DE69705312T2 - N6-heterocyclisch-substituierte adenosin-derivate - Google Patents

N6-heterocyclisch-substituierte adenosin-derivate

Info

Publication number
DE69705312T2
DE69705312T2 DE69705312T DE69705312T DE69705312T2 DE 69705312 T2 DE69705312 T2 DE 69705312T2 DE 69705312 T DE69705312 T DE 69705312T DE 69705312 T DE69705312 T DE 69705312T DE 69705312 T2 DE69705312 T2 DE 69705312T2
Authority
DE
Germany
Prior art keywords
heterocyclic
adenosine derivatives
substituted adenosine
substituted
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69705312T
Other languages
English (en)
Other versions
DE69705312D1 (de
Inventor
Robert T Lum
Jurg R Pfister
Steven R Schow
Michael M Wick
Marek G Nelson
George F Schreiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gilead Palo Alto Inc
Original Assignee
CV Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CV Therapeutics Inc filed Critical CV Therapeutics Inc
Publication of DE69705312D1 publication Critical patent/DE69705312D1/de
Application granted granted Critical
Publication of DE69705312T2 publication Critical patent/DE69705312T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69705312T 1996-08-27 1997-08-20 N6-heterocyclisch-substituierte adenosin-derivate Expired - Lifetime DE69705312T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08702234 US5789416B1 (en) 1996-08-27 1996-08-27 N6 mono heterocyclic substituted adenosine derivatives
PCT/US1997/014724 WO1998008855A2 (en) 1996-08-27 1997-08-20 N6 heterocyclic substituted adenosine derivatives

Publications (2)

Publication Number Publication Date
DE69705312D1 DE69705312D1 (de) 2001-07-26
DE69705312T2 true DE69705312T2 (de) 2001-10-11

Family

ID=24820367

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69719816T Expired - Lifetime DE69719816T2 (de) 1996-08-27 1997-08-20 N6-heterocyclisch substituierte Adenosin-Derivate
DE69705312T Expired - Lifetime DE69705312T2 (de) 1996-08-27 1997-08-20 N6-heterocyclisch-substituierte adenosin-derivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69719816T Expired - Lifetime DE69719816T2 (de) 1996-08-27 1997-08-20 N6-heterocyclisch substituierte Adenosin-Derivate

Country Status (25)

Country Link
US (1) US5789416B1 (de)
EP (3) EP0920438B1 (de)
JP (1) JP3157842B2 (de)
KR (1) KR100331775B1 (de)
CN (1) CN100363377C (de)
AT (2) ATE234323T1 (de)
AU (1) AU726597B2 (de)
BR (1) BR9711444A (de)
CA (1) CA2264155C (de)
CZ (1) CZ296855B6 (de)
DE (2) DE69719816T2 (de)
DK (2) DK0992510T3 (de)
ES (2) ES2189330T3 (de)
GE (1) GEP20012419B (de)
GR (1) GR3036332T3 (de)
HK (1) HK1020967A1 (de)
HU (1) HU226057B1 (de)
IL (2) IL128652A0 (de)
NO (3) NO312679B1 (de)
NZ (3) NZ505428A (de)
PL (1) PL187635B1 (de)
PT (1) PT920438E (de)
TR (2) TR200202287T2 (de)
UA (1) UA62936C2 (de)
WO (1) WO1998008855A2 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL127947A0 (en) 1999-01-07 1999-11-30 Can Fite Technologies Ltd Pharmaceutical use of adenosine agonists
US6790839B2 (en) 1999-01-07 2004-09-14 Can-Fite Biopharma Ltd. Pharmaceutical administration of adenosine agonists
US6576619B2 (en) * 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
CA2373279A1 (en) * 1999-05-25 2000-12-14 The Penn State Research Foundation Dna methyltransferase inhibitors
EP1420021A1 (de) * 1999-05-25 2004-05-19 The Penn State Research Foundation DNA Methyltransferas-Inhibitoren
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
US6784165B1 (en) 1999-11-23 2004-08-31 Aderis Pharmaceuticals, Inc. Treatment of heart rhythm disturbances with N6-substituted-5′-(N-substituted) carboxamidoadenosines
AU4138601A (en) * 1999-12-03 2001-06-12 Cv Therapeutics, Inc. Method of identifying partial adenosine a1 receptor agonists and their use in the treatment of arrhythmias
US6258793B1 (en) 1999-12-03 2001-07-10 Cv Therapeutics, Inc. N6 heterocyclic 5′ modified adenosine derivatives
US6605597B1 (en) * 1999-12-03 2003-08-12 Cv Therapeutics, Inc. Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives
US6294522B1 (en) * 1999-12-03 2001-09-25 Cv Therapeutics, Inc. N6 heterocyclic 8-modified adenosine derivatives
US6537974B2 (en) * 2000-09-08 2003-03-25 Cv Therapeutics, Inc. Method of treating arrhythmias
GB0100623D0 (en) * 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds IV
EP1241176A1 (de) * 2001-03-16 2002-09-18 Pfizer Products Inc. Purinderivate zur Behandlung von Ischämie
US20050227933A1 (en) * 2001-11-29 2005-10-13 Benkovic Stephen J Treatment of bacterial induced diseases using DNA methyl transferase inhibitors
US7405304B2 (en) * 2002-01-10 2008-07-29 The Penn State Research Foundation Methods for the preparation of alkyl diaryl borinates and complexed diarylboronic acids
IL163613A0 (en) 2002-02-19 2005-12-18 Cv Therapeutics Inc Partial and full agonists of a1 adenosine receptors
US7005425B2 (en) * 2002-04-18 2006-02-28 Cv Therapeutics, Inc. Method for treating arrhythmias
ATE333455T1 (de) 2002-05-17 2006-08-15 Neurogen Corp Substituierte, ringkondensierte imidazolderivate: gabaa-rezeptorliganden
NZ541651A (en) * 2003-02-03 2009-01-31 Cv Therapeutics Inc Partial and full agonists of A1 adenosine receptors
EP1615930A2 (de) 2003-04-09 2006-01-18 Biogen Idec MA, Inc. Als a2a-adenosinrezeptor-antagonisten geeignete triazolotriazine und pyrazolotriazine
EP1615931A1 (de) 2003-04-09 2006-01-18 Biogen Idec MA Inc. Triazolopyrazine und verfahren zu deren herstellung und anwendung
EP1633756B1 (de) 2003-04-09 2008-12-24 Biogen Idec MA Inc. A2a-adenosinrezeptorantagonisten
CA2523746A1 (en) * 2003-04-24 2004-11-25 Aderis Pharmaceuticals, Inc. Method of treating atrial fibrillation or atrial flutter
US20050118262A1 (en) * 2003-09-17 2005-06-02 Jack Aurora Controlled release formulation
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
US6881851B1 (en) * 2004-04-21 2005-04-19 Eastman Chemical Company Preparation of tetrahydro-3-furoic acid
JP4484928B2 (ja) * 2004-05-26 2010-06-16 イノテック ファーマシューティカルズ コーポレイション アデノシンａ１レセプター・アゴニストとしてのプリン誘導体およびその使用方法
MX2007003271A (es) * 2004-09-20 2007-06-05 Inotek Pharmaceuticals Corp Derivados de purina y metodos de uso de los mismos.
CN100451010C (zh) * 2004-12-21 2009-01-14 厦门大学 一种合成(r)-3-氨基四氢呋喃的方法
EP1883646A1 (de) * 2005-05-19 2008-02-06 Cv Therapeutics, Inc. A1-adenosinrezeptoragonisten
KR20080065704A (ko) 2005-11-09 2008-07-14 콤비네이토릭스, 인코포레이티드 의학적 이상의 치료 방법들, 조성물들, 및 키트들
CN100344768C (zh) * 2005-11-24 2007-10-24 东华大学 一种3－(s)－氨基四氢呋喃的酶法合成方法
EP1962597A4 (de) * 2005-11-30 2008-12-17 Inotek Pharmaceuticals Corp Purinderivate und anwendungsverfahren
CN102016036B (zh) 2008-02-11 2015-04-08 阿克赛医药公司 经修饰的RNAi多核苷酸及其用途
WO2010008582A2 (en) 2008-07-18 2010-01-21 Rxi Pharmaceuticals Corporation Phagocytic cell drug delivery system
CA2746527A1 (en) 2008-09-22 2010-03-25 Rxi Pharmaceuticals Corporation Rna interference in skin indications
WO2010059226A2 (en) 2008-11-19 2010-05-27 Rxi Pharmaceuticals Corporation Inhibition of map4k4 through rnai
US9493774B2 (en) 2009-01-05 2016-11-15 Rxi Pharmaceuticals Corporation Inhibition of PCSK9 through RNAi
WO2010090762A1 (en) 2009-02-04 2010-08-12 Rxi Pharmaceuticals Corporation Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
EA025415B1 (ru) 2010-01-11 2016-12-30 Инотек Фармасьютикалз Корпорейшн Комбинация, набор и способ снижения внутриглазного давления
CN103200945B (zh) 2010-03-24 2016-07-06 雷克西制药公司 眼部症候中的rna干扰
WO2011119887A1 (en) 2010-03-24 2011-09-29 Rxi Pharmaceuticals Corporation Rna interference in dermal and fibrotic indications
WO2011119852A1 (en) 2010-03-24 2011-09-29 Rxi Pharmaceuticals Corporation Reduced size self-delivering rnai compounds
EP2569325A4 (de) 2010-03-26 2013-10-09 Inotek Pharmaceuticals Corp Verfahren zur reduzierung des innenaugendrucks beim menschen mithilfe von n6-cyclopentyladenosin (cpa), cpa-derivaten oder prodrugs davon
DE102011005232A1 (de) 2011-03-08 2012-09-13 AristoCon GmbH & Co. KG Adenosin und seine Derivate zur Verwendung in der Schmerztherapie
JP2015508751A (ja) 2012-01-26 2015-03-23 イノテック ファーマシューティカルズ コーポレイション ［（２ｒ，３ｓ，４ｒ，５ｒ）−５−（６−（シクロペンチルアミノ）−９ｈ−プリン−９−イル）−３，４−ジヒドロキシテトラヒドロフラン−２−イル］メチルナイトレートの無水多形体及びその製造方法
MX2015013234A (es) 2013-03-15 2016-04-15 Inotek Pharmaceuticals Corp Formulaciones oftalmicas.
CN113151180A (zh) 2013-12-02 2021-07-23 菲奥医药公司 癌症的免疫治疗
CN105960265A (zh) 2013-12-04 2016-09-21 阿克赛医药公司 利用经化学修饰的寡核苷酸处理伤口愈合的方法
EP3137119B1 (de) 2014-04-28 2020-07-01 Phio Pharmaceuticals Corp. Verfahren zur behandlung von krebs mithilfe von einer nukleinsaüre gegen mdm2
WO2015168605A1 (en) 2014-05-01 2015-11-05 Rxi Pharmaceuticals Corporation Methods for treatment of disorders in the front of the eye utilizing nucleic acid molecules
WO2016037071A2 (en) 2014-09-05 2016-03-10 Rxi Pharmaceuticals Corporation Methods for treating aging and skin disorders using nucleic acids targeting tyr or mmp1
WO2017007825A1 (en) 2015-07-06 2017-01-12 Rxi Pharmaceuticals Corporation Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
KR20180026739A (ko) 2015-07-06 2018-03-13 알엑스아이 파마슈티칼스 코포레이션 슈퍼옥시드 디스뮤타제 1 (sod1)을 표적화하는 핵산 분자
EP3365446A4 (de) 2015-10-19 2019-06-26 Phio Pharmaceuticals Corp. Gegen lange nichtcodierende rna gerichtete kleine selbstfreisetzende nukleinsäureverbindungen
CN105218490B (zh) * 2015-11-10 2017-05-03 山东川成医药股份有限公司 一种（r）‑3‑氨基四氢呋喃的制备方法
EP4055167A2 (de) 2019-11-08 2022-09-14 Phio Pharmaceuticals Corp. Auf das bromodomainhaltige protein 4 (brd4) abzielende chemisch modifizierte oligonukleotide für die immuntherapie
EP4085136A1 (de) 2019-12-31 2022-11-09 Phio Pharmaceuticals Corp. Chemisch modifizierte oligonukleotide mit verbesserter systemischer abgabe
WO2023015264A1 (en) 2021-08-04 2023-02-09 Phio Pharmaceuticals Corp. Immunotherapy of cancer utilizing natural killer cells treated with chemically modified oligonucleotides
KR20240041973A (ko) 2021-08-04 2024-04-01 피오 파마슈티칼스 코프. 화학적으로 변형된 올리고뉴클레오티드

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460929A1 (de) * 1974-12-21 1976-06-24 Boehringer Sohn Ingelheim Neue xanthinderivate, verfahren zu ihrer herstellung und ihre anwendung
US4364922A (en) * 1980-10-14 1982-12-21 University Of Virginia Alumni Patents Foundation Adenosine antagonists in the treatment and diagnosis of A-V node conduction disturbances
JPS57171998A (en) * 1981-04-15 1982-10-22 Fujisawa Pharmaceut Co Ltd Adenosine derivative and its salt, preparation thereof and medicinal composition containing the same
DE3138397A1 (de) * 1981-09-26 1983-04-07 Hoechst Ag, 6230 Frankfurt "arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen"
CA1255297A (en) * 1984-10-26 1989-06-06 Bharat Trivedi N.sup.6-benzopyrano and benzothiopyrano adenosines
AU8274187A (en) * 1986-10-31 1988-05-25 Warner-Lambert Company Heteroaromatic derivatives of adenosine
US4954504A (en) * 1986-11-14 1990-09-04 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity
US5565566A (en) * 1987-04-24 1996-10-15 Discovery Therapeutics, Inc. N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US4980379A (en) * 1988-06-30 1990-12-25 The University Of Virginia Use of adenosine antagonists in the treatment of bradyarrhythmias and hemodynamic depression associated with cardiopulmonary resucitation and/or cardiovascular collapse
IE882585L (en) * 1988-08-25 1990-02-25 Prendergast Patrick T Viral treatment system
DE8817122U1 (de) * 1988-12-22 1993-02-04 Boehringer Ingelheim Kg, 6507 Ingelheim, De
KR910700253A (ko) * 1989-01-31 1991-03-14 로버트 제이, 바란 N_6-치환-9-메틸아데닌: 신규한 부류의 아데노신 수용체 길항질
US5155098A (en) * 1989-06-09 1992-10-13 Hoechst-Roussel Pharmaceuticals Inc. N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods employing them
US5017578A (en) * 1989-06-09 1991-05-21 Hoechst-Roussel Pharmaceuticals Inc. N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
US5432164A (en) * 1991-10-24 1995-07-11 Novo Nordisk A/S C2,N6 -disubstituted adenosine derivatives
DE4205306B4 (de) * 1992-02-21 2005-11-24 Glüsenkamp, Karl-Heinz, Dr. Säureamide, Arzneimittel mit denselben und Verfahren zur Herstellung von Säureamiden
US5288721A (en) * 1992-09-22 1994-02-22 Cell Therapeutics, Inc. Substituted epoxyalkyl xanthines
WO1994016702A1 (en) * 1993-01-26 1994-08-04 Kyowa Hakko Kogyo Co., Ltd. Remedy for irregular bowel movement
US5736528A (en) * 1993-10-28 1998-04-07 University Of Florida Research Foundation, Inc. N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists
US5446046A (en) * 1993-10-28 1995-08-29 University Of Florida Research Foundation A1 adenosine receptor agonists and antagonists as diuretics
EP0704215A3 (de) * 1994-06-02 1998-04-01 Takeda Chemical Industries, Ltd. Hemmer der Erhöhung vaskulärer Permeabilität

Also Published As

Publication number Publication date
EP0920438A2 (de) 1999-06-09
NO20020759D0 (no) 2002-02-15
AU4080997A (en) 1998-03-19
WO1998008855A2 (en) 1998-03-05
HUP0001640A3 (en) 2002-04-29
EP0920438B1 (de) 2001-06-20
EP0992510B1 (de) 2003-03-12
NZ505428A (en) 2005-03-24
JP2000501426A (ja) 2000-02-08
DE69719816T2 (de) 2003-12-18
TR200202287T2 (tr) 2003-01-21
UA62936C2 (en) 2004-01-15
WO1998008855A3 (en) 1998-09-03
EP1081155A3 (de) 2003-05-02
IL128652A (en) 2008-06-05
NO322459B1 (no) 2006-10-09
PL331853A1 (en) 1999-08-16
ATE234323T1 (de) 2003-03-15
ATE202361T1 (de) 2001-07-15
US5789416B1 (en) 1999-10-05
HUP0001640A2 (hu) 2001-05-28
NO20020758L (no) 1999-02-19
NZ334095A (en) 2000-10-27
DE69719816D1 (de) 2003-04-17
EP0992510A1 (de) 2000-04-12
PT920438E (pt) 2001-10-30
AU726597B2 (en) 2000-11-16
HU226057B1 (en) 2008-04-28
TR199900377T2 (xx) 1999-05-21
JP3157842B2 (ja) 2001-04-16
NO20020759L (no) 1999-02-19
EP1081155A2 (de) 2001-03-07
HK1020967A1 (en) 2000-05-26
IL128652A0 (en) 2000-01-31
NO990787L (no) 1999-02-19
NZ512242A (en) 2004-01-30
DE69705312D1 (de) 2001-07-26
DK0920438T3 (da) 2001-09-10
CA2264155C (en) 2003-11-18
PL187635B1 (pl) 2004-08-31
KR20000035867A (ko) 2000-06-26
CN100363377C (zh) 2008-01-23
GR3036332T3 (en) 2001-11-30
ES2189330T3 (es) 2003-07-01
CN1234803A (zh) 1999-11-10
CZ296855B6 (cs) 2006-07-12
KR100331775B1 (ko) 2002-04-09
GEP20012419B (en) 2001-04-25
NO990787D0 (no) 1999-02-19
US5789416A (en) 1998-08-04
CZ61499A3 (cs) 1999-10-13
NO20020758D0 (no) 2002-02-15
DK0992510T3 (da) 2003-07-07
CA2264155A1 (en) 1998-03-05
BR9711444A (pt) 2000-01-18
NO312679B1 (no) 2002-06-17
ES2157593T3 (es) 2001-08-16

Similar Documents

Publication Publication Date Title
ATE234323T1 (de) N6-heterocyclisch substituierte adenosin-derivate
IS4963A (is) Setnar 6,5-heteró-bísýklískar afleiður
DK0925298T3 (da) Substituerede 6,6-heterobicykliske derivater
DK0920429T3 (da) Substituerede pyrido- eller pyrimidoholdige, 6,6- eller 6,7-bicykliske derivater
LU91758I2 (fr) Denosumab et ses dérivés pharmaceutiquement acceptables (PROLIA®)
DK1000048T3 (da) Substituerede 1,2,3,4-tetrahydronapthalenderivater
ATE231847T1 (de) Substituierte 1,2,3,4- tetrahydronaphthalinderivate
ATE246199T1 (de) 3-descladinose-2,3-anhydroerythromycin-derivate
ATE220674T1 (de) 12h-dibenzo(d,g)(1,3)dioxocin derivate
TR199802607A3 (tr) Alkil-veya benzil türevlerinin alkillenmesine yönelik usul.
TR199700219A3 (tr) 1,25-Dihidroksi-16, 22, 23-Trisdihidro-kolkalsiferol türevleri.
BR9609310A (pt) Derivados de 1,3-OXA(TIA)ZINA

Legal Events

Date Code Title Description
8364 No opposition during term of opposition