PL369819A1 - Pyrimidine derivatives - Google Patents

Pyrimidine derivatives

Info

Publication number
PL369819A1
PL369819A1 PL02369819A PL36981902A PL369819A1 PL 369819 A1 PL369819 A1 PL 369819A1 PL 02369819 A PL02369819 A PL 02369819A PL 36981902 A PL36981902 A PL 36981902A PL 369819 A1 PL369819 A1 PL 369819A1
Authority
PL
Poland
Prior art keywords
sup
pyrimidine derivatives
treatment
inhibition
therapy
Prior art date
Application number
PL02369819A
Other languages
Polish (pl)
Inventor
Hans-Michael Eggenweiler
Manfred Baumgarth
Pierre Schelling
Norbert Beier
Maria Christadler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL369819A1 publication Critical patent/PL369819A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Pyrimidine derivatives of the formula (I) and physiologically acceptable salts thereof, in which R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, W, X, Y and Z are as defined in claim 1, exhibit phosphodiesterase V inhibition and can be employed for the treatment of diseases of the cardiovascular system and for the treatment and/or therapy of potency disorders
PL02369819A 2001-10-04 2002-09-05 Pyrimidine derivatives PL369819A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10148883A DE10148883A1 (en) 2001-10-04 2001-10-04 New fused bi- or tricyclic pyrimidine derivatives, are phosphodiesterase V inhibitors useful e.g. for treating impotence, cardiovascular disorders, inflammation or tumors

Publications (1)

Publication Number Publication Date
PL369819A1 true PL369819A1 (en) 2005-05-02

Family

ID=7701322

Family Applications (1)

Application Number Title Priority Date Filing Date
PL02369819A PL369819A1 (en) 2001-10-04 2002-09-05 Pyrimidine derivatives

Country Status (16)

Country Link
US (1) US7312224B2 (en)
EP (1) EP1432715B1 (en)
JP (1) JP4782376B2 (en)
KR (1) KR20040041166A (en)
CN (1) CN1863803A (en)
AT (1) ATE389655T1 (en)
AU (1) AU2002362806B2 (en)
BR (1) BR0213037A (en)
CA (1) CA2462799C (en)
DE (2) DE10148883A1 (en)
ES (1) ES2303564T3 (en)
HU (1) HUP0401654A3 (en)
PL (1) PL369819A1 (en)
RU (1) RU2004114239A (en)
WO (1) WO2003031447A2 (en)
ZA (1) ZA200403334B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005061170A1 (en) * 2005-12-21 2007-07-05 Bayer Healthcare Ag New furo-pyrimidine derivatives, useful for treating cardiovascular disease, e. g. angina or hypertension, are activators of prostacyclin receptors
DE102005061171A1 (en) * 2005-12-21 2007-07-05 Bayer Healthcare Ag New furopyrimidine derivatives useful for treating cardiovascular diseases
AR062501A1 (en) * 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd THERAPEUTIC COMPOSITIONS
ES2544082T3 (en) * 2006-12-07 2015-08-27 F. Hoffmann-La Roche Ag Phosphoinositide 3-kinase inhibitor compounds and methods of use
DE102007027799A1 (en) * 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituted furopyrimidines and their use
DE102007027800A1 (en) * 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituted bicyclic heteroaryl compounds and their use
DE102007051762A1 (en) * 2007-10-30 2009-05-07 Bayer Healthcare Ag Substituted pyrrolotriazines and their use
DE102007054786A1 (en) * 2007-11-16 2009-05-20 Bayer Healthcare Ag Trisubstituted Furopyrimidines and their Use
WO2011143607A1 (en) * 2010-05-14 2011-11-17 The Regents Of The University Of California Modulation of bioactive epoxy-fatty acid levels by phosphodiesterase inhibitors
CN103119047B (en) 2010-07-23 2016-06-15 哈佛大学校长及研究员协会 Tricyclic antidepressants proteasome activity strengthens compound
WO2013112651A2 (en) * 2012-01-25 2013-08-01 Proteostasis Therapeutics, Inc. Proteasome activity modulating compounds
US10344032B2 (en) 2014-09-17 2019-07-09 Pécsi Tudományegyetem Agents for treating neurogenic inflammation and neuropathic hyperalgesia related disorders
WO2016133788A1 (en) 2015-02-20 2016-08-25 The Regents Of The University Of California Methods of inhibiting pain
CN108137614B (en) * 2015-12-02 2021-01-05 深圳市塔吉瑞生物医药有限公司 Fused pyrimidine compound, composition containing compound and application of compound
CN105461728A (en) * 2015-12-29 2016-04-06 中山大学 4-substituted amino-6-methoxycarbonyl group benzofuran and [2,3-d] pyrimidine compound and preparing method
RU2625316C1 (en) * 2016-04-13 2017-07-13 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) 2-amino-substituted 6-methoxy-4-trifluoromethyl-9h-pyrimido[4,5b]indoles, method for their production, application and prediminaries

Family Cites Families (17)

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US3037980A (en) * 1955-08-18 1962-06-05 Burroughs Wellcome Co Pyrrolopyrimidine vasodilators and method of making them
GB915303A (en) * 1958-03-13 1963-01-09 Wellcome Found Pyrrolo[2,3-d]pyrimidine derivatives and the manufacture thereof
JPS5542999B2 (en) * 1972-02-14 1980-11-04
CH592668A5 (en) * 1973-10-02 1977-10-31 Delalande Sa
ZA815765B (en) * 1980-08-22 1983-04-27 Du Pont Herbicidal sulfonamides
US4487626A (en) 1980-08-22 1984-12-11 E. I. Du Pont De Nemours And Company Herbicidal sulfonamides
JP2562520B2 (en) * 1989-09-19 1996-12-11 帝人株式会社 Pyrrolo [2,3-d] pyrimidine derivative, method for producing the same and pharmaceutical preparation containing the same as an active ingredient
DE69027862T2 (en) 1989-09-19 1997-03-06 Teijin Ltd., Osaka PYRROLO [2,3-D] PYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION AND MEDICINAL COMPOSITIONS CONTAINING THEM
US5869486A (en) 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
DE19644228A1 (en) 1996-10-24 1998-04-30 Merck Patent Gmbh Thienopyrimidines
DE19752952A1 (en) 1997-11-28 1999-06-02 Merck Patent Gmbh Thienopyrimidines
DE19819023A1 (en) 1998-04-29 1999-11-04 Merck Patent Gmbh Thienopyrimidines
AR020590A1 (en) 1998-06-02 2002-05-22 Cadus Pharmaceutical Corp 7-DIAZAPURINA-N-6 REPLACED, A METHOD FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND IT
DE19942474A1 (en) 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo [4,3-d] pyrimidines
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JP2003519102A (en) 1999-12-02 2003-06-17 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド Compounds specific for the adenosine A 1 lower, 2 A lower and 3 A lower receptors and uses thereof
EA007254B1 (en) 2000-12-01 2006-08-25 Оси Фармасьютикалз, Инк. Compounds specific to adenosine a, aand areceptor and uses thereof

Also Published As

Publication number Publication date
ES2303564T3 (en) 2008-08-16
EP1432715A2 (en) 2004-06-30
BR0213037A (en) 2004-10-05
HUP0401654A2 (en) 2004-11-29
KR20040041166A (en) 2004-05-14
ATE389655T1 (en) 2008-04-15
DE10148883A1 (en) 2003-04-10
JP4782376B2 (en) 2011-09-28
JP2005504847A (en) 2005-02-17
ZA200403334B (en) 2006-05-31
HUP0401654A3 (en) 2006-02-28
CN1863803A (en) 2006-11-15
US7312224B2 (en) 2007-12-25
US20040242595A1 (en) 2004-12-02
AU2002362806B2 (en) 2008-09-18
EP1432715B1 (en) 2008-03-19
CA2462799C (en) 2010-11-02
WO2003031447A3 (en) 2003-08-28
CA2462799A1 (en) 2003-04-17
WO2003031447A2 (en) 2003-04-17
DE50211929D1 (en) 2008-04-30
RU2004114239A (en) 2005-10-27

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Legal Events

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DISC Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)