PE20010068A1 - Compuestos derivados de piperidina como inhibidores de renina - Google Patents
Compuestos derivados de piperidina como inhibidores de reninaInfo
- Publication number
- PE20010068A1 PE20010068A1 PE2000000377A PE0003772000A PE20010068A1 PE 20010068 A1 PE20010068 A1 PE 20010068A1 PE 2000000377 A PE2000000377 A PE 2000000377A PE 0003772000 A PE0003772000 A PE 0003772000A PE 20010068 A1 PE20010068 A1 PE 20010068A1
- Authority
- PE
- Peru
- Prior art keywords
- piperidine
- phenyl
- compounds
- iloximethyl
- propoxi
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIPERIDINA DE FORMULA I, DONDE:M R1 ES -(CH2)k-N(R3,R4), -(CH2)k-O-R3, -(CH2)m-R5, -(CH2)l-R6; k ES 2-4; m ES 1-2; l ES 1-3; R2 ES CICLOALQUILALQUILO, 1,1,1-TRIFLUOROETILO, FENILO, BENCILO OPCIONALMENTE SUSTITUIDO CON 1-3 HALOGENO, CIANO, ALCOXILO C1-C3, NITRO; R3 ES H, ALQUILO C1-C3; R4 ES H, ALQUILO C1-C3, ALQUILSULFONILO C1-C3, AMINOSULFONILO, ALQUILAMINOSULFONILO C1-C3, ALQUILAMINOCARBONILO C1-C3, ENTRE OTROS; R5 ES ALCOXICARBONILO C1-C3, AMINOCARBONILO, ALQUILAMINOCARBONILO C1-C3, DIALQUILAMINOCARBONILO C1-C3, CIANO; R6 ES IMIDAZOLILO, TRIAZOLILO; CON LA CONDICION QUE SI EL IMIDAZOLILO O TRIAZOLILO ESTA UNIDO VIA UN ENLACE C-N, l ES 2-3. SON COMPUESTOS PREFERIDOS (3R,4R)-N-[2-[7-[4-[4-[3-(2-METOXI-BENCILOXI)-PROPOXI]-FENIL]-PIPERIDIN-3-ILOXIMETIL]-3,4-DIHIDRO-2H-QUINOLIN-1-IL]-ETIL]-ACETAMIDA; (3R,4R)-3-[7-[4-[4-[3-(2-METOXI-BENCILOXI)-PROPOXI]-FENIL]-PIPERIDIN-3-ILOXIMETIL]-3,4-DIHIDRO-2H-QUINOLIN-1-IL]-PROPAN-1-OL, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS DERIVADOS DE PIPERIDINA SON INHIBIDORES DE LA ENZIMA RENINA POR LO QUE PUEDEN SER UTILES EN EL TRAMIENTO DE ENFERMEDADES COMO RESTENOSIS, GLAUCOMA, INFARTO CARDIACO, HIPERTENSION, INSUFICIENCIA RENAL
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99108200 | 1999-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20010068A1 true PE20010068A1 (es) | 2001-01-29 |
Family
ID=8238051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000000377A PE20010068A1 (es) | 1999-04-27 | 2000-04-24 | Compuestos derivados de piperidina como inhibidores de renina |
Country Status (22)
Country | Link |
---|---|
US (1) | US6197959B1 (es) |
EP (1) | EP1180103B1 (es) |
JP (1) | JP3602449B2 (es) |
KR (1) | KR100476916B1 (es) |
CN (1) | CN1323079C (es) |
AR (1) | AR018717A1 (es) |
AT (1) | ATE363478T1 (es) |
AU (1) | AU761392B2 (es) |
BR (1) | BR0010076A (es) |
CA (1) | CA2370244C (es) |
CO (1) | CO5170512A1 (es) |
CZ (1) | CZ20013737A3 (es) |
DE (1) | DE60035039T2 (es) |
ES (1) | ES2286021T3 (es) |
HU (1) | HUP0200881A3 (es) |
MX (1) | MXPA01010855A (es) |
PE (1) | PE20010068A1 (es) |
PL (1) | PL362903A1 (es) |
SK (1) | SK15172001A3 (es) |
TR (1) | TR200103067T2 (es) |
WO (1) | WO2000064887A1 (es) |
ZA (1) | ZA200108739B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040214832A1 (en) * | 2003-04-10 | 2004-10-28 | Cuiman Cai | Piperazine derivative renin inhibitors |
TW200513461A (en) * | 2003-10-01 | 2005-04-16 | Speedel Experimenta Ag | Organische verbindungen |
AR045950A1 (es) * | 2003-10-09 | 2005-11-16 | Speedel Experimenta Ag | Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos. |
CA2546264A1 (en) * | 2003-11-26 | 2005-06-09 | Novartis Ag | 4-phenylpiperidine derivatives as renin inhibitors |
AR053406A1 (es) * | 2004-07-09 | 2007-05-09 | Speedel Experimenta Ag | Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas |
ATE551052T1 (de) | 2004-10-08 | 2012-04-15 | Novartis Ag | Verwendung von reninhemmern zur prävention oder behandlung von diastolischer dysfunktion oder diastolischer herzinsuffizienz |
GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
GB0500784D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
EP1707202A1 (de) * | 2005-03-31 | 2006-10-04 | Speedel Experimenta AG | Organische Verbindungen |
EP1897879A3 (en) * | 2005-03-31 | 2008-06-11 | Speedel Experimenta AG | 2,4,5-substituted piperidines as renin inhibitors |
ES2352564T3 (es) * | 2005-03-31 | 2011-02-21 | Novartis Ag | Piperidinas sustituidas. |
AR053836A1 (es) * | 2005-03-31 | 2007-05-23 | Speedel Experimenta Ag | Piperdinas 3,4,5-sustituidas |
TW200833687A (en) * | 2005-03-31 | 2008-08-16 | Speedel Experimenta Ag | Substituted piperidines |
GB0508992D0 (en) * | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
EP1885718B1 (en) * | 2005-05-11 | 2017-03-15 | Life Technologies Corporation | Fluorescent chemical compounds having high selectivity for double stranded dna, and methods for their use |
WO2006129237A2 (en) | 2005-05-27 | 2006-12-07 | Actelion Pharmaceuticals Ltd | Novel piperidine carboxylic acid amide derivatives |
GB0514203D0 (en) * | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
PL2420491T3 (pl) * | 2005-12-30 | 2013-12-31 | Novartis Ag | 3,5-Podstawione piperydyny jako inhibitory reniny |
TW200804359A (en) * | 2006-01-19 | 2008-01-16 | Speedel Experimenta Ag | Substituted 4-phenylpiperidines |
EP1908761A1 (en) * | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Organic compounds |
AU2008267287B2 (en) | 2007-06-25 | 2012-02-16 | Novartis Ag | N5-(2-ethoxyethyl)-N3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
AU2008320806A1 (en) * | 2007-11-02 | 2009-05-07 | Novartis Ag | 4,4-disubstituted piperidines as renin inhibitors |
MX2011011735A (es) * | 2009-05-04 | 2011-11-29 | Plexxikon Inc | Compuestos y metodos para la inhibicion de renina, e indicaciones para ello. |
WO2013045505A1 (en) | 2011-09-28 | 2013-04-04 | Novartis Ag | Biomarkers for raas combination therapy |
EP2810644A1 (en) | 2013-06-06 | 2014-12-10 | Ferrer Internacional, S.A. | Oral formulation for the treatment of cardiovascular diseases |
WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1256326C (zh) * | 1995-09-07 | 2006-05-17 | 弗·哈夫曼-拉罗切有限公司 | 治疗心脏和肾功能不全的新型4-(氧烷氧基苯基)-3-氧哌啶化合物 |
-
2000
- 2000-04-04 US US09/542,598 patent/US6197959B1/en not_active Expired - Fee Related
- 2000-04-20 CZ CZ20013737A patent/CZ20013737A3/cs unknown
- 2000-04-20 SK SK1517-2001A patent/SK15172001A3/sk unknown
- 2000-04-20 DE DE60035039T patent/DE60035039T2/de not_active Expired - Fee Related
- 2000-04-20 JP JP2000614239A patent/JP3602449B2/ja not_active Expired - Fee Related
- 2000-04-20 CN CNB008067988A patent/CN1323079C/zh not_active Expired - Fee Related
- 2000-04-20 EP EP00929401A patent/EP1180103B1/en not_active Expired - Lifetime
- 2000-04-20 AT AT00929401T patent/ATE363478T1/de not_active IP Right Cessation
- 2000-04-20 AU AU47501/00A patent/AU761392B2/en not_active Ceased
- 2000-04-20 MX MXPA01010855A patent/MXPA01010855A/es active IP Right Grant
- 2000-04-20 PL PL00362903A patent/PL362903A1/xx unknown
- 2000-04-20 KR KR10-2001-7013726A patent/KR100476916B1/ko not_active IP Right Cessation
- 2000-04-20 WO PCT/EP2000/003597 patent/WO2000064887A1/en not_active Application Discontinuation
- 2000-04-20 ES ES00929401T patent/ES2286021T3/es not_active Expired - Lifetime
- 2000-04-20 CA CA002370244A patent/CA2370244C/en not_active Expired - Fee Related
- 2000-04-20 TR TR2001/03067T patent/TR200103067T2/xx unknown
- 2000-04-20 BR BR0010076-5A patent/BR0010076A/pt not_active IP Right Cessation
- 2000-04-20 HU HU0200881A patent/HUP0200881A3/hu unknown
- 2000-04-24 PE PE2000000377A patent/PE20010068A1/es not_active Application Discontinuation
- 2000-04-25 CO CO00029684A patent/CO5170512A1/es not_active Application Discontinuation
- 2000-04-25 AR ARP000101933A patent/AR018717A1/es active IP Right Grant
-
2001
- 2001-10-23 ZA ZA200108739A patent/ZA200108739B/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP3602449B2 (ja) | 2004-12-15 |
AU4750100A (en) | 2000-11-10 |
CO5170512A1 (es) | 2002-06-27 |
CA2370244C (en) | 2007-03-27 |
ES2286021T3 (es) | 2007-12-01 |
ZA200108739B (en) | 2003-01-23 |
EP1180103B1 (en) | 2007-05-30 |
DE60035039T2 (de) | 2008-02-07 |
KR20020005017A (ko) | 2002-01-16 |
TR200103067T2 (tr) | 2002-05-21 |
CA2370244A1 (en) | 2000-11-02 |
CZ20013737A3 (cs) | 2002-04-17 |
JP2002543072A (ja) | 2002-12-17 |
MXPA01010855A (es) | 2002-05-06 |
DE60035039D1 (de) | 2007-07-12 |
BR0010076A (pt) | 2002-01-15 |
WO2000064887A1 (en) | 2000-11-02 |
HUP0200881A2 (en) | 2002-08-28 |
SK15172001A3 (sk) | 2002-06-04 |
HUP0200881A3 (en) | 2003-05-28 |
ATE363478T1 (de) | 2007-06-15 |
AU761392B2 (en) | 2003-06-05 |
PL362903A1 (en) | 2004-11-02 |
CN1349524A (zh) | 2002-05-15 |
US6197959B1 (en) | 2001-03-06 |
EP1180103A1 (en) | 2002-02-20 |
AR018717A1 (es) | 2001-11-28 |
KR100476916B1 (ko) | 2005-03-17 |
CN1323079C (zh) | 2007-06-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |