HUP0103165A2 - Tiazolinsavszármazékok, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk - Google Patents
Tiazolinsavszármazékok, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásukInfo
- Publication number
- HUP0103165A2 HUP0103165A2 HU0103165A HUP0103165A HUP0103165A2 HU P0103165 A2 HUP0103165 A2 HU P0103165A2 HU 0103165 A HU0103165 A HU 0103165A HU P0103165 A HUP0103165 A HU P0103165A HU P0103165 A2 HUP0103165 A2 HU P0103165A2
- Authority
- HU
- Hungary
- Prior art keywords
- compound
- same
- hydrogen atom
- pharmaceutical compositions
- acid derivatives
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical compound C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 238000004140 cleaning Methods 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Game Rules And Presentations Of Slot Machines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
A találmány tárgya az (I) általános képletű - ahol Z jelentése CHcsoport vagy nitrogénatom; R jelentése hidrogénatom vagy acilcsoport;R1, R2, R3 és R5 jelentése egymástól függetlenül hidrogénatom, maximum14 szénatomos alkil- vagy szénhidrogén aril-alkil-csoport; és R4jelentése hidrogénatom vagy 1-4 szénatomos alkilcsoport - vegyület,gyógyászati szempontból alkalmazható savval képzett sója vagygyógyászati szempontból alkalmazható komplexe. A találmány továbbitárgyát képezik az említett vegyületet tartalmazógyógyszerkészítmények, valamint az említett vegyületet felhasználó, aszervezetnek háromértékű fémektől történő megtisztítására ésdiagnosztikai célokra szolgáló eljárás. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/144,103 US6083966A (en) | 1998-08-31 | 1998-08-31 | Thiazoline acid derivatives |
PCT/US1999/019691 WO2000012493A1 (en) | 1998-08-31 | 1999-08-31 | Thiazoline acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0103165A2 true HUP0103165A2 (hu) | 2002-01-28 |
HUP0103165A3 HUP0103165A3 (en) | 2003-03-28 |
Family
ID=22507049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0103165A HUP0103165A3 (en) | 1998-08-31 | 1999-08-31 | Thiazoline acid derivatives, pharmaceutical compositions containig the same and their use |
Country Status (24)
Country | Link |
---|---|
US (9) | US6083966A (hu) |
EP (1) | EP1109795B1 (hu) |
JP (3) | JP4817498B2 (hu) |
KR (1) | KR20010074907A (hu) |
CN (1) | CN100455574C (hu) |
AT (1) | ATE317392T1 (hu) |
AU (1) | AU759851B2 (hu) |
BR (1) | BR9913441B1 (hu) |
CA (1) | CA2342210C (hu) |
CZ (1) | CZ2001711A3 (hu) |
DE (1) | DE69929807T2 (hu) |
EA (1) | EA200100261A1 (hu) |
ES (1) | ES2260933T3 (hu) |
HK (1) | HK1035720A1 (hu) |
HU (1) | HUP0103165A3 (hu) |
IL (2) | IL141611A0 (hu) |
NO (1) | NO321028B1 (hu) |
NZ (1) | NZ509899A (hu) |
PL (1) | PL346852A1 (hu) |
PT (1) | PT1109795E (hu) |
TR (1) | TR200100541T2 (hu) |
UA (1) | UA57161C2 (hu) |
WO (1) | WO2000012493A1 (hu) |
YU (1) | YU21801A (hu) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6083966A (en) * | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
NZ526880A (en) * | 1998-09-21 | 2005-05-27 | Univ Florida | Antimalarial agents |
EP1488791A3 (en) * | 1998-09-21 | 2005-04-06 | University Of Florida Research Foundation, Inc. | Antimalarial agents |
US6806363B1 (en) * | 1999-04-16 | 2004-10-19 | Mayo Foundation For Medical Education & Research | Cobalamin conjugates useful as antitumor agents |
EP1239887A1 (en) | 1999-10-15 | 2002-09-18 | Mayo Foundation For Medical Education And Research | Cobalamin conjugates useful as imaging and therapeutic agents |
US6689788B1 (en) * | 2000-08-25 | 2004-02-10 | University Of Florida | Method and composition for treatment of inflammatory bowel disease |
WO2002055530A2 (en) * | 2000-10-25 | 2002-07-18 | Mayo Foundation | Transcobalamin binding conjugates useful for treating abnormal cellular proliferation |
US6875883B2 (en) * | 2002-05-15 | 2005-04-05 | Genzyme Corporation | Synthesis of benzonitriles from substituted benzaldehyde |
US20040132789A1 (en) * | 2002-08-22 | 2004-07-08 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
US20040044220A1 (en) * | 2002-08-22 | 2004-03-04 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
AU2003268706A1 (en) * | 2002-10-01 | 2004-04-23 | Kaneka Corporation | PROCESS FOR PRODUCING OPTICALLY ACTIVE Alpha-SUBSTITUTED CYSTEINE OR SALT THEREOF, INTERMEDIATE THEREFOR, AND PROCESS FOR PRODUCING THE SAME |
US20040185028A1 (en) * | 2003-03-19 | 2004-09-23 | Zhenze Hu | Antimicrobial compositions containing ethanolamine buffer and biguanide disinfectant |
AU2003270473A1 (en) * | 2003-09-09 | 2005-04-27 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
CA2538159A1 (en) * | 2003-09-09 | 2005-03-17 | University Of Florida Research Foundation, Inc. | Polyamine-metal chelator conjugates |
EP1694325A4 (en) * | 2003-12-03 | 2009-03-25 | Univ New Jersey Med | METHOD FOR PREVENTING SURVIVAL OF RETROVIRAL CELLS AND FORMATION OF INFECTIOUS RETROVIRUSES |
EP1714966A4 (en) * | 2004-02-04 | 2008-01-02 | Shionogi & Co | NAPHTHYLIDINE DERIVATIVE HAVING HIGH INTEGRASE HIV INHIBITING ACTIVITY |
BRPI0610644B8 (pt) * | 2005-04-04 | 2021-05-25 | Univ Florida | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. |
US7365371B2 (en) | 2005-08-04 | 2008-04-29 | Cree, Inc. | Packages for semiconductor light emitting devices utilizing dispensed encapsulants |
EP2101764A4 (en) * | 2006-12-12 | 2010-02-17 | Univ Florida | ACTINIDE DECORPORATION AGENTS ANALOGUES OF DESFERRITHIOCIN |
NZ579994A (en) * | 2007-03-15 | 2011-09-30 | Univ Florida | Desferrithiocin polyether analogues useful in the treatment of pathological conditions responsive to chelation or sequestration of trivalent metal |
NZ590302A (en) | 2008-07-14 | 2013-02-22 | Ferrokin Biosciences Inc | Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
AU2011248158A1 (en) | 2010-05-04 | 2012-12-20 | Ferrokin Biosciences, Inc. | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
CN103562379A (zh) * | 2011-05-19 | 2014-02-05 | 国立大学法人德岛大学 | 细胞分化诱导剂以及分化诱导方法 |
AU2012352025B2 (en) | 2011-12-16 | 2018-01-18 | University Of Florida Research Foundation, Inc. | Uses of 4'-desferrithiocin analogs |
JP6353751B2 (ja) * | 2013-09-25 | 2018-07-04 | 国立大学法人電気通信大学 | 新規複素環式化合物及びその塩、並びに、発光基質組成物 |
EP3071201A4 (en) * | 2013-11-22 | 2017-04-26 | University of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
KR20170140306A (ko) | 2015-04-27 | 2017-12-20 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 대사적으로 프로그램화된 금속 킬레이트화제 및 그의 용도 |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3274207A (en) | 1966-09-20 | Processes for preparing thiazole carboxylic acids | ||
US3809754A (en) | 1968-12-31 | 1974-05-07 | Medial De Toledo & Cie | Method of treating diseases of the mucous membrane using compounds of a thiazolidine carboxylic acid and pharmaceutical preparations thereof |
US3882110A (en) | 1969-06-11 | 1975-05-06 | Roussel Uclaf | Novel 2-alkyl-5-thiazole-carboxylic acid derivatives |
DE2045818A1 (de) | 1969-09-17 | 1971-04-08 | Godo Shusei Kabushiki Kaisha, Tokio | Aeruginoinsäure und Verfahren zu ihrer Herstellung |
FR2062120A5 (hu) | 1969-10-10 | 1971-06-25 | Messier Fa | |
FR2141526B1 (hu) | 1971-06-14 | 1975-05-30 | Roussel Uclaf | |
DE2245560A1 (de) | 1972-09-16 | 1974-03-21 | Basf Ag | Verfahren zur herstellung von 4alkoxycarbonyl-2-thiazolinen |
AU528115B2 (en) | 1978-04-08 | 1983-04-14 | Santen Pharmaceutical Co. Ltd. | Antihypertensive 4-thiazolidine/carboxylic acids |
CS205217B1 (cs) | 1979-04-05 | 1981-05-29 | Zdenek Vitamvas | Dozimetr ionizujícího záření |
DE3002989A1 (de) * | 1980-01-29 | 1981-07-30 | Hoechst Ag, 6000 Frankfurt | Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels |
EP0045281B1 (de) * | 1980-07-28 | 1985-05-08 | Ciba-Geigy Ag | Thiazolinderivate und Verfahren zu ihrer Herstellung |
JPS5758682A (en) * | 1980-07-28 | 1982-04-08 | Ciba Geigy Ag | Thiazoline derivatives, manufacture and medicinal composition containing same |
JPS5772975A (en) | 1980-10-24 | 1982-05-07 | Kureha Chem Ind Co Ltd | 2-substituted phenylthiazole derviative, and medicine for peptic ulcer containing said derivative as active component |
US4367233A (en) | 1981-10-02 | 1983-01-04 | American Home Products Corporation | Inhibitors of mammalian collagenase |
JPS62501769A (ja) | 1984-12-18 | 1987-07-16 | デイビツト ラビン | 細胞毒性アルデヒドとベニシラミンとの反応性成物を含有する抗腫瘍組成物及びその使用方法 |
HU200177B (en) | 1985-06-18 | 1990-04-28 | Biogal Gyogyszergyar | Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds |
US4736060A (en) | 1985-08-06 | 1988-04-05 | Nippon Rikagakuyakuhin Co., Ltd. | Method for optical resolution of DL-cysteine and (R,S)-1-(1-naphthyl) ethylamine |
EP0214101A3 (de) | 1985-09-03 | 1989-05-31 | Ciba-Geigy Ag | Verwendung von Eisen(III)-Chelatoren vom Typ Desferrioxamin B und Desferriferrithiocin zur Behandlung von Malaria |
EP0214933A3 (de) | 1985-09-03 | 1989-05-24 | Ciba-Geigy Ag | Kombinationspräparate zur Behandlung von Malaria |
JPS62142168A (ja) | 1985-10-16 | 1987-06-25 | Mitsubishi Chem Ind Ltd | チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤 |
DE3735757A1 (de) | 1987-10-22 | 1989-05-03 | Degussa | Optisch aktive salze aus einem substituierten thiazolidin-4-carboxylat und 3-chlor-2-hydroxypropyltrimethylammonium, deren herstellung und verwendung |
ATE98631T1 (de) | 1988-01-20 | 1994-01-15 | Ciba Geigy Ag | Verfahren zur herstellung von komplexverbindungen. |
US5182402A (en) | 1988-11-07 | 1993-01-26 | Imperial Chemical Industries Plc | Herbicidal compositions |
GB8826035D0 (en) | 1988-11-07 | 1988-12-14 | Ici Plc | Herbicidal compositions |
US5106992A (en) | 1989-07-28 | 1992-04-21 | E. R. Squibb & Sons, Inc. | 3,5-dihydroxypentanoic acid derivatives useful as antihypercholesterolemic agents and method for preparing same |
NL9001955A (nl) | 1990-09-05 | 1992-04-01 | Cedona Pharm Bv | Nieuwe thiazolidinederivaten. |
US5393777A (en) | 1990-11-15 | 1995-02-28 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University | Deferration using anguibactin siderophore |
DE69132006T2 (de) | 1990-11-30 | 2000-08-03 | Otsuka Pharma Co Ltd | Thiazolederivate als inhibitoren von aktivem sauerstoff |
ATE142494T1 (de) | 1990-11-30 | 1996-09-15 | Teijin Ltd | 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel |
FR2677021B1 (fr) | 1991-05-31 | 1993-10-01 | Upsa Laboratoires | Nouveaux derives de thiazole antagonistes des recepteurs a l'angiotensine ii; leurs procedes de preparation, compositions pharmaceutiques les contenant. |
WO1994011367A1 (en) * | 1992-11-16 | 1994-05-26 | University Of Florida Research Foundation Inc. | 2-(pyrid-2'-yl)-2-thiazoline-4(s)-carboxylic acid derivatives |
US5840739A (en) * | 1992-11-16 | 1998-11-24 | University Of Florida Research Foundation, Inc. | Thiazoline acid derivatives |
DE4301356A1 (de) | 1993-01-20 | 1994-07-21 | Basf Ag | Verfahren zur Herstellung von 2-Alkyl-4-fluormethyl-thiazolcarbonsäure-alkylestern |
FR2749583B1 (fr) | 1996-06-07 | 1998-08-21 | Lipha | Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant |
US20020049316A1 (en) | 1997-04-29 | 2002-04-25 | Halbert Stacie Marie | Protease inhibitors |
US6373912B1 (en) * | 1997-06-16 | 2002-04-16 | Legerity, Inc. | Phase-locked loop arrangement with fast lock mode |
US6174070B1 (en) * | 1998-03-02 | 2001-01-16 | Elna Kabushiki Kaisha | Portable lighting instrument having a light emitting diode assembly |
MA26618A1 (fr) | 1998-04-09 | 2004-12-20 | Smithkline Beecham Corp | Composes et compositions pharmaceutiques pour le traitement du paludisme |
US6147070A (en) | 1998-06-05 | 2000-11-14 | Facchini; Francesco | Methods and compositions for controlling iron stores to treat and cure disease states |
US6083966A (en) * | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
US6159983A (en) | 1998-09-18 | 2000-12-12 | University Of Florida | Method and composition for treatment of inflammatory bowel disease |
NZ526880A (en) | 1998-09-21 | 2005-05-27 | Univ Florida | Antimalarial agents |
US6251927B1 (en) * | 1999-04-20 | 2001-06-26 | Medinox, Inc. | Methods for treatment of sickle cell anemia |
DE19919336A1 (de) | 1999-04-27 | 2000-11-16 | Consortium Elektrochem Ind | Verfahren zur Ringspaltung von Thiazolidinderivaten |
DE19948434A1 (de) | 1999-10-08 | 2001-06-07 | Gruenenthal Gmbh | Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine |
US20040132789A1 (en) * | 2002-08-22 | 2004-07-08 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
US20040044220A1 (en) * | 2002-08-22 | 2004-03-04 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
AU2003270473A1 (en) * | 2003-09-09 | 2005-04-27 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
CA2538159A1 (en) | 2003-09-09 | 2005-03-17 | University Of Florida Research Foundation, Inc. | Polyamine-metal chelator conjugates |
WO2006055412A1 (en) | 2004-11-19 | 2006-05-26 | Shiva Biomedical, Llc | Methods of treating erythropoietin-resistance |
BRPI0610644B8 (pt) | 2005-04-04 | 2021-05-25 | Univ Florida | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. |
EP2101764A4 (en) * | 2006-12-12 | 2010-02-17 | Univ Florida | ACTINIDE DECORPORATION AGENTS ANALOGUES OF DESFERRITHIOCIN |
NZ579994A (en) * | 2007-03-15 | 2011-09-30 | Univ Florida | Desferrithiocin polyether analogues useful in the treatment of pathological conditions responsive to chelation or sequestration of trivalent metal |
-
1998
- 1998-08-31 US US09/144,103 patent/US6083966A/en not_active Ceased
-
1999
- 1999-08-31 PL PL99346852A patent/PL346852A1/xx not_active Application Discontinuation
- 1999-08-31 EP EP99945267A patent/EP1109795B1/en not_active Expired - Lifetime
- 1999-08-31 PT PT99945267T patent/PT1109795E/pt unknown
- 1999-08-31 IL IL14161199A patent/IL141611A0/xx active IP Right Grant
- 1999-08-31 EA EA200100261A patent/EA200100261A1/ru unknown
- 1999-08-31 NZ NZ509899A patent/NZ509899A/en not_active IP Right Cessation
- 1999-08-31 UA UA2001032117A patent/UA57161C2/uk unknown
- 1999-08-31 AT AT99945267T patent/ATE317392T1/de not_active IP Right Cessation
- 1999-08-31 CA CA002342210A patent/CA2342210C/en not_active Expired - Fee Related
- 1999-08-31 TR TR2001/00541T patent/TR200100541T2/xx unknown
- 1999-08-31 CN CNB998099899A patent/CN100455574C/zh not_active Expired - Fee Related
- 1999-08-31 ES ES99945267T patent/ES2260933T3/es not_active Expired - Lifetime
- 1999-08-31 KR KR1020017002702A patent/KR20010074907A/ko not_active Application Discontinuation
- 1999-08-31 HU HU0103165A patent/HUP0103165A3/hu unknown
- 1999-08-31 DE DE69929807T patent/DE69929807T2/de not_active Expired - Lifetime
- 1999-08-31 CZ CZ2001711A patent/CZ2001711A3/cs unknown
- 1999-08-31 BR BRPI9913441-1B1A patent/BR9913441B1/pt not_active IP Right Cessation
- 1999-08-31 AU AU57897/99A patent/AU759851B2/en not_active Ceased
- 1999-08-31 JP JP2000567521A patent/JP4817498B2/ja not_active Expired - Fee Related
- 1999-08-31 YU YU21801A patent/YU21801A/sh unknown
- 1999-08-31 WO PCT/US1999/019691 patent/WO2000012493A1/en not_active Application Discontinuation
-
2000
- 2000-03-20 US US09/531,753 patent/US6559315B1/en not_active Expired - Lifetime
- 2000-03-20 US US09/531,755 patent/US6525080B1/en not_active Expired - Lifetime
- 2000-03-20 US US09/531,754 patent/US6521652B1/en not_active Expired - Lifetime
-
2001
- 2001-02-22 IL IL141611A patent/IL141611A/en not_active IP Right Cessation
- 2001-02-27 NO NO20011003A patent/NO321028B1/no not_active IP Right Cessation
- 2001-09-04 HK HK01106220A patent/HK1035720A1/xx not_active IP Right Cessation
- 2001-10-17 US US09/981,586 patent/USRE39132E1/en not_active Expired - Lifetime
-
2002
- 2002-11-20 US US10/300,071 patent/US20030236417A1/en not_active Abandoned
-
2004
- 2004-09-17 US US10/944,150 patent/US7126004B2/en not_active Expired - Fee Related
-
2006
- 2006-09-15 US US11/522,299 patent/US7531563B2/en not_active Expired - Fee Related
-
2009
- 2009-03-27 US US12/383,854 patent/US8008502B2/en not_active Expired - Fee Related
-
2011
- 2011-04-22 JP JP2011095879A patent/JP5520875B2/ja not_active Expired - Fee Related
-
2013
- 2013-12-12 JP JP2013257270A patent/JP2014065730A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0103165A2 (hu) | Tiazolinsavszármazékok, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk | |
HUP0004529A2 (hu) | VLA-4 által mediált leukocita adhéziót gátló szulfonilezett dipeptid-származékok, ezeket tartalmazó gyógyászati készítmények, valamint alkalmazásuk | |
HUP0402507A2 (hu) | N(fenilszulfonil)glicin-származékok, alkalmazásuk és az ezeket tartalmazó gyógyászati készítmények | |
HUP0300393A2 (hu) | C-aril glükozid SGLT2 inhibitorok és alkalmazásuk, valamint ezeket tartalmazó gyógyszerkészítmények | |
HUP0302943A2 (hu) | Új heterociklusos vegyületek, előállításuk és alkalmazásuk gyógyszerekként, különösen antibakteriális szerekként | |
DE3854454D1 (de) | Pyrazolopyridinverbindungen und Verfahren zu ihrer Herstellung. | |
HUP0004531A2 (hu) | VLA-4 által mediált leukocita adhéziót gátló 4-aminofenilalanin-vegyületek, ezeket tartalmazó gyógyászati készítmények, valamint alkalmazásuk | |
EP1070710A3 (en) | Dithiolan derivatives, their preparation and their therapeutic effect | |
HUP0004259A2 (hu) | VLA-4 által mediált leukocita adhéziót gátló szubsztituált fenilalanin-származékok, ezeket tartalmazó gyógyászati készítmények | |
HUP0204474A2 (hu) | 1H-imidazopiridin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
FI965020A (fi) | Uusia yhdisteitä, menetelmiä niiden valmistamiseksi ja kasvaintenvastaisia aineita | |
DE3876813T4 (de) | 3(2H)Pyridazinon, Verfahren zu dessen Herstellung und dieses enthaltendes Mittel gegen SRS-A. | |
HUP9903707A2 (hu) | 17Béta-karboxi-,-tio-karboxi-vagy -amido-androsztánszármazékok laktonszármazékai, előállításuk, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
TW368501B (en) | 7-(2-aminoethyl)-benzothiazolones | |
HUP0402235A2 (hu) | 4,4-Difluor-1,2,3,4-tetrahidro-5H-1-benzazepin-származékok és ezek sói és ezeket tartalmazó gyógyszerkészítmények | |
HUP0302157A2 (hu) | 4-(2-Fenil-tiazol-5-il)-1,4-diazabiciklo[3.2.2]nonán-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények | |
HUP9902017A2 (hu) | Aminosav- és hidroxisav-származékokkal szubsztituált benzamidinszármazékok és antikoagulánsokként történő alkalmazásuk | |
HUP0004085A2 (hu) | A 9a-azaleidek csoportjához tartozó, új 3,6-hemiketálszármazékok | |
ATE44748T1 (de) | 4-substituierte 6-alkylidene-androsten-3,17-dion- derivate und verfahren zu ihrer herstellung. | |
HUP0104033A2 (hu) | Benzoilpiridazin-származékok, a vegyületeket tartalmazó gyógyszerkészítmények, eljárás az előállításukra és alkalmazásuk | |
HUP9901212A2 (hu) | N,N-dialkil-N-[2-(3-alkoxi-fenoxi)-etil]-amin-származékok, az ezeket tartalmazó gyógyszerkészítmények és helyi érzéstelenítőkként való alkalmazásuk | |
HUP0105308A2 (hu) | Eletriptán-hidrobromid-monohidrát, eljárás az előállítására és a vegyületet tartalmazó gyógyszerkészítmények | |
HUP0402602A2 (hu) | Eljárás echinokandin-származékok előállítására, ezek alkalmazása, ezeket tartalmazó gyógyszerkészítmények és intermedierek | |
GR3005961T3 (hu) | ||
ES2032501T3 (es) | Un procedimiento de preparacion de derivados de urileno-2,4,6-triamino-3-oxido. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |