AR020199A1 - Compuestos agonistas y antagonistas muscarinicos que comprenden un sistema de anillo azaciclico, una composicion farmaceutica que los comprende, y el usode los mismos para la manufactura de un medicamento. - Google Patents
Compuestos agonistas y antagonistas muscarinicos que comprenden un sistema de anillo azaciclico, una composicion farmaceutica que los comprende, y el usode los mismos para la manufactura de un medicamento.Info
- Publication number
- AR020199A1 AR020199A1 ARP990104100A ARP990104100A AR020199A1 AR 020199 A1 AR020199 A1 AR 020199A1 AR P990104100 A ARP990104100 A AR P990104100A AR P990104100 A ARP990104100 A AR P990104100A AR 020199 A1 AR020199 A1 AR 020199A1
- Authority
- AR
- Argentina
- Prior art keywords
- independently
- alkyl
- halogen
- alkoxy
- branched
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Compuestos agonistas y antagonistas muscarínicos que comprenden un sistema de anillo azacíclico que tiene la formula 1 incluyendo sus isomeros geométricos,enantiomeros, diastereomeros, racematos, sales de adicion de ácido, sales de los mismos con unácido faramcéuticamente aceptable y pro-drogas de los mismos, endonde Q es de formula 2 a 10 , X es CH2, NH O o S; V, W, Y y Z son independientemente CH o N; n y m son independientemente 0, 1, 2, 3 o 4; R1 y R2 están encualquier posicion en elanillo azacíclico, incluyendo el punto de union del heterocíclo Q e independientemente, son hidrogeno, -OH, halogeno, -NH2, carboxi,alquil C1-10, recto o ramificado, alquenil C1-10 o alquinil C1-10, alcoxi C1-10 recto o ramificado o alquil C1-10recto o ra mificado, sustituido con -OH, -CN,-CHO, -OH, -OR3, - SR3, -NH2, NHR3, NR3R4, -NO2, SOR3, SO2R3, -COR3, CO2R3, -CONH2, CONHR3, CONR3R4 o -CH=NOR3; o R1 y R2 son independientemente fenil, fenoxi,benzoil, bencil o benciloxicarbonil, cada unode los cual es está no-sustituido o sustituido con halogeno, -CN, alquil C1-10, alcoxi C1-10 o alquiltio C1-10,R es hidrogeno, halogeno, -CN, -CHO, -OH, OR3, -SR3, -NH2, NHR3, -NR3R4, -NO2, -SOR3, -SO2R3, -COR3, -CO2R3, CONH2, -CONHR3, -CONR3R4 oCH=NOR3; o R es fenil,fenoxi, benzoíl, bencil o benciloxicarbonil, cada uno de los cuales está no sustituido o sustituido con halogeno, -CN, alquil C1-15, alcoxi C1-10 o alquiltioC1-10; o R es un anillo heterocíclico de 5 o 6 miembros saturado,parcialmente saturad o o aromático que contiene uno a tres heteroátomos; y R3 y R4 sonindependientemente alquil C1-15, recto, ramificado o cíclico, alquenil C2-15, alquinil C2-15 o combinaciones de los mismos, o R3 y R4 son independientementegruposfenil, fenoxi, benzoi l, bencil, o benciloxicarbonil, cada uno de los cuales están no sustituidos o sustituidos con H, halogeno, -CN, alquil C1-15,alcoxi C1-10, alquiltio C1-10 o aril; o R3 y R4 son independientemetne anillos heterocíclicos de 5 o6 miembros, saturados, parcialmente saturados o aromáticos, que contienen uno a tres heteroátomos, composicion farmacéutica que los comprende, y el uso de los mismos para la manufactura de un medicamento.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9697798P | 1998-08-18 | 1998-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020199A1 true AR020199A1 (es) | 2002-05-02 |
Family
ID=22260061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990104100A AR020199A1 (es) | 1998-08-18 | 1999-08-17 | Compuestos agonistas y antagonistas muscarinicos que comprenden un sistema de anillo azaciclico, una composicion farmaceutica que los comprende, y el usode los mismos para la manufactura de un medicamento. |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US6093724A (es) |
| EP (1) | EP1112272B1 (es) |
| JP (1) | JP2002523416A (es) |
| KR (1) | KR20010072784A (es) |
| CN (1) | CN1312812A (es) |
| AR (1) | AR020199A1 (es) |
| AT (1) | ATE227724T1 (es) |
| AU (1) | AU750566B2 (es) |
| BG (1) | BG105256A (es) |
| BR (1) | BR9913072A (es) |
| CA (1) | CA2340946A1 (es) |
| CO (1) | CO5130018A1 (es) |
| DE (1) | DE69903961T2 (es) |
| EE (1) | EE200100096A (es) |
| ES (1) | ES2191455T3 (es) |
| HK (1) | HK1038918A1 (es) |
| HU (1) | HUP0103203A3 (es) |
| ID (1) | ID27544A (es) |
| IL (1) | IL141050A0 (es) |
| IS (1) | IS5827A (es) |
| NO (1) | NO20010804L (es) |
| NZ (1) | NZ509762A (es) |
| PE (1) | PE20000988A1 (es) |
| PL (1) | PL346247A1 (es) |
| RU (1) | RU2219179C2 (es) |
| SK (1) | SK1892001A3 (es) |
| TR (1) | TR200100462T2 (es) |
| WO (1) | WO2000011001A1 (es) |
| YU (1) | YU13301A (es) |
| ZA (1) | ZA200100978B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2423789A1 (en) * | 2000-10-19 | 2002-04-25 | Pfizer Products Inc. | Bridged piperazine derivatives |
| GB0117950D0 (en) * | 2001-02-16 | 2001-09-19 | Aventis Pharma Inc | Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands |
| WO2002094827A1 (en) * | 2001-05-23 | 2002-11-28 | Neurosearch A/S | Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US20030064979A1 (en) * | 2001-06-29 | 2003-04-03 | Hansen Thomas Kruse | Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48 |
| US6828328B1 (en) * | 2002-03-01 | 2004-12-07 | Ucb S.A. | Analgesic combination of muscarinic agonists |
| US7897766B2 (en) * | 2005-09-23 | 2011-03-01 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
| US8314119B2 (en) * | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
| US8076350B2 (en) | 2006-12-22 | 2011-12-13 | Abbott Laboratories | Spirocyclic azaadamantane derivatives and methods of use |
| EP2069346B1 (en) | 2007-03-23 | 2011-12-21 | Abbott Laboratories | Acetamide and carboxamide derivatives of azaadamantane and methods of use thereof |
| CA2679876A1 (en) | 2007-03-23 | 2008-10-02 | Abbott Laboratories | 4-substituted azaadamantane derivatives and methods of use thereof |
| WO2010145208A1 (en) * | 2009-06-19 | 2010-12-23 | Abbott Laboratories | Diazahomoadamantane derivatives and methods of use thereof |
| US10265311B2 (en) | 2009-07-22 | 2019-04-23 | PureTech Health LLC | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| CA2804215C (en) | 2009-07-22 | 2019-10-01 | Eric Elenko | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| BR112013005434A2 (pt) * | 2010-09-23 | 2016-06-07 | Abbott Lab | novo mono-hidrato de derivados de aza-adamantano |
| US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
| WO2019126559A1 (en) | 2017-12-20 | 2019-06-27 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor m4 |
| AU2019346626B2 (en) | 2018-09-28 | 2022-06-02 | Karuna Therapeutics, Inc. | Compositions and methods for treating disorders ameliorated by muscarinic receptor activation |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4739074A (en) * | 1986-01-22 | 1988-04-19 | Pennwalt Corporation | Adamantane spiro-pyrrolidine derivatives |
| IE63906B1 (en) * | 1987-11-13 | 1995-06-14 | Novo Nordisk As | Azabicyclic compounds and their preparation and use |
| US5527813A (en) * | 1990-08-21 | 1996-06-18 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
| WO1992011261A1 (en) * | 1990-12-21 | 1992-07-09 | Merck Sharp & Dohme Limited | 4-azatricyclo[2.2.1.02,6]heptanes and pharmaceutical compositions |
| US5955470A (en) * | 1991-06-11 | 1999-09-21 | Merrell Pharmaceuticals, Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
| US5641791A (en) * | 1991-08-13 | 1997-06-24 | Novo Nordisk A.S | Heterocyclic compounds and their preparation and use |
| HUP9802534A3 (en) * | 1995-11-02 | 1999-06-28 | Neurosearch As | Fused tropane-derivatives as neurotransmitter reuptake inhibitors |
| US5914338A (en) * | 1996-04-02 | 1999-06-22 | Novo Nordisk | Heterocyclic compounds and their preparation and use |
| US5986100A (en) * | 1998-04-02 | 1999-11-16 | Crooks; Peter Anthony | Pharmaceutical compositions and methods for use |
| US5952339A (en) * | 1998-04-02 | 1999-09-14 | Bencherif; Merouane | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
| US6057446A (en) * | 1998-04-02 | 2000-05-02 | Crooks; Peter Anthony | Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds |
-
1999
- 1999-08-16 NZ NZ509762A patent/NZ509762A/xx unknown
- 1999-08-16 SK SK189-2001A patent/SK1892001A3/sk unknown
- 1999-08-16 AU AU57758/99A patent/AU750566B2/en not_active Ceased
- 1999-08-16 PL PL99346247A patent/PL346247A1/xx not_active Application Discontinuation
- 1999-08-16 JP JP2000566274A patent/JP2002523416A/ja active Pending
- 1999-08-16 TR TR2001/00462T patent/TR200100462T2/xx unknown
- 1999-08-16 WO PCT/US1999/018570 patent/WO2000011001A1/en not_active Application Discontinuation
- 1999-08-16 BR BR9913072-6A patent/BR9913072A/pt not_active IP Right Cessation
- 1999-08-16 ES ES99945064T patent/ES2191455T3/es not_active Expired - Lifetime
- 1999-08-16 US US09/375,149 patent/US6093724A/en not_active Expired - Fee Related
- 1999-08-16 DE DE69903961T patent/DE69903961T2/de not_active Expired - Fee Related
- 1999-08-16 YU YU13301A patent/YU13301A/sh unknown
- 1999-08-16 KR KR1020017002128A patent/KR20010072784A/ko not_active Application Discontinuation
- 1999-08-16 HU HU0103203A patent/HUP0103203A3/hu unknown
- 1999-08-16 CN CN99809775A patent/CN1312812A/zh active Pending
- 1999-08-16 RU RU2001107139/04A patent/RU2219179C2/ru not_active IP Right Cessation
- 1999-08-16 AT AT99945064T patent/ATE227724T1/de not_active IP Right Cessation
- 1999-08-16 IL IL14105099A patent/IL141050A0/xx unknown
- 1999-08-16 CA CA002340946A patent/CA2340946A1/en not_active Abandoned
- 1999-08-16 ID IDW20010377A patent/ID27544A/id unknown
- 1999-08-16 EE EEP200100096A patent/EE200100096A/xx unknown
- 1999-08-16 EP EP99945064A patent/EP1112272B1/en not_active Expired - Lifetime
- 1999-08-17 AR ARP990104100A patent/AR020199A1/es unknown
- 1999-08-18 CO CO99052330A patent/CO5130018A1/es unknown
- 1999-08-18 PE PE1999000838A patent/PE20000988A1/es not_active Application Discontinuation
-
2000
- 2000-05-09 US US09/567,785 patent/US6251916B1/en not_active Expired - Fee Related
- 2000-10-17 US US09/690,494 patent/US6323194B1/en not_active Expired - Fee Related
-
2001
- 2001-01-26 IS IS5827A patent/IS5827A/is unknown
- 2001-02-05 ZA ZA200100978A patent/ZA200100978B/xx unknown
- 2001-02-14 BG BG105256A patent/BG105256A/xx unknown
- 2001-02-16 NO NO20010804A patent/NO20010804L/no not_active Application Discontinuation
- 2001-10-05 US US09/972,415 patent/US6423842B1/en not_active Expired - Fee Related
-
2002
- 2002-01-18 HK HK02100409.3A patent/HK1038918A1/zh unknown
- 2002-03-27 US US10/108,046 patent/US6555550B1/en not_active Expired - Fee Related
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