UY25230A1 - Derivados de la d-prolina - Google Patents
Derivados de la d-prolinaInfo
- Publication number
- UY25230A1 UY25230A1 UY25230A UY25230A UY25230A1 UY 25230 A1 UY25230 A1 UY 25230A1 UY 25230 A UY25230 A UY 25230A UY 25230 A UY25230 A UY 25230A UY 25230 A1 UY25230 A1 UY 25230A1
- Authority
- UY
- Uruguay
- Prior art keywords
- pyrrolidin
- benzyl
- methyl
- formula
- amyloidosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La invención se refiere a d-prolinas de fórmula (I); útiles en el tratamiento o prevención de todas las formas de amiloidosis central o sistémica. El compuesto de fórmula (I-A) y (I-B) donde R es SH, bencilo o fenilo, opcionalmente sustituído con hidroxilo o alcoxilo inferior o el gruo (II); R1 es H o halógeno; X es -(CH2)n, etc; Y es -S-S-, -(CH2)n, etc; X`es-(CH2)n, bencilo; R2 es alquilo inferior, etc, n es de 0-3 y las sales farmacéuticamente aceptables y a los mono y diésteres. Los trastornos asociados con la amiloidosis son la enfermedad de Alzheimer, diabetes mellitus.También para estos compuestos se asocia la actividad antibacteriana e inhibidores de la enzimas transformadoras de angiotensina. Ejemplo: ácido (R)-1-((S)-3-((R)-2-carboxi-pirrolidín-1-il)-2-metil-3-oxopropil-disulfanil)-2-metil-propionil-pirrolidin-2-carboxílico
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97119031 | 1997-10-31 | ||
EP98113851 | 1998-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25230A1 true UY25230A1 (es) | 2001-01-31 |
Family
ID=26145860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25230A UY25230A1 (es) | 1997-10-31 | 1998-10-29 | Derivados de la d-prolina |
Country Status (35)
Country | Link |
---|---|
US (4) | US6103910A (es) |
EP (1) | EP0915088B1 (es) |
JP (1) | JP3048558B2 (es) |
KR (2) | KR100313637B1 (es) |
CN (1) | CN100357270C (es) |
AR (1) | AR015473A1 (es) |
AT (1) | ATE224366T1 (es) |
AU (1) | AU750734B2 (es) |
BR (1) | BR9804378B1 (es) |
CA (1) | CA2252163C (es) |
CO (1) | CO5011076A1 (es) |
CZ (1) | CZ296252B6 (es) |
DE (1) | DE69808017T2 (es) |
DK (1) | DK0915088T3 (es) |
EG (1) | EG23756A (es) |
ES (1) | ES2182203T3 (es) |
HK (1) | HK1019875A1 (es) |
HR (1) | HRP980572B1 (es) |
HU (1) | HUP9802465A1 (es) |
ID (1) | ID21194A (es) |
IL (1) | IL126787A (es) |
MA (1) | MA26559A1 (es) |
MY (1) | MY142803A (es) |
NO (1) | NO312064B1 (es) |
PE (1) | PE123499A1 (es) |
PL (1) | PL196967B1 (es) |
PT (1) | PT915088E (es) |
RS (1) | RS49589B (es) |
RU (1) | RU2201937C2 (es) |
SA (1) | SA98190749B1 (es) |
SG (1) | SG74094A1 (es) |
SI (1) | SI0915088T1 (es) |
TR (1) | TR199802197A2 (es) |
TW (1) | TW585854B (es) |
UY (1) | UY25230A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060211731A1 (en) * | 1999-05-05 | 2006-09-21 | Les Laboratories Servier | New substituted pyridine or piperidine compounds |
FR2793245B1 (fr) * | 1999-05-05 | 2002-10-11 | Adir | Nouveaux composes pyridiniques ou piperidiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
AU6611800A (en) * | 1999-08-05 | 2001-03-05 | Procter & Gamble Company, The | Method of treating hair loss using multivalent ketoamides and amides |
CA2413418A1 (en) | 2000-06-21 | 2001-12-27 | Joseph B. Santella | Piperidine amides as modulators of chemokine receptor activity |
FI20011466A0 (fi) | 2001-07-04 | 2001-07-04 | Orion Corp | Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä, niiden valmistusmenetelmiä ja käyttö |
GB0119370D0 (en) | 2001-08-08 | 2001-10-03 | Univ London | Therapeutic agent |
JP4472333B2 (ja) * | 2001-08-08 | 2010-06-02 | ペントラキシン セラピューティクス リミテッド | 好ましくないタンパク質群を患者の血漿から除去するための薬剤 |
US6903129B2 (en) * | 2001-12-14 | 2005-06-07 | Hoffman-La Roche Inc. | D-proline prodrugs |
US7091357B2 (en) * | 2001-12-26 | 2006-08-15 | University Of Kentucky Research Foundation | Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies |
AU2003223708A1 (en) * | 2002-04-23 | 2003-11-10 | Axys Pharmaceuticals, Inc. | Novel phenyl derivatives as inducers of apoptosis |
DE10240026A1 (de) * | 2002-08-27 | 2004-03-11 | Merck Patent Gmbh | Verfahren zur Herstellung von Monoalkylaminoketonen |
FI20030014A0 (fi) * | 2003-01-03 | 2003-01-03 | Orion Corp | Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä |
US7553819B2 (en) | 2003-05-12 | 2009-06-30 | Theracarb Inc. | Multivalent inhibitors of serum amyloid P component |
WO2004103995A1 (en) * | 2003-05-20 | 2004-12-02 | Novartis Ag | N-acyl nitrogen heterocycles as ligands of peroxisome proliferator-activated receptors |
GB0313386D0 (en) * | 2003-06-10 | 2003-07-16 | Univ London | Treatment of disease |
DE102004010943A1 (de) * | 2004-03-03 | 2005-09-29 | Degussa Ag | Verfahren zur Herstellung von N-geschützten 4-Ketprolinderivaten |
ITMI20041567A1 (it) * | 2004-07-30 | 2004-10-30 | Maycos Italiana Di Comini Miro | "derivati n-acilati di acidi bicarbossilici con amminoacidi e con idrolizzati proteici vegetali e loro applicazione in prodotti cosmetici, dermofarmaceutici e farmaceutici" |
CN1834095B (zh) * | 2005-03-18 | 2011-04-20 | 中国科学院上海药物研究所 | 一类非核苷类抗病毒抑制剂及其制备方法和用途 |
JP2009504756A (ja) * | 2005-08-17 | 2009-02-05 | シェーリング コーポレイション | 新規な高親和性のチオフェンベースおよびフランベースのキナーゼリガンド |
WO2008014232A2 (en) * | 2006-07-24 | 2008-01-31 | Emisphere Technologies, Inc. | Pharmaceutical formulations for the treatment of alzheimer's disease |
GB0712503D0 (en) | 2007-06-27 | 2007-08-08 | Therapeutics Pentraxin Ltd | Use |
WO2009155962A1 (en) * | 2008-06-27 | 2009-12-30 | Pentraxin Therapeutics Limited | Use |
GB2470187A (en) * | 2009-05-11 | 2010-11-17 | Pharmapatents Global Ltd | Captopril polymers |
US9434716B2 (en) | 2011-03-01 | 2016-09-06 | Glaxo Group Limited | Antigen binding proteins |
UA108227C2 (xx) | 2010-03-03 | 2015-04-10 | Антигензв'язуючий білок | |
CN104219964B (zh) * | 2012-03-30 | 2016-09-21 | 奇华顿股份有限公司 | 作为食品加香化合物的n-酰基脯氨酸衍生物 |
CN103333095B (zh) * | 2013-06-26 | 2015-06-24 | 中国人民解放军第二军医大学 | 己二酰二d-羟脯氨酸衍生物及其作为核酸疫苗佐剂的应用 |
DE102013012622A1 (de) * | 2013-07-30 | 2015-02-05 | Clariant lnternational Ltd | Neue sterisch gehinderte cyclische Amine |
GB201407506D0 (en) * | 2014-04-29 | 2014-06-11 | Glaxosmithkline Ip Dev Ltd | Novel compound |
DE102015000124A1 (de) * | 2015-01-07 | 2016-07-07 | Clariant International Ltd. | Verfahren zur Stabilisierung von Polyamiden |
GB201518950D0 (en) * | 2015-10-27 | 2015-12-09 | Glaxosmithkline Ip Dev Ltd | Compound |
WO2017072090A1 (en) * | 2015-10-27 | 2017-05-04 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2328391A1 (de) * | 1972-06-19 | 1974-01-10 | Degussa | Trialkoxycinnamoylaminocarbonsaeuren |
US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
US4046889A (en) * | 1976-02-13 | 1977-09-06 | E. R. Squibb & Sons, Inc. | Azetidine-2-carboxylic acid derivatives |
AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
JPS53108922A (en) * | 1977-03-04 | 1978-09-22 | Sumitomo Chem Co Ltd | Novel synthesis of opticallactive hydroxyacid |
US4499102A (en) * | 1979-12-13 | 1985-02-12 | Santen Pharmaceutical Co., Ltd. | Thiazolidine and pyrrolidine compounds and pharmaceutical compositions containing them |
US4386075A (en) * | 1982-02-17 | 1983-05-31 | Smithkline Beckman Corporation | Renally active tetrapeptides |
CA1247086A (en) * | 1982-02-17 | 1988-12-20 | Francis R. Pfeiffer | Renally active tetrapeptides |
CA1333807C (en) * | 1987-06-15 | 1995-01-03 | David R. Kronenthal | Process for preparing (trans)-4-phenyl-l-proline derivatives |
JPH0832704B2 (ja) * | 1987-11-30 | 1996-03-29 | キッセイ薬品工業株式会社 | プロリルエンドペプチダーゼ阻害剤 |
JPH01250370A (ja) * | 1987-12-23 | 1989-10-05 | Zeria Pharmaceut Co Ltd | 新規アミノ酸イミド誘導体、製法ならびに用途 |
JPH02157262A (ja) * | 1988-12-10 | 1990-06-18 | Meiji Seika Kaisha Ltd | 生理活性を有する新規なピロリジン誘導体 |
US4999417A (en) * | 1989-03-30 | 1991-03-12 | Nova Pharmaceutical Corporation | Biodegradable polymer compositions |
GB8912303D0 (en) * | 1989-05-27 | 1989-07-12 | Pfizer Ltd | Therapeutic agents |
US5439930A (en) * | 1992-04-14 | 1995-08-08 | Russian-American Institute For New Drug Development | Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects |
JPH0661099A (ja) * | 1992-08-05 | 1994-03-04 | Mitsubishi Petrochem Co Ltd | 電解コンデンサ駆動用電解液 |
JP3274247B2 (ja) * | 1993-09-20 | 2002-04-15 | 杏林製薬株式会社 | 光学活性なインドリン誘導体の製法と中間体 |
FR2712888B1 (fr) * | 1993-11-23 | 1996-02-09 | Bioeurope | Utilisation de alpha-D-alkylglucopyranosides et esters de ceux-ci pour la préparation de prodrogues capables de traverser la barrière hématoencéphalique, prodrogues obtenues et précurseurs de celles-ci. |
JPH0840896A (ja) * | 1994-08-04 | 1996-02-13 | Teisan Seiyaku Kk | カプトプリル類似体からなる医薬製剤 |
EP0850230A1 (en) * | 1995-09-15 | 1998-07-01 | Smithkline Beecham Plc | Pyrrolidine and thiazole derivatives with antibacterial and metallo-beta-lactamase inhibitory properties |
JPH09157251A (ja) * | 1995-10-06 | 1997-06-17 | Kanegafuchi Chem Ind Co Ltd | N−(D−α−メチル−β−メルカプトプロピオニル)−L−プロリン及び該中間体の製造方法 |
AU1072897A (en) * | 1995-12-12 | 1997-07-03 | Karolinska Innovations Ab | Peptide binding the klvff-sequence of amyloid beta |
-
1998
- 1998-10-22 EP EP98119986A patent/EP0915088B1/en not_active Expired - Lifetime
- 1998-10-22 PT PT98119986T patent/PT915088E/pt unknown
- 1998-10-22 SI SI9830254T patent/SI0915088T1/xx unknown
- 1998-10-22 AT AT98119986T patent/ATE224366T1/de active
- 1998-10-22 ES ES98119986T patent/ES2182203T3/es not_active Expired - Lifetime
- 1998-10-22 DE DE69808017T patent/DE69808017T2/de not_active Expired - Lifetime
- 1998-10-22 DK DK98119986T patent/DK0915088T3/da active
- 1998-10-26 HU HU9802465A patent/HUP9802465A1/hu unknown
- 1998-10-27 US US09/179,652 patent/US6103910A/en not_active Expired - Lifetime
- 1998-10-28 CA CA002252163A patent/CA2252163C/en not_active Expired - Fee Related
- 1998-10-28 TR TR1998/02197A patent/TR199802197A2/xx unknown
- 1998-10-28 RS YUP-476/98A patent/RS49589B/sr unknown
- 1998-10-28 IL IL12678798A patent/IL126787A/xx not_active IP Right Cessation
- 1998-10-29 EG EG132998A patent/EG23756A/xx active
- 1998-10-29 JP JP10307719A patent/JP3048558B2/ja not_active Expired - Fee Related
- 1998-10-29 TW TW087117984A patent/TW585854B/zh not_active IP Right Cessation
- 1998-10-29 MY MYPI98004942A patent/MY142803A/en unknown
- 1998-10-29 ID IDP981417A patent/ID21194A/id unknown
- 1998-10-29 AR ARP980105433A patent/AR015473A1/es active IP Right Grant
- 1998-10-29 UY UY25230A patent/UY25230A1/es not_active IP Right Cessation
- 1998-10-29 AU AU89599/98A patent/AU750734B2/en not_active Ceased
- 1998-10-29 CO CO98063547A patent/CO5011076A1/es unknown
- 1998-10-29 CZ CZ0346398A patent/CZ296252B6/cs not_active IP Right Cessation
- 1998-10-30 SG SG1998004381A patent/SG74094A1/en unknown
- 1998-10-30 KR KR1019980046216A patent/KR100313637B1/ko not_active IP Right Cessation
- 1998-10-30 NO NO19985059A patent/NO312064B1/no not_active IP Right Cessation
- 1998-10-30 BR BRPI9804378-1A patent/BR9804378B1/pt not_active IP Right Cessation
- 1998-10-30 HR HR980572A patent/HRP980572B1/xx not_active IP Right Cessation
- 1998-10-30 PL PL329440A patent/PL196967B1/pl not_active IP Right Cessation
- 1998-10-30 CN CNB98123674XA patent/CN100357270C/zh not_active Expired - Fee Related
- 1998-10-30 PE PE1998001027A patent/PE123499A1/es not_active Application Discontinuation
- 1998-10-30 MA MA25327A patent/MA26559A1/fr unknown
- 1998-10-30 RU RU98120057/04A patent/RU2201937C2/ru not_active IP Right Cessation
- 1998-11-14 SA SA98190749A patent/SA98190749B1/ar unknown
-
1999
- 1999-10-17 HK HK99104814A patent/HK1019875A1/xx not_active IP Right Cessation
-
2000
- 2000-02-16 US US09/505,375 patent/US6262089B1/en not_active Expired - Lifetime
- 2000-08-10 US US09/636,076 patent/US6512001B1/en not_active Expired - Lifetime
-
2001
- 2001-05-24 KR KR1020010028656A patent/KR100342284B1/ko not_active IP Right Cessation
-
2002
- 2002-07-01 US US10/186,781 patent/US6740760B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY25230A1 (es) | Derivados de la d-prolina | |
DK0675886T3 (da) | Aminomethylensubstituerede ikke-aromatiske heterocykler og deres anvendelse som substance P-antagonister | |
ATE239727T1 (de) | Fungizide trifluoromethylalkylamino- triazolopyrimidine-derivate | |
ES2166379T3 (es) | 2-aminotetralinas sustituidas. | |
MX9307332A (es) | 3-(aminoalquilamino)-1,2-bencisoxasoles substituidos y compuestos relacionados. | |
NO20051282L (no) | Antitumorale analoger av lamellariner. | |
ID24846A (id) | Turunan-turunan bifenilamidina | |
CA2356985A1 (en) | 5ht1 antagonists for antidepressant therapy | |
DE69629341D1 (de) | Pyrrolocarbazolderivate | |
DE69828197D1 (de) | Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut | |
ATE196464T1 (de) | Benzol-derivate, verwendbar für ischämische erkrankungen | |
ATE226585T1 (de) | Thiazolobenzoheterocyclen, ihre herstellung und diese enthaltende phatrmazeutische zubereitungen | |
FI895229A0 (fi) | Foereningar foer behandling av urininkontinens och framstaellning daerav. | |
ATE146481T1 (de) | Epoxysuccinamidsäurederivat | |
FI914219A0 (fi) | 3-(1h-indazol-3-yl)-4-pyridinaminer, foerfarande och mellanprodukter foer deras framstaellning och deras anvaendning som laekemedel. | |
DE3660171D1 (de) | Benzaldoxime carbamate derivatives | |
RS50791B (sr) | Farmaceutske kombinacije zasnovane na derivatima piridoindolona | |
FI933652A (fi) | Foerfarande foer framstaellning av 1-osubstituerade 3-aminopyrroler |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
110 | Patent granted |
Effective date: 20100625 |
|
VENC | Patent expired |
Effective date: 20181029 |