TR200100541T2 - Tiyazolin Asit Türevleri. - Google Patents

Tiyazolin Asit Türevleri.

Info

Publication number
TR200100541T2
TR200100541T2 TR2001/00541T TR200100541T TR200100541T2 TR 200100541 T2 TR200100541 T2 TR 200100541T2 TR 2001/00541 T TR2001/00541 T TR 2001/00541T TR 200100541 T TR200100541 T TR 200100541T TR 200100541 T2 TR200100541 T2 TR 200100541T2
Authority
TR
Turkey
Prior art keywords
acid derivatives
trivalent metal
thiazoline
thiazoline acid
pathological condition
Prior art date
Application number
TR2001/00541T
Other languages
English (en)
Inventor
Raymond J. Jr. Bergeron
Original Assignee
University Of Florida Research Foundation, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Florida Research Foundation, Inc. filed Critical University Of Florida Research Foundation, Inc.
Publication of TR200100541T2 publication Critical patent/TR200100541T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Game Rules And Presentations Of Slot Machines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Penyl ve pyridyl ile yer degistirme reaksiyonuna giren tiyazolin asit türevleri, memelilerdeki üç degerli metalin metal birlestirme ya da sekester olusmuna (sequestration) yanit verdigi bir patolojik kosulun teshis ve tedavisinde yararlidir. Patolojik kosoul, söz konusu memelinin dokularinda üç degerli metal iyonlarinin birikmesiyle ya da asiri miktarda üç degerli metal iyonuyla ilgili olabilir. patolojik kosul örnegin, haemochromatosis, haemosiderosis ya da cirrhosis olabilir.
TR2001/00541T 1998-08-31 1999-08-31 Tiyazolin Asit Türevleri. TR200100541T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/144,103 US6083966A (en) 1998-08-31 1998-08-31 Thiazoline acid derivatives

Publications (1)

Publication Number Publication Date
TR200100541T2 true TR200100541T2 (tr) 2001-11-21

Family

ID=22507049

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00541T TR200100541T2 (tr) 1998-08-31 1999-08-31 Tiyazolin Asit Türevleri.

Country Status (24)

Country Link
US (9) US6083966A (tr)
EP (1) EP1109795B1 (tr)
JP (3) JP4817498B2 (tr)
KR (1) KR20010074907A (tr)
CN (1) CN100455574C (tr)
AT (1) ATE317392T1 (tr)
AU (1) AU759851B2 (tr)
BR (1) BR9913441B1 (tr)
CA (1) CA2342210C (tr)
CZ (1) CZ2001711A3 (tr)
DE (1) DE69929807T2 (tr)
EA (1) EA200100261A1 (tr)
ES (1) ES2260933T3 (tr)
HK (1) HK1035720A1 (tr)
HU (1) HUP0103165A3 (tr)
IL (2) IL141611A0 (tr)
NO (1) NO321028B1 (tr)
NZ (1) NZ509899A (tr)
PL (1) PL346852A1 (tr)
PT (1) PT1109795E (tr)
TR (1) TR200100541T2 (tr)
UA (1) UA57161C2 (tr)
WO (1) WO2000012493A1 (tr)
YU (1) YU21801A (tr)

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NZ526880A (en) * 1998-09-21 2005-05-27 Univ Florida Antimalarial agents
EP1488791A3 (en) * 1998-09-21 2005-04-06 University Of Florida Research Foundation, Inc. Antimalarial agents
US6806363B1 (en) * 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
MXPA02003772A (es) 1999-10-15 2005-04-28 Mayo Foundation Conjugados de cobalamina, utiles como agentes para obtencion de imagen y como agentes terapeuticos.
US6689788B1 (en) * 2000-08-25 2004-02-10 University Of Florida Method and composition for treatment of inflammatory bowel disease
WO2002055530A2 (en) * 2000-10-25 2002-07-18 Mayo Foundation Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
JP4414331B2 (ja) * 2002-05-15 2010-02-10 ジェンザイム、コーポレーション ベンゾニトリルおよびベンズイミデートの合成
US20040132789A1 (en) * 2002-08-22 2004-07-08 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
US20040044220A1 (en) * 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
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US20040185028A1 (en) * 2003-03-19 2004-09-23 Zhenze Hu Antimicrobial compositions containing ethanolamine buffer and biguanide disinfectant
AU2004270261B2 (en) * 2003-09-09 2008-12-04 University Of Florida Research Foundation, Inc. Polyamine-metal chelator conjugates
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
US20120095058A1 (en) * 2003-12-03 2012-04-19 Hanauske-Abel H M Method of preventing survival of retrovirally cells and of inhibiting formation of infectious retroviruses
EP1714966A4 (en) * 2004-02-04 2008-01-02 Shionogi & Co NAPHTHYLIDINE DERIVATIVE HAVING HIGH INTEGRASE HIV INHIBITING ACTIVITY
PL1866296T3 (pl) 2005-04-04 2017-05-31 University Of Florida Research Foundation, Inc. Polieterowe analogi desferritiocyny
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WO2008130395A2 (en) * 2006-12-12 2008-10-30 University Of Florida Desferrithiocin analogue actinide decorporation agents
CA2680592C (en) 2007-03-15 2016-07-05 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues and uses thereof in treating pathological conditions
JP2011528037A (ja) 2008-07-14 2011-11-10 フェロキン・バイオサイエンシーズ・インコーポレイテッド 金属キレート化剤としてのデスアザデスフェリチオシンポリエーテル類似体の新規の塩及び多形体
NZ603774A (en) 2010-05-04 2014-11-28 Ferrokin Biosciences Inc Desazadesferrothiocin analogues as metal chelation agents
WO2012157612A1 (ja) * 2011-05-19 2012-11-22 国立大学法人徳島大学 細胞分化誘導剤および分化誘導方法
US20140343110A1 (en) 2011-12-16 2014-11-20 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
JP6353751B2 (ja) * 2013-09-25 2018-07-04 国立大学法人電気通信大学 新規複素環式化合物及びその塩、並びに、発光基質組成物
CA2930966A1 (en) * 2013-11-22 2015-05-28 University Of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
KR20170140306A (ko) 2015-04-27 2017-12-20 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 대사적으로 프로그램화된 금속 킬레이트화제 및 그의 용도

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US20040044220A1 (en) 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
WO2005034949A1 (en) 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
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WO2008130395A2 (en) 2006-12-12 2008-10-30 University Of Florida Desferrithiocin analogue actinide decorporation agents
CA2680592C (en) 2007-03-15 2016-07-05 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues and uses thereof in treating pathological conditions

Also Published As

Publication number Publication date
EP1109795A1 (en) 2001-06-27
CZ2001711A3 (cs) 2001-09-12
CN1313856A (zh) 2001-09-19
JP2011178797A (ja) 2011-09-15
ATE317392T1 (de) 2006-02-15
BR9913441B1 (pt) 2013-10-29
US20030236417A1 (en) 2003-12-25
US6083966A (en) 2000-07-04
DE69929807D1 (de) 2006-04-20
YU21801A (sh) 2005-07-19
JP4817498B2 (ja) 2011-11-16
IL141611A (en) 2006-12-31
EP1109795A4 (en) 2002-01-16
US20100094016A1 (en) 2010-04-15
US7126004B2 (en) 2006-10-24
US7531563B2 (en) 2009-05-12
HK1035720A1 (en) 2003-04-24
DE69929807T2 (de) 2006-11-02
IL141611A0 (en) 2002-03-10
US6521652B1 (en) 2003-02-18
CA2342210A1 (en) 2000-03-09
JP5520875B2 (ja) 2014-06-11
JP2014065730A (ja) 2014-04-17
PL346852A1 (en) 2002-03-11
US6525080B1 (en) 2003-02-25
NZ509899A (en) 2003-12-19
ES2260933T3 (es) 2006-11-01
CA2342210C (en) 2009-03-10
US20050033057A1 (en) 2005-02-10
AU759851B2 (en) 2003-05-01
KR20010074907A (ko) 2001-08-09
BR9913441A (pt) 2001-10-23
US20070238767A1 (en) 2007-10-11
WO2000012493A9 (en) 2002-04-11
NO321028B1 (no) 2006-02-27
HUP0103165A2 (hu) 2002-01-28
CN100455574C (zh) 2009-01-28
HUP0103165A3 (en) 2003-03-28
US6559315B1 (en) 2003-05-06
US8008502B2 (en) 2011-08-30
AU5789799A (en) 2000-03-21
NO20011003D0 (no) 2001-02-27
EA200100261A1 (ru) 2001-10-22
JP2002523500A (ja) 2002-07-30
NO20011003L (no) 2001-02-27
EP1109795B1 (en) 2006-02-08
UA57161C2 (uk) 2003-06-16
WO2000012493A1 (en) 2000-03-09
USRE39132E1 (en) 2006-06-13
PT1109795E (pt) 2006-06-30

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