AR029332A1 - Compuesto derivado de una 2-alquinilpurina y su uso en la preparacion de un medicamento para tratar la respuesta inflamatoria - Google Patents
Compuesto derivado de una 2-alquinilpurina y su uso en la preparacion de un medicamento para tratar la respuesta inflamatoriaInfo
- Publication number
- AR029332A1 AR029332A1 ARP000100433A ARP000100433A AR029332A1 AR 029332 A1 AR029332 A1 AR 029332A1 AR P000100433 A ARP000100433 A AR P000100433A AR P000100433 A ARP000100433 A AR P000100433A AR 029332 A1 AR029332 A1 AR 029332A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- amino
- aryl
- inflammatory response
- mono
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos y métodos para ser usados en el tratamiento de la actividad inflamatoria en tejidos de mamíferos. Los presentes compuestos comprenden una nueva clase de derivados de 2-alquiladenosina, de formula general (1) donde (a) cada R es en forma individual hidrogeno, C1-6 alquilo, C3-7 cicloalquilo, fenilo o fenil (C1-3) alquilo, (b) X es ûCH2OH, -CO2R2, -OC(O)R2, CH2OC(O)R2 o C(O)NR3R4, (c) cada uno de R2, R3 y R4 es en forma individual H, C1,-6 alquilo, C1-6 alquilo sustituido con 1 a 3 C1-6 alcoxilo, C3-7 cicloalquilo, C1-6 alquitilo, halogeno, hidroxilo, amino, mono (C1-6 alquil) amino, di (C1-6 alquil) amino o C6-10 arilo, donde el arilo puede estar sustituido con 1 a 3 halogenos, C1-6 alquilo, hidroxilo, amino, mono (C1-6 alquil) amino o di(C1-6 alquil)amino, C6-10 arilo o C6-10 arilo sustituido con 1 a 3 halogeno, hidroxilo, amino, mono (C1-6 alquil) amino, di (C1-6alquil)amino o C1-6 alquilo. (d) Z y Z' son en forma individual (C1-6) alquilo, opcionalmente interrumpidos por 1 a 3 S u O no peroxido, o están ausentes, y n es 1 a 3, o una sal del mismo aceptable para el uso farmacéutico. Se provee un compuesto de formula (1) para su uso en terapia médica, preferiblemente para su uso en el tratamiento o en la proteccion del tejido de inflamacion, por ejemplo, de una respuesta inflamatoria, así como el uso de un compuesto de formula (1) para la fabricacion de una medicamento para el tratamiento de una respuesta inflamatoria debida a una condicion o a un síntoma patologico de un mamífero, tal como un humano que ese asocia con la inflamacion de distintos orígenes.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11802999P | 1999-02-01 | 1999-02-01 | |
US12431699P | 1999-03-12 | 1999-03-12 | |
US13337499P | 1999-05-10 | 1999-05-10 | |
US13557399P | 1999-05-24 | 1999-05-24 | |
US09/333,387 US6232297B1 (en) | 1999-02-01 | 1999-06-15 | Methods and compositions for treating inflammatory response |
US15141299P | 1999-08-30 | 1999-08-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR029332A1 true AR029332A1 (es) | 2003-06-25 |
Family
ID=27557920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000100433A AR029332A1 (es) | 1999-02-01 | 2000-02-01 | Compuesto derivado de una 2-alquinilpurina y su uso en la preparacion de un medicamento para tratar la respuesta inflamatoria |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP1150991B1 (es) |
JP (1) | JP4837831B2 (es) |
KR (1) | KR100668006B1 (es) |
CN (1) | CN1191266C (es) |
AR (1) | AR029332A1 (es) |
AT (1) | ATE263777T1 (es) |
AU (2) | AU778870B2 (es) |
BR (1) | BR0007864A (es) |
CA (1) | CA2361614C (es) |
CZ (1) | CZ296404B6 (es) |
DE (1) | DE60009665T2 (es) |
DK (1) | DK1150991T3 (es) |
EE (1) | EE05185B1 (es) |
ES (1) | ES2215609T3 (es) |
HK (1) | HK1047288A1 (es) |
HU (1) | HU228937B1 (es) |
IL (2) | IL144188A0 (es) |
MX (1) | MXPA01007850A (es) |
MY (1) | MY129445A (es) |
NO (1) | NO321216B1 (es) |
NZ (1) | NZ513096A (es) |
PL (1) | PL199953B1 (es) |
PT (1) | PT1150991E (es) |
SK (1) | SK284877B6 (es) |
UA (1) | UA72912C2 (es) |
WO (1) | WO2000044763A2 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6514949B1 (en) | 1994-07-11 | 2003-02-04 | University Of Virginia Patent Foundation | Method compositions for treating the inflammatory response |
US6448235B1 (en) | 1994-07-11 | 2002-09-10 | University Of Virginia Patent Foundation | Method for treating restenosis with A2A adenosine receptor agonists |
US6232297B1 (en) | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
US7214665B2 (en) | 2001-10-01 | 2007-05-08 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof |
US7427606B2 (en) | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US6322771B1 (en) | 1999-06-18 | 2001-11-27 | University Of Virginia Patent Foundation | Induction of pharmacological stress with adenosine receptor agonists |
IL133680A0 (en) | 1999-09-10 | 2001-04-30 | Can Fite Technologies Ltd | Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist |
US20050033044A1 (en) | 2003-05-19 | 2005-02-10 | Bristol-Myers Squibb Pharma Company | Methods for preparing 2-alkynyladenosine derivatives |
EP1740587A4 (en) * | 2004-04-02 | 2009-07-15 | Adenosine Therapeutics Llc | SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS |
JP2007536241A (ja) * | 2004-05-03 | 2007-12-13 | ユニバーシティ オブ バージニア パテント ファウンデーション | 糖尿病性腎症の処置のためのa2aアデノシンレセプターアゴニスト |
US7442687B2 (en) | 2004-08-02 | 2008-10-28 | The University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
WO2006028618A1 (en) | 2004-08-02 | 2006-03-16 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
EP1778712B1 (en) | 2004-08-02 | 2013-01-30 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
US8178509B2 (en) | 2006-02-10 | 2012-05-15 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
WO2007107598A1 (en) | 2006-03-21 | 2007-09-27 | Heinrich-Heine-Universität Düsseldorf | Phosphorylated a2a receptor agonists |
US8188063B2 (en) | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
US8058259B2 (en) | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
MY161655A (en) * | 2008-07-03 | 2017-04-28 | Univ Virginia Patent Foundation | Unit dosage of apadenoson |
KR20120107065A (ko) | 2009-06-30 | 2012-09-28 | 포레스트 래보러토리즈 홀딩스 리미티드 | A2ar 효현제용 알콕시 카르보닐 아미노 알키닐 아데노신 화합물 및 그 유도체 |
FR2960876B1 (fr) | 2010-06-03 | 2012-07-27 | Sanofi Aventis | Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique. |
WO2020253867A1 (zh) * | 2019-06-21 | 2020-12-24 | 中国人民解放军军事科学院军事医学研究院 | 具有a2a腺苷受体拮抗作用的小分子化合物 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3537228A1 (de) * | 1985-10-19 | 1987-04-23 | Huels Chemische Werke Ag | Verfahren zur herstellung von cyclohexylverbindungen |
JPS6299330A (ja) * | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | 抗高血圧剤 |
KR0137786B1 (ko) * | 1988-11-15 | 1998-05-15 | 하마구찌 미찌오 | 심장 또는 뇌의 허혈성 질환의 치료, 예방제 |
DE69022176T2 (de) * | 1989-06-20 | 1996-02-15 | Toa Eiyo Ltd., Tokio/Tokyo | Zwischenverbindung für 2-alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2-alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat. |
WO1991009864A1 (en) * | 1990-01-04 | 1991-07-11 | Yamasa Shoyu Kabushiki Kaisha | Drug for treating or preventing ischemic diseases of heart or brain |
JPH03287537A (ja) * | 1990-03-31 | 1991-12-18 | Yamasa Shoyu Co Ltd | 抗動脈硬化症剤 |
JP3025559B2 (ja) * | 1990-07-19 | 2000-03-27 | ヤマサ醤油株式会社 | アデノシン誘導体 |
JP3053908B2 (ja) * | 1991-06-28 | 2000-06-19 | ヤマサ醤油株式会社 | 2‐アルキニルアデノシン誘導体 |
JP3025557B2 (ja) * | 1991-06-28 | 2000-03-27 | ヤマサ醤油株式会社 | 2‐アルキニルアデノシン誘導体 |
IT1254915B (it) * | 1992-04-24 | 1995-10-11 | Gloria Cristalli | Derivati di adenosina ad attivita' a2 agonista |
EP0983768A1 (en) * | 1997-05-23 | 2000-03-08 | Nippon Shinyaku Co., Ltd. | Medicinal composition for prevention or treatment of hepatopathy |
AU740770B2 (en) * | 1997-06-18 | 2001-11-15 | Aderis Pharmaceuticals, Inc. | Compositions and methods for preventing restenosis following revascularization procedures |
JPH11335302A (ja) * | 1998-05-26 | 1999-12-07 | Toa Eiyo Ltd | 安定な医薬組成物 |
JP3619017B2 (ja) * | 1998-06-24 | 2005-02-09 | 日本臓器製薬株式会社 | 新規アラビノシルアデニン誘導体 |
JP2002173427A (ja) * | 1998-09-01 | 2002-06-21 | Yamasa Shoyu Co Ltd | 眼疾患治療用医薬組成物 |
-
2000
- 2000-01-31 EP EP00905833A patent/EP1150991B1/en not_active Expired - Lifetime
- 2000-01-31 UA UA2001086055A patent/UA72912C2/uk unknown
- 2000-01-31 MX MXPA01007850A patent/MXPA01007850A/es active IP Right Grant
- 2000-01-31 SK SK1097-2001A patent/SK284877B6/sk not_active IP Right Cessation
- 2000-01-31 DE DE60009665T patent/DE60009665T2/de not_active Expired - Lifetime
- 2000-01-31 CN CNB008055092A patent/CN1191266C/zh not_active Expired - Fee Related
- 2000-01-31 MY MYPI20000343A patent/MY129445A/en unknown
- 2000-01-31 KR KR1020017009640A patent/KR100668006B1/ko not_active IP Right Cessation
- 2000-01-31 BR BR0007864-6A patent/BR0007864A/pt not_active Application Discontinuation
- 2000-01-31 JP JP2000596019A patent/JP4837831B2/ja not_active Expired - Fee Related
- 2000-01-31 AU AU27454/00A patent/AU778870B2/en not_active Ceased
- 2000-01-31 DK DK00905833T patent/DK1150991T3/da active
- 2000-01-31 CA CA002361614A patent/CA2361614C/en not_active Expired - Fee Related
- 2000-01-31 AT AT00905833T patent/ATE263777T1/de active
- 2000-01-31 IL IL14418800A patent/IL144188A0/xx unknown
- 2000-01-31 WO PCT/US2000/002324 patent/WO2000044763A2/en active IP Right Grant
- 2000-01-31 PT PT00905833T patent/PT1150991E/pt unknown
- 2000-01-31 HU HU0200224A patent/HU228937B1/hu not_active IP Right Cessation
- 2000-01-31 PL PL349644A patent/PL199953B1/pl unknown
- 2000-01-31 NZ NZ513096A patent/NZ513096A/xx not_active IP Right Cessation
- 2000-01-31 EE EEP200100397A patent/EE05185B1/xx not_active IP Right Cessation
- 2000-01-31 CZ CZ20012781A patent/CZ296404B6/cs not_active IP Right Cessation
- 2000-01-31 ES ES00905833T patent/ES2215609T3/es not_active Expired - Lifetime
- 2000-02-01 AR ARP000100433A patent/AR029332A1/es not_active Application Discontinuation
-
2001
- 2001-07-05 IL IL144188A patent/IL144188A/en not_active IP Right Cessation
- 2001-07-13 NO NO20013507A patent/NO321216B1/no not_active IP Right Cessation
-
2002
- 2002-12-10 HK HK02108948A patent/HK1047288A1/xx not_active IP Right Cessation
-
2005
- 2005-03-23 AU AU2005201255A patent/AU2005201255B2/en not_active Ceased
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed, e.g., due to non-payment of fee |