ATE433962T1 - Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors - Google Patents
Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptorsInfo
- Publication number
- ATE433962T1 ATE433962T1 AT01983901T AT01983901T ATE433962T1 AT E433962 T1 ATE433962 T1 AT E433962T1 AT 01983901 T AT01983901 T AT 01983901T AT 01983901 T AT01983901 T AT 01983901T AT E433962 T1 ATE433962 T1 AT E433962T1
- Authority
- AT
- Austria
- Prior art keywords
- serotonin
- receptor
- antagonists
- compounds
- piperazinylpyrazine
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title abstract 4
- 229940076279 serotonin Drugs 0.000 title abstract 2
- HCGFLVDMFDHYJD-UHFFFAOYSA-N 2-piperazin-1-ylpyrazine Chemical class C1CNCCN1C1=CN=CC=N1 HCGFLVDMFDHYJD-UHFFFAOYSA-N 0.000 title 1
- 108091005479 5-HT2 receptors Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000006902 5-HT2C Serotonin Receptor Human genes 0.000 abstract 1
- 108010072553 5-HT2C Serotonin Receptor Proteins 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0004244A SE0004244D0 (sv) | 2000-11-20 | 2000-11-20 | Novel compounds and their use |
| US25370200P | 2000-11-28 | 2000-11-28 | |
| PCT/SE2001/002570 WO2002040457A1 (en) | 2000-11-20 | 2001-11-20 | Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE433962T1 true ATE433962T1 (de) | 2009-07-15 |
Family
ID=26655310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01983901T ATE433962T1 (de) | 2000-11-20 | 2001-11-20 | Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1337518B1 (de) |
| JP (1) | JP4204315B2 (de) |
| KR (1) | KR100831909B1 (de) |
| CN (1) | CN1227237C (de) |
| AT (1) | ATE433962T1 (de) |
| AU (1) | AU1529402A (de) |
| BR (1) | BR0115436A (de) |
| CA (2) | CA2428905A1 (de) |
| DE (1) | DE60139021D1 (de) |
| DK (1) | DK1337518T3 (de) |
| EA (1) | EA005975B1 (de) |
| ES (1) | ES2328671T3 (de) |
| IL (2) | IL155875A0 (de) |
| MX (1) | MXPA03004391A (de) |
| NO (1) | NO325321B1 (de) |
| NZ (1) | NZ525699A (de) |
| PL (1) | PL360982A1 (de) |
| WO (1) | WO2002040457A1 (de) |
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| CL2004000826A1 (es) * | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
| WO2005028438A1 (ja) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | 新規ピペリジン誘導体 |
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| JP5173190B2 (ja) | 2004-08-25 | 2013-03-27 | 武田薬品工業株式会社 | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
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| EP1892241B1 (de) | 2005-05-30 | 2016-03-30 | Msd K.K. | Neues piperidinderivat |
| EP1916239A4 (de) | 2005-08-10 | 2009-10-21 | Banyu Pharma Co Ltd | Pyridolverbindung |
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| RU2008119687A (ru) | 2005-10-21 | 2009-11-27 | Новартис АГ (CH) | Комбинации органических соединений |
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| RU2428423C2 (ru) | 2005-11-10 | 2011-09-10 | Баниу Фармасьютикал Ко., Лтд. | Азазамещенные спиропроизводные |
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| WO2000077001A1 (en) | 1999-06-15 | 2000-12-21 | Du Pont Pharmaceuticals Company | Substituted heterocycle fused gamma-carbolines |
| WO2001009122A2 (en) | 1999-07-29 | 2001-02-08 | Eli Lilly And Company | Serotonergic benzofurans |
| CA2378878A1 (en) | 1999-07-29 | 2001-02-08 | Jeffrey Thomas Mullaney | Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists |
| AU6339000A (en) | 1999-07-29 | 2001-02-19 | Eli Lilly And Company | Serotonergic benzothiophenes |
| DK1204658T3 (da) | 1999-07-29 | 2003-09-01 | Lilly Co Eli | Benzofurylpiperazin-serotoninagonister |
| GB9918965D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
| GB9918962D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxii |
-
2001
- 2001-11-20 JP JP2002542785A patent/JP4204315B2/ja not_active Expired - Fee Related
- 2001-11-20 AT AT01983901T patent/ATE433962T1/de not_active IP Right Cessation
- 2001-11-20 BR BR0115436-2A patent/BR0115436A/pt not_active IP Right Cessation
- 2001-11-20 KR KR1020037006822A patent/KR100831909B1/ko not_active Expired - Fee Related
- 2001-11-20 IL IL15587501A patent/IL155875A0/xx active IP Right Grant
- 2001-11-20 EP EP01983901A patent/EP1337518B1/de not_active Expired - Lifetime
- 2001-11-20 MX MXPA03004391A patent/MXPA03004391A/es active IP Right Grant
- 2001-11-20 CA CA002428905A patent/CA2428905A1/en active Pending
- 2001-11-20 ES ES01983901T patent/ES2328671T3/es not_active Expired - Lifetime
- 2001-11-20 DE DE60139021T patent/DE60139021D1/de not_active Expired - Lifetime
- 2001-11-20 CN CNB018192416A patent/CN1227237C/zh not_active Expired - Fee Related
- 2001-11-20 DK DK01983901T patent/DK1337518T3/da active
- 2001-11-20 NZ NZ525699A patent/NZ525699A/en unknown
- 2001-11-20 PL PL36098201A patent/PL360982A1/xx unknown
- 2001-11-20 AU AU1529402A patent/AU1529402A/xx not_active Withdrawn
- 2001-11-20 CA CA2449899A patent/CA2449899C/en not_active Expired - Fee Related
- 2001-11-20 WO PCT/SE2001/002570 patent/WO2002040457A1/en not_active Ceased
- 2001-11-20 EA EA200300595A patent/EA005975B1/ru not_active IP Right Cessation
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2003
- 2003-05-12 IL IL155875A patent/IL155875A/en not_active IP Right Cessation
- 2003-05-19 NO NO20032253A patent/NO325321B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EA200300595A1 (ru) | 2003-10-30 |
| WO2002040457A1 (en) | 2002-05-23 |
| CA2428905A1 (en) | 2002-05-23 |
| EP1337518A1 (de) | 2003-08-27 |
| NO20032253D0 (no) | 2003-05-19 |
| DK1337518T3 (da) | 2009-10-19 |
| NO325321B1 (no) | 2008-03-31 |
| MXPA03004391A (es) | 2004-05-31 |
| JP4204315B2 (ja) | 2009-01-07 |
| EP1337518B1 (de) | 2009-06-17 |
| CA2449899C (en) | 2010-04-06 |
| CN1227237C (zh) | 2005-11-16 |
| NZ525699A (en) | 2005-03-24 |
| KR20030060946A (ko) | 2003-07-16 |
| EA005975B1 (ru) | 2005-08-25 |
| ES2328671T3 (es) | 2009-11-17 |
| DE60139021D1 (de) | 2009-07-30 |
| PL360982A1 (en) | 2004-09-20 |
| AU1529402A (en) | 2002-05-27 |
| IL155875A0 (en) | 2003-12-23 |
| NO20032253L (no) | 2003-07-18 |
| IL155875A (en) | 2007-06-17 |
| BR0115436A (pt) | 2004-01-06 |
| KR100831909B1 (ko) | 2008-05-26 |
| JP2004531465A (ja) | 2004-10-14 |
| CA2449899A1 (en) | 2002-05-23 |
| HK1066810A1 (en) | 2005-04-01 |
| CN1520404A (zh) | 2004-08-11 |
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