CO2017001884A2 - Polimorfos de selinexor - Google Patents

Polimorfos de selinexor

Info

Publication number
CO2017001884A2
CO2017001884A2 CONC2017/0001884A CO2017001884A CO2017001884A2 CO 2017001884 A2 CO2017001884 A2 CO 2017001884A2 CO 2017001884 A CO2017001884 A CO 2017001884A CO 2017001884 A2 CO2017001884 A2 CO 2017001884A2
Authority
CO
Colombia
Prior art keywords
structural formula
crystalline forms
compound
compositions
selinexor
Prior art date
Application number
CONC2017/0001884A
Other languages
English (en)
Inventor
Brian Clinton Austad
G David Roe
Original Assignee
Karyopharm Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karyopharm Therapeutics Inc filed Critical Karyopharm Therapeutics Inc
Publication of CO2017001884A2 publication Critical patent/CO2017001884A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a formas cristalinas del compuesto representado por la Fórmula estructural I y a composiciones que comprenden formas cristalinas del compuesto representado por la Fórmula estructural I descrita en la presente. Las formas cristalinas del compuesto de Fórmula estructural I y las composiciones que comprenden las formas cristalinas del compuesto de Fórmula estructural I proporcionadas en la presente, en particular, la Forma cristalina única A, se pueden incorporar en composiciones farmacéuticas, las cuales se pueden utilizarpara tratar varios trastornos asociados con la actividad de CRM1, incluido el cáncer. En la presente también se describen métodos para preparar el compuesto de Fórmula structural I y sus formas cristalinas únicas.
CONC2017/0001884A 2014-08-15 2017-02-24 Polimorfos de selinexor CO2017001884A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462038069P 2014-08-15 2014-08-15
PCT/US2015/045395 WO2016025904A1 (en) 2014-08-15 2015-08-14 Polymorphs of selinexor

Publications (1)

Publication Number Publication Date
CO2017001884A2 true CO2017001884A2 (es) 2017-07-19

Family

ID=53969460

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0001884A CO2017001884A2 (es) 2014-08-15 2017-02-24 Polimorfos de selinexor

Country Status (18)

Country Link
US (6) US10519139B2 (es)
EP (2) EP4112615A1 (es)
JP (3) JP6777626B2 (es)
KR (1) KR102608259B1 (es)
CN (3) CN107072992B (es)
AU (4) AU2015301484B2 (es)
CA (1) CA2957266A1 (es)
CO (1) CO2017001884A2 (es)
DK (1) DK3180331T3 (es)
EA (1) EA201790384A1 (es)
ES (1) ES2926377T3 (es)
IL (1) IL250328B (es)
MA (1) MA40254B1 (es)
MX (2) MX2017002013A (es)
SG (2) SG10201808624VA (es)
UA (1) UA123535C2 (es)
WO (1) WO2016025904A1 (es)
ZA (1) ZA201700880B (es)

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Also Published As

Publication number Publication date
ZA201700880B (en) 2020-01-29
SG10201808624VA (en) 2018-11-29
AU2021286266A1 (en) 2022-01-06
CN111484483B (zh) 2023-05-26
IL250328A0 (en) 2017-03-30
JP2017527549A (ja) 2017-09-21
EA201790384A1 (ru) 2017-08-31
MX2017002013A (es) 2017-05-12
MA40254A (fr) 2021-05-19
CN111481553B (zh) 2023-09-01
EP3180331B1 (en) 2022-06-08
AU2015301484B2 (en) 2020-02-20
US20180215733A1 (en) 2018-08-02
UA123535C2 (uk) 2021-04-21
MX2021014128A (es) 2022-01-04
JP2023052622A (ja) 2023-04-11
US20230242517A1 (en) 2023-08-03
CN111484483A (zh) 2020-08-04
KR20170043561A (ko) 2017-04-21
CA2957266A1 (en) 2016-02-18
WO2016025904A1 (en) 2016-02-18
AU2020203246B2 (en) 2021-09-16
AU2024202835A1 (en) 2024-05-23
DK3180331T3 (da) 2022-09-12
CN107072992A (zh) 2017-08-18
US11746102B2 (en) 2023-09-05
US20200283419A1 (en) 2020-09-10
AU2015301484A1 (en) 2017-03-02
NZ728850A (en) 2024-03-22
JP7218323B2 (ja) 2023-02-06
JP6777626B2 (ja) 2020-10-28
JP2020143144A (ja) 2020-09-10
AU2020203246A1 (en) 2020-06-04
MA40254B1 (fr) 2022-09-30
US10519139B2 (en) 2019-12-31
US20220135545A1 (en) 2022-05-05
ES2926377T3 (es) 2022-10-25
US11807629B2 (en) 2023-11-07
AU2021286266B2 (en) 2024-02-01
EP4112615A1 (en) 2023-01-04
JP7558310B2 (ja) 2024-09-30
US11753401B2 (en) 2023-09-12
US20240208943A1 (en) 2024-06-27
US20230242516A1 (en) 2023-08-03
IL250328B (en) 2022-05-01
SG11201700789SA (en) 2017-02-27
CN107072992B (zh) 2020-03-10
KR102608259B1 (ko) 2023-11-29
US11078190B2 (en) 2021-08-03
EP3180331A1 (en) 2017-06-21
CN111481553A (zh) 2020-08-04

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