GB1188416A - Heterocyclic Amines - Google Patents

Heterocyclic Amines

Info

Publication number
GB1188416A
GB1188416A GB1553968A GB1553968A GB1188416A GB 1188416 A GB1188416 A GB 1188416A GB 1553968 A GB1553968 A GB 1553968A GB 1553968 A GB1553968 A GB 1553968A GB 1188416 A GB1188416 A GB 1188416A
Authority
GB
United Kingdom
Prior art keywords
agents
signifies
agent
suspensions
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1553968A
Inventor
Walter Hepworth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB1553968A priority Critical patent/GB1188416A/en
Priority to IL31796A priority patent/IL31796A0/en
Priority to DE19691913471 priority patent/DE1913471A1/en
Priority to BE730833D priority patent/BE730833A/xx
Priority to FR6909732A priority patent/FR2005291A1/en
Priority to NL6905060A priority patent/NL6905060A/xx
Publication of GB1188416A publication Critical patent/GB1188416A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

1,188,416. Antiinflammatory medicines. IMPERIAL CHEMICAL INDUSTRIES Ltd. 18 Feb., 1969 [1 April, 1968], No. 15539/68. Heading A5B. [Also in Division C2] Pharmaceutical preparations showing antiinflammatory, analgesic and antipyretic activity contain as active ingredient compounds I (including salts thereof) wherein Her signifies a 5- or 6-membered heteroaromatic ring containing one or two hetero-atoms selected from N, O and S, X signifies H or C 1 or 2 alkyl, Y signifies a phenyl radical which is substituted by one or two halogens selected from F, Cl or Br, R<SP>1</SP> and R<SP>3</SP> signify H or C 1 or 3 alkyl and R<SP>3</SP> signifies H or C 1 to 4 alkyl excluding the t-butyl radical and wherein each X, Y and CR<SP>1</SP>R<SP>2</SP> CH 2 .NHR<SP>3</SP> is attached to a carbon atom of Het and Y and CR<SP>1</SP>R<SP>2</SP>.CH 2 .NHR<SP>3</SP> are attached to non-adjacent carbon atoms. Optional ingridients include known anti-inflammatory and/or analgesic agents, e.g. aspirin, paracetamol, codeine, chloroquine, phenylbutazone, oxyphenbutazone, indomethacin, mefenamic acid, flufenamic acid, ibufenac or a steroid, e.g. prednisolone. Orally administered preparations may, in addition, optionally contain at least one anti-cholinergic agent, e.g. homatropine methyl bromide, and/or an antacid, and/or a uricosuric agent, e.g. probenecid. Topical applications may, in addition, optionally contain a vasodilating agent, e.g. tolazoline or a vasoconstricting agent, e.g. adrenaline; a local anaesthetic, e.g. amethocain, or a counter-irritant, e.g. capsicum; and/or at least one known agent chosen from anti-bacterial agents, e.g. neomycin, anti-fungal agents, e.g. hydroxyquinoline, anti-histaminic agents, e.g. promethazine, and rubefacient agents, e.g. methyl micotinate. Suitable forms for administration include, e.g. tablets, pills, capsules, suppositories, non-sterile aqueous or non-aqueous solutions or suspensions, emulsions, ous solutions or suspensions, sterile injectable aqueous or non-aqueous solutions or suspensions, emulsions, creams, lotions or ointments. The examples describe preparations which contain in addition to a compoud I a mixed tocopherols concentrate, propyl gallate, soya bean licithin, pyridoxine hydrochloride, cane sugar solution, sodium benzoate, polyethylene sorbitol monooleate condensate, wheat germ oil and sunflower seed oil.
GB1553968A 1968-04-01 1968-04-01 Heterocyclic Amines Expired GB1188416A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB1553968A GB1188416A (en) 1968-04-01 1968-04-01 Heterocyclic Amines
IL31796A IL31796A0 (en) 1968-04-01 1969-03-13 Heterocyclic compounds
DE19691913471 DE1913471A1 (en) 1968-04-01 1969-03-17 Heterocyclic compounds and processes for their preparation
BE730833D BE730833A (en) 1968-04-01 1969-03-31
FR6909732A FR2005291A1 (en) 1968-04-01 1969-03-31 Heterocyclic amines, analgesic, antiinflammatory
NL6905060A NL6905060A (en) 1968-04-01 1969-04-01

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1553968A GB1188416A (en) 1968-04-01 1968-04-01 Heterocyclic Amines
GB1553969 1969-02-18

Publications (1)

Publication Number Publication Date
GB1188416A true GB1188416A (en) 1970-04-15

Family

ID=26251367

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1553968A Expired GB1188416A (en) 1968-04-01 1968-04-01 Heterocyclic Amines

Country Status (5)

Country Link
BE (1) BE730833A (en)
DE (1) DE1913471A1 (en)
FR (1) FR2005291A1 (en)
GB (1) GB1188416A (en)
NL (1) NL6905060A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7342115B2 (en) * 2002-11-08 2008-03-11 Neurogen Corporation 3-substituted-6-aryl pyridines

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1741709A1 (en) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB630671A (en) * 1945-07-11 1949-10-19 Ward Blenkinsop & Co Ltd Process for the production of amino alkyl thiazole derivatives
GB606714A (en) * 1945-11-21 1948-08-19 Ward Blenkinsop & Co Ltd Process for the production of 2-(aminoalkyl) pyrimidines and derivatives thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7342115B2 (en) * 2002-11-08 2008-03-11 Neurogen Corporation 3-substituted-6-aryl pyridines

Also Published As

Publication number Publication date
DE1913471A1 (en) 1969-11-13
FR2005291A1 (en) 1969-12-12
NL6905060A (en) 1969-10-03
BE730833A (en) 1969-09-30

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees