PL376733A1 - Środek do zapobiegania lub leczenia neuropatii - Google Patents

Środek do zapobiegania lub leczenia neuropatii

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Publication number
PL376733A1
PL376733A1 PL376733A PL37673303A PL376733A1 PL 376733 A1 PL376733 A1 PL 376733A1 PL 376733 A PL376733 A PL 376733A PL 37673303 A PL37673303 A PL 37673303A PL 376733 A1 PL376733 A1 PL 376733A1
Authority
PL
Poland
Prior art keywords
preventing
agent
treating neuropathy
neuropathy
treating
Prior art date
Application number
PL376733A
Other languages
English (en)
Inventor
Yu Momose
Nozomu Sakai
Tsuyoshi Maekawa
Masatoshi Hazama
Toru Kawamura
Misayo Sera
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of PL376733A1 publication Critical patent/PL376733A1/pl

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    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7339052B2 (en) * 2005-02-08 2008-03-04 Honeywell International Inc. Phosphoramidite activator for oligonucleotide synthesis
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
EP1754476A1 (en) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia
EA019757B1 (ru) * 2006-06-15 2014-06-30 ЮСиБи ФАРМА ГМБХ Фармацевтическая композиция с синергетическим противосудорожным эффектом
US20100029724A1 (en) * 2006-07-19 2010-02-04 Takeda Pharmaceutical Company Limited Screening method
EP1939180A1 (en) 2006-12-20 2008-07-02 sanofi-aventis Heteroarylacrylamides and their use as pharmaceuticals for the stimulation of the expression of endothelial NO synthase
EP2116618A1 (en) 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnosis and treatment of Kawasaki disease
UY32126A (es) 2008-09-25 2010-04-30 Takeda Pharmaceutical Composición farmacéutica sólida
EP2351743A4 (en) 2008-10-27 2012-05-09 Takeda Pharmaceutical BICYCLIC CONNECTION
WO2010076884A1 (ja) 2008-12-29 2010-07-08 武田薬品工業株式会社 新規縮合環化合物およびその用途
FR2943246B1 (fr) * 2009-03-19 2011-07-29 Biocodex Compose pour son utilisation dans le traitement des neuropathies peripheriques
EP2440541A1 (en) 2009-06-09 2012-04-18 Takeda Pharmaceutical Company Limited Novel fused cyclic compound and use thereof
CN102548556A (zh) 2009-07-28 2012-07-04 武田药品工业株式会社 片剂
KR101149821B1 (ko) 2010-04-05 2012-05-24 하나제약 주식회사 디페닐아세테이트 유도체의 새로운 제조방법
NZ603777A (en) 2010-04-27 2013-08-30 Takeda Pharmaceutical Bicyclic compound derivatives and their use as acc inhibitors.
PE20130283A1 (es) 2010-06-16 2013-03-25 Takeda Pharmaceutical Cristal de compuesto de amida
EP2617726A4 (en) 2010-09-17 2014-05-14 Takeda Pharmaceutical DIABETES THERAPEUTIC
JP5824517B2 (ja) 2010-11-30 2015-11-25 武田薬品工業株式会社 二環性化合物
RU2445066C1 (ru) * 2011-01-13 2012-03-20 Государственное образовательное учреждение высшего профессионального образования "Астраханская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО АГМА Росздрава) Способ лечения невропатии лицевого нерва
US8952185B2 (en) 2011-02-17 2015-02-10 Takeda Pharmaceutical Company Limited Production method of optically active dihydrobenzofuran derivative
EP2736887B1 (en) 2011-07-29 2017-10-18 Karyopharm Therapeutics, Inc. Hydrazide containing nuclear transport modulators and uses thereof
US9428490B2 (en) * 2011-07-29 2016-08-30 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
EP2772485A4 (en) 2011-10-24 2015-06-10 Takeda Pharmaceutical BICYCLIC CONNECTION
RU2486918C1 (ru) * 2011-10-25 2013-07-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ стимулирования восстановления периферической иннервации тканей с помощью векторных конструкций
JP6129850B2 (ja) 2012-01-12 2017-05-17 武田薬品工業株式会社 Mch受容体拮抗剤としてのベンゾイミダゾール誘導体
EP2816032A4 (en) 2012-02-13 2015-09-30 Takeda Pharmaceutical AROMATIC CORE COMPOUND
JP6095580B2 (ja) 2012-02-13 2017-03-15 武田薬品工業株式会社 芳香環化合物
CN104254322B (zh) 2012-02-15 2017-06-13 武田药品工业株式会社 片剂
US9238639B2 (en) 2012-02-24 2016-01-19 Takeda Pharmaceutical Company Limited Aromatic ring compound
CA2868713A1 (en) 2012-03-29 2013-10-03 Takeda Pharmaceutical Company Limited Aromatic ring compound
US9096543B2 (en) 2012-05-09 2015-08-04 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
EP2848621A4 (en) 2012-05-10 2016-06-01 Takeda Pharmaceutical AROMATIC CYCLIC COMPOUND
EP2848622A4 (en) 2012-05-10 2015-11-04 Takeda Pharmaceutical AROMATIC RING CONNECTION
JP6122879B2 (ja) 2012-06-05 2017-04-26 武田薬品工業株式会社 固形製剤
JP2015127299A (ja) 2012-07-19 2015-07-09 武田薬品工業株式会社 固形製剤
WO2014142363A1 (en) 2013-03-14 2014-09-18 Takeda Pharmaceutical Company Limited Spiro azetidine isoxazole derivatives and their use as sstr5 antagonists
US10202366B2 (en) 2013-03-15 2019-02-12 Karyopharm Therapeutics Inc. Methods of promoting wound healing using CRM1 inhibitors
WO2014165816A1 (en) 2013-04-05 2014-10-09 North Carolina Central University Compounds useful for the treatment of metabolic disorders and synthesis of the same
RU2538621C2 (ru) * 2013-05-08 2015-01-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ стимулирования восстановления иннервации тканей после травм и ишемии с помощью векторной конструкции
EP3010892B8 (en) 2013-06-21 2019-05-22 Karyopharm Therapeutics Inc. 1,2,4-triazoles as nuclear transport modulators and uses thereof
AR096848A1 (es) 2013-07-09 2016-02-03 Takeda Pharmaceuticals Co Derivados de indazol con actividad antagonista del receptor de la hormona concentradora de melanina (mch)
JP6397410B2 (ja) 2013-08-09 2018-09-26 武田薬品工業株式会社 芳香環化合物
JO3442B1 (ar) 2013-10-07 2019-10-20 Takeda Pharmaceuticals Co مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5)
ITMI20132201A1 (it) 2013-12-23 2015-06-24 Isagro Spa Processo per la sintesi regioselettiva di pirazoli
US9346776B2 (en) 2014-02-13 2016-05-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
US9428470B2 (en) 2014-02-13 2016-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2015155713A1 (en) 2014-04-09 2015-10-15 Isagro S.P.A. Process for the regioselective synthesis of 1,3, 4 -substituted pyrazoles
CN111484483B (zh) 2014-08-15 2023-05-26 卡尔约药物治疗公司 赛灵克斯的多晶型物
US10709706B2 (en) 2015-12-31 2020-07-14 Karopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
WO2017117529A1 (en) 2015-12-31 2017-07-06 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
US11602530B2 (en) 2016-11-28 2023-03-14 Biogen Ma Inc. CRM1 inhibitors for treating epilepsy
JOP20180029A1 (ar) 2017-03-30 2019-01-30 Takeda Pharmaceuticals Co مركب حلقي غير متجانس
JPWO2018181847A1 (ja) 2017-03-31 2020-03-05 武田薬品工業株式会社 芳香環化合物
AR111199A1 (es) 2017-03-31 2019-06-12 Takeda Pharmaceuticals Co Compuesto aromático agonista de gpr40
JOP20180028A1 (ar) 2017-03-31 2019-01-30 Takeda Pharmaceuticals Co مركب ببتيد
IL277495B1 (en) 2018-03-23 2024-04-01 Carmot Therapeutics Inc Modulators of protein-coupled receptors - G
EP3650440A4 (en) 2018-08-27 2020-11-25 Scohia Pharma, Inc. BENZOIC ESTER COMPOUND
EP3856768A2 (en) 2018-09-24 2021-08-04 Takeda Pharmaceutical Company Limited Gip receptor agonist peptide compounds and uses thereof
WO2020067575A1 (en) 2018-09-24 2020-04-02 Takeda Pharmaceutical Company Limited Gip receptor agonist peptide compounds and uses thereof
GB201901559D0 (en) * 2019-02-05 2019-03-27 Syngenta Crop Protection Ag Herbicidal compositions
MX2022011816A (es) 2020-03-25 2022-10-10 Takeda Pharmaceuticals Co Dosificacion qd de compuestos peptidicos agonistas del receptor de gip y sus usos.
AR121649A1 (es) 2020-03-25 2022-06-22 Takeda Pharmaceuticals Co Dosificación qw de compuestos peptídicos agonistas del receptor de gip y sus usos
KR20240007251A (ko) 2021-05-13 2024-01-16 카모트 테라퓨틱스, 인크. G-단백질 결합 수용체의 조절제
WO2023169456A1 (en) 2022-03-09 2023-09-14 Gasherbrum Bio , Inc. Heterocyclic glp-1 agonists
WO2023179542A1 (en) 2022-03-21 2023-09-28 Gasherbrum Bio , Inc. 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes
WO2023198140A1 (en) 2022-04-14 2023-10-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3702330A (en) * 1970-10-05 1972-11-07 Merck & Co Inc Imidazolyl acrylic acid derivatives
US4172136A (en) * 1975-12-23 1979-10-23 Boehringer Mannheim Gmbh 3-Nitropyrazole compounds and anti-microbial compositions
DE2739689C2 (de) * 1977-09-02 1986-10-16 Euratom Thermische Wärmepumpe
DE2853854A1 (de) * 1978-12-13 1980-07-03 Patra Patent Treuhand Leuchtstofflampen-set
DE3002413A1 (de) * 1980-01-24 1981-07-30 Hoechst Ag, 6000 Frankfurt N,n-dialkyl-o-(pyrazol-5-yl)-carbaminsaeureester, verfahren zu ihrer herstellung und ihre verwendung als insektizide
JPH064584B2 (ja) * 1984-02-29 1994-01-19 沢井製薬株式会社 新規アニリド誘導体
EP0200736B1 (en) 1984-06-22 1991-04-24 Sandoz Ag Pyrazole analogs of mevalonolactone and derivatives thereof, processes for their production and their use
US4835280A (en) * 1985-01-18 1989-05-30 Boehringer Mannheim Gmbh Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles
US5464860A (en) * 1988-11-30 1995-11-07 Novapharme N(pyrazol-3-yl) benzamides and pharmaceutical compositions
JPH04184435A (ja) 1990-11-20 1992-07-01 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料及びその処理方法
US5172136A (en) * 1991-09-06 1992-12-15 Eastman Kodak Company Color registration is scanning thermal printer
US5250504A (en) * 1991-11-20 1993-10-05 Fmc Corporation Herbicidal β-pyrazolylacrylic acids
US5541213A (en) 1993-06-24 1996-07-30 Eisai Co., Ltd. Propenoic acid derivatives diazole propenoic acid compounds which have useful pharmaceutical utility
US5552420A (en) * 1994-05-13 1996-09-03 Sterling Winthrop Inc. Therapeutic phenoxyalkylazoles and phenoxyalkylazines
JPH10195063A (ja) * 1996-10-21 1998-07-28 Dai Ichi Seiyaku Co Ltd エチニルチアゾール誘導体
HUP0102470A3 (en) 1998-07-01 2002-05-28 Takeda Chemical Industries Ltd 1,3-azole derivatives as retinoid-associated receptor regulators and their use
AU3076700A (en) * 1999-01-26 2000-08-18 Ono Pharmaceutical Co. Ltd. 2h-phthalazin-1-one derivatives and drugs comprising these derivatives as the active ingredient
UA71971C2 (en) * 1999-06-04 2005-01-17 Agoron Pharmaceuticals Inc Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
AR035016A1 (es) 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
FR2825706B1 (fr) 2001-06-06 2003-12-12 Pf Medicament Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase
PL373484A1 (pl) 2001-12-10 2005-09-05 Amgen Inc. Ligandy receptora waniloidowego oraz ich medycznezastosowania
WO2003072554A1 (en) 2002-02-28 2003-09-04 Takeda Chemical Industries, Ltd. Azole compounds
US20060148858A1 (en) 2002-05-24 2006-07-06 Tsuyoshi Maekawa 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity

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