ATE53376T1 - Entzuendungshemmende agentien. - Google Patents

Entzuendungshemmende agentien.

Info

Publication number
ATE53376T1
ATE53376T1 AT88300163T AT88300163T ATE53376T1 AT E53376 T1 ATE53376 T1 AT E53376T1 AT 88300163 T AT88300163 T AT 88300163T AT 88300163 T AT88300163 T AT 88300163T AT E53376 T1 ATE53376 T1 AT E53376T1
Authority
AT
Austria
Prior art keywords
inflammatory agents
derivatives
mammals
inflammation
chem
Prior art date
Application number
AT88300163T
Other languages
English (en)
Inventor
Nancy Grace Bollinger
Theodore Goodson Jr
David Kent Herron
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE53376T1 publication Critical patent/ATE53376T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
AT88300163T 1987-01-12 1988-01-11 Entzuendungshemmende agentien. ATE53376T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US254287A 1987-01-12 1987-01-12
EP88300163A EP0276065B1 (de) 1987-01-12 1988-01-11 Entzündungshemmende Agentien

Publications (1)

Publication Number Publication Date
ATE53376T1 true ATE53376T1 (de) 1990-06-15

Family

ID=21701261

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88300163T ATE53376T1 (de) 1987-01-12 1988-01-11 Entzuendungshemmende agentien.

Country Status (18)

Country Link
EP (1) EP0276065B1 (de)
JP (1) JP2710619B2 (de)
KR (1) KR880008969A (de)
CN (1) CN88100650A (de)
AT (1) ATE53376T1 (de)
CA (1) CA1315279C (de)
DE (1) DE3860201D1 (de)
DK (1) DK10488A (de)
ES (1) ES2036259T3 (de)
GR (1) GR3000750T3 (de)
HU (1) HU200313B (de)
IE (1) IE61256B1 (de)
MX (1) MX10059A (de)
NZ (1) NZ223151A (de)
PH (1) PH25130A (de)
PT (1) PT86520B (de)
RU (1) RU1833372C (de)
ZA (1) ZA88154B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5294613A (en) * 1987-01-12 1994-03-15 Eli Lilly And Company Method of treating endotoxic shock in mammals
US4945099A (en) * 1987-01-12 1990-07-31 Eli Lilly And Company Anti-inflammatory agents
US5098613A (en) * 1987-01-12 1992-03-24 Eli Lilly And Company Anti-inflammatory agents
US4820723A (en) * 1987-08-14 1989-04-11 Eli Lilly And Company Disubstituted tetrazole leukotriene antagonists and methods for their use thereas
US5527945A (en) * 1989-02-10 1996-06-18 Basf Aktiengesellschaft Diphenylheteroalkyl derivatives, the preparation thereof and drugs and cosmetics prepared therefrom
DE3903989A1 (de) * 1989-02-10 1990-09-20 Basf Ag Diphenylheteroalkylderivate, ihre herstellung und daraus hergestellte arzneimittel und kosmetika
CA2019335C (en) * 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
US6001877A (en) * 1989-06-27 1999-12-14 Ono Pharmaceutical Co., Ltd. Phenylalkan(en)oic acid
US5256686A (en) * 1989-06-27 1993-10-26 Ono Pharmaceutical Co., Ltd. Phenylalkan(en)oic acid
JP2638653B2 (ja) * 1990-01-19 1997-08-06 富士写真フイルム株式会社 写真プリント作成方法
JPH04297466A (ja) * 1990-06-22 1992-10-21 Nippon Shinyaku Co Ltd テトラゾール誘導体及び医薬
FR2665159B1 (fr) * 1990-07-24 1992-11-13 Rhone Poulenc Sante Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent.
JP2613311B2 (ja) * 1990-09-03 1997-05-28 富士写真フイルム株式会社 写真プリント方法
EP0548250B1 (de) * 1990-09-10 1996-03-27 Rhone-Poulenc Rorer International (Holdings) Inc. Substituierte bizyklische arylderivate mit selektiver leukotrien b4 antagonistischer wirkung
DE4201942A1 (de) * 1991-02-26 1992-09-24 Plantamed Arzneimittel Gmbh Phenonverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DK0516069T3 (da) * 1991-05-31 1996-05-13 Sumitomo Pharma Leukotrien B4-antagonister
WO2003045306A2 (en) * 2001-11-13 2003-06-05 Emisphere Technologies, Inc. Phenoxy amine compounds and compositions for delivering active agents
US20090270470A1 (en) * 2005-05-09 2009-10-29 Astrazeneca Ab Compounds I
JP6500024B2 (ja) 2013-12-20 2019-04-10 ノバルティス アーゲー Ｌｔａ４ｈ阻害剤としてのヘテロアリールブタン酸誘導体

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1111338A (en) * 1964-07-24 1968-04-24 Fisons Pharmaceuticals Ltd Aralkyl substituted resorcinols
JPS5233623B2 (de) * 1972-01-11 1977-08-30
JPS5233107B2 (de) * 1971-09-13 1977-08-26
JPS5233108B2 (de) * 1971-09-13 1977-08-26
JPS5233109B2 (de) * 1971-12-29 1977-08-26
BE788749A (fr) * 1971-09-13 1973-03-13 Takeda Chemical Industries Ltd Acide 3-(benzoyl trisubstitue)-propionique et son procede de preparation
US3830764A (en) * 1972-07-06 1974-08-20 Princeton Polymer Lab Degradable hydrocarbon polymers
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
US4166819A (en) * 1975-09-24 1979-09-04 Abbott Laboratories 4-Aroyl substituted phenoxy methylene-5-tetrazoles
US4301267A (en) * 1980-08-26 1981-11-17 Gaf Corporation Ultraviolet light stable copolymer compositions comprising monomers which are α,62 -unsaturated dicarboxylic acid half-esters of 2-hydroxy, alkoxy, methylolbenzophenones and styrene-butadiene comonomers
CA1206964A (en) * 1980-11-12 1986-07-02 Nobuo Shinma Tetra-substituted benzene derivatives
US4507498A (en) * 1982-04-09 1985-03-26 Hoffmann-La Roche Inc. Phenoxycarboxylic acids
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
DD235450B1 (de) * 1983-12-29 1988-02-03 Humboldt Uni Z Berlin Verfahren zur herstellung neuer 1-(2-hydroxyaryl)-alkan-1-on-oxime

Also Published As

Publication number Publication date
IE61256B1 (en) 1994-10-19
ES2036259T3 (es) 1993-05-16
AU1016488A (en) 1988-07-14
ZA88154B (en) 1989-09-27
HU200313B (en) 1990-05-28
JP2710619B2 (ja) 1998-02-10
RU1833372C (ru) 1993-08-07
NZ223151A (en) 1989-10-27
JPS63188644A (ja) 1988-08-04
CN88100650A (zh) 1988-10-19
IE880061L (en) 1988-07-12
PT86520B (pt) 1991-12-31
KR880008969A (ko) 1988-09-13
HUT45960A (en) 1988-09-28
GR3000750T3 (en) 1991-10-10
PT86520A (en) 1988-02-01
EP0276065B1 (de) 1990-06-06
CA1315279C (en) 1993-03-30
MX10059A (es) 1993-12-01
AU601011B2 (en) 1990-08-30
DE3860201D1 (de) 1990-07-12
DK10488D0 (da) 1988-01-11
EP0276065A1 (de) 1988-07-27
DK10488A (da) 1988-09-19
PH25130A (en) 1991-02-19

Similar Documents

Publication Publication Date Title
DE3860201D1 (de) Entzuendungshemmende agentien.
MX9300014A (es) Nuevos derivados de 1,2,4-triaminobenceno y procedimiento para su elaboracion.
DE3587316T2 (de) Benzodiazepin-derivate und diese enthaltende arzneimittel.
ATE57910T1 (de) Entzuendungshemmende mittel.
IS1564B (is) Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar
DK249389A (da) 2-acylamino-benzothiazol-forbindelser og deres anvendelse til fremstilling af laegemidler til behandling af tumorer
DE3881073T2 (de) Naphthalenverbindungen und antiallergische und antiinflammatorische pharmazeutische mittel.
ES2089136T3 (es) Tratamiento de enfermedades inflamatorias con la ayuda de derivados 15-ceto-prostaglandinas.
DE68903092T2 (de) Laktamimide in der behandlung arzneiresistenter protozoeninjektionen.
NO891703D0 (no) Farmasoeytiske sammensetninger for behandling av psoriasis.
FI892222A (fi) Peptidalkoholer med antikoagulantverkan.
ATE87476T1 (de) Fluessige orale formulierung.
DK0617959T3 (da) Lægemiddel til behandling af hudsygdomme
ATE87905T1 (de) Anticonvulsive agenzien.
BR9302809A (pt) Composto,processo para sua preparacao,processo de purificacao dos compostos,medicmanto,emprego e processo para a preparacao de um agente anti-tumoral
IT1224897B (it) Composizione farmaceutica per il trattamento delle affezioni parodontali
IT8619873A0 (it) Procedimento per la preparazione di derivati dell'azetidinone.