YU47698A - Derivati d-prolina - Google Patents
Derivati d-prolinaInfo
- Publication number
- YU47698A YU47698A YU47698A YU47698A YU47698A YU 47698 A YU47698 A YU 47698A YU 47698 A YU47698 A YU 47698A YU 47698 A YU47698 A YU 47698A YU 47698 A YU47698 A YU 47698A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- benzyl
- ch2c6h5
- phenylene
- naphthyl
- cyclohexyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Ovaj pronalazak se odnosi na D-proline formule ili u kojoj oznacavaju R SH, benzil ili fenil, koji je opciono supstituisan hidroksi- ili nizom alkoksi-grupom, ili grupu R1 vodonik ili halogen, X -(CH2)n-, -CH(R2)(CH2)n-, -CH2O(CH2)n-, -CH2NH-, benzil, -C(R2)=CH-, -CH2CH(OH)- ili tiazol-2,5-diil, Y -S-S-, -(CH2)n-, -O-, -NH-, -N(R2)-, -CH=CH-, -NHC(O)NH-, -N(R2)C(O)N(R2)-, -N[CH2C6H3(OCH3)2]-, -N(CH2C6H5)-, -N(CH2C6H5)C(O)N(CH2C6H5)-, -N(alkoksialkil)-, -N(cikloalkil-metil)-, 2,6-piridil, 2,5-furanil, 2,5-tienil, 1,2-cikloheksil, 1,3-cikloheksil, 1,4-cikloheksil, 1,2-naftil, 1,4-naftil, 1,5-naftil, 1,6-naftil, bifenilen ili 1,2-fenilen, 1,3-fenilen i 1,4-fenilen, pri cemu su fenilen grupe opciono supstituisane sa 1-4 supstituenata, koji su odabrani izmedju halogena, nize alkil-, nize alkoksi-, hidroksi-, karboksi-, -COO-nize alkil-, nitrilo-, 5-tetrazol-, (2-karboksilna kiselina-pirolidin-1-il)-2-okso-etoksi-, N-hidroksikarbami-midoil-, 5-okso-[1,2,4]oksadiazolil, 2-okso[1,2,3,5]- oksatiadiazolil-, 5-tiokso-[1,2,4] oksadiazolil i 5-terc-butilsulfanil-[1,2,4] oksadiazolil-grupe, X' -(CH2)n-, -(CH2)nCH(R2)-, -(CH2)nOCH2-, -NHCH2-, benzil, -CH=C(R2)-, -CH(OH)CH2- ili tiazol-2,5-diil, R2 nizi alkil, nizi alkoksi ili benzil i n 0-3, i na njihove farmaceutski prihvatljive soli i mono- i diestre. D-Prolini formule I-A i I-B mogu se primeniti u lecenju ili prevenciji svih oblika centralne i sistemske amiloidoze.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97119031 | 1997-10-31 | ||
| EP98113851 | 1998-07-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU47698A true YU47698A (sh) | 2001-07-10 |
| RS49589B RS49589B (sr) | 2007-06-04 |
Family
ID=26145860
Country Status (35)
| Country | Link |
|---|---|
| US (4) | US6103910A (sh) |
| EP (1) | EP0915088B1 (sh) |
| JP (1) | JP3048558B2 (sh) |
| KR (2) | KR100313637B1 (sh) |
| CN (1) | CN100357270C (sh) |
| AR (1) | AR015473A1 (sh) |
| AT (1) | ATE224366T1 (sh) |
| AU (1) | AU750734B2 (sh) |
| BR (1) | BR9804378B1 (sh) |
| CA (1) | CA2252163C (sh) |
| CO (1) | CO5011076A1 (sh) |
| CZ (1) | CZ296252B6 (sh) |
| DE (1) | DE69808017T2 (sh) |
| DK (1) | DK0915088T3 (sh) |
| EG (1) | EG23756A (sh) |
| ES (1) | ES2182203T3 (sh) |
| HK (1) | HK1019875A1 (sh) |
| HR (1) | HRP980572B1 (sh) |
| HU (1) | HUP9802465A1 (sh) |
| ID (1) | ID21194A (sh) |
| IL (1) | IL126787A (sh) |
| MA (1) | MA26559A1 (sh) |
| MY (1) | MY142803A (sh) |
| NO (1) | NO312064B1 (sh) |
| PE (1) | PE123499A1 (sh) |
| PL (1) | PL196967B1 (sh) |
| PT (1) | PT915088E (sh) |
| RS (1) | RS49589B (sh) |
| RU (1) | RU2201937C2 (sh) |
| SA (1) | SA98190749B1 (sh) |
| SG (1) | SG74094A1 (sh) |
| SI (1) | SI0915088T1 (sh) |
| TR (1) | TR199802197A2 (sh) |
| TW (1) | TW585854B (sh) |
| UY (1) | UY25230A1 (sh) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2793245B1 (fr) * | 1999-05-05 | 2002-10-11 | Adir | Nouveaux composes pyridiniques ou piperidiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US20060211731A1 (en) * | 1999-05-05 | 2006-09-21 | Les Laboratories Servier | New substituted pyridine or piperidine compounds |
| WO2001010836A1 (en) * | 1999-08-05 | 2001-02-15 | The Procter & Gamble Company | Method of treating hair loss using multivalent ketoamides and amides |
| EP1296949A2 (en) | 2000-06-21 | 2003-04-02 | Bristol-Myers Squibb Pharma Company | Piperidine amides as modulators of chemokine receptor activity |
| FI20011466A0 (fi) * | 2001-07-04 | 2001-07-04 | Orion Corp | Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä, niiden valmistusmenetelmiä ja käyttö |
| ATE361068T1 (de) | 2001-08-08 | 2007-05-15 | Pentraxin Therapeutics Ltd | Wirkstoff zur entfernung einer unerwünschten proteinpopulation aus dem plasma |
| GB0119370D0 (en) * | 2001-08-08 | 2001-10-03 | Univ London | Therapeutic agent |
| US6903129B2 (en) * | 2001-12-14 | 2005-06-07 | Hoffman-La Roche Inc. | D-proline prodrugs |
| US7091357B2 (en) * | 2001-12-26 | 2006-08-15 | University Of Kentucky Research Foundation | Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies |
| WO2003090680A2 (en) * | 2002-04-23 | 2003-11-06 | Axys Pharmaceuticals, Inc. | Novel phenyl derivatives as inducers of apoptosis |
| DE10240026A1 (de) * | 2002-08-27 | 2004-03-11 | Merck Patent Gmbh | Verfahren zur Herstellung von Monoalkylaminoketonen |
| FI20030014A0 (fi) * | 2003-01-03 | 2003-01-03 | Orion Corp | Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä |
| CA2525302A1 (en) | 2003-05-12 | 2004-11-18 | David Bundle | Multivalent inhibitors of serum amyloid p component |
| AR044399A1 (es) | 2003-05-20 | 2005-09-14 | Novartis Ag | Compuestos heterociclicos y su uso como activadores de receptores de ppar. composiciones farmaceuticas que los contienen |
| GB0313386D0 (en) | 2003-06-10 | 2003-07-16 | Univ London | Treatment of disease |
| DE102004010943A1 (de) * | 2004-03-03 | 2005-09-29 | Degussa Ag | Verfahren zur Herstellung von N-geschützten 4-Ketprolinderivaten |
| ITMI20041567A1 (it) * | 2004-07-30 | 2004-10-30 | Maycos Italiana Di Comini Miro | "derivati n-acilati di acidi bicarbossilici con amminoacidi e con idrolizzati proteici vegetali e loro applicazione in prodotti cosmetici, dermofarmaceutici e farmaceutici" |
| CN1834095B (zh) * | 2005-03-18 | 2011-04-20 | 中国科学院上海药物研究所 | 一类非核苷类抗病毒抑制剂及其制备方法和用途 |
| JP2009504756A (ja) * | 2005-08-17 | 2009-02-05 | シェーリング コーポレイション | 新規な高親和性のチオフェンベースおよびフランベースのキナーゼリガンド |
| WO2008014232A2 (en) * | 2006-07-24 | 2008-01-31 | Emisphere Technologies, Inc. | Pharmaceutical formulations for the treatment of alzheimer's disease |
| GB0712503D0 (en) | 2007-06-27 | 2007-08-08 | Therapeutics Pentraxin Ltd | Use |
| AU2008358292B2 (en) * | 2008-06-27 | 2015-05-07 | Pentraxin Therapeutics Limited | Use |
| GB2470187A (en) * | 2009-05-11 | 2010-11-17 | Pharmapatents Global Ltd | Captopril polymers |
| UA108227C2 (xx) | 2010-03-03 | 2015-04-10 | Антигензв'язуючий білок | |
| US9434716B2 (en) | 2011-03-01 | 2016-09-06 | Glaxo Group Limited | Antigen binding proteins |
| US10711230B2 (en) * | 2012-03-30 | 2020-07-14 | Givaudan Sa | N-acyl proline derivatives as food flavoring compounds |
| CN103333095B (zh) * | 2013-06-26 | 2015-06-24 | 中国人民解放军第二军医大学 | 己二酰二d-羟脯氨酸衍生物及其作为核酸疫苗佐剂的应用 |
| DE102013012622A1 (de) * | 2013-07-30 | 2015-02-05 | Clariant lnternational Ltd | Neue sterisch gehinderte cyclische Amine |
| GB201407506D0 (en) * | 2014-04-29 | 2014-06-11 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| DE102015000124A1 (de) * | 2015-01-07 | 2016-07-07 | Clariant International Ltd. | Verfahren zur Stabilisierung von Polyamiden |
| WO2017072090A1 (en) * | 2015-10-27 | 2017-05-04 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy |
| GB201518950D0 (en) * | 2015-10-27 | 2015-12-09 | Glaxosmithkline Ip Dev Ltd | Compound |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2328391A1 (de) * | 1972-06-19 | 1974-01-10 | Degussa | Trialkoxycinnamoylaminocarbonsaeuren |
| US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
| AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
| US4046889A (en) * | 1976-02-13 | 1977-09-06 | E. R. Squibb & Sons, Inc. | Azetidine-2-carboxylic acid derivatives |
| JPS53108922A (en) * | 1977-03-04 | 1978-09-22 | Sumitomo Chem Co Ltd | Novel synthesis of opticallactive hydroxyacid |
| US4499102A (en) * | 1979-12-13 | 1985-02-12 | Santen Pharmaceutical Co., Ltd. | Thiazolidine and pyrrolidine compounds and pharmaceutical compositions containing them |
| CA1247086A (en) * | 1982-02-17 | 1988-12-20 | Francis R. Pfeiffer | Renally active tetrapeptides |
| US4386075A (en) * | 1982-02-17 | 1983-05-31 | Smithkline Beckman Corporation | Renally active tetrapeptides |
| CA1333807C (en) * | 1987-06-15 | 1995-01-03 | David R. Kronenthal | Process for preparing (trans)-4-phenyl-l-proline derivatives |
| JPH0832704B2 (ja) * | 1987-11-30 | 1996-03-29 | キッセイ薬品工業株式会社 | プロリルエンドペプチダーゼ阻害剤 |
| JPH01250370A (ja) * | 1987-12-23 | 1989-10-05 | Zeria Pharmaceut Co Ltd | 新規アミノ酸イミド誘導体、製法ならびに用途 |
| JPH02157262A (ja) * | 1988-12-10 | 1990-06-18 | Meiji Seika Kaisha Ltd | 生理活性を有する新規なピロリジン誘導体 |
| US4999417A (en) * | 1989-03-30 | 1991-03-12 | Nova Pharmaceutical Corporation | Biodegradable polymer compositions |
| GB8912303D0 (en) * | 1989-05-27 | 1989-07-12 | Pfizer Ltd | Therapeutic agents |
| US5439930A (en) * | 1992-04-14 | 1995-08-08 | Russian-American Institute For New Drug Development | Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects |
| JPH0661099A (ja) * | 1992-08-05 | 1994-03-04 | Mitsubishi Petrochem Co Ltd | 電解コンデンサ駆動用電解液 |
| JP3274247B2 (ja) * | 1993-09-20 | 2002-04-15 | 杏林製薬株式会社 | 光学活性なインドリン誘導体の製法と中間体 |
| FR2712888B1 (fr) * | 1993-11-23 | 1996-02-09 | Bioeurope | Utilisation de alpha-D-alkylglucopyranosides et esters de ceux-ci pour la préparation de prodrogues capables de traverser la barrière hématoencéphalique, prodrogues obtenues et précurseurs de celles-ci. |
| JPH0840896A (ja) * | 1994-08-04 | 1996-02-13 | Teisan Seiyaku Kk | カプトプリル類似体からなる医薬製剤 |
| AU7084996A (en) * | 1995-09-15 | 1997-04-01 | Smithkline Beecham Plc | Pyrrolidine and thiazole derivatives with antibacterial and metallo-beta-lactamase inhibitory properties |
| JPH09157251A (ja) * | 1995-10-06 | 1997-06-17 | Kanegafuchi Chem Ind Co Ltd | Ｎ−（Ｄ−α−メチル−β−メルカプトプロピオニル）−Ｌ−プロリン及び該中間体の製造方法 |
| WO1997021728A1 (en) * | 1995-12-12 | 1997-06-19 | Karolinska Innovations Ab | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
-
1998
- 1998-10-22 PT PT98119986T patent/PT915088E/pt unknown
- 1998-10-22 DK DK98119986T patent/DK0915088T3/da active
- 1998-10-22 DE DE69808017T patent/DE69808017T2/de not_active Expired - Lifetime
- 1998-10-22 EP EP98119986A patent/EP0915088B1/en not_active Expired - Lifetime
- 1998-10-22 SI SI9830254T patent/SI0915088T1/xx unknown
- 1998-10-22 ES ES98119986T patent/ES2182203T3/es not_active Expired - Lifetime
- 1998-10-22 AT AT98119986T patent/ATE224366T1/de active
- 1998-10-26 HU HU9802465A patent/HUP9802465A1/hu unknown
- 1998-10-27 US US09/179,652 patent/US6103910A/en not_active Expired - Lifetime
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