PE20040609A1 - Compuestos heterociclicos aromaticos como promotores de un factor neurotrofico - Google Patents

Compuestos heterociclicos aromaticos como promotores de un factor neurotrofico

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Publication number
PE20040609A1
PE20040609A1 PE2003001101A PE2003001101A PE20040609A1 PE 20040609 A1 PE20040609 A1 PE 20040609A1 PE 2003001101 A PE2003001101 A PE 2003001101A PE 2003001101 A PE2003001101 A PE 2003001101A PE 20040609 A1 PE20040609 A1 PE 20040609A1
Authority
PE
Peru
Prior art keywords
methyl
optionally substituted
pyrazo
fluorophenyl
compounds
Prior art date
Application number
PE2003001101A
Other languages
English (en)
Inventor
Yu Momose
Nozomu Sakai
Tsuyoshi Maekawa
Masatoshi Hazama
Toru Kawamura
Misayo Sera
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20040609A1 publication Critical patent/PE20040609A1/es

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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

SE REFIER A UN COMPUESTO DE FORMULA (I), DONDE A ES HETEROCICLICO AROMATICO DE 5 MIEMBROS CON 2 O MAS N, OPCIONALMENTE SUSTITUIDO COMO:PIRAZOL, OXADIAZOL, TIDIAZOL, TRIAZOL O TETRAZOL; B ES UN HIDROCARBURO O HETEROCICLICO OPCIONALMENTE SUSTITUIDOS, X ES UN HIDROCARBURO ACICLICO DIVALENTE; Z ES -O-, -S-, -NR2-, -CONR2- O -NR2CO-, DONDE R2 ES H O ALQUILO OPCIONALMENTE SUSTITUIDO; Y ES UN ENLACE O UN HIDROCARBURO DIVALENTE Y R1 ES CICLICO, AMINO O ACILO OPCIONALMENTE SUSTITUIDOS, CON LA CONDICION QUE SI A ES IMIDAZOL, Z NO DEBERA SER -O-. SON COMPUESTOS PREFERIDOS: (2E)-N-[4-(DIETILFOSFONOMETIL)FENIL]-3-[5-(4-FLUOROFENIL)-1-METIL-1H-PIRAZO-4-LIL}ACRILAMIDA, DIETIL[4-({(2E)-3-[5-(4-FLUOROFENIL)-1-METIL-1H-PIRAZO-4-LIL]PRO-2-PENOIL}AMINO)BENCIL]FOSFONATO, (2E)-3-[5-(4-FLUOROFENIL)-1-METIL-1H-PIRAZO-4-LIL]-N-{4-[HIDROXI(2-PIRIDINIL)METIL]FENIL}ACRILAMIDA, ENTRE OTROS. ESTOS COMPUESTOS PROMUVEN LA PRODUCCION Y SECRECION DE UN FACTOR NEUTROTOFICO COMO NEUTOTROFINA, LA SUPERFAMILIA TGF-ß, ENTRE OTROS, PREFERENTEMENTE LOS FACTORES NGF, GDNF, NT-3, BDNF Y SIMILARES, PRESENTANDO UNA ACCION MEJORADA DE LA FUNCION NERVIOSA, EN CONSECUENCIA PRESENTAN UNA ACCION ALIVIADORA DEL DOLOR NEUROPATICO Y NEUROPROTECTORA. TAMBIEN SE REFIERE A UN PROCESO DE ELABORACION DE LOS COMPUESTOS.
PE2003001101A 2002-11-01 2003-10-30 Compuestos heterociclicos aromaticos como promotores de un factor neurotrofico PE20040609A1 (es)

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RU2337682C2 (ru) 2008-11-10
PL376733A1 (pl) 2006-01-09
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BR0315815A (pt) 2005-09-13
CR7849A (es) 2005-09-19
RU2005116689A (ru) 2006-01-20
CO5570666A2 (es) 2005-10-31
US7423159B2 (en) 2008-09-09
NO20052626L (no) 2005-07-01
CR10127A (es) 2008-08-18
TW200416029A (en) 2004-09-01
MXPA05004505A (es) 2005-07-26
AU2003278600A1 (en) 2004-05-25
ZA200503967B (en) 2006-11-29
US20080287438A1 (en) 2008-11-20
AR041867A1 (es) 2005-06-01
US20060004069A1 (en) 2006-01-05
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EP1556032A1 (en) 2005-07-27
WO2004039365A1 (en) 2004-05-13
NO20052626D0 (no) 2005-05-31

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