ATE227724T1 - Muscarinagonisten und antagonisten - Google Patents

Muscarinagonisten und antagonisten

Info

Publication number
ATE227724T1
ATE227724T1 AT99945064T AT99945064T ATE227724T1 AT E227724 T1 ATE227724 T1 AT E227724T1 AT 99945064 T AT99945064 T AT 99945064T AT 99945064 T AT99945064 T AT 99945064T AT E227724 T1 ATE227724 T1 AT E227724T1
Authority
AT
Austria
Prior art keywords
muscarinagonists
antagonists
Prior art date
Application number
AT99945064T
Other languages
English (en)
Inventor
Gurmit Grewal
Anna Toy-Palmer
Xiong Cai
George Mark Latham
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Application granted granted Critical
Publication of ATE227724T1 publication Critical patent/ATE227724T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT99945064T 1998-08-18 1999-08-16 Muscarinagonisten und antagonisten ATE227724T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9697798P 1998-08-18 1998-08-18
PCT/US1999/018570 WO2000011001A1 (en) 1998-08-18 1999-08-16 Muscarinic agonists and antagonists

Publications (1)

Publication Number Publication Date
ATE227724T1 true ATE227724T1 (de) 2002-11-15

Family

ID=22260061

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99945064T ATE227724T1 (de) 1998-08-18 1999-08-16 Muscarinagonisten und antagonisten

Country Status (30)

Country Link
US (5) US6093724A (de)
EP (1) EP1112272B1 (de)
JP (1) JP2002523416A (de)
KR (1) KR20010072784A (de)
CN (1) CN1312812A (de)
AR (1) AR020199A1 (de)
AT (1) ATE227724T1 (de)
AU (1) AU750566B2 (de)
BG (1) BG105256A (de)
BR (1) BR9913072A (de)
CA (1) CA2340946A1 (de)
CO (1) CO5130018A1 (de)
DE (1) DE69903961T2 (de)
EE (1) EE200100096A (de)
ES (1) ES2191455T3 (de)
HK (1) HK1038918A1 (de)
HU (1) HUP0103203A3 (de)
ID (1) ID27544A (de)
IL (1) IL141050A0 (de)
IS (1) IS5827A (de)
NO (1) NO20010804L (de)
NZ (1) NZ509762A (de)
PE (1) PE20000988A1 (de)
PL (1) PL346247A1 (de)
RU (1) RU2219179C2 (de)
SK (1) SK1892001A3 (de)
TR (1) TR200100462T2 (de)
WO (1) WO2000011001A1 (de)
YU (1) YU13301A (de)
ZA (1) ZA200100978B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2423789A1 (en) * 2000-10-19 2002-04-25 Pfizer Products Inc. Bridged piperazine derivatives
GB0117950D0 (en) * 2001-02-16 2001-09-19 Aventis Pharma Inc Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
WO2002094827A1 (en) * 2001-05-23 2002-11-28 Neurosearch A/S Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20030064979A1 (en) * 2001-06-29 2003-04-03 Hansen Thomas Kruse Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48
US6828328B1 (en) * 2002-03-01 2004-12-07 Ucb S.A. Analgesic combination of muscarinic agonists
US7897766B2 (en) 2005-09-23 2011-03-01 Abbott Laboratories Amino-aza-adamantane derivatives and methods of use
US8314119B2 (en) * 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US8076350B2 (en) 2006-12-22 2011-12-13 Abbott Laboratories Spirocyclic azaadamantane derivatives and methods of use
EP2139891B1 (de) * 2007-03-23 2012-09-05 Abbott Laboratories 4-substituierte azaadamantan-derivate und verfahren zu ihrer verwendung
MX2009010175A (es) 2007-03-23 2009-10-12 Abbott Lab Derivados de acetamida y carboxamida de aza-adamantano y metodos de uso de los mismos.
EP2443122B1 (de) * 2009-06-19 2014-03-05 AbbVie Inc. Diazahomoadamantanderivate und verwendungsverfahren dafür
EP2456868A4 (de) 2009-07-22 2013-11-06 Puretech Ventures Verfahren und zusammensetzungen zur behandlung von durch muscarinrezeptoraktivierung gelinderten leiden
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
EP2560488B1 (de) 2010-04-23 2015-10-28 Cytokinetics, Inc. Bestimmte aminopyrimidine und aminotriazine, zusammensetzungen daraus und verfahren zu ihrer verwendung
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
KR20130108586A (ko) * 2010-09-23 2013-10-04 애브비 인코포레이티드 아자아다만탄 유도체의 일수화물
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
IL273924B2 (en) 2017-10-20 2024-07-01 Univ Vanderbilt Antagonists of the muscarinic acetylcholine receptor m4
WO2019126559A1 (en) * 2017-12-20 2019-06-27 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
UA128017C2 (uk) 2018-09-28 2024-03-13 Каруна Тереп'Ютікс, Інк. Композиція і спосіб лікування розладу, що послаблюється активацією мускаринових рецепторів (варіанти)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4739074A (en) * 1986-01-22 1988-04-19 Pennwalt Corporation Adamantane spiro-pyrrolidine derivatives
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
WO1992011261A1 (en) * 1990-12-21 1992-07-09 Merck Sharp & Dohme Limited 4-azatricyclo[2.2.1.02,6]heptanes and pharmaceutical compositions
US5955470A (en) * 1991-06-11 1999-09-21 Merrell Pharmaceuticals, Inc. Derivatives of amide analogs of certain methano bridged quinolizines
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
PL184843B1 (pl) * 1995-11-02 2002-12-31 Neurosearch As Nowe skondensowane pochodne tropanu, sposób ich otrzymywania i zastosowanie oraz kompozycje farmaceutyczne
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
US5986100A (en) * 1998-04-02 1999-11-16 Crooks; Peter Anthony Pharmaceutical compositions and methods for use
US6057446A (en) * 1998-04-02 2000-05-02 Crooks; Peter Anthony Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds
US5952339A (en) * 1998-04-02 1999-09-14 Bencherif; Merouane Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release

Also Published As

Publication number Publication date
DE69903961T2 (de) 2003-07-03
NO20010804L (no) 2001-04-11
US6555550B1 (en) 2003-04-29
EP1112272B1 (de) 2002-11-13
KR20010072784A (ko) 2001-07-31
DE69903961D1 (de) 2002-12-19
US6323194B1 (en) 2001-11-27
YU13301A (sh) 2005-06-10
US20020045617A1 (en) 2002-04-18
WO2000011001A1 (en) 2000-03-02
HUP0103203A2 (hu) 2002-01-28
BG105256A (en) 2001-11-30
BR9913072A (pt) 2001-05-15
HK1038918A1 (zh) 2002-04-04
PE20000988A1 (es) 2000-09-30
US6251916B1 (en) 2001-06-26
US6423842B1 (en) 2002-07-23
CN1312812A (zh) 2001-09-12
CA2340946A1 (en) 2000-03-02
JP2002523416A (ja) 2002-07-30
EE200100096A (et) 2002-06-17
SK1892001A3 (en) 2001-11-06
ZA200100978B (en) 2002-02-05
IL141050A0 (en) 2002-02-10
IS5827A (is) 2001-01-26
NZ509762A (en) 2002-12-20
TR200100462T2 (tr) 2001-09-21
RU2219179C2 (ru) 2003-12-20
AU5775899A (en) 2000-03-14
AU750566B2 (en) 2002-07-25
PL346247A1 (en) 2002-01-28
EP1112272A1 (de) 2001-07-04
US6093724A (en) 2000-07-25
CO5130018A1 (es) 2002-02-27
AR020199A1 (es) 2002-05-02
ID27544A (id) 2001-04-12
HUP0103203A3 (en) 2002-10-28
NO20010804D0 (no) 2001-02-16
ES2191455T3 (es) 2003-09-01

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties