YU13301A - Muskarinski agonisti i antagonisti - Google Patents

Muskarinski agonisti i antagonisti

Info

Publication number
YU13301A
YU13301A YU13301A YU13301A YU13301A YU 13301 A YU13301 A YU 13301A YU 13301 A YU13301 A YU 13301A YU 13301 A YU13301 A YU 13301A YU 13301 A YU13301 A YU 13301A
Authority
YU
Yugoslavia
Prior art keywords
antagonists
muscarinic agonists
present
compounds
muscarinic
Prior art date
Application number
YU13301A
Other languages
English (en)
Inventor
Gurmit Grewal
Anna Toy-Palmer
Xiong Cai
George Mark Latham
Original Assignee
Ucb S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb S.A. filed Critical Ucb S.A.
Publication of YU13301A publication Critical patent/YU13301A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Predmetni pronalazak obezbedjuje nove smeše i njihov farmaceutski sastav koristan u tretmanu bola. Smeše predmetnog pronalaska su azaadamantani, azanoradamantani i azahomoadamantani.[The present invention provides novel compounds and pharmaceutical compositions thereof useful in the treatment of pain. The compounds of the present invention are azaadamantanes, azanoradamantanes and azahomoadamantanes.
YU13301A 1998-08-18 1999-08-16 Muskarinski agonisti i antagonisti YU13301A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9697798P 1998-08-18 1998-08-18

Publications (1)

Publication Number Publication Date
YU13301A true YU13301A (sh) 2005-06-10

Family

ID=22260061

Family Applications (1)

Application Number Title Priority Date Filing Date
YU13301A YU13301A (sh) 1998-08-18 1999-08-16 Muskarinski agonisti i antagonisti

Country Status (30)

Country Link
US (5) US6093724A (sh)
EP (1) EP1112272B1 (sh)
JP (1) JP2002523416A (sh)
KR (1) KR20010072784A (sh)
CN (1) CN1312812A (sh)
AR (1) AR020199A1 (sh)
AT (1) ATE227724T1 (sh)
AU (1) AU750566B2 (sh)
BG (1) BG105256A (sh)
BR (1) BR9913072A (sh)
CA (1) CA2340946A1 (sh)
CO (1) CO5130018A1 (sh)
DE (1) DE69903961T2 (sh)
EE (1) EE200100096A (sh)
ES (1) ES2191455T3 (sh)
HK (1) HK1038918A1 (sh)
HU (1) HUP0103203A3 (sh)
ID (1) ID27544A (sh)
IL (1) IL141050A0 (sh)
IS (1) IS5827A (sh)
NO (1) NO20010804L (sh)
NZ (1) NZ509762A (sh)
PE (1) PE20000988A1 (sh)
PL (1) PL346247A1 (sh)
RU (1) RU2219179C2 (sh)
SK (1) SK1892001A3 (sh)
TR (1) TR200100462T2 (sh)
WO (1) WO2000011001A1 (sh)
YU (1) YU13301A (sh)
ZA (1) ZA200100978B (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004511558A (ja) * 2000-10-19 2004-04-15 ファイザー・プロダクツ・インク 架橋ピペラジン誘導体
GB0117950D0 (en) * 2001-02-16 2001-09-19 Aventis Pharma Inc Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
WO2002094827A1 (en) * 2001-05-23 2002-11-28 Neurosearch A/S Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20030064979A1 (en) * 2001-06-29 2003-04-03 Hansen Thomas Kruse Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48
US6828328B1 (en) * 2002-03-01 2004-12-07 Ucb S.A. Analgesic combination of muscarinic agonists
US7897766B2 (en) * 2005-09-23 2011-03-01 Abbott Laboratories Amino-aza-adamantane derivatives and methods of use
US8314119B2 (en) * 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US8076350B2 (en) * 2006-12-22 2011-12-13 Abbott Laboratories Spirocyclic azaadamantane derivatives and methods of use
WO2008118745A1 (en) * 2007-03-23 2008-10-02 Abbott Laboratories 4-substituted azaadamantane derivatives and methods of use thereof
WO2008118743A1 (en) * 2007-03-23 2008-10-02 Abbott Laboratories Acetamide and carboxamide derivatives of azaadamantane and methods of use thereof
NZ597511A (en) * 2009-06-19 2014-01-31 Abbvie Inc Diazahomoadamantane derivatives and methods of use thereof
HUE044653T2 (hu) 2009-07-22 2019-11-28 PureTech Health LLC Készítmények olyan rendellenességek kezelésére, amelyek muszkarin-receptor aktiválással enyhíthetõk
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
CN106074548A (zh) 2010-09-23 2016-11-09 艾伯维巴哈马有限公司 氮杂金刚烷衍生物的一水合物
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
US11325896B2 (en) 2017-12-20 2022-05-10 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
CA3180743A1 (en) 2018-09-28 2020-04-02 Karuna Therapeutics, Inc. Composition comprising xanomeline and trospium for treating disorders ameliorated by muscarinic receptor activation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4739074A (en) * 1986-01-22 1988-04-19 Pennwalt Corporation Adamantane spiro-pyrrolidine derivatives
IL88156A (en) * 1987-11-13 1997-02-18 Novo Nordisk As Azacyclic compounds their preparation and pharmaceutical compositions containing them
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
EP0563036A1 (en) * 1990-12-21 1993-10-06 Merck Sharp & Dohme Ltd. 4-azatricyclo 2.2.1.0?2,6 ]heptanes and pharmaceutical compositions
US5955470A (en) * 1991-06-11 1999-09-21 Merrell Pharmaceuticals, Inc. Derivatives of amide analogs of certain methano bridged quinolizines
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
DE69623799T2 (de) * 1995-11-02 2003-01-30 Neurosearch As Ballerup Kondensierte tropanderivate als neurotransmitter-reuptake-inhibitoren
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
US5986100A (en) * 1998-04-02 1999-11-16 Crooks; Peter Anthony Pharmaceutical compositions and methods for use
US5952339A (en) * 1998-04-02 1999-09-14 Bencherif; Merouane Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
US6057446A (en) * 1998-04-02 2000-05-02 Crooks; Peter Anthony Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds

Also Published As

Publication number Publication date
NZ509762A (en) 2002-12-20
AR020199A1 (es) 2002-05-02
ATE227724T1 (de) 2002-11-15
WO2000011001A1 (en) 2000-03-02
SK1892001A3 (en) 2001-11-06
NO20010804L (no) 2001-04-11
US6251916B1 (en) 2001-06-26
US6555550B1 (en) 2003-04-29
IS5827A (is) 2001-01-26
KR20010072784A (ko) 2001-07-31
NO20010804D0 (no) 2001-02-16
US20020045617A1 (en) 2002-04-18
PE20000988A1 (es) 2000-09-30
TR200100462T2 (tr) 2001-09-21
EE200100096A (et) 2002-06-17
RU2219179C2 (ru) 2003-12-20
PL346247A1 (en) 2002-01-28
CA2340946A1 (en) 2000-03-02
DE69903961D1 (de) 2002-12-19
DE69903961T2 (de) 2003-07-03
HUP0103203A2 (hu) 2002-01-28
JP2002523416A (ja) 2002-07-30
EP1112272B1 (en) 2002-11-13
AU750566B2 (en) 2002-07-25
US6323194B1 (en) 2001-11-27
ID27544A (id) 2001-04-12
CN1312812A (zh) 2001-09-12
HUP0103203A3 (en) 2002-10-28
ES2191455T3 (es) 2003-09-01
AU5775899A (en) 2000-03-14
HK1038918A1 (zh) 2002-04-04
CO5130018A1 (es) 2002-02-27
US6093724A (en) 2000-07-25
IL141050A0 (en) 2002-02-10
BG105256A (en) 2001-11-30
ZA200100978B (en) 2002-02-05
US6423842B1 (en) 2002-07-23
BR9913072A (pt) 2001-05-15
EP1112272A1 (en) 2001-07-04

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