AR018717A1 - COMPUESTOS DERIVADOS DE PIPERIDINA, SU USO, UN PROCESO PARA SU PREPARACIoN, COMPOSICIONES FARMACÉUTICAS QUE LOS COMPRENDEN, Y COMPUESTOS INTERMEDIARIOS. - Google Patents
COMPUESTOS DERIVADOS DE PIPERIDINA, SU USO, UN PROCESO PARA SU PREPARACIoN, COMPOSICIONES FARMACÉUTICAS QUE LOS COMPRENDEN, Y COMPUESTOS INTERMEDIARIOS.Info
- Publication number
- AR018717A1 AR018717A1 ARP000101933A ARP000101933A AR018717A1 AR 018717 A1 AR018717 A1 AR 018717A1 AR P000101933 A ARP000101933 A AR P000101933A AR P000101933 A ARP000101933 A AR P000101933A AR 018717 A1 AR018717 A1 AR 018717A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- piperidine
- understand
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos de la formula (I) en donde R1 y R2 son como se ha definido en la descripcion y reivindicaciones y sales farmacéuticamente aceptables de losmismos. Los compuestos son utiles para el tratamiento de enfermedades que están asociadas con lares tenosis, glaucoma, infarto cardíaco, presion sanguíneaelevada y lesiones en el organo final p.e. insuficiencia cardíaca e insuficiencia renal.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99108200 | 1999-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR018717A1 true AR018717A1 (es) | 2001-11-28 |
Family
ID=8238051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000101933A AR018717A1 (es) | 1999-04-27 | 2000-04-25 | COMPUESTOS DERIVADOS DE PIPERIDINA, SU USO, UN PROCESO PARA SU PREPARACIoN, COMPOSICIONES FARMACÉUTICAS QUE LOS COMPRENDEN, Y COMPUESTOS INTERMEDIARIOS. |
Country Status (22)
Country | Link |
---|---|
US (1) | US6197959B1 (es) |
EP (1) | EP1180103B1 (es) |
JP (1) | JP3602449B2 (es) |
KR (1) | KR100476916B1 (es) |
CN (1) | CN1323079C (es) |
AR (1) | AR018717A1 (es) |
AT (1) | ATE363478T1 (es) |
AU (1) | AU761392B2 (es) |
BR (1) | BR0010076A (es) |
CA (1) | CA2370244C (es) |
CO (1) | CO5170512A1 (es) |
CZ (1) | CZ20013737A3 (es) |
DE (1) | DE60035039T2 (es) |
ES (1) | ES2286021T3 (es) |
HU (1) | HUP0200881A3 (es) |
MX (1) | MXPA01010855A (es) |
PE (1) | PE20010068A1 (es) |
PL (1) | PL362903A1 (es) |
SK (1) | SK15172001A3 (es) |
TR (1) | TR200103067T2 (es) |
WO (1) | WO2000064887A1 (es) |
ZA (1) | ZA200108739B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040214832A1 (en) * | 2003-04-10 | 2004-10-28 | Cuiman Cai | Piperazine derivative renin inhibitors |
TW200900399A (en) * | 2003-10-01 | 2009-01-01 | Speedel Experimenta Ag | Organic compounds |
AR045950A1 (es) * | 2003-10-09 | 2005-11-16 | Speedel Experimenta Ag | Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos. |
CN1906163A (zh) | 2003-11-26 | 2007-01-31 | 诺瓦提斯公司 | 作为肾素抑制剂的4-苯基哌啶衍生物 |
AR053406A1 (es) * | 2004-07-09 | 2007-05-09 | Speedel Experimenta Ag | Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas |
PL1799199T3 (pl) | 2004-10-08 | 2012-09-28 | Novartis Ag | Zastosowanie inhibitorów reniny do zapobiegania lub leczenia dysfunkcji rozkurczowej albo rozkurczowej niewydolności serca |
GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
GB0500784D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
CN101230060A (zh) * | 2005-03-31 | 2008-07-30 | 斯皮德尔实验股份公司 | 取代的哌啶 |
EP1897879A3 (en) * | 2005-03-31 | 2008-06-11 | Speedel Experimenta AG | 2,4,5-substituted piperidines as renin inhibitors |
US20090270380A1 (en) * | 2005-03-31 | 2009-10-29 | Peter Herold | 3,4,5-Substituted Piperidines as Renin Inhibitors |
EP1707202A1 (de) * | 2005-03-31 | 2006-10-04 | Speedel Experimenta AG | Organische Verbindungen |
AR055756A1 (es) * | 2005-03-31 | 2007-09-05 | Speedel Experimenta Ag | Piperidinas sustituidas; procesos de preparacion y su uso como medicamentos |
GB0508992D0 (en) * | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
JP5306811B2 (ja) * | 2005-05-11 | 2013-10-02 | ライフ テクノロジーズ コーポレーション | 2本鎖dnaへの高い選択性を有する蛍光化学物質及びそれらの使用 |
CA2608212A1 (en) | 2005-05-27 | 2006-12-07 | Actelion Pharmaceuticals Ltd | Novel piperidine carboxylic acid amide derivatives |
GB0514203D0 (en) * | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
ES2430139T3 (es) * | 2005-12-30 | 2013-11-19 | Novartis Ag | Compuestos de piperidina 3,5-sustituido como inhibidores de renina |
TW200804359A (en) * | 2006-01-19 | 2008-01-16 | Speedel Experimenta Ag | Substituted 4-phenylpiperidines |
EP1908761A1 (en) * | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Organic compounds |
KR101238479B1 (ko) | 2007-06-25 | 2013-03-04 | 노파르티스 아게 | 레닌 억제제로 사용하기 위한 n5-(2-에톡시에틸)-n3-(2-피리디닐)-3,5-피페리딘디카르복스아미드 유도체 |
US20100267713A1 (en) * | 2007-11-02 | 2010-10-21 | Peter Herold | 4,4-disubstituted piperidines |
WO2010129467A1 (en) * | 2009-05-04 | 2010-11-11 | Plexxikon, Inc. | Compounds and methods for inhibition of renin, and indications therefor |
WO2013045505A1 (en) | 2011-09-28 | 2013-04-04 | Novartis Ag | Biomarkers for raas combination therapy |
EP2810644A1 (en) | 2013-06-06 | 2014-12-10 | Ferrer Internacional, S.A. | Oral formulation for the treatment of cardiovascular diseases |
WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0863875T3 (da) * | 1995-09-07 | 2003-12-01 | Hoffmann La Roche | Hidtil ukendte 4-(oxyalkoxyphenyl)-3-oxy-piperiner til behandling af hjerte- og nyrelidelser |
-
2000
- 2000-04-04 US US09/542,598 patent/US6197959B1/en not_active Expired - Fee Related
- 2000-04-20 MX MXPA01010855A patent/MXPA01010855A/es active IP Right Grant
- 2000-04-20 CA CA002370244A patent/CA2370244C/en not_active Expired - Fee Related
- 2000-04-20 KR KR10-2001-7013726A patent/KR100476916B1/ko not_active IP Right Cessation
- 2000-04-20 DE DE60035039T patent/DE60035039T2/de not_active Expired - Fee Related
- 2000-04-20 TR TR2001/03067T patent/TR200103067T2/xx unknown
- 2000-04-20 WO PCT/EP2000/003597 patent/WO2000064887A1/en not_active Application Discontinuation
- 2000-04-20 BR BR0010076-5A patent/BR0010076A/pt not_active IP Right Cessation
- 2000-04-20 SK SK1517-2001A patent/SK15172001A3/sk unknown
- 2000-04-20 AT AT00929401T patent/ATE363478T1/de not_active IP Right Cessation
- 2000-04-20 CN CNB008067988A patent/CN1323079C/zh not_active Expired - Fee Related
- 2000-04-20 CZ CZ20013737A patent/CZ20013737A3/cs unknown
- 2000-04-20 HU HU0200881A patent/HUP0200881A3/hu unknown
- 2000-04-20 ES ES00929401T patent/ES2286021T3/es not_active Expired - Lifetime
- 2000-04-20 EP EP00929401A patent/EP1180103B1/en not_active Expired - Lifetime
- 2000-04-20 PL PL00362903A patent/PL362903A1/xx unknown
- 2000-04-20 AU AU47501/00A patent/AU761392B2/en not_active Ceased
- 2000-04-20 JP JP2000614239A patent/JP3602449B2/ja not_active Expired - Fee Related
- 2000-04-24 PE PE2000000377A patent/PE20010068A1/es not_active Application Discontinuation
- 2000-04-25 AR ARP000101933A patent/AR018717A1/es active IP Right Grant
- 2000-04-25 CO CO00029684A patent/CO5170512A1/es not_active Application Discontinuation
-
2001
- 2001-10-23 ZA ZA200108739A patent/ZA200108739B/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUP0200881A2 (en) | 2002-08-28 |
DE60035039D1 (de) | 2007-07-12 |
JP2002543072A (ja) | 2002-12-17 |
WO2000064887A1 (en) | 2000-11-02 |
HUP0200881A3 (en) | 2003-05-28 |
DE60035039T2 (de) | 2008-02-07 |
PL362903A1 (en) | 2004-11-02 |
ES2286021T3 (es) | 2007-12-01 |
CA2370244C (en) | 2007-03-27 |
KR100476916B1 (ko) | 2005-03-17 |
CZ20013737A3 (cs) | 2002-04-17 |
AU4750100A (en) | 2000-11-10 |
EP1180103B1 (en) | 2007-05-30 |
KR20020005017A (ko) | 2002-01-16 |
TR200103067T2 (tr) | 2002-05-21 |
PE20010068A1 (es) | 2001-01-29 |
ZA200108739B (en) | 2003-01-23 |
JP3602449B2 (ja) | 2004-12-15 |
ATE363478T1 (de) | 2007-06-15 |
CN1349524A (zh) | 2002-05-15 |
SK15172001A3 (sk) | 2002-06-04 |
EP1180103A1 (en) | 2002-02-20 |
CN1323079C (zh) | 2007-06-27 |
US6197959B1 (en) | 2001-03-06 |
CA2370244A1 (en) | 2000-11-02 |
BR0010076A (pt) | 2002-01-15 |
MXPA01010855A (es) | 2002-05-06 |
AU761392B2 (en) | 2003-06-05 |
CO5170512A1 (es) | 2002-06-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |