JP4680903B2 - ピリダジニル−ピペラジンおよびそれらのヒスタミンh3受容体リガンドとしての使用 - Google Patents
ピリダジニル−ピペラジンおよびそれらのヒスタミンh3受容体リガンドとしての使用 Download PDFInfo
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- JP4680903B2 JP4680903B2 JP2006521396A JP2006521396A JP4680903B2 JP 4680903 B2 JP4680903 B2 JP 4680903B2 JP 2006521396 A JP2006521396 A JP 2006521396A JP 2006521396 A JP2006521396 A JP 2006521396A JP 4680903 B2 JP4680903 B2 JP 4680903B2
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- histamine
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- receptor
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical class C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000004525 thiadiazinyl group Chemical group S1NN=C(C=C1)* 0.000 description 1
- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 229960002277 tolazamide Drugs 0.000 description 1
- OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229960004394 topiramate Drugs 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- 229950002929 trinitrophenol Drugs 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 229960001130 urapidil Drugs 0.000 description 1
- 239000000777 urocortin Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229960001729 voglibose Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/00—Drugs for disorders of the metabolism
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Description
本発明は、新規ピペラジン、医薬組成物におけるこれらの化合物の使用、当該化合物を含む医薬組成物、およびこれらの化合物または組成物を使用する治療方法に関する。本発明の化合物は、ヒスタミンH3受容体に対する高く、且つ選択的な結合親和性を示し、ヒスタミンH3受容体アンタゴニスト、インバースアゴニストまたはアゴニスト活性を示すものである。結果として、当該化合物は、ヒスタミンH3受容体に関連する疾病または障害の治療に対して有用である。
ヒスタミンH3受容体の存在は、数年で知られるようになってきており、当該受容体は、現在では新規薬物の開発のために興味を持たれている。最近、当該ヒトヒスタミンH3受容体がクローニングされた。当該ヒスタミンH3受容体は、中枢および抹消神経系の両方、皮膚および肺、腸、恐らく脾臓および胃腸管などの臓器中に位置するシナプス前の自己受容体である。最近の証拠では、当該H3 受容体が内因性の恒常的な活性、インビトロ並びにインビボにおいても示す(即ち、それはアゴニストが不在であっても活性である)ことを示唆している。インバースアゴニストとして作用する化合物は、この活性を阻害することが可能である。当該ヒスタミンH3受容体は、ヒスタミンの放出を制御すること、また、他の神経伝達物質、例えば、セロトニンおよびアセチルコリンなどの放出も制御することが証明されている。従って、ヒスタミンH3受容体アンタゴニストまたはインバースアゴニストは、脳においてこれらの神経伝達物質の放出を増加させることが期待されるだろう。その反対に、ヒスタミンH3受容体アゴニストは、ヒスタミンの生合成の阻害、ヒスタミンおよび、他の神経伝達物質、例えば、セロトニンおよびアセチルコリンなどの放出も阻害するよう導く。これらの知見は、ヒスタミンH3受容体アンタゴニスト、インバースアゴニスト、およびアンタゴニストが、重要なニューロン活性のメディエータであり得ることを示唆する。従って、当該ヒスタミンH3受容体は、新規治療のために重要な標的である。
ここで問題となる本明細書中の構造式において、以下の用語は、次に指示される意味を有する:
ここで使用される用語「アルキル」は、飽和した、分岐鎖または直鎖の炭化水素基を示し、表示される数の炭素原子を有している。従って、ここで用語される「C1-3-アルキル」、「C1-6-アルキル」および「C2-6-アルキル」は、1から3の炭素原子、1から8の炭素原子および2から6の炭素原子をそれぞれに有する飽和した分岐鎖または直鎖の炭化水素基を表す。限定するものではないが、典型的なアルキル基は、メチル、エチル、n-プロピル、イソプロピル、ブチル、イソブチル、sec-ブチル、tert-ブチル、ペンチル、ヘキシルなどを含む。
1態様において、R1 は、ブロモまたはシアノを意味する。
CL-316243、AJ-9677、GW-0604、LY362884、LY377267またはAZ-40140など、MSH (メラニン細胞刺激ホルモン)アゴニスト、MCH(メラニン細胞集中ホルモン,melanocyte-concentrating hormone)アンタゴニスト、CCK(コレシストキニン)アゴニスト、セロトニン再取り込み阻害剤、例えば、フルオキセチン(fluoxetine)、セロキサット(seroxat)またはシタロプラム(citalopram)など、、セロトニンおよびノルアドレナリン再取り込み阻害剤、セロトニン・ノルアドレナリン混合作動性化合物(mixed serotonin and noradrenergic compaund)、5HT(セロトニン)アゴニスト、ボンベシンアゴニスト、ガラニンアンタゴニスト、成長ホルモン、例えば、プロラクチンまたは胎盤性ラクトゲン、成長ホルモン放出化合物、TRH(チレオトロピン放出ホルモン)アゴニスト、UCP 2 または 3 (非カップリング蛋白質 2 または 3)モジュレーター、レプチンアゴニスト、DA アゴニスト(ブロモクリプチン、ドプレキシン(doprexin))、リパーゼ/アミラーゼ阻害剤、PPAR(ペルオキシソーム増幅因子活性化受容体)モジュレーター、RXR(レチノイド X 受容体)モジュレーター、TR β アゴニスト、AGRP(アグーチ関連蛋白質)阻害剤、オピオイドアンタゴニスト(例えば、ナルトレキソン)、エキセジン-4、GLP-1 および毛様体神経栄養性因子などからなる群より選択されてもよい。
本発明の化合物は、単独で投与されても、または薬学的に許容される担体若しくは賦形剤と組み合わせて投与されてもよく、単一用量若しくは複数用量の何れでもよい。本発明に従う当該薬学的組成物は、薬学的に許容される担体または希釈剤、並びに何れかの他の公知のアジュバントおよび従来技術と一致する賦形剤、例えばレミントン(Remington:The Science and Practice of Pharmacy, 19th Edition, Gennaro, Ed.,Mack Publishing Co., Easton, PA, 1995)に記載されるものと共に形成されてもよい。当該薬学的組成物は、特異的に何れの適切な経路による投与のために形成されてよく、例えば、経口、直腸内、経鼻、肺、局所的(バッカルおよび舌下を含む)、経皮的、嚢内、腹腔内、膣内または非経口(皮下、筋肉内、くも膜下腔内、静脈内および皮内を含む)経路などによる投与のために特に剤形化されてもよく、当該経口経路が好ましい。好ましい経路は、治療されるべき対象の一般的な状態および年齢、治療されるべき状態の性質、および選択される活性成分に依存されるであろうことが理解されるだろう。
コア:
本発明の化合物、例えば、例1〜8の何れかの化合物
(遊離化合物またはその塩として) 5.0 mg
乳糖、欧州局方 67.8 mg
セルロース、ミクロクリスト(microcryst.(Avicel)) 31.4 mg
アンベルライト(登録商標、Amberlite) IRP88* 1.0 mg
ステアリン酸マグネシウム、欧州局方 q.s.
コーティング:
ヒドロキシプロピルメチルセルロース 約9 mg
ミワセット(Mywacett) 9-40 T** 約0.9 mg
* ポラクリリンカリウム NF、崩壊錠、ロームハース社。
当該例において、以下の用語は、以下の一般的な意味を示すことを意図する:
DIPEA: ジイソプロピルエチルアミン
DMSO: ジメチルスルホキシド
NMR
NMR スペクトルは、ブルーカー(Bruker)の 300 MHz と 400 MHz の機器で記録した。
HPLC-MS はパーキンエルマーインスツルメント(Perkin Elmer instrument (API 100))において実施した。使用したカラムは、X−テラ(X-Terra)C18、5μm、50 X 3 mmであり、溶出は、室温で、1.5 ml/minで、5〜90% で水中のアセトニトリルと0.01% のトリフルオロ酢酸の 7.5 分周期のグラジエントで行った。
RP-分析は、ウォーターズ 2487 デュアルバンド検出器(Waters 2487 dual-band detector)を装備したアライアンスウォーターズ 2695 システム(Alliance Waters 2695 system)を用いて行った。UV 検出は、シンメトリー(Symmetry) C18 、3.5 um、3.0 mm x 100 mm カラムを用いて収集した。溶出は、5〜90% アセトニトリル、90〜0% 水および 5% の 1%水性トリフルオロ酢酸からなる8 分周期のリニアグラジエントで、流速 1.0 min/minで実施した。
HPLC-MS: m/z 308.2 (MH+); Rt: 1.76 min。
HPLC: Rt = 3.49 min。
HPLC: Rt = 4.73 min。
HPLC: Rt = 4.10 min。
HPLC: Rt =6.46 min。
HPLC: Rt = 5.52 min。
HPLC: Rt = 5.60 min。
HPLC: Rt = 4.76 min。
当該化合物のヒスタミンH3受容体との相互作用する能力は、以下のインビトロのバインディングアッセイにより測定した。
ラット大脳皮質を氷冷したK-ヘペス、5 mM MgCl2 pH 7.1 バッファー中でホモジナイズする。2つの異なる遠心分離の後、その最終ペレットを、 1 mg/ml バシトラシン(bacitracin)を含む新鮮なヘペスバッファーに再懸濁する。当該膜懸濁液(400 μg/ml)の一定分量を、30 pM [125I]-ヨードプロキシファン(iodoproxifan、公知のヒスタミンH3受容体アンタゴニスト)および種々の濃度で当該テスト化合物と共に、60分間、25℃でインキュベートする。当該インキュベーションは、氷冷した培地で希釈することにより停止し、続いて、1時間、0.5% ポリエチレンイミンを用いて前処理されたワットマン GF/B フィルターで急速濾過を行う。当該フィルタに保持された放射能活性をコブラIIオートガンマカウンター(Cobra II auto gamma counter)を用いてカウントする。当該フィルターの放射能活性は、間接的に試験化合物のバインディングアフィニティに比例する。結果は、非線形回帰解析により分析した。
H3-受容体アゴニストリガンドR-αメチル[3H]ヒスタミン (RAMHA)は、単離されたラット皮質細胞膜と25℃で1時間インキュベートし、ワットマン GF/B フィルターを経てインキュベートしたものを濾過する。当該フィルターに保持された放射能活性をベータカウンターを使用して測定する。雄性ウィスターラット (150-200 g)を断頭し、大脳皮質を迅速に解剖し、ドライアイス上で即時に凍結する。組織は、-80℃で膜調製まで保存する。膜調製の間、当該組織は常に氷上に保持される。ラット大脳皮質は、10体積 (w/w) の氷冷Hepesバッファー(20 mM Hepes、5 mM MgCl2 pH 7.1 (KOH) + 1 mg/ml バシトラシン)中で、ウルトラトゥラックス・ホモジナイザー(Ultra-Turrax homogenizer)を使用して30秒間ホモジナイズする。当該ホモジネートは、140gで10分間、遠心分離する。その上清を新しい試験管に移し、30分間、23000 gで遠心する。ペレットを、5〜10 ml のHepes バッファーに再懸濁し、ホモジナイズと 10 分間、23 000 gで遠心する。この短い遠心分離の工程は、2度繰り返される。最後の遠心の後、当該ペレットを2〜4 ml のHepes バッファーに再懸濁し、そのタンパク濃度を測定する。当該膜を、タンパク濃度で 5 mg/ml に Hepes バッファーで希釈し、一定分量とし、使用時まで-80℃で保存する。
ヒトH3 受容体は、PCRによりクローニングし、pcDNA3 発現ベクターにサブクローニングする。H3 受容体を安定して発現する細胞を、HEK 293 cellsへのH3-発現ベクターのトランスフェクションにより作成し、G418を使用して、H3 クローンの選択する。ヒト H3-HEK 293 クローンは、グルタマックス(glutamax)、10%ウシ胎仔血清、1% ペニシリン/ストレプトアビジンおよび 1 mg/ml G 418を含むDMEM(GIBCO-BRL)中で37℃、 5% CO2 で培養する。回収の前に、そのコンフルエントの細胞をPBSですすぎ、 バーセン(Versene ,proteinase、GIBCO-BRL)と共に、約5分間インキュベートする。細胞をPBSとDMEMで洗い流し、その細胞懸濁液をチューブに回収し、5〜10 分間、1500 rpm でヘラエウススパテックメガヒュージ(Heraeus Sepatech Megafuge)1.0において遠心する。そのペレットを10〜20 volのHepes バッファー [20 mM Hepes、5 mM MgCl2、pH 7.1 (KOH)] に最懸濁し、ウルトラ-トゥーラックスホモジナイザー(Ultra-Turrax homogenizer)を使用し、10〜20秒間のホモジネートをする。ホモジネートは、30分間、23 000 gで遠心する。当該ペレットは、5〜10 ml Hepes バッファー中に再懸濁し、ウルトラ-トゥーラックスホモジナイザー(Ultra-Turrax homogenizer)で5〜10秒間ホモジナイズし、23 000 g で10 分間遠心する。この遠心の工程に続いて、当該膜ペレットを、2〜4 ml Hepes バッファーに再懸濁し、シリンジまたはテフロン(登録商標)ホモジナイザーでホモジナイズし、タンパク濃度を決定する。当該膜は、タンパク濃度が 1〜5 mg/ml となるように Hepes バッファー中で希釈し、一定分量にして、使用時まで-80℃で保存する。
好ましくは、本発明に従う化合物は、1以上のアッセイにより測定されたIC50 値が、10μM未満、より好ましくは1μM未満、更に、より好ましくは500nM 未満、例えば、100nM 未満である。
当該化合物のヒスタミンH3受容体との相互作用、例えば、アゴニスト、インバースアゴニストおよび/またはアンタゴニストなどとしての能力を、ヒト H3 受容体を発現しているHEK 293細胞からの膜を利用するインビトロの機能性アッセイにより、測定する。
アゴニスト、インバースアゴニストおよび/またはアンタゴニストとしての、当該化合物の、ヒトH3 受容体との結合および相互作用の能力は、機能性アッセイ、即ち、[35S] GTPγS アッセイと命名されているアッセイにより測定される。当該アッセイは、Gタンパクの活性を、α-サブユニットでのグアノシン5'-トリポスフェート(GTP)によるグアノシン5'-ジポスフェート(GDP)の変換を触媒することによって測定する。当該GTP結合Gタンパクは、2つのサブユニット、GαGTPとGβγに分離し、次には、細胞内酵素およびイオンシャネルを調節する。GTPはGα-サブユニット(GTPases)によって迅速に加水分解され、Gタンパクは不活性化され、新しいGTP変換回路のための準備をする。Gタンパクでのグアニンヌクレオチド変換の増加によるリガンド誘発Gタンパク結合受容体(GPGR)活性の機能を研究するために、[35S]-グアノシン-5'−O- (3-チオ)トリホスフェート[35S]GTPγSの結合、GTPの非加水分解類似体を測定した。この過程は、GDPと[35S]GTPγSを有するGタンパク結合受容体H3を含む細胞膜をインキュベートすることにより、インビトロにおいてモニターされ得る。細胞膜は、安定してヒトH3受容体を発現可能なCHO細胞から得る。当該細胞は、PBS中で2回洗浄され、PBS+1mM EDTA、pH 7.4で回収され、1000rpmで5分で遠心される。細胞ペレットは10ml氷冷Hepesバッファー(20mM Hepes、10mM EDTA、pH 7.4(NaOH))中で、ウルトラトゥラックス・ホモジナイザー(Ultra-Turrax homogenizer)を使用して30秒のホモジナイズと、15分間で、20.000rpmでの遠心分離を行った。この遠心分離の工程に続いて、当該膜ペレットを10mlの氷冷Hepesバッファー(20 mM Hepes、0.1 mM EDTA pH 7.4 (NaOH))に再懸濁し、上述した通りにホモジナイズを行った。この手順を最後のホモジナイズ工程以外は二回繰り返し、タンパク濃度を測定し、膜をタンパク濃度が2mg/mlとなるように希釈し、一定分量にして、-80℃で使用時まで保存する。
本化合物の減量能力を、インビボオープンケージスケジュール給餌ラットモデルを使用して測定した。
Claims (3)
- 請求項1に記載の化合物であって、ここで R1 がブロモまたはシアノである化合物。
- 以下から成る群から選択される請求項1に記載の化合物、またはその薬学的に許容される塩もしくは溶媒和化合物:
4-[6-(4-イソプロピルピペラジン-1-イル)-ピリダジン-3-イル]ベンゾニトリル;
3-(4-ブロモフェニル)-6-(4-イソプロピルピペラジン-1-イル)ピリダジン;
3-(4-エタンスルホニルフェニル)-6-(4-イソプロピルピペラジン-1-イル)ピリダジン;
3-(4-エタンスルフィニルフェニル)-6-(4-イソプロピルピペラジン-1-イル)ピリダジン;
3-[4-(ブタン-1-スルホニル)フェニル]-6-(4-イソプロピルピペラジン-1-イル)ピリダジン;
3-[4-(ブタン-1-スルフィニル)フェニル]-6-(4-イソプロピルピペラジン-1-イル)ピリダジン;
3-(4-イソプロピルピペラジン-1-イル)-6-[4-(プロパン-1-スルホニル)フェニル]ピリダジン;および
3-(4-イソプロピルピペラジン-1-イル)-6-[4-(プロパン-1-スルフィニル)フェニル]ピリダジン。
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PCT/DK2004/000483 WO2005009976A1 (en) | 2003-07-29 | 2004-07-06 | Pyridazinyl- piperazines and their use as histamine h3 receptor ligands |
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IL173161A0 (en) | 2006-06-11 |
PL1651615T3 (pl) | 2010-08-31 |
DK1651615T3 (da) | 2010-05-25 |
DE602004026068D1 (de) | 2010-04-29 |
EP1651615B1 (en) | 2010-03-17 |
CN100584831C (zh) | 2010-01-27 |
BRPI0413048A (pt) | 2006-10-17 |
RU2006101452A (ru) | 2006-06-27 |
CA2532236C (en) | 2011-08-23 |
CN1829699A (zh) | 2006-09-06 |
PT1651615E (pt) | 2010-04-29 |
JP2007500135A (ja) | 2007-01-11 |
US7294626B2 (en) | 2007-11-13 |
WO2005009976A1 (en) | 2005-02-03 |
MXPA06001053A (es) | 2006-04-11 |
ES2342605T3 (es) | 2010-07-09 |
NO20061003L (no) | 2006-04-26 |
CA2532236A1 (en) | 2005-02-03 |
AU2004259263B2 (en) | 2010-12-16 |
AU2004259263A1 (en) | 2005-02-03 |
KR20060054392A (ko) | 2006-05-22 |
US20060173012A1 (en) | 2006-08-03 |
EP1651615A1 (en) | 2006-05-03 |
ATE461178T1 (de) | 2010-04-15 |
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