―デオキシタキソールおよび1―デオキシタキソール類似体、ならびにこれらの製造方法 |
WO1998017656A1 (en) * | 1996-10-24 | 1998-04-30 | Institute Armand-Frappier | A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof |
CN1380882A (zh) * | 2000-02-02 | 2002-11-20 | 佛罗里达州立大学研究基金有限公司 | 作为抗肿瘤剂的c10酯取代的紫杉烷 |
BR0104353A (pt) * | 2000-02-02 | 2002-04-16 | Univ Florida State Res Found | Taxanos heterosubstituìdos com acetato c7 como agentes antitumor |
CO5280224A1 (es) * | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
CN1886400A (zh) | 2003-09-25 | 2006-12-27 | 泰普斯特医药公司 | 9,10-α,α-OH紫杉烷类似物及其制备方法 |
SI1664033T1 (sl) * | 2003-09-25 | 2008-04-30 | Tapestry Pharmaceuticals Inc | Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh |
SV2006002036A (es) * | 2004-03-05 | 2006-03-16 | Univ Florida State Res Found | Taxanos con sustituyente lactiloxilo en el c7 |
WO2006135669A2 (en) * | 2005-06-10 | 2006-12-21 | Florida State University Research Foundation, Inc. | RESOLUTION OF ENANTIOMERIC MIXTURES OF β-LACTAMS |
US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
WO2008106621A1 (en) | 2007-02-28 | 2008-09-04 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6075458A (ja) * | 1983-06-17 | 1985-04-27 | Osaka Soda Co Ltd | 3,4−ジフエニル−1−(4−置換)アリ−ルメチルアゼチジン−2−オンの製法 |
US4751299A (en) * | 1983-11-18 | 1988-06-14 | Takeda Chemical Industries, Ltd. | Optically active β-lactams and method of their production |
JPS61243079A (ja) * | 1985-04-01 | 1986-10-29 | Mect Corp | 1−(アルコキシカルボニルアルキル)−4−(2−フリル)−3−置換−2−アゼチジノン及びその製造方法 |
FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
US5006650A (en) * | 1987-02-11 | 1991-04-09 | The Upjohn Company | Novel N-1 substituted beta-lactams as antibiotics |
US4942184A (en) * | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
US5175315A (en) * | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
AU637109B2 (en) * | 1989-06-22 | 1993-05-20 | Rijksuniversiteit Utrecht | Improved synthesis of beta-lactams using a metal compound |
US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
US5283253A (en) * | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5229526A (en) * | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
US5250683A (en) * | 1991-09-23 | 1993-10-05 | Florida State University | Certain substituted taxanes and pharmaceutical compositions containing them |
CA2254273C (en) * | 1991-09-23 | 2003-03-25 | Florida State University | Preparation of substituted isoserine esters using metal alkoxides and .beta.-lactams |
US5243045A (en) * | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
US5284865A (en) * | 1991-09-23 | 1994-02-08 | Holton Robert A | Cyclohexyl substituted taxanes and pharmaceutical compositions containing them |
UA39860C2 (uk) * | 1991-09-23 | 2001-07-16 | Флоріда Стейт Юніверсіті | 10-дезацетокситаксол та його похідні |
FR2688518B1 (fr) * | 1992-03-13 | 1994-05-06 | Rhone Poulenc Rorer Sa | Procede de preparation de derives du taxane. |
EP0639186B1 (en) * | 1992-04-17 | 1999-06-23 | Abbott Laboratories | Taxol derivatives |
FR2696460B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
-
1994
- 1994-03-21 AT AT02009839T patent/ATE284689T1/de not_active IP Right Cessation
- 1994-03-21 WO PCT/US1994/003053 patent/WO1994021250A1/en active IP Right Grant
- 1994-03-21 EP EP03027078A patent/EP1398028A3/en not_active Withdrawn
- 1994-03-21 AT AT94910982T patent/ATE254914T1/de not_active IP Right Cessation
- 1994-03-21 DK DK94910982T patent/DK0689436T3/da active
- 1994-03-21 AT AT94911675T patent/ATE232871T1/de not_active IP Right Cessation
- 1994-03-21 CA CA002158862A patent/CA2158862C/en not_active Expired - Fee Related
- 1994-03-21 SG SG9904638A patent/SG89298A1/en unknown
- 1994-03-21 AU AU64138/94A patent/AU691804B2/en not_active Ceased
- 1994-03-21 DE DE69433355T patent/DE69433355T2/de not_active Expired - Fee Related
- 1994-03-21 WO PCT/US1994/003097 patent/WO1994021651A1/en active IP Right Grant
- 1994-03-21 DE DE69434373T patent/DE69434373T2/de not_active Expired - Fee Related
- 1994-03-21 IL IL109052A patent/IL109052A/en not_active IP Right Cessation
- 1994-03-21 ES ES02009839T patent/ES2232694T3/es not_active Expired - Lifetime
- 1994-03-21 EP EP02009839A patent/EP1228759B1/en not_active Expired - Lifetime
- 1994-03-21 EP EP94911675A patent/EP0690867B1/en not_active Expired - Lifetime
- 1994-03-21 DK DK94911675T patent/DK0690867T3/da active
- 1994-03-21 PT PT02019282T patent/PT1260223E/pt unknown
- 1994-03-21 DK DK02009840T patent/DK1227093T3/da active
- 1994-03-21 EP EP94910982A patent/EP0689436B1/en not_active Expired - Lifetime
- 1994-03-21 SG SG1996006328A patent/SG73401A1/en unknown
- 1994-03-21 DE DE69432141T patent/DE69432141T2/de not_active Expired - Fee Related
- 1994-03-21 ES ES94911675T patent/ES2193155T3/es not_active Expired - Lifetime
- 1994-03-21 ES ES02019282T patent/ES2242807T3/es not_active Expired - Lifetime
- 1994-03-21 AT AT02009840T patent/ATE295363T1/de not_active IP Right Cessation
- 1994-03-21 AU AU63679/94A patent/AU6367994A/en not_active Abandoned
- 1994-03-21 JP JP6521307A patent/JPH08508469A/ja active Pending
- 1994-03-21 SG SG9801036A patent/SG68049A1/en unknown
- 1994-03-21 AT AT02019282T patent/ATE295164T1/de not_active IP Right Cessation
- 1994-03-21 PT PT02009839T patent/PT1228759E/pt unknown
- 1994-03-21 ES ES02009840T patent/ES2241923T3/es not_active Expired - Lifetime
- 1994-03-21 JP JP6521330A patent/JPH08508255A/ja active Pending
- 1994-03-21 PT PT02009840T patent/PT1227093E/pt unknown
- 1994-03-21 EP EP02009840A patent/EP1227093B1/en not_active Expired - Lifetime
- 1994-03-21 DE DE69434190T patent/DE69434190T2/de not_active Expired - Fee Related
- 1994-03-21 IL IL180090A patent/IL180090A0/en unknown
- 1994-03-21 DE DE69434374T patent/DE69434374T2/de not_active Expired - Fee Related
- 1994-03-21 DK DK02009839T patent/DK1228759T3/da active
- 1994-03-21 ES ES94910982T patent/ES2211879T3/es not_active Expired - Lifetime
- 1994-03-21 EP EP02019282A patent/EP1260223B1/en not_active Expired - Lifetime
- 1994-03-21 DK DK02019282T patent/DK1260223T3/da active
- 1994-03-21 CA CA002158454A patent/CA2158454C/en not_active Expired - Fee Related
- 1994-03-21 IL IL10905094A patent/IL109050A0/xx unknown
- 1994-03-21 PT PT94910982T patent/PT689436E/pt unknown
- 1994-03-21 PT PT94911675T patent/PT690867E/pt unknown
-
1998
- 1998-08-03 AU AU78636/98A patent/AU714180B2/en not_active Ceased
-
2008
- 2008-04-17 IL IL190945A patent/IL190945A0/en unknown
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