FI914319A0 - Nya karbocykliska adenosinanaloger anvaendbara som immunosupressanter. - Google Patents

Nya karbocykliska adenosinanaloger anvaendbara som immunosupressanter.

Info

Publication number
FI914319A0
FI914319A0 FI914319A FI914319A FI914319A0 FI 914319 A0 FI914319 A0 FI 914319A0 FI 914319 A FI914319 A FI 914319A FI 914319 A FI914319 A FI 914319A FI 914319 A0 FI914319 A0 FI 914319A0
Authority
FI
Finland
Prior art keywords
karbocykliska
immunosupressanter
adenosinanaloger
nya
anvaendbara som
Prior art date
Application number
FI914319A
Other languages
English (en)
Other versions
FI102755B (fi
FI914319A (fi
FI102755B1 (fi
Inventor
David Roger Borcherding
Carl Keith Edwards Iii
Ronald Eugene Esser
Douglas Cole
Original Assignee
Marion Merrell Dow Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Marion Merrell Dow Inc filed Critical Marion Merrell Dow Inc
Publication of FI914319A0 publication Critical patent/FI914319A0/fi
Publication of FI914319A publication Critical patent/FI914319A/fi
Application granted granted Critical
Publication of FI102755B publication Critical patent/FI102755B/fi
Publication of FI102755B1 publication Critical patent/FI102755B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI914319A 1990-09-14 1991-09-13 Menetelmä uuden, terapeuttisesti käyttökelpoisen yhdisteen tai sen suolan valmistamiseksi FI102755B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58228090A 1990-09-14 1990-09-14
US58228090 1990-09-14
US74817291A 1991-08-23 1991-08-23
US74817291 1991-08-23

Publications (4)

Publication Number Publication Date
FI914319A0 true FI914319A0 (fi) 1991-09-13
FI914319A FI914319A (fi) 1992-03-15
FI102755B FI102755B (fi) 1999-02-15
FI102755B1 FI102755B1 (fi) 1999-02-15

Family

ID=27078528

Family Applications (1)

Application Number Title Priority Date Filing Date
FI914319A FI102755B1 (fi) 1990-09-14 1991-09-13 Menetelmä uuden, terapeuttisesti käyttökelpoisen yhdisteen tai sen suolan valmistamiseksi

Country Status (19)

Country Link
EP (1) EP0475411B1 (fi)
JP (1) JP3099280B2 (fi)
KR (1) KR100249111B1 (fi)
CN (1) CN1031132C (fi)
AR (1) AR247566A1 (fi)
AT (1) ATE202106T1 (fi)
AU (1) AU647822B2 (fi)
CA (1) CA2051012C (fi)
DE (1) DE69132632T2 (fi)
DK (1) DK0475411T3 (fi)
ES (1) ES2158840T3 (fi)
FI (1) FI102755B1 (fi)
GR (1) GR3036577T3 (fi)
HU (1) HU209304B (fi)
IE (1) IE913247A1 (fi)
IL (1) IL99466A (fi)
NO (1) NO179908C (fi)
NZ (1) NZ239750A (fi)
PT (1) PT98943B (fi)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU642526B2 (en) * 1990-09-14 1993-10-21 Marion Merrell Dow Inc. Method of immunosuppression using cyclopentenyl substituted nucleoside analogs and compositions thereof
US5470857A (en) * 1990-09-14 1995-11-28 Marion Merrell Dow Inc. Carbocyclic nucleoside analogs useful as immunosuppressants
US5817660A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817672A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5723466A (en) * 1991-12-06 1998-03-03 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
AU658698B2 (en) * 1991-12-06 1995-04-27 Aventis Pharmaceuticals Inc. Novel trans cyclopentanyl purine analogs useful as immunosuppressants
US5817661A (en) * 1991-12-06 1998-10-06 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants
US5292513A (en) * 1992-05-18 1994-03-08 Anthony G. Gristina Method for nonspecific cellular immune stimulation
WO1994013676A1 (en) * 1992-12-17 1994-06-23 Pfizer Inc. Pyrrolopyrimidines as crf antagonists
CN1041631C (zh) * 1993-06-21 1999-01-13 默里尔药物公司 用作炎症前细胞因子选择性抑制剂的新的碳环核苷药物
KR960705825A (ko) * 1993-11-12 1996-11-08 게리 디. 스트리트 면역억제제로서 유용한 6-옥소-뉴클레오시드(6-Oxo-nucleosides useful as immunosuppressants)
TW282470B (fi) * 1993-11-18 1996-08-01 Ajinomoto Kk
DE59500788D1 (de) * 1994-05-03 1997-11-20 Ciba Geigy Ag Pyrrolopyrimidinderivate mit antiproliferativer Wirkung
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US6956047B1 (en) 1995-06-06 2005-10-18 Pfizer Inc. Corticotropin releasing factor antagonists
US6403599B1 (en) 1995-11-08 2002-06-11 Pfizer Inc Corticotropin releasing factor antagonists
US7067664B1 (en) 1995-06-06 2006-06-27 Pfizer Inc. Corticotropin releasing factor antagonists
OA12157A (en) 2000-01-18 2006-05-08 Pfizer Prod Inc Corticotropin releasing factor antagonists.
MXPA06002001A (es) * 2003-08-26 2006-06-20 Teijin Pharma Ltd Derivados pirrolopirimidinona.
US8945505B2 (en) 2007-02-02 2015-02-03 Panaphix, Inc. Use of arsenic compounds for treatment of pain and inflammation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551428A (en) * 1956-02-10 1970-12-29 Ciba Geigy Corp New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines
US3917837A (en) * 1974-10-21 1975-11-04 American Cyanamid Co Method of using trans-2-(6-amino-9H-purin-9-yl)-cyclopentanol
US4076711A (en) * 1976-04-05 1978-02-28 Schering Corporation Triazolo [4,5-d]-pyrimidines
US4221794A (en) * 1979-06-21 1980-09-09 Newport Pharmaceuticals International, Inc. Method of imparting immunomodulating and antiviral activity
US4386093A (en) * 1981-09-16 1983-05-31 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services (±)3-Deazaaristeromycin and uses
IN164556B (fi) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
US4859677A (en) * 1987-04-17 1989-08-22 University Of Kansas Nucleoside analogues having antiviral activity
US4782062A (en) * 1987-05-11 1988-11-01 Merck & Co., Inc. 9-(2-hydroxymethyl)cycloalkylmethyl) guanines
IL86381A0 (en) * 1987-05-19 1988-11-15 Nippon Kayaku Kk Oxetanocins and pharmaceutical compositions containing the same
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
HUT59138A (en) 1992-04-28
KR100249111B1 (ko) 2000-08-01
CA2051012A1 (en) 1992-03-15
CA2051012C (en) 2002-04-02
AR247566A1 (es) 1995-01-31
GR3036577T3 (en) 2001-12-31
HU209304B (en) 1994-04-28
IL99466A (en) 1996-07-23
EP0475411A1 (en) 1992-03-18
CN1059909A (zh) 1992-04-01
JP3099280B2 (ja) 2000-10-16
KR920006357A (ko) 1992-04-27
IE913247A1 (en) 1992-02-25
ATE202106T1 (de) 2001-06-15
AU8372991A (en) 1992-03-19
DE69132632D1 (de) 2001-07-19
DE69132632T2 (de) 2002-04-18
HU912961D0 (en) 1992-01-28
CN1031132C (zh) 1996-02-28
JPH04270282A (ja) 1992-09-25
NO179908C (no) 1997-01-08
PT98943A (pt) 1992-07-31
FI102755B (fi) 1999-02-15
PT98943B (pt) 1999-02-26
FI914319A (fi) 1992-03-15
NO179908B (no) 1996-09-30
DK0475411T3 (da) 2001-10-01
NO913625L (no) 1992-03-16
NZ239750A (en) 1994-02-25
NO913625D0 (no) 1991-09-13
IL99466A0 (en) 1992-08-18
EP0475411B1 (en) 2001-06-13
FI102755B1 (fi) 1999-02-15
AU647822B2 (en) 1994-03-31
ES2158840T3 (es) 2001-09-16

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