SG89298A1 - Novel taxanes having a furyl or thienyl substituted side-chain and pharmaceutical compositions containing them - Google Patents

Novel taxanes having a furyl or thienyl substituted side-chain and pharmaceutical compositions containing them

Info

Publication number
SG89298A1
SG89298A1 SG9904638A SG1999004638A SG89298A1 SG 89298 A1 SG89298 A1 SG 89298A1 SG 9904638 A SG9904638 A SG 9904638A SG 1999004638 A SG1999004638 A SG 1999004638A SG 89298 A1 SG89298 A1 SG 89298A1
Authority
SG
Singapore
Prior art keywords
furyl
pharmaceutical compositions
chain
compositions containing
thienyl substituted
Prior art date
Application number
SG9904638A
Other languages
English (en)
Inventor
Ronald J Biediger
Ki-Byung Chai
Robert A Holton
Hamid Idmoumaz
Hossain Nadizadeh
Kasthuri Rengan
Yukio Suzuki
Chunlin Tao
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida State filed Critical Univ Florida State
Publication of SG89298A1 publication Critical patent/SG89298A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/62—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
SG9904638A 1993-03-22 1994-03-21 Novel taxanes having a furyl or thienyl substituted side-chain and pharmaceutical compositions containing them SG89298A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3485293A 1993-03-22 1993-03-22
US9471793A 1993-07-20 1993-07-20

Publications (1)

Publication Number Publication Date
SG89298A1 true SG89298A1 (en) 2002-06-18

Family

ID=26711460

Family Applications (3)

Application Number Title Priority Date Filing Date
SG1996006328A SG73401A1 (en) 1993-03-22 1994-03-21 Taxanes having alkoxy alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing the same
SG9801036A SG68049A1 (en) 1993-03-22 1994-03-21 Taxanes having alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing same
SG9904638A SG89298A1 (en) 1993-03-22 1994-03-21 Novel taxanes having a furyl or thienyl substituted side-chain and pharmaceutical compositions containing them

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG1996006328A SG73401A1 (en) 1993-03-22 1994-03-21 Taxanes having alkoxy alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing the same
SG9801036A SG68049A1 (en) 1993-03-22 1994-03-21 Taxanes having alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing same

Country Status (12)

Country Link
EP (6) EP1398028A3 (pt)
JP (2) JPH08508469A (pt)
AT (5) ATE284689T1 (pt)
AU (3) AU6367994A (pt)
CA (2) CA2158454C (pt)
DE (5) DE69433355T2 (pt)
DK (5) DK0690867T3 (pt)
ES (5) ES2242807T3 (pt)
IL (4) IL109052A (pt)
PT (5) PT1227093E (pt)
SG (3) SG73401A1 (pt)
WO (2) WO1994021250A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2712289B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
US6500858B2 (en) 1994-10-28 2002-12-31 The Research Foundation Of The State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
JPH10508022A (ja) * 1994-10-28 1998-08-04 ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用
US6458976B1 (en) 1994-10-28 2002-10-01 The Research Foundation Of State University Of New York Taxoid anti-tumor agents, pharmaceutical compositions, and treatment methods
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
CN1094940C (zh) * 1995-04-28 2002-11-27 第一制药株式会社 具有抗肿瘤活性的紫杉酚衍生物
AU728057B2 (en) * 1995-09-13 2001-01-04 Florida State University Radiosensitizing taxanes and their pharmaceutical preparations
FR2745814B1 (fr) * 1996-03-06 1998-04-03 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2746797B1 (fr) * 1996-03-27 1998-06-19 Centre Nat Rech Scient Nouveaux derives du 10-acetyldocetaxel et leur procede de preparation
US6545168B1 (en) * 1996-05-06 2003-04-08 Florida State University 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof
WO1998017656A1 (en) * 1996-10-24 1998-04-30 Institute Armand-Frappier A family of canadensol taxanes, the semi-synthetic preparation and therapeutic use thereof
CN1362957A (zh) * 2000-02-02 2002-08-07 佛罗里达州立大学研究基金有限公司 作为抗肿瘤剂的c7杂取代乙酸酯取代的紫杉烷
AR030188A1 (es) * 2000-02-02 2003-08-13 Univ Florida State Res Found Compuestos de taxano sustituidos con esteres en el c7; composiciones farmaceuticas que los contienen y proceso para tratar un sujeto mamifero que sufre de una condicion que responde a los taxanos
HUP0600302A2 (en) * 2000-02-02 2006-07-28 Univ Florida State Res Found C10 ester substituted taxanes as antitumor agents
EP1664033B1 (en) 2003-09-25 2007-11-07 Tapestry Pharmaceuticals, Inc. 9,10-alpha,alpha-oh-taxane analogs and methods for production the reof
SI1664033T1 (sl) * 2003-09-25 2008-04-30 Tapestry Pharmaceuticals Inc Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh
WO2005087222A1 (en) * 2004-03-05 2005-09-22 Florida State University Research Foundation, Inc. C7 lactyloxy-substituted taxanes
US20060281918A1 (en) * 2005-06-10 2006-12-14 Florida State University Research Foundation, Inc. Resolution of enantiomeric mixtures of beta-lactams
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
WO2008106621A1 (en) 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
WO2008121476A1 (en) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0400971A2 (en) * 1989-05-31 1990-12-05 Florida State University Method for preparation of taxol
EP0428376A1 (en) * 1989-11-14 1991-05-22 Florida State University Method for preparation of taxol using an oxazinone
EP0534708A1 (en) * 1991-09-23 1993-03-31 Florida State University Furyl and thienyl substituted taxanes as antitumour agents
EP0534707A1 (en) * 1991-09-23 1993-03-31 Florida State University Alkoxy substituted taxanes as antitumour agents
EP0534709A1 (en) * 1991-09-23 1993-03-31 Florida State University Substituted taxanes as antitumour agents
WO1993006079A1 (en) * 1991-09-23 1993-04-01 Florida State University PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND β-LACTAMS
WO1993006094A1 (en) * 1991-09-23 1993-04-01 Florida State University Metal alkoxides
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6075458A (ja) * 1983-06-17 1985-04-27 Osaka Soda Co Ltd ３，４−ジフエニル−１−（４−置換）アリ−ルメチルアゼチジン−２−オンの製法
US4751299A (en) * 1983-11-18 1988-06-14 Takeda Chemical Industries, Ltd. Optically active β-lactams and method of their production
JPS61243079A (ja) * 1985-04-01 1986-10-29 Mect Corp １−（アルコキシカルボニルアルキル）−４−（２−フリル）−３−置換−２−アゼチジノン及びその製造方法
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5006650A (en) * 1987-02-11 1991-04-09 The Upjohn Company Novel N-1 substituted beta-lactams as antibiotics
US4942184A (en) * 1988-03-07 1990-07-17 The United States Of America As Represented By The Department Of Health And Human Services Water soluble, antineoplastic derivatives of taxol
AU637109B2 (en) * 1989-06-22 1993-05-20 Rijksuniversiteit Utrecht Improved synthesis of beta-lactams using a metal compound
AU663732B2 (en) * 1991-09-23 1995-10-19 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
FR2688518B1 (fr) * 1992-03-13 1994-05-06 Rhone Poulenc Rorer Sa Procede de preparation de derives du taxane.
EP0639186B1 (en) * 1992-04-17 1999-06-23 Abbott Laboratories Taxol derivatives
FR2696460B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0400971A2 (en) * 1989-05-31 1990-12-05 Florida State University Method for preparation of taxol
EP0428376A1 (en) * 1989-11-14 1991-05-22 Florida State University Method for preparation of taxol using an oxazinone
EP0534708A1 (en) * 1991-09-23 1993-03-31 Florida State University Furyl and thienyl substituted taxanes as antitumour agents
EP0534707A1 (en) * 1991-09-23 1993-03-31 Florida State University Alkoxy substituted taxanes as antitumour agents
EP0534709A1 (en) * 1991-09-23 1993-03-31 Florida State University Substituted taxanes as antitumour agents
WO1993006079A1 (en) * 1991-09-23 1993-04-01 Florida State University PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND β-LACTAMS
WO1993006094A1 (en) * 1991-09-23 1993-04-01 Florida State University Metal alkoxides
US5283253A (en) * 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5284865A (en) * 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5284864A (en) * 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU7863698A (en) 1998-10-01
ES2193155T3 (es) 2003-11-01
EP0689436A1 (en) 1996-01-03
EP1260223B1 (en) 2005-05-11
AU6413894A (en) 1994-10-11
CA2158454A1 (en) 1994-09-29
DK0690867T3 (da) 2003-06-10
ATE295363T1 (de) 2005-05-15
EP0690867B1 (en) 2003-02-19
EP1398028A3 (en) 2004-03-24
DE69433355T2 (de) 2004-05-27
DE69432141T2 (de) 2003-07-31
JPH08508255A (ja) 1996-09-03
CA2158862C (en) 2006-10-10
ATE284689T1 (de) 2005-01-15
WO1994021250A1 (en) 1994-09-29
DE69434374T2 (de) 2005-11-24
AU6367994A (en) 1994-10-11
PT1227093E (pt) 2005-09-30
PT689436E (pt) 2004-04-30
ATE295164T1 (de) 2005-05-15
DE69434374D1 (de) 2005-06-16
WO1994021651A1 (en) 1994-09-29
EP1228759A3 (en) 2002-09-25
SG73401A1 (en) 2000-06-20
EP1398028A2 (en) 2004-03-17
EP1260223A1 (en) 2002-11-27
ES2232694T3 (es) 2005-06-01
EP0689436B1 (en) 2003-11-26
ATE254914T1 (de) 2003-12-15
PT1228759E (pt) 2005-04-29
IL190945A0 (en) 2009-02-11
EP0690867A4 (en) 1996-03-20
DE69434373D1 (de) 2005-06-16
IL180090A0 (en) 2007-05-15
DK1260223T3 (da) 2005-09-05
DK1228759T3 (da) 2005-04-18
DE69434190D1 (de) 2005-01-20
DE69432141D1 (de) 2003-03-27
AU714180B2 (en) 1999-12-23
SG68049A1 (en) 2001-08-21
DE69434190T2 (de) 2005-05-25
DK1227093T3 (da) 2005-08-29
EP1227093A2 (en) 2002-07-31
IL109052A0 (en) 1994-06-24
ES2211879T3 (es) 2004-07-16
ES2241923T3 (es) 2005-11-01
IL109052A (en) 2009-07-20
IL109050A0 (en) 1994-06-24
ATE232871T1 (de) 2003-03-15
EP0690867A1 (en) 1996-01-10
ES2242807T3 (es) 2005-11-16
DE69433355D1 (de) 2004-01-08
CA2158454C (en) 2006-05-23
EP0689436A4 (pt) 1996-02-07
PT1260223E (pt) 2005-09-30
JPH08508469A (ja) 1996-09-10
EP1227093A3 (en) 2002-08-07
DK0689436T3 (da) 2004-03-29
EP1228759B1 (en) 2004-12-15
AU691804B2 (en) 1998-05-28
PT690867E (pt) 2003-06-30
DE69434373T2 (de) 2006-03-09
EP1227093B1 (en) 2005-05-11
EP1228759A2 (en) 2002-08-07
CA2158862A1 (en) 1994-09-29

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