BR0315815A - Agentes para prevenir ou tratar neuropatia, para promover a produção ou a secreção de um fator neurotrópico, para melhorar a dor, neuroprotetor e farmacêutico, composto, métodos para prevenir ou tratar neuropatia e para promover a produção ou a secreção de um fator neurotrópico, para melhorar a dor para proteger um nervo em um mamìfero e para produzir um composto e uso de um composto - Google Patents

Agentes para prevenir ou tratar neuropatia, para promover a produção ou a secreção de um fator neurotrópico, para melhorar a dor, neuroprotetor e farmacêutico, composto, métodos para prevenir ou tratar neuropatia e para promover a produção ou a secreção de um fator neurotrópico, para melhorar a dor para proteger um nervo em um mamìfero e para produzir um composto e uso de um composto

Info

Publication number
BR0315815A
BR0315815A BR0315815-2A BR0315815A BR0315815A BR 0315815 A BR0315815 A BR 0315815A BR 0315815 A BR0315815 A BR 0315815A BR 0315815 A BR0315815 A BR 0315815A
Authority
BR
Brazil
Prior art keywords
compound
secretion
optionally substituted
preventing
production
Prior art date
Application number
BR0315815-2A
Other languages
English (en)
Inventor
Yu Momose
Nozomu Sakai
Tsuyoshi Maekawa
Masatoshi Hazama
Toru Kawamura
Misayo Sera
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of BR0315815A publication Critical patent/BR0315815A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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Abstract

"AGENTES PARA PREVENIR OU TRATAR NEUROPATIA, PARA PROMOVER A PRODUçãO OU A SECREçãO DE UM FATOR NEUROTRóPICO, PARA MELHORAR A DOR, NEUROPROTETOR E FARMACêUTICO, COMPOSTO, MéTODOS PARA PREVENIR OU TRATAR NEUROPATIA E PARA PROMOVER A PRODUçãO OU A SECREçãO DE UM FATOR NEUROTRóPICO, PARA MELHORAR A DOR PARA PROTEGER UM NERVO EM UM MAMìFERO E PARA PRODUZIR UM COMPOSTO E USO DE UM COMPOSTO". A presente invenção fornece um agente para prevenir ou tratar neuropatia tendo ação superior e toxicidade baixa. Este agente compreende um composto representado pela fórmula: em que o anel A é um heterociclo aromático de 5 membros que contém 2 ou mais átomos de nitrogênio, que também podem ter substituinte(s); B é um grupo de hidrocarboneto opcionalmente substituído ou um grupo heterocíclico opcionalmente substituído; X é um grupo de hidrocarboneto acíclico bivalente; Z é -O-, -S-, -NR¬ 2¬, -CONR¬ 2¬- ou -NR¬ 2¬CO- (R¬ 2¬ é um átomo de hidrogênio ou um grupo alquila opcionalmente substituído); Y é uma ligação ou um grupo de hidrocarboneto acíclico bivalente; R~ 1~ é um grupo cíclico opcionalmente substituído bivalente, um grupo amino opcionalmente substituído ou um grupo acila opcionalmente substituído, contanto que quando o heterociclo aromático de 5 membros representado pelo anel A for imidazol, então Z não deve ser -O- ou um sal deste.
BR0315815-2A 2002-11-01 2003-10-30 Agentes para prevenir ou tratar neuropatia, para promover a produção ou a secreção de um fator neurotrópico, para melhorar a dor, neuroprotetor e farmacêutico, composto, métodos para prevenir ou tratar neuropatia e para promover a produção ou a secreção de um fator neurotrópico, para melhorar a dor para proteger um nervo em um mamìfero e para produzir um composto e uso de um composto BR0315815A (pt)

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PCT/JP2003/013901 WO2004039365A1 (en) 2002-11-01 2003-10-30 Agent for preventing or treating neuropathy

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US20080287438A1 (en) 2008-11-20
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JP2008231115A (ja) 2008-10-02
NZ540381A (en) 2007-11-30
US7423159B2 (en) 2008-09-09
PL376733A1 (pl) 2006-01-09
CO5570666A2 (es) 2005-10-31
WO2004039365A1 (en) 2004-05-13
NO20052626L (no) 2005-07-01
AR041867A1 (es) 2005-06-01
MXPA05004505A (es) 2005-07-26
CN1731994A (zh) 2006-02-08
NO20052626D0 (no) 2005-05-31
CR10127A (es) 2008-08-18
RU2337682C2 (ru) 2008-11-10
ZA200503967B (en) 2006-11-29
RU2005116689A (ru) 2006-01-20
AU2003278600A1 (en) 2004-05-25
TW200416029A (en) 2004-09-01
KR20050062645A (ko) 2005-06-23
PE20040609A1 (es) 2004-10-29
CA2504511A1 (en) 2004-05-13

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