ATE354568T1 - Nicht-imidazol aryloxypiperidine als h3 rezeptor liganden - Google Patents

Nicht-imidazol aryloxypiperidine als h3 rezeptor liganden

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Publication number
ATE354568T1
ATE354568T1 AT01959582T AT01959582T ATE354568T1 AT E354568 T1 ATE354568 T1 AT E354568T1 AT 01959582 T AT01959582 T AT 01959582T AT 01959582 T AT01959582 T AT 01959582T AT E354568 T1 ATE354568 T1 AT E354568T1
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Austria
Prior art keywords
aryloxypiperidine
imidazole
receptor ligands
treat
compounds
Prior art date
Application number
AT01959582T
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English (en)
Inventor
Richard Apodaca
Nicholas I Carruthers
Curt A Dvorak
Chandravadan R Shah
Wei Xiao
Original Assignee
Ortho Mcneil Pharm Inc
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Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
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Publication of ATE354568T1 publication Critical patent/ATE354568T1/de

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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WO2002012190A3 (en) 2002-08-01
KR100852362B1 (ko) 2008-08-14
CN1468221A (zh) 2004-01-14
PL360373A1 (en) 2004-09-06
US7241778B2 (en) 2007-07-10
ES2282279T3 (es) 2007-10-16
DE60126785T2 (de) 2007-10-25
JP2004511438A (ja) 2004-04-15
EP1311482B1 (de) 2007-02-21
BR0113161A (pt) 2004-04-06
DK1311482T3 (da) 2007-05-07
DE60126785D1 (de) 2007-04-05
CZ2003686A3 (cs) 2003-08-13
US7071191B2 (en) 2006-07-04
US20020040024A1 (en) 2002-04-04
US20050227979A1 (en) 2005-10-13
CA2419036A1 (en) 2002-02-14
PT1311482E (pt) 2007-04-30
CN100396668C (zh) 2008-06-25
HUP0302893A2 (hu) 2003-12-29
AU8112101A (en) 2002-02-18
AU2001281121B2 (en) 2007-08-23
KR20030048007A (ko) 2003-06-18
WO2002012190A2 (en) 2002-02-14
MXPA03001268A (es) 2004-09-06
EP1311482A2 (de) 2003-05-21

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