BR0010076A - Inibidores de renina - Google Patents

Inibidores de renina

Info

Publication number
BR0010076A
BR0010076A BR0010076-5A BR0010076A BR0010076A BR 0010076 A BR0010076 A BR 0010076A BR 0010076 A BR0010076 A BR 0010076A BR 0010076 A BR0010076 A BR 0010076A
Authority
BR
Brazil
Prior art keywords
compounds
renin inhibitors
failure
glaucoma
restenosis
Prior art date
Application number
BR0010076-5A
Other languages
English (en)
Inventor
Volker Breu
Daniel Bur
Hans-Peter Maerki
Eric Vieira
Wolfgang Wostl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0010076A publication Critical patent/BR0010076A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: "INIBIDORES DE RENINA". A presente invenção refere-se a compostos de fórmula (1): em que R^ 1^ e R^ 2^ são conforme definidos na descrição e nas reivindicações e sais farmaceuticamente aceitáveis dos mesmos. Os compostos são úteis para o tratamento de doenças as quais estão associadas à restenose, glaucoma, enfarte cardíaco, pressão sang³ínea elevada e danos a órgãos, por exemplo, insuficiência cardíaca e insuficiência renal.
BR0010076-5A 1999-04-27 2000-04-20 Inibidores de renina BR0010076A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99108200 1999-04-27
PCT/EP2000/003597 WO2000064887A1 (en) 1999-04-27 2000-04-20 Renin inhibitors

Publications (1)

Publication Number Publication Date
BR0010076A true BR0010076A (pt) 2002-01-15

Family

ID=8238051

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010076-5A BR0010076A (pt) 1999-04-27 2000-04-20 Inibidores de renina

Country Status (22)

Country Link
US (1) US6197959B1 (pt)
EP (1) EP1180103B1 (pt)
JP (1) JP3602449B2 (pt)
KR (1) KR100476916B1 (pt)
CN (1) CN1323079C (pt)
AR (1) AR018717A1 (pt)
AT (1) ATE363478T1 (pt)
AU (1) AU761392B2 (pt)
BR (1) BR0010076A (pt)
CA (1) CA2370244C (pt)
CO (1) CO5170512A1 (pt)
CZ (1) CZ20013737A3 (pt)
DE (1) DE60035039T2 (pt)
ES (1) ES2286021T3 (pt)
HU (1) HUP0200881A3 (pt)
MX (1) MXPA01010855A (pt)
PE (1) PE20010068A1 (pt)
PL (1) PL362903A1 (pt)
SK (1) SK15172001A3 (pt)
TR (1) TR200103067T2 (pt)
WO (1) WO2000064887A1 (pt)
ZA (1) ZA200108739B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040214832A1 (en) * 2003-04-10 2004-10-28 Cuiman Cai Piperazine derivative renin inhibitors
TW200900399A (en) * 2003-10-01 2009-01-01 Speedel Experimenta Ag Organic compounds
AR045950A1 (es) * 2003-10-09 2005-11-16 Speedel Experimenta Ag Compuestos derivados de piperazina, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos.
CN1906163A (zh) 2003-11-26 2007-01-31 诺瓦提斯公司 作为肾素抑制剂的4－苯基哌啶衍生物
AR053406A1 (es) * 2004-07-09 2007-05-09 Speedel Experimenta Ag Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas
PL1799199T3 (pl) 2004-10-08 2012-09-28 Novartis Ag Zastosowanie inhibitorów reniny do zapobiegania lub leczenia dysfunkcji rozkurczowej albo rozkurczowej niewydolności serca
GB0428526D0 (en) 2004-12-30 2005-02-09 Novartis Ag Organic compounds
GB0500784D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
CN101230060A (zh) * 2005-03-31 2008-07-30 斯皮德尔实验股份公司 取代的哌啶
EP1897879A3 (en) * 2005-03-31 2008-06-11 Speedel Experimenta AG 2,4,5-substituted piperidines as renin inhibitors
US20090270380A1 (en) * 2005-03-31 2009-10-29 Peter Herold 3,4,5-Substituted Piperidines as Renin Inhibitors
EP1707202A1 (de) * 2005-03-31 2006-10-04 Speedel Experimenta AG Organische Verbindungen
AR055756A1 (es) * 2005-03-31 2007-09-05 Speedel Experimenta Ag Piperidinas sustituidas; procesos de preparacion y su uso como medicamentos
GB0508992D0 (en) * 2005-05-03 2005-06-08 Novartis Ag Organic compounds
JP5306811B2 (ja) * 2005-05-11 2013-10-02 ライフ テクノロジーズ コーポレーション ２本鎖ｄｎａへの高い選択性を有する蛍光化学物質及びそれらの使用
CA2608212A1 (en) 2005-05-27 2006-12-07 Actelion Pharmaceuticals Ltd Novel piperidine carboxylic acid amide derivatives
GB0514203D0 (en) * 2005-07-11 2005-08-17 Novartis Ag Organic compounds
ES2430139T3 (es) * 2005-12-30 2013-11-19 Novartis Ag Compuestos de piperidina 3,5-sustituido como inhibidores de renina
TW200804359A (en) * 2006-01-19 2008-01-16 Speedel Experimenta Ag Substituted 4-phenylpiperidines
EP1908761A1 (en) * 2006-10-04 2008-04-09 Speedel Experimenta AG Organic compounds
KR101238479B1 (ko) 2007-06-25 2013-03-04 노파르티스 아게 레닌 억제제로 사용하기 위한 ｎ５-(２-에톡시에틸)-ｎ３-(２-피리디닐)-３,５-피페리딘디카르복스아미드 유도체
US20100267713A1 (en) * 2007-11-02 2010-10-21 Peter Herold 4,4-disubstituted piperidines
WO2010129467A1 (en) * 2009-05-04 2010-11-11 Plexxikon, Inc. Compounds and methods for inhibition of renin, and indications therefor
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
EP2810644A1 (en) 2013-06-06 2014-12-10 Ferrer Internacional, S.A. Oral formulation for the treatment of cardiovascular diseases
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0863875T3 (da) * 1995-09-07 2003-12-01 Hoffmann La Roche Hidtil ukendte 4-(oxyalkoxyphenyl)-3-oxy-piperiner til behandling af hjerte- og nyrelidelser

Also Published As

Publication number Publication date
HUP0200881A2 (en) 2002-08-28
DE60035039D1 (de) 2007-07-12
JP2002543072A (ja) 2002-12-17
WO2000064887A1 (en) 2000-11-02
HUP0200881A3 (en) 2003-05-28
DE60035039T2 (de) 2008-02-07
PL362903A1 (en) 2004-11-02
ES2286021T3 (es) 2007-12-01
CA2370244C (en) 2007-03-27
KR100476916B1 (ko) 2005-03-17
CZ20013737A3 (cs) 2002-04-17
AU4750100A (en) 2000-11-10
EP1180103B1 (en) 2007-05-30
KR20020005017A (ko) 2002-01-16
TR200103067T2 (tr) 2002-05-21
PE20010068A1 (es) 2001-01-29
AR018717A1 (es) 2001-11-28
ZA200108739B (en) 2003-01-23
JP3602449B2 (ja) 2004-12-15
ATE363478T1 (de) 2007-06-15
CN1349524A (zh) 2002-05-15
SK15172001A3 (sk) 2002-06-04
EP1180103A1 (en) 2002-02-20
CN1323079C (zh) 2007-06-27
US6197959B1 (en) 2001-03-06
CA2370244A1 (en) 2000-11-02
MXPA01010855A (es) 2002-05-06
AU761392B2 (en) 2003-06-05
CO5170512A1 (es) 2002-06-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 9A. ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009.