DE60035039D1 - Renin inhibitoren - Google Patents

Renin inhibitoren

Info

Publication number
DE60035039D1
DE60035039D1 DE60035039T DE60035039T DE60035039D1 DE 60035039 D1 DE60035039 D1 DE 60035039D1 DE 60035039 T DE60035039 T DE 60035039T DE 60035039 T DE60035039 T DE 60035039T DE 60035039 D1 DE60035039 D1 DE 60035039D1
Authority
DE
Germany
Prior art keywords
renin inhibitors
renin
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60035039T
Other languages
English (en)
Other versions
DE60035039T2 (de
Inventor
Volker Breu
Daniel Bur
Hans-Peter Maerki
Eric Vieira
Wolfgang Wostl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE60035039D1 publication Critical patent/DE60035039D1/de
Publication of DE60035039T2 publication Critical patent/DE60035039T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
DE60035039T 1999-04-27 2000-04-20 Renin-inhibitoren Expired - Fee Related DE60035039T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99108200 1999-04-27
EP99108200 1999-04-27
PCT/EP2000/003597 WO2000064887A1 (en) 1999-04-27 2000-04-20 Renin inhibitors

Publications (2)

Publication Number Publication Date
DE60035039D1 true DE60035039D1 (de) 2007-07-12
DE60035039T2 DE60035039T2 (de) 2008-02-07

Family

ID=8238051

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60035039T Expired - Fee Related DE60035039T2 (de) 1999-04-27 2000-04-20 Renin-inhibitoren

Country Status (22)

Country Link
US (1) US6197959B1 (de)
EP (1) EP1180103B1 (de)
JP (1) JP3602449B2 (de)
KR (1) KR100476916B1 (de)
CN (1) CN1323079C (de)
AR (1) AR018717A1 (de)
AT (1) ATE363478T1 (de)
AU (1) AU761392B2 (de)
BR (1) BR0010076A (de)
CA (1) CA2370244C (de)
CO (1) CO5170512A1 (de)
CZ (1) CZ20013737A3 (de)
DE (1) DE60035039T2 (de)
ES (1) ES2286021T3 (de)
HU (1) HUP0200881A3 (de)
MX (1) MXPA01010855A (de)
PE (1) PE20010068A1 (de)
PL (1) PL362903A1 (de)
SK (1) SK15172001A3 (de)
TR (1) TR200103067T2 (de)
WO (1) WO2000064887A1 (de)
ZA (1) ZA200108739B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040214832A1 (en) * 2003-04-10 2004-10-28 Cuiman Cai Piperazine derivative renin inhibitors
TW200900399A (en) 2003-10-01 2009-01-01 Speedel Experimenta Ag Organic compounds
AR045950A1 (es) * 2003-10-09 2005-11-16 Speedel Experimenta Ag Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos.
CA2546264A1 (en) 2003-11-26 2005-06-09 Novartis Ag 4-phenylpiperidine derivatives as renin inhibitors
AR053406A1 (es) * 2004-07-09 2007-05-09 Speedel Experimenta Ag Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas
RU2407523C2 (ru) 2004-10-08 2010-12-27 Новартис Аг Применение ингибиторов ренина для профилактики или лечения диастолической дисфункции или диастолической сердечной недостаточности
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0500784D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
EP1707202A1 (de) * 2005-03-31 2006-10-04 Speedel Experimenta AG Organische Verbindungen
EP1897879A3 (de) * 2005-03-31 2008-06-11 Speedel Experimenta AG 2,4,5-Substituierte Piperidine als Renin-Inhibitoren
TW200833687A (en) * 2005-03-31 2008-08-16 Speedel Experimenta Ag Substituted piperidines
CN101230060A (zh) * 2005-03-31 2008-07-30 斯皮德尔实验股份公司 取代的哌啶
US20090270380A1 (en) * 2005-03-31 2009-10-29 Peter Herold 3,4,5-Substituted Piperidines as Renin Inhibitors
GB0508992D0 (en) * 2005-05-03 2005-06-08 Novartis Ag Organic compounds
EP1885718B1 (de) * 2005-05-11 2017-03-15 Life Technologies Corporation Chemische fluoreszente verbindungen mit hoher selektivität für doppelstrang-dna sowie verfahren zu ihrer verwendung
US7799805B2 (en) 2005-05-27 2010-09-21 Actelion Pharmaceuticals Ltd. Piperidine carboxylic acid amide derivatives
GB0514203D0 (en) * 2005-07-11 2005-08-17 Novartis Ag Organic compounds
ES2476422T3 (es) * 2005-12-30 2014-07-14 Novartis Ag Compuestos de piperidina 3,5-sustituida como inhibidores de renina
TW200804359A (en) * 2006-01-19 2008-01-16 Speedel Experimenta Ag Substituted 4-phenylpiperidines
EP1908761A1 (de) * 2006-10-04 2008-04-09 Speedel Experimenta AG Organische Verbindungen
NZ582098A (en) 2007-06-25 2012-03-30 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
MX2010004759A (es) * 2007-11-02 2010-05-19 Novartis Ag Piperidinas 4,4-disustituidas como inhibidoras de renina.
SG175877A1 (en) * 2009-05-04 2011-12-29 Plexxikon Inc Compounds and methods for inhibition of renin, and indications therefor
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
EP2810644A1 (de) 2013-06-06 2014-12-10 Ferrer Internacional, S.A. Orale Formulierung zur Behandlung von Herz-Kreislauf-Erkrankungen
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR199800409T1 (xx) * 1995-09-07 1998-05-21 F.Hoffmann-La Roche Ag Kalp ve b�brek yetersizli�inin tedavii�in yeni 4-(oksialkoksifenil)-3-oksi-piperidinler

Also Published As

Publication number Publication date
CN1323079C (zh) 2007-06-27
JP2002543072A (ja) 2002-12-17
CZ20013737A3 (cs) 2002-04-17
CA2370244A1 (en) 2000-11-02
CA2370244C (en) 2007-03-27
PL362903A1 (en) 2004-11-02
AU4750100A (en) 2000-11-10
CO5170512A1 (es) 2002-06-27
TR200103067T2 (tr) 2002-05-21
AR018717A1 (es) 2001-11-28
BR0010076A (pt) 2002-01-15
JP3602449B2 (ja) 2004-12-15
MXPA01010855A (es) 2002-05-06
HUP0200881A3 (en) 2003-05-28
ES2286021T3 (es) 2007-12-01
US6197959B1 (en) 2001-03-06
ATE363478T1 (de) 2007-06-15
KR100476916B1 (ko) 2005-03-17
KR20020005017A (ko) 2002-01-16
HUP0200881A2 (en) 2002-08-28
EP1180103A1 (de) 2002-02-20
DE60035039T2 (de) 2008-02-07
SK15172001A3 (sk) 2002-06-04
CN1349524A (zh) 2002-05-15
ZA200108739B (en) 2003-01-23
WO2000064887A1 (en) 2000-11-02
EP1180103B1 (de) 2007-05-30
PE20010068A1 (es) 2001-01-29
AU761392B2 (en) 2003-06-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee