DE69306591T2 - Verfahren für die herstellung von toxane derivaten - Google Patents

Verfahren für die herstellung von toxane derivaten

Info

Publication number
DE69306591T2
DE69306591T2 DE69306591T DE69306591T DE69306591T2 DE 69306591 T2 DE69306591 T2 DE 69306591T2 DE 69306591 T DE69306591 T DE 69306591T DE 69306591 T DE69306591 T DE 69306591T DE 69306591 T2 DE69306591 T2 DE 69306591T2
Authority
DE
Germany
Prior art keywords
pct
vii
date
alkyl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69306591T
Other languages
English (en)
Other versions
DE69306591D1 (de
Inventor
Jean-Manuel Mas
Viviane Charriere B Massonneau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of DE69306591D1 publication Critical patent/DE69306591D1/de
Application granted granted Critical
Publication of DE69306591T2 publication Critical patent/DE69306591T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69306591T 1992-10-05 1993-10-04 Verfahren für die herstellung von toxane derivaten Expired - Lifetime DE69306591T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9211741A FR2696458B1 (fr) 1992-10-05 1992-10-05 Procédé de préparation de dérivés du taxane.
PCT/FR1993/000967 WO1994007877A1 (fr) 1992-10-05 1993-10-04 Procede de preparation de derives du taxane

Publications (2)

Publication Number Publication Date
DE69306591D1 DE69306591D1 (de) 1997-01-23
DE69306591T2 true DE69306591T2 (de) 1997-04-17

Family

ID=9434119

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69306591T Expired - Lifetime DE69306591T2 (de) 1992-10-05 1993-10-04 Verfahren für die herstellung von toxane derivaten

Country Status (24)

Country Link
US (3) US5616739A (de)
EP (1) EP0663906B1 (de)
JP (1) JP3014760B2 (de)
KR (1) KR100311198B1 (de)
AT (1) ATE146174T1 (de)
AU (1) AU689080B2 (de)
CA (1) CA2146250C (de)
CZ (1) CZ283261B6 (de)
DE (1) DE69306591T2 (de)
DK (1) DK0663906T3 (de)
ES (1) ES2095081T3 (de)
FI (1) FI109793B (de)
FR (1) FR2696458B1 (de)
GR (1) GR3021997T3 (de)
HU (1) HU226412B1 (de)
MX (1) MX9305766A (de)
NO (1) NO309089B1 (de)
NZ (1) NZ256445A (de)
PL (1) PL182284B1 (de)
RU (1) RU2116303C1 (de)
SK (1) SK280627B6 (de)
TW (1) TW419472B (de)
WO (1) WO1994007877A1 (de)
ZA (1) ZA937318B (de)

Families Citing this family (78)

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FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2697522B1 (fr) * 1992-10-30 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
DK0982301T3 (da) * 1993-06-11 2003-12-08 Upjohn Co Delta 6,7-taxoler antineoplastisk anvendelse og farmaceutiske præparater indeholdende disse
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
EP1247804A1 (de) * 1993-11-12 2002-10-09 PHARMACIA & UPJOHN COMPANY Pyrimidin-thioalkyl und alkyläther Verbindungen
IL127598A (en) * 1994-01-28 2003-04-10 Upjohn Co Process for preparing isotaxol analogs
US5679807A (en) * 1995-01-30 1997-10-21 Hauser, Inc. Preparation of taxol and docetaxel through primary amines
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
GB9512471D0 (en) * 1995-06-20 1995-08-23 Pharmacia Spa Method for the preparation of taxol and its derivatives
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
ATE277898T1 (de) * 1996-05-08 2004-10-15 Upjohn Co Verfahren zu herstellung von taxol
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
ATE234800T1 (de) 1997-08-21 2003-04-15 Univ Florida State Verfahren zur synthese von taxanen
WO1999032109A1 (en) * 1997-12-23 1999-07-01 Bristol-Myers Squibb Company 7-deoxy-6-nitrogen substituted paclitaxels
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HUP0302599A3 (en) * 2000-09-22 2005-05-30 Bristol Myers Squibb Co Method for reducing toxicity of combined chemotherapic compositions
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
CA2491216C (en) 2002-06-26 2012-01-03 Medigene Oncology Gmbh Method of producing a cationic liposomal preparation comprising a lipophilic compound
DE60327651D1 (de) * 2002-10-09 2009-06-25 Chatham Biotec Ltd Thio-analoga von paclitaxel und deren vorprodukte
US6838569B2 (en) 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
WO2005016241A2 (en) 2003-05-16 2005-02-24 Intermune, Inc. Synthetic chemokine receptor ligands and methods of use thereof
US7407973B2 (en) * 2003-10-24 2008-08-05 Intermune, Inc. Use of pirfenidone in therapeutic regimens
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
WO2006020580A2 (en) * 2004-08-09 2006-02-23 Alios Biopharma Inc. Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
US7446126B2 (en) * 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
EP1712552A1 (de) * 2005-04-11 2006-10-18 INDENA S.p.A. Teilsynthese für die Herstellung von 10-deacetyl-n-debenzoyl-paclitaxel
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US20110172293A1 (en) 2008-07-08 2011-07-14 Fish Jason E Methods and Compositions for Modulating Angiogenesis
CN101735179B (zh) * 2008-11-19 2012-09-12 上海百灵医药科技有限公司 一种多烯紫杉醇的制备方法，其中间体及制备方法
WO2010059916A2 (en) * 2008-11-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Preparation of docetaxel
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US10654875B2 (en) 2015-11-12 2020-05-19 The Board Of Trustees Of The Leland Stanford Junior University Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery
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Family Cites Families (5)

* Cited by examiner, † Cited by third party
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US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol

Also Published As

Publication number Publication date
JPH08501788A (ja) 1996-02-27
MX9305766A (es) 1995-01-31
HU9500971D0 (en) 1995-06-28
HUT72679A (en) 1996-05-28
NO309089B1 (no) 2000-12-11
FR2696458B1 (fr) 1994-11-10
SK43695A3 (en) 1995-08-09
FI951595A0 (fi) 1995-04-04
ATE146174T1 (de) 1996-12-15
CA2146250C (fr) 2003-03-11
AU689080B2 (en) 1998-03-26
TW419472B (en) 2001-01-21
US5869680A (en) 1999-02-09
NO951201L (no) 1995-03-29
DE69306591D1 (de) 1997-01-23
NO951201D0 (no) 1995-03-29
RU95113717A (ru) 1996-12-27
EP0663906B1 (de) 1996-12-11
EP0663906A1 (de) 1995-07-26
CA2146250A1 (fr) 1994-04-14
PL182284B1 (pl) 2001-12-31
HU226412B1 (en) 2008-11-28
RU2116303C1 (ru) 1998-07-27
FI109793B (fi) 2002-10-15
AU5115093A (en) 1994-04-26
NZ256445A (en) 1997-01-29
DK0663906T3 (da) 1996-12-30
GR3021997T3 (en) 1997-03-31
WO1994007877A1 (fr) 1994-04-14
CZ283261B6 (cs) 1998-02-18
US5677462A (en) 1997-10-14
FR2696458A1 (fr) 1994-04-08
CZ84195A3 (en) 1995-09-13
FI951595A (fi) 1995-04-04
KR100311198B1 (ko) 2002-04-24
US5616739A (en) 1997-04-01
JP3014760B2 (ja) 2000-02-28
ZA937318B (en) 1994-04-25
KR950703546A (ko) 1995-09-20
ES2095081T3 (es) 1997-02-01
PL308241A1 (en) 1995-07-24
SK280627B6 (sk) 2000-05-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY, FR

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC