ES2157593T3 - Derivados de la adenosina heterociclicos sustituidos en n6. - Google Patents
Derivados de la adenosina heterociclicos sustituidos en n6.Info
- Publication number
- ES2157593T3 ES2157593T3 ES97938502T ES97938502T ES2157593T3 ES 2157593 T3 ES2157593 T3 ES 2157593T3 ES 97938502 T ES97938502 T ES 97938502T ES 97938502 T ES97938502 T ES 97938502T ES 2157593 T3 ES2157593 T3 ES 2157593T3
- Authority
- ES
- Spain
- Prior art keywords
- heterociclic
- derived
- adenosine
- adenosine replaced
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title abstract 5
- 239000002126 C01EB10 - Adenosine Substances 0.000 title abstract 2
- 229960005305 adenosine Drugs 0.000 title abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 150000002118 epoxides Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE DESCRIBE UN DERIVADO SUSTITUIDO DE LA ADENOSINA POR N SUP,6 OXA, TIA, TIOXA Y AZACICLOALQUILO DE FORMULA (I) Y UN PROCEDIMIENTO PARA EL USO DE LA COMPOSICION COMO RECEPTOR DE LA ADENOSINA CARDIACA A I . EN DICHA FORMULA, R 1 ES UN GRUPO HETEROCICLICO, MONOCICLICO O POLICICLICO, QUE CONTIENE DE 3 A 15 ATOMOS DE CARBONO, DE LOS QUE AL MENOS UNO SE SELECCIONA DEL GRUPO FORMADO POR N, O, P Y S-(O) 0-2 , Y EN EL QUE R 1 NO CONTIENE UN GRUPO EPOXIDO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08702234 US5789416B1 (en) | 1996-08-27 | 1996-08-27 | N6 mono heterocyclic substituted adenosine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2157593T3 true ES2157593T3 (es) | 2001-08-16 |
Family
ID=24820367
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99119389T Expired - Lifetime ES2189330T3 (es) | 1996-08-27 | 1997-08-20 | Derivados heterociclicos n6 de la adenosina sustituidos. |
ES97938502T Expired - Lifetime ES2157593T3 (es) | 1996-08-27 | 1997-08-20 | Derivados de la adenosina heterociclicos sustituidos en n6. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99119389T Expired - Lifetime ES2189330T3 (es) | 1996-08-27 | 1997-08-20 | Derivados heterociclicos n6 de la adenosina sustituidos. |
Country Status (25)
Country | Link |
---|---|
US (1) | US5789416B1 (es) |
EP (3) | EP0920438B1 (es) |
JP (1) | JP3157842B2 (es) |
KR (1) | KR100331775B1 (es) |
CN (1) | CN100363377C (es) |
AT (2) | ATE202361T1 (es) |
AU (1) | AU726597B2 (es) |
BR (1) | BR9711444A (es) |
CA (1) | CA2264155C (es) |
CZ (1) | CZ296855B6 (es) |
DE (2) | DE69705312T2 (es) |
DK (2) | DK0920438T3 (es) |
ES (2) | ES2189330T3 (es) |
GE (1) | GEP20012419B (es) |
GR (1) | GR3036332T3 (es) |
HK (1) | HK1020967A1 (es) |
HU (1) | HU226057B1 (es) |
IL (2) | IL128652A0 (es) |
NO (3) | NO312679B1 (es) |
NZ (3) | NZ334095A (es) |
PL (1) | PL187635B1 (es) |
PT (1) | PT920438E (es) |
TR (2) | TR200202287T2 (es) |
UA (1) | UA62936C2 (es) |
WO (1) | WO1998008855A2 (es) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6790839B2 (en) | 1999-01-07 | 2004-09-14 | Can-Fite Biopharma Ltd. | Pharmaceutical administration of adenosine agonists |
IL127947A0 (en) | 1999-01-07 | 1999-11-30 | Can Fite Technologies Ltd | Pharmaceutical use of adenosine agonists |
US6576619B2 (en) * | 1999-05-24 | 2003-06-10 | Cv Therapeutics, Inc. | Orally active A1 adenosine receptor agonists |
WO2000075142A2 (en) * | 1999-05-25 | 2000-12-14 | The Penn State Research Foundation | Dna methyltransferase inhibitors |
EP1420021A1 (en) * | 1999-05-25 | 2004-05-19 | The Penn State Research Foundation | DNA Methyltransferase inhibitors |
US6180615B1 (en) * | 1999-06-22 | 2001-01-30 | Cv Therapeutics, Inc. | Propargyl phenyl ether A2A receptor agonists |
US6784165B1 (en) | 1999-11-23 | 2004-08-31 | Aderis Pharmaceuticals, Inc. | Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines |
US6605597B1 (en) * | 1999-12-03 | 2003-08-12 | Cv Therapeutics, Inc. | Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives |
AU4138601A (en) * | 1999-12-03 | 2001-06-12 | Cv Therapeutics, Inc. | Method of identifying partial adenosine a1 receptor agonists and their use in the treatment of arrhythmias |
US6258793B1 (en) * | 1999-12-03 | 2001-07-10 | Cv Therapeutics, Inc. | N6 heterocyclic 5′ modified adenosine derivatives |
US6294522B1 (en) * | 1999-12-03 | 2001-09-25 | Cv Therapeutics, Inc. | N6 heterocyclic 8-modified adenosine derivatives |
AU9259101A (en) * | 2000-09-08 | 2002-03-22 | Cv Therapeutics Inc | Purine ribosides as antiarrhythmics |
GB0100623D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds IV |
EP1241176A1 (en) * | 2001-03-16 | 2002-09-18 | Pfizer Products Inc. | Purine derivatives for the treatment of ischemia |
US20050227933A1 (en) * | 2001-11-29 | 2005-10-13 | Benkovic Stephen J | Treatment of bacterial induced diseases using DNA methyl transferase inhibitors |
CA2473238A1 (en) * | 2002-01-10 | 2003-07-24 | The Penn State Research Foundation | Methods for the preparation of alkyl diaryl borinates and complexed diarylboronic acids |
MXPA04008008A (es) | 2002-02-19 | 2005-03-23 | Cv Therapeutics Inc | Agonistas parciales y completos de receptores de adenosina a1. |
DE60325572D1 (de) * | 2002-04-18 | 2009-02-12 | Cv Therapeutics Inc | Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker |
WO2003097643A1 (en) | 2002-05-17 | 2003-11-27 | Neurogen Corporation | Substituted ring-fused imidazole derivates: gabaa receptor ligands |
NZ541651A (en) * | 2003-02-03 | 2009-01-31 | Cv Therapeutics Inc | Partial and full agonists of A1 adenosine receptors |
EP1615930A2 (en) | 2003-04-09 | 2006-01-18 | Biogen Idec MA, Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists |
WO2004092177A1 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
ATE418555T1 (de) | 2003-04-09 | 2009-01-15 | Biogen Idec Inc | A2a-adenosinrezeptorantagonisten |
WO2004100964A1 (en) * | 2003-04-24 | 2004-11-25 | Aderis Pharmaceuticals, Inc. | Method of treating atrial fibrillation or atrial flutter |
US20050118262A1 (en) * | 2003-09-17 | 2005-06-02 | Jack Aurora | Controlled release formulation |
US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
US6881851B1 (en) * | 2004-04-21 | 2005-04-19 | Eastman Chemical Company | Preparation of tetrahydro-3-furoic acid |
PT1758596E (pt) | 2004-05-26 | 2010-06-23 | Inotek Pharmaceuticals Corp | Derivados de purina como agonistas do receptor de adenosina a1 e processos para a sua utilização |
JP5011112B2 (ja) * | 2004-09-20 | 2012-08-29 | イノテック ファーマシューティカルズ コーポレイション | プリン誘導体を含有する炎症性疾患の治療用医薬 |
CN100451010C (zh) * | 2004-12-21 | 2009-01-14 | 厦门大学 | 一种合成(r)-3-氨基四氢呋喃的方法 |
CA2609051A1 (en) * | 2005-05-19 | 2006-11-23 | Cv Therapeutics, Inc. | A1 adenosine receptor agonists |
BRPI0618643A2 (pt) | 2005-11-09 | 2011-09-06 | Combinatorx Inc | composição compreendendo um par de fármacos, composição compreendendo um corticosteróide e um imunossupressor dependente de imunofilina não-esteróide, kits e uso |
CN100344768C (zh) * | 2005-11-24 | 2007-10-24 | 东华大学 | 一种3-(s)-氨基四氢呋喃的酶法合成方法 |
CA2627319A1 (en) * | 2005-11-30 | 2007-06-07 | Prakash Jagtap | Purine derivatives and methods of use thereof |
WO2009102427A2 (en) | 2008-02-11 | 2009-08-20 | Rxi Pharmaceuticals Corp. | Modified rnai polynucleotides and uses thereof |
US8815818B2 (en) | 2008-07-18 | 2014-08-26 | Rxi Pharmaceuticals Corporation | Phagocytic cell delivery of RNAI |
EP3336188B1 (en) | 2008-09-22 | 2020-05-06 | Phio Pharmaceuticals Corp. | Reduced size self-delivering rnai compounds |
WO2010059226A2 (en) | 2008-11-19 | 2010-05-27 | Rxi Pharmaceuticals Corporation | Inhibition of map4k4 through rnai |
US9493774B2 (en) | 2009-01-05 | 2016-11-15 | Rxi Pharmaceuticals Corporation | Inhibition of PCSK9 through RNAi |
WO2010090762A1 (en) | 2009-02-04 | 2010-08-12 | Rxi Pharmaceuticals Corporation | Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
PT2523669T (pt) | 2010-01-11 | 2017-01-31 | Inotek Pharmaceuticals Corp | Associação, conjunto ( kit ) e método de redução da pressão intraocular |
WO2011119852A1 (en) | 2010-03-24 | 2011-09-29 | Rxi Pharmaceuticals Corporation | Reduced size self-delivering rnai compounds |
EP2550001B1 (en) | 2010-03-24 | 2019-05-22 | Phio Pharmaceuticals Corp. | Rna interference in ocular indications |
WO2011119887A1 (en) | 2010-03-24 | 2011-09-29 | Rxi Pharmaceuticals Corporation | Rna interference in dermal and fibrotic indications |
US8476247B2 (en) | 2010-03-26 | 2013-07-02 | Inotek Pharmaceuticals Corporation | Method of reducing intraocular pressure in humans |
DE102011005232A1 (de) | 2011-03-08 | 2012-09-13 | AristoCon GmbH & Co. KG | Adenosin und seine Derivate zur Verwendung in der Schmerztherapie |
AU2013211957B2 (en) | 2012-01-26 | 2017-08-10 | Inotek Pharmaceuticals Corporation | Anhydrous polymorphs of (2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof |
MX2015013234A (es) | 2013-03-15 | 2016-04-15 | Inotek Pharmaceuticals Corp | Formulaciones oftalmicas. |
RU2744194C2 (ru) | 2013-12-02 | 2021-03-03 | Фио Фармасьютикалс Корп | Иммунотерапия рака |
JP6883987B2 (ja) | 2013-12-04 | 2021-06-09 | フィオ ファーマシューティカルズ コーポレーションPhio Pharmaceuticals Corp. | 化学修飾されたオリゴヌクレオチドを利用する創傷治癒の処置のための方法 |
US11279934B2 (en) | 2014-04-28 | 2022-03-22 | Phio Pharmaceuticals Corp. | Methods for treating cancer using nucleic acids targeting MDM2 or MYCN |
US20170051290A1 (en) | 2014-05-01 | 2017-02-23 | Rxi Pharmaceuticals Corporation | Methods for treatment of disorders in the front of the eye utilizing nucleic acid molecules |
KR102506169B1 (ko) | 2014-09-05 | 2023-03-08 | 피오 파마슈티칼스 코프. | Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법 |
US10808247B2 (en) | 2015-07-06 | 2020-10-20 | Phio Pharmaceuticals Corp. | Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach |
KR20180026739A (ko) | 2015-07-06 | 2018-03-13 | 알엑스아이 파마슈티칼스 코포레이션 | 슈퍼옥시드 디스뮤타제 1 (sod1)을 표적화하는 핵산 분자 |
EP3365446A4 (en) | 2015-10-19 | 2019-06-26 | Phio Pharmaceuticals Corp. | SELF ADMINISTRATION-REDUCED SIZE NUCLEIC ACID COMPOUNDS TARGETING LONGS NON-CODING LONGS |
CN105218490B (zh) * | 2015-11-10 | 2017-05-03 | 山东川成医药股份有限公司 | 一种(r)‑3‑氨基四氢呋喃的制备方法 |
JP2023501445A (ja) | 2019-11-08 | 2023-01-18 | フィオ ファーマシューティカルズ コーポレーション | 免疫治療のためのブロモドメイン含有タンパク質4(brd4)を標的とする化学修飾されたオリゴヌクレオチド |
EP4085136A1 (en) | 2019-12-31 | 2022-11-09 | Phio Pharmaceuticals Corp. | Chemically modified oligonucleotides with improved systemic delivery |
WO2023015264A1 (en) | 2021-08-04 | 2023-02-09 | Phio Pharmaceuticals Corp. | Immunotherapy of cancer utilizing natural killer cells treated with chemically modified oligonucleotides |
KR20240041973A (ko) | 2021-08-04 | 2024-04-01 | 피오 파마슈티칼스 코프. | 화학적으로 변형된 올리고뉴클레오티드 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2460929A1 (de) * | 1974-12-21 | 1976-06-24 | Boehringer Sohn Ingelheim | Neue xanthinderivate, verfahren zu ihrer herstellung und ihre anwendung |
US4364922A (en) * | 1980-10-14 | 1982-12-21 | University Of Virginia Alumni Patents Foundation | Adenosine antagonists in the treatment and diagnosis of A-V node conduction disturbances |
JPS57171998A (en) * | 1981-04-15 | 1982-10-22 | Fujisawa Pharmaceut Co Ltd | Adenosine derivative and its salt, preparation thereof and medicinal composition containing the same |
DE3138397A1 (de) * | 1981-09-26 | 1983-04-07 | Hoechst Ag, 6230 Frankfurt | "arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen" |
AU577743B2 (en) * | 1984-10-26 | 1988-09-29 | Warner-Lambert Company | N6-benzopyrano and benzothiopyrano adenosines |
AU8274187A (en) * | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Heteroaromatic derivatives of adenosine |
US4954504A (en) * | 1986-11-14 | 1990-09-04 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity |
US5565566A (en) * | 1987-04-24 | 1996-10-15 | Discovery Therapeutics, Inc. | N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists |
US4980379A (en) * | 1988-06-30 | 1990-12-25 | The University Of Virginia | Use of adenosine antagonists in the treatment of bradyarrhythmias and hemodynamic depression associated with cardiopulmonary resucitation and/or cardiovascular collapse |
IE882585L (en) * | 1988-08-25 | 1990-02-25 | Prendergast Patrick T | Viral treatment system |
DE8817122U1 (es) * | 1988-12-22 | 1993-02-04 | Boehringer Ingelheim Kg, 6507 Ingelheim, De | |
EP0457773A4 (en) * | 1989-01-31 | 1993-03-10 | Whitby Research Incorporated | N?6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists |
US5017578A (en) * | 1989-06-09 | 1991-05-21 | Hoechst-Roussel Pharmaceuticals Inc. | N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents |
US5155098A (en) * | 1989-06-09 | 1992-10-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods employing them |
JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
DE4019892A1 (de) * | 1990-06-22 | 1992-01-02 | Boehringer Ingelheim Kg | Neue xanthinderivate |
US5432164A (en) * | 1991-10-24 | 1995-07-11 | Novo Nordisk A/S | C2,N6 -disubstituted adenosine derivatives |
DE4205306B4 (de) * | 1992-02-21 | 2005-11-24 | Glüsenkamp, Karl-Heinz, Dr. | Säureamide, Arzneimittel mit denselben und Verfahren zur Herstellung von Säureamiden |
US5288721A (en) * | 1992-09-22 | 1994-02-22 | Cell Therapeutics, Inc. | Substituted epoxyalkyl xanthines |
WO1994016702A1 (en) * | 1993-01-26 | 1994-08-04 | Kyowa Hakko Kogyo Co., Ltd. | Remedy for irregular bowel movement |
US5446046A (en) * | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
US5736528A (en) * | 1993-10-28 | 1998-04-07 | University Of Florida Research Foundation, Inc. | N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists |
EP0704215A3 (en) * | 1994-06-02 | 1998-04-01 | Takeda Chemical Industries, Ltd. | Inhibitor of vascular permeability enhancer |
-
1996
- 1996-08-27 US US08702234 patent/US5789416B1/en not_active Expired - Lifetime
-
1997
- 1997-08-20 CZ CZ0061499A patent/CZ296855B6/cs not_active IP Right Cessation
- 1997-08-20 IL IL12865297A patent/IL128652A0/xx active IP Right Grant
- 1997-08-20 DE DE69705312T patent/DE69705312T2/de not_active Expired - Lifetime
- 1997-08-20 NZ NZ334095A patent/NZ334095A/xx not_active IP Right Cessation
- 1997-08-20 UA UA99021148A patent/UA62936C2/uk unknown
- 1997-08-20 AT AT97938502T patent/ATE202361T1/de active
- 1997-08-20 DE DE69719816T patent/DE69719816T2/de not_active Expired - Lifetime
- 1997-08-20 EP EP97938502A patent/EP0920438B1/en not_active Expired - Lifetime
- 1997-08-20 AT AT99119389T patent/ATE234323T1/de active
- 1997-08-20 DK DK97938502T patent/DK0920438T3/da active
- 1997-08-20 ES ES99119389T patent/ES2189330T3/es not_active Expired - Lifetime
- 1997-08-20 GE GEAP19974728A patent/GEP20012419B/en unknown
- 1997-08-20 WO PCT/US1997/014724 patent/WO1998008855A2/en active IP Right Grant
- 1997-08-20 EP EP99119389A patent/EP0992510B1/en not_active Expired - Lifetime
- 1997-08-20 PT PT97938502T patent/PT920438E/pt unknown
- 1997-08-20 EP EP00123879A patent/EP1081155A3/en not_active Withdrawn
- 1997-08-20 NZ NZ505428A patent/NZ505428A/en unknown
- 1997-08-20 ES ES97938502T patent/ES2157593T3/es not_active Expired - Lifetime
- 1997-08-20 TR TR2002/02287T patent/TR200202287T2/xx unknown
- 1997-08-20 HU HU0001640A patent/HU226057B1/hu not_active IP Right Cessation
- 1997-08-20 PL PL97331853A patent/PL187635B1/pl not_active IP Right Cessation
- 1997-08-20 KR KR1019997001563A patent/KR100331775B1/ko not_active IP Right Cessation
- 1997-08-20 TR TR1999/00377T patent/TR199900377T2/xx unknown
- 1997-08-20 DK DK99119389T patent/DK0992510T3/da active
- 1997-08-20 BR BR9711444-8A patent/BR9711444A/pt active Search and Examination
- 1997-08-20 CA CA002264155A patent/CA2264155C/en not_active Expired - Fee Related
- 1997-08-20 CN CNB971991790A patent/CN100363377C/zh not_active Expired - Fee Related
- 1997-08-20 AU AU40809/97A patent/AU726597B2/en not_active Ceased
- 1997-08-20 JP JP51173698A patent/JP3157842B2/ja not_active Expired - Fee Related
-
1999
- 1999-02-19 NO NO19990787A patent/NO312679B1/no not_active IP Right Cessation
- 1999-02-22 IL IL128652A patent/IL128652A/en not_active IP Right Cessation
- 1999-12-30 HK HK99106191A patent/HK1020967A1/xx not_active IP Right Cessation
-
2001
- 2001-06-08 NZ NZ512242A patent/NZ512242A/xx not_active IP Right Cessation
- 2001-08-06 GR GR20010401184T patent/GR3036332T3/el unknown
-
2002
- 2002-02-15 NO NO20020759A patent/NO20020759D0/no not_active Application Discontinuation
- 2002-02-15 NO NO20020758A patent/NO322459B1/no not_active IP Right Cessation
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