PL369819A1 - Pyrimidine derivatives - Google Patents
Pyrimidine derivativesInfo
- Publication number
- PL369819A1 PL369819A1 PL02369819A PL36981902A PL369819A1 PL 369819 A1 PL369819 A1 PL 369819A1 PL 02369819 A PL02369819 A PL 02369819A PL 36981902 A PL36981902 A PL 36981902A PL 369819 A1 PL369819 A1 PL 369819A1
- Authority
- PL
- Poland
- Prior art keywords
- sup
- pyrimidine derivatives
- treatment
- inhibition
- therapy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Pyrimidine derivatives of the formula (I) and physiologically acceptable salts thereof, in which R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, W, X, Y and Z are as defined in claim 1, exhibit phosphodiesterase V inhibition and can be employed for the treatment of diseases of the cardiovascular system and for the treatment and/or therapy of potency disorders
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10148883A DE10148883A1 (en) | 2001-10-04 | 2001-10-04 | New fused bi- or tricyclic pyrimidine derivatives, are phosphodiesterase V inhibitors useful e.g. for treating impotence, cardiovascular disorders, inflammation or tumors |
Publications (1)
Publication Number | Publication Date |
---|---|
PL369819A1 true PL369819A1 (en) | 2005-05-02 |
Family
ID=7701322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL02369819A PL369819A1 (en) | 2001-10-04 | 2002-09-05 | Pyrimidine derivatives |
Country Status (16)
Country | Link |
---|---|
US (1) | US7312224B2 (en) |
EP (1) | EP1432715B1 (en) |
JP (1) | JP4782376B2 (en) |
KR (1) | KR20040041166A (en) |
CN (1) | CN1863803A (en) |
AT (1) | ATE389655T1 (en) |
AU (1) | AU2002362806B2 (en) |
BR (1) | BR0213037A (en) |
CA (1) | CA2462799C (en) |
DE (2) | DE10148883A1 (en) |
ES (1) | ES2303564T3 (en) |
HU (1) | HUP0401654A3 (en) |
PL (1) | PL369819A1 (en) |
RU (1) | RU2004114239A (en) |
WO (1) | WO2003031447A2 (en) |
ZA (1) | ZA200403334B (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005061170A1 (en) * | 2005-12-21 | 2007-07-05 | Bayer Healthcare Ag | New furo-pyrimidine derivatives, useful for treating cardiovascular disease, e. g. angina or hypertension, are activators of prostacyclin receptors |
DE102005061171A1 (en) * | 2005-12-21 | 2007-07-05 | Bayer Healthcare Ag | New furopyrimidine derivatives useful for treating cardiovascular diseases |
AR062501A1 (en) * | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | THERAPEUTIC COMPOSITIONS |
ES2544082T3 (en) * | 2006-12-07 | 2015-08-27 | F. Hoffmann-La Roche Ag | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
DE102007027799A1 (en) * | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituted furopyrimidines and their use |
DE102007027800A1 (en) * | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituted bicyclic heteroaryl compounds and their use |
DE102007051762A1 (en) * | 2007-10-30 | 2009-05-07 | Bayer Healthcare Ag | Substituted pyrrolotriazines and their use |
DE102007054786A1 (en) * | 2007-11-16 | 2009-05-20 | Bayer Healthcare Ag | Trisubstituted Furopyrimidines and their Use |
WO2011143607A1 (en) * | 2010-05-14 | 2011-11-17 | The Regents Of The University Of California | Modulation of bioactive epoxy-fatty acid levels by phosphodiesterase inhibitors |
CN103119047B (en) | 2010-07-23 | 2016-06-15 | 哈佛大学校长及研究员协会 | Tricyclic antidepressants proteasome activity strengthens compound |
WO2013112651A2 (en) * | 2012-01-25 | 2013-08-01 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating compounds |
US10344032B2 (en) | 2014-09-17 | 2019-07-09 | Pécsi Tudományegyetem | Agents for treating neurogenic inflammation and neuropathic hyperalgesia related disorders |
WO2016133788A1 (en) | 2015-02-20 | 2016-08-25 | The Regents Of The University Of California | Methods of inhibiting pain |
CN108137614B (en) * | 2015-12-02 | 2021-01-05 | 深圳市塔吉瑞生物医药有限公司 | Fused pyrimidine compound, composition containing compound and application of compound |
CN105461728A (en) * | 2015-12-29 | 2016-04-06 | 中山大学 | 4-substituted amino-6-methoxycarbonyl group benzofuran and [2,3-d] pyrimidine compound and preparing method |
RU2625316C1 (en) * | 2016-04-13 | 2017-07-13 | Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) | 2-amino-substituted 6-methoxy-4-trifluoromethyl-9h-pyrimido[4,5b]indoles, method for their production, application and prediminaries |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3037980A (en) * | 1955-08-18 | 1962-06-05 | Burroughs Wellcome Co | Pyrrolopyrimidine vasodilators and method of making them |
GB915303A (en) * | 1958-03-13 | 1963-01-09 | Wellcome Found | Pyrrolo[2,3-d]pyrimidine derivatives and the manufacture thereof |
JPS5542999B2 (en) * | 1972-02-14 | 1980-11-04 | ||
CH592668A5 (en) * | 1973-10-02 | 1977-10-31 | Delalande Sa | |
ZA815765B (en) * | 1980-08-22 | 1983-04-27 | Du Pont | Herbicidal sulfonamides |
US4487626A (en) | 1980-08-22 | 1984-12-11 | E. I. Du Pont De Nemours And Company | Herbicidal sulfonamides |
JP2562520B2 (en) * | 1989-09-19 | 1996-12-11 | 帝人株式会社 | Pyrrolo [2,3-d] pyrimidine derivative, method for producing the same and pharmaceutical preparation containing the same as an active ingredient |
DE69027862T2 (en) | 1989-09-19 | 1997-03-06 | Teijin Ltd., Osaka | PYRROLO [2,3-D] PYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION AND MEDICINAL COMPOSITIONS CONTAINING THEM |
US5869486A (en) | 1995-02-24 | 1999-02-09 | Ono Pharmaceutical Co., Ltd. | Fused pyrimidines and pyriazines as pharmaceutical compounds |
DE19644228A1 (en) | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidines |
DE19752952A1 (en) | 1997-11-28 | 1999-06-02 | Merck Patent Gmbh | Thienopyrimidines |
DE19819023A1 (en) | 1998-04-29 | 1999-11-04 | Merck Patent Gmbh | Thienopyrimidines |
AR020590A1 (en) | 1998-06-02 | 2002-05-22 | Cadus Pharmaceutical Corp | 7-DIAZAPURINA-N-6 REPLACED, A METHOD FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND IT |
DE19942474A1 (en) | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo [4,3-d] pyrimidines |
DE19944604A1 (en) | 1999-09-17 | 2001-03-22 | Merck Patent Gmbh | Amine derivatives |
JP2003519102A (en) | 1999-12-02 | 2003-06-17 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | Compounds specific for the adenosine A 1 lower, 2 A lower and 3 A lower receptors and uses thereof |
EA007254B1 (en) | 2000-12-01 | 2006-08-25 | Оси Фармасьютикалз, Инк. | Compounds specific to adenosine a, aand areceptor and uses thereof |
-
2001
- 2001-10-04 DE DE10148883A patent/DE10148883A1/en not_active Withdrawn
-
2002
- 2002-09-04 US US10/491,680 patent/US7312224B2/en not_active Expired - Fee Related
- 2002-09-05 HU HU0401654A patent/HUP0401654A3/en unknown
- 2002-09-05 CN CNA028195817A patent/CN1863803A/en active Pending
- 2002-09-05 AT AT02800556T patent/ATE389655T1/en not_active IP Right Cessation
- 2002-09-05 RU RU2004114239/04A patent/RU2004114239A/en not_active Application Discontinuation
- 2002-09-05 JP JP2003534430A patent/JP4782376B2/en not_active Expired - Fee Related
- 2002-09-05 KR KR10-2004-7003997A patent/KR20040041166A/en not_active Application Discontinuation
- 2002-09-05 PL PL02369819A patent/PL369819A1/en unknown
- 2002-09-05 ES ES02800556T patent/ES2303564T3/en not_active Expired - Lifetime
- 2002-09-05 DE DE50211929T patent/DE50211929D1/en not_active Expired - Lifetime
- 2002-09-05 BR BR0213037-8A patent/BR0213037A/en not_active Application Discontinuation
- 2002-09-05 EP EP02800556A patent/EP1432715B1/en not_active Expired - Lifetime
- 2002-09-05 CA CA2462799A patent/CA2462799C/en not_active Expired - Fee Related
- 2002-09-05 WO PCT/EP2002/009935 patent/WO2003031447A2/en active IP Right Grant
- 2002-09-05 AU AU2002362806A patent/AU2002362806B2/en not_active Ceased
-
2004
- 2004-05-03 ZA ZA200403334A patent/ZA200403334B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES2303564T3 (en) | 2008-08-16 |
EP1432715A2 (en) | 2004-06-30 |
BR0213037A (en) | 2004-10-05 |
HUP0401654A2 (en) | 2004-11-29 |
KR20040041166A (en) | 2004-05-14 |
ATE389655T1 (en) | 2008-04-15 |
DE10148883A1 (en) | 2003-04-10 |
JP4782376B2 (en) | 2011-09-28 |
JP2005504847A (en) | 2005-02-17 |
ZA200403334B (en) | 2006-05-31 |
HUP0401654A3 (en) | 2006-02-28 |
CN1863803A (en) | 2006-11-15 |
US7312224B2 (en) | 2007-12-25 |
US20040242595A1 (en) | 2004-12-02 |
AU2002362806B2 (en) | 2008-09-18 |
EP1432715B1 (en) | 2008-03-19 |
CA2462799C (en) | 2010-11-02 |
WO2003031447A3 (en) | 2003-08-28 |
CA2462799A1 (en) | 2003-04-17 |
WO2003031447A2 (en) | 2003-04-17 |
DE50211929D1 (en) | 2008-04-30 |
RU2004114239A (en) | 2005-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DISC | Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications) |