DE4394931T1 - Verwendung von Norastemizol zur Behandlung von allergischen Erkrankungen - Google Patents

Verwendung von Norastemizol zur Behandlung von allergischen Erkrankungen

Info

Publication number
DE4394931T1
DE4394931T1 DE4394931T DE4394931T DE4394931T1 DE 4394931 T1 DE4394931 T1 DE 4394931T1 DE 4394931 T DE4394931 T DE 4394931T DE 4394931 T DE4394931 T DE 4394931T DE 4394931 T1 DE4394931 T1 DE 4394931T1
Authority
DE
Germany
Prior art keywords
treatment
norastemizole
allergic diseases
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE4394931T
Other languages
English (en)
Inventor
Raymond L Woosley
A K Gunnar Aberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunovion Pharmaceuticals Inc
Original Assignee
Georgetown University
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University, Sepracor Inc filed Critical Georgetown University
Publication of DE4394931T1 publication Critical patent/DE4394931T1/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE4394931T 1992-09-03 1993-09-03 Verwendung von Norastemizol zur Behandlung von allergischen Erkrankungen Ceased DE4394931T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94005492A 1992-09-03 1992-09-03
PCT/US1993/008349 WO1994007495A1 (en) 1992-09-03 1993-09-03 Use of norastemizole for the treatment of allergic disorders

Publications (1)

Publication Number Publication Date
DE4394931T1 true DE4394931T1 (de) 1995-07-20

Family

ID=25474141

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69333387T Expired - Fee Related DE69333387T2 (de) 1992-09-03 1993-09-03 Pharmazeutische Zusammensetzungen enthaltend Norastemizol.
DE4394931T Ceased DE4394931T1 (de) 1992-09-03 1993-09-03 Verwendung von Norastemizol zur Behandlung von allergischen Erkrankungen
DE69327328T Expired - Fee Related DE69327328T2 (de) 1992-09-03 1993-09-03 Verwendund von norastemizol zur behandlung der allergischen rhinitis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69333387T Expired - Fee Related DE69333387T2 (de) 1992-09-03 1993-09-03 Pharmazeutische Zusammensetzungen enthaltend Norastemizol.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69327328T Expired - Fee Related DE69327328T2 (de) 1992-09-03 1993-09-03 Verwendund von norastemizol zur behandlung der allergischen rhinitis

Country Status (13)

Country Link
US (5) US6130233A (de)
EP (3) EP1262183A1 (de)
JP (3) JPH08501083A (de)
AT (2) ATE187642T1 (de)
AU (1) AU687746B2 (de)
CA (1) CA2143610C (de)
DE (3) DE69333387T2 (de)
DK (2) DK0920865T3 (de)
ES (2) ES2210957T3 (de)
GB (1) GB2285219B (de)
GR (1) GR3032541T3 (de)
PT (2) PT658110E (de)
WO (1) WO1994007495A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
CN1257431A (zh) * 1997-03-26 2000-06-21 塞普拉科有限公司 化学和热稳定的诺尔阿司咪唑制剂
US6248308B1 (en) * 1998-04-14 2001-06-19 Sepracor Inc. Methods of using norastemizole in combination with leukotriene inhibitors to treat or prevent asthma
MXPA03011705A (es) * 2001-06-20 2004-03-19 Schering Corp Antihistaminas para el tratamiento de congestion nasal y obstruccion nasal.
US6627646B2 (en) 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
US6863901B2 (en) 2001-11-30 2005-03-08 Collegium Pharmaceutical, Inc. Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration
US6827946B2 (en) * 2001-12-05 2004-12-07 Collegium Pharmaceutical, Inc. Compositions containing both sedative and non-sedative antihistamines
EP2266590A3 (de) 2002-02-22 2011-04-20 Shire LLC Wirkstoff-Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Wirkstoffen
EP2120945A1 (de) * 2007-02-28 2009-11-25 Collegium Pharmaceutical, Inc. Antihistamin-kombination
US20080306116A1 (en) * 2007-06-08 2008-12-11 Christ Andreas D Aryloxazole, aryloxadiazole and benzimidazole derivatives
CA2956278C (en) * 2008-01-04 2022-03-01 Schabar Research Associates Llc Unit oral dose compositions composed of ibuprofen and famotidine and applications thereof
EP2106784B1 (de) * 2008-04-03 2015-04-22 Rohm and Haas Company Haarstylingzusammensetzung
US11324727B2 (en) 2020-07-15 2022-05-10 Schabar Research Associates, Llc Unit oral dose compositions composed of naproxen sodium and famotidine for the treatment of acute pain and the reduction of the severity of heartburn and/or the risk of heartburn
CN116194102A (zh) 2020-07-15 2023-05-30 沙巴研究联合有限责任公司 用于治疗急性疼痛和降低胃灼热的严重程度和/或风险的包含布洛芬和法莫替丁的单位口服剂量组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
EP0144101B1 (de) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bizyklisches Heterozyklyl aufveisende N-(bizyklisches Heterozyklyl-4-piperidinamine
ES2052544T3 (es) * 1986-02-03 1994-07-16 Janssen Pharmaceutica Nv Composiciones anti-histaminicas que contienen n-heterociclil-4-piperidinaminas.
US4835161A (en) * 1986-02-03 1989-05-30 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
US5019591A (en) * 1989-02-17 1991-05-28 Pennsylvania Research Corporation Method for treating retinopathy and other small vessel disorders associated with diabetes
SK286103B6 (sk) 1997-12-23 2008-03-05 Schering Corporation Farmaceutický prostriedok na liečenie respiračných a kožných ochorení s obsahom aspoň jedného antagonistu leukotriénu a aspoň jedného antihistaminikaa jeho použitie

Also Published As

Publication number Publication date
US6268382B1 (en) 2001-07-31
WO1994007495A1 (en) 1994-04-14
ATE187642T1 (de) 2000-01-15
JP2002308772A (ja) 2002-10-23
GB9504329D0 (en) 1995-04-26
EP1262183A1 (de) 2002-12-04
DE69327328T2 (de) 2000-06-21
JPH08501083A (ja) 1996-02-06
ATE257704T1 (de) 2004-01-15
JP2002255817A (ja) 2002-09-11
AU4848093A (en) 1994-04-26
DE69333387D1 (de) 2004-02-19
PT920865E (pt) 2004-06-30
CA2143610C (en) 2004-08-24
EP0920865B1 (de) 2004-01-14
DE69327328D1 (de) 2000-01-20
ES2139673T3 (es) 2000-02-16
US6187795B1 (en) 2001-02-13
AU687746B2 (en) 1998-03-05
CA2143610A1 (en) 1994-04-14
ES2210957T3 (es) 2004-07-01
EP0920865A1 (de) 1999-06-09
DK0920865T3 (da) 2004-04-19
US6130233A (en) 2000-10-10
US6124320A (en) 2000-09-26
EP0658110A1 (de) 1995-06-21
EP0658110B1 (de) 1999-12-15
GB2285219B (en) 1996-09-11
US6187794B1 (en) 2001-02-13
GR3032541T3 (en) 2000-05-31
DK0658110T3 (da) 2000-04-17
GB2285219A (en) 1995-07-05
PT658110E (pt) 2000-06-30
DE69333387T2 (de) 2004-12-09

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: SEPRACOR INC., MARLBOROUGH, MASS., US

8110 Request for examination paragraph 44
8607 Notification of search results after publication
8131 Rejection