AR220901A1 - Process for the preparation of new derivatives of spiro hydantoin, useful in the field of medicinal chemistry - Google Patents

Process for the preparation of new derivatives of spiro hydantoin, useful in the field of medicinal chemistry

Info

Publication number
AR220901A1
AR220901A1 AR269623A AR26962377A AR220901A1 AR 220901 A1 AR220901 A1 AR 220901A1 AR 269623 A AR269623 A AR 269623A AR 26962377 A AR26962377 A AR 26962377A AR 220901 A1 AR220901 A1 AR 220901A1
Authority
AR
Argentina
Prior art keywords
useful
medicinal chemistry
new derivatives
spiro hydantoin
hydantoin
Prior art date
Application number
AR269623A
Other languages
Spanish (es)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US73306276A priority Critical
Priority to US05/767,803 priority patent/US4117230A/en
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of AR220901A1 publication Critical patent/AR220901A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10Spiro-condensed systems
AR269623A 1976-10-18 1977-10-18 Process for the preparation of new derivatives of spiro hydantoin, useful in the field of medicinal chemistry AR220901A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US73306276A true 1976-10-18 1976-10-18
US05/767,803 US4117230A (en) 1976-10-18 1977-02-11 Hydantoin derivatives as therapeutic agents

Publications (1)

Publication Number Publication Date
AR220901A1 true AR220901A1 (en) 1980-12-15

Family

ID=27112515

Family Applications (1)

Application Number Title Priority Date Filing Date
AR269623A AR220901A1 (en) 1976-10-18 1977-10-18 Process for the preparation of new derivatives of spiro hydantoin, useful in the field of medicinal chemistry

Country Status (29)

Country Link
JP (3) JPS5534132B2 (en)
AR (1) AR220901A1 (en)
AT (1) AT356136B (en)
AU (1) AU504978B2 (en)
BG (1) BG28847A3 (en)
CA (1) CA1088945A (en)
CH (1) CH625511A5 (en)
DD (1) DD131931A5 (en)
DE (4) DE2759543C2 (en)
DK (1) DK150302C (en)
ES (1) ES463267A1 (en)
FI (1) FI62307C (en)
FR (1) FR2367754B1 (en)
GB (1) GB1566171A (en)
GR (1) GR70201B (en)
HK (1) HK53881A (en)
IE (1) IE45805B1 (en)
IL (1) IL53094D0 (en)
KE (1) KE3167A (en)
LU (1) LU78330A1 (en)
MX (1) MX4899E (en)
MY (1) MY8200157A (en)
NL (1) NL167434C (en)
NO (1) NO148453C (en)
NZ (1) NZ185358A (en)
PH (1) PH15639A (en)
PT (1) PT67164B (en)
SE (1) SE437024B (en)
YU (1) YU40821B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4127665A (en) * 1978-01-18 1978-11-28 Pfizer Inc. Thienohydantoin derivatives
US4147797A (en) * 1978-08-11 1979-04-03 Pfizer Inc. Spiro-furanohydantoin derivatives
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4181728A (en) * 1978-11-16 1980-01-01 Pfizer Inc. Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) * 1979-03-21 1980-01-01 Pfizer Inc. Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4235911A (en) * 1979-06-13 1980-11-25 Pfizer Inc. Hydantoin derivatives
US4283409A (en) * 1979-10-29 1981-08-11 Pfizer Inc. Imidazolone derivatives
US4286098A (en) * 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins
JPS6332793B2 (en) * 1980-07-21 1988-07-01 Eisai Co Ltd
DE3262294D1 (en) * 1981-05-13 1985-03-28 Ici Plc Pharmaceutical compositions containing spiro succinimide derivatives
JPH0451527B2 (en) * 1982-01-20 1992-08-19 Eisai Co Ltd
JPS59500617A (en) * 1983-04-11 1984-04-12
SU1380610A3 (en) * 1982-12-06 1988-03-07 Пфайзер Инк. (Фирма) Method of producing spiroheteroazolydindiones or pharmaceutically acceptable salts thereof
US4474967A (en) * 1983-04-27 1984-10-02 Pfizer Inc. 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
HU198051B (en) * 1984-10-30 1989-07-28 Pfizer Process for producing spiro square brackets open imidazolidine-4,5'(6h)-quinoline square brackets closed-2,5-dione derivatives
JPH0372226B2 (en) * 1985-03-04 1991-11-18 Sanwa Kagaku Kenkyusho Co
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JPH0372227B2 (en) * 1986-08-28 1991-11-18 Sanwa Kagaku Kenkyusho Co
WO1989001775A1 (en) * 1987-09-04 1989-03-09 Pfizer Inc. Azolidinedione derivatives
GB2355264A (en) 1999-09-30 2001-04-18 Merck & Co Inc Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
WO2003088915A2 (en) 2002-04-18 2003-10-30 University Of Virginia Patent Foundation Novel sodium channel blockers
FR2955107B1 (en) 2010-01-08 2012-03-02 Servier Lab Novel thiochroman derivatives, process for their preparation and pharmaceutical compositions containing same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB818724A (en) * 1956-10-18 1959-08-19 Ici Ltd Hydantoin derivatives
DE1135915B (en) * 1961-06-29 1962-09-06 Asta Werke Ag Chem Fab Process for the production of new, more effective anticonvulsant Spirohydantoine
US3532744A (en) * 1967-07-28 1970-10-06 American Home Prod 1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
DE2449030A1 (en) * 1974-10-11 1976-05-20 Schering Ag New pyridine derivatives
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents

Also Published As

Publication number Publication date
YU244277A (en) 1982-08-31
JPS5495575A (en) 1979-07-28
AU504978B2 (en) 1979-11-01
IE45805B1 (en) 1982-12-01
DK150302C (en) 1987-09-28
MY8200157A (en) 1982-12-31
FR2367754B1 (en) 1982-07-09
DE2746244C2 (en) 1983-05-19
NL7711358A (en) 1978-04-20
NL167434B (en) 1981-07-16
FR2367754A1 (en) 1978-05-12
PT67164B (en) 1979-03-20
IL53094D0 (en) 1977-12-30
PH15639A (en) 1983-03-11
GR70201B (en) 1982-08-31
NO773548L (en) 1978-04-19
IE45805L (en) 1978-04-18
CA1088945A1 (en)
JPS5495570A (en) 1979-07-28
HK53881A (en) 1981-11-13
NZ185358A (en) 1979-06-08
AU2943177A (en) 1979-04-12
KE3167A (en) 1981-11-06
PT67164A (en) 1977-11-01
ATA745977A (en) 1979-09-15
JPS5353653A (en) 1978-05-16
DE2759543C2 (en) 1987-04-09
JPS5940388B2 (en) 1984-09-29
NO148453C (en) 1983-10-12
BG28847A3 (en) 1980-07-15
ES463267A1 (en) 1978-07-16
JPS607997B2 (en) 1985-02-28
CA1088945A (en) 1980-11-04
FI773060A (en) 1978-04-19
LU78330A1 (en) 1979-06-01
SE7711053L (en) 1978-04-19
MX4899E (en) 1982-12-14
DK150302B (en) 1987-02-02
FI62307C (en) 1982-12-10
DE2759542C2 (en) 1988-07-07
JPS5534132B2 (en) 1980-09-04
NO148453B (en) 1983-07-04
DK461377A (en) 1978-04-19
GB1566171A (en) 1980-04-30
DE2746244A1 (en) 1978-04-20
AT356136B (en) 1980-04-10
DD131931A5 (en) 1978-08-09
CH625511A5 (en) 1981-09-30
FI62307B (en) 1982-08-31
YU40821B (en) 1986-06-30
SE437024B (en) 1985-02-04
NL167434C (en) 1981-12-16
DE2759927C2 (en) 1986-12-04

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